The effect of mesenchymal stem cells' secretome on lung cancer progression is contingent on their origin: primary or metastatic niche

Legrier, 2007, Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression, Cancer Res, 67, 11300, 10.1158/0008-5472.CAN-07-0702 Chen, 2014, Non-small-cell lung cancers: a heterogeneous set of diseases, Nat Rev Cancer, 14, 535, 10.1038/nrc3775 Balkwill, 2012, The tumor microenvironment at a glance, J Cell Sci, 125, 5591, 10.1242/jcs.116392 Quail, 2013, Microenvironmental regulation of tumor progression and metastasis, Nat Med, 19, 1423, 10.1038/nm.3394 Korkaya, 2013, Breast cancer stem cells: we've got them surrounded, Clin Cancer Res, 19, 511, 10.1158/1078-0432.CCR-12-3450 Serakinci N, Tulay P, Kalkan R. Role of mesenchymal stem cells in cancer development and their use in cancer therapy. Adv Exp Med Biol. Springer, Boston, MA 2017. Ullah, 2015, Human mesenchymal stem cells - current trends and future prospective, Bioscience Reports, 35, 1, 10.1042/BSR20150025 Yagi, 2013, The role of mesenchymal stem cells in cancer development, Front Genet, 4, 261, 10.3389/fgene.2013.00261 Steeg, 2016, Targeting metastasis, Nat Rev Cancer, 16, 201, 10.1038/nrc.2016.25 Yoneda, 2005, Crosstalk between cancer cells and bone microenvironment in bone metastasis, Biochem Biophys Res Commun, 328, 679, 10.1016/j.bbrc.2004.11.070 Attar-Schneider, 2016, Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation, Tumour Biol, 37, 4755, 10.1007/s13277-015-4304-3 Klaus, 2010, Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes, Stem Cells Dev, 19, 1043, 10.1089/scd.2009.0286 Gottschling, 2013, Mesenchymal stem cells in non-small cell lung cancer--different from others? Insights from comparative molecular and functional analyses, Lung Cancer, 80, 19, 10.1016/j.lungcan.2012.12.015 Attar-Schneider, 2016, Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI, Lab Investig, 96, 1004, 10.1038/labinvest.2016.77 Zismanov, 2009, Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling, Br J Cancer, 101, 1402, 10.1038/sj.bjc.6605291 Attar-Schneider, 2012, Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells, Lab Invest, 92, 178, 10.1038/labinvest.2011.162 Zismanov, 2013, ER homeostasis and motility of NSCLC cell lines can be therapeutically targeted with combined Hsp90 and HDAC inhibitors, Pulm Pharmacol Ther, 26, 388, 10.1016/j.pupt.2013.02.004 O'Hayre, 2008, Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment, Biochem J, 409, 635, 10.1042/BJ20071493 Jumper, 2004, Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment, Respir Med, 98, 173, 10.1016/j.rmed.2003.08.014 Leinonen, 2008, Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumour recurrence and unfavourable outcome in non-small cell lung cancer, Histol Histopathol, 23, 693 Deryugina, 2006, Matrix metalloproteinases and tumor metastasis, Cancer Metastasis Rev, 25, 9, 10.1007/s10555-006-7886-9 Dolfi, 2013, The metabolic demands of cancer cells are coupled to their size and protein synthesis rates, Cancer Metab, 1, 20, 10.1186/2049-3002-1-20 Zismanov, 2012, Tetraspanins stimulate protein synthesis in myeloma cell lines, J Cell Biochem, 113, 2500, 10.1002/jcb.24126 Thornton, 2003, Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis, J Mol Med, 81, 536, 10.1007/s00109-003-0461-8 Robert, 2009, Translation initiation: a critical signalling node in cancer, Expert Opin Ther Targets, 13, 1279, 10.1517/14728220903241625 Liu G, Pei F, Yang F, Li L, Amin AD, Liu S, et al. Role of autophagy and apoptosis in non-small-cell lung cancer. Int J Mol Sci. 2017;18. Lau, 2013, Fibroblast growth factor 2 induces E-cadherin down-regulation via PI3K/Akt/mTOR and MAPK/ERK signaling in ovarian cancer cells, PLoS ONE, 8, e59083, 10.1371/journal.pone.0059083 Shveygert, 2010, Regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction, Mol Cell Biol, 30, 5160, 10.1128/MCB.00448-10 Polakis, 1999, The oncogenic activation of beta-catenin, Curr Opin Genet Dev, 9, 15, 10.1016/S0959-437X(99)80003-3 Turner, 2006, Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes, J Biol Chem, 281, 21321, 10.1074/jbc.M509731200 Aigner, 2007, The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity, Oncogene, 26, 6979, 10.1038/sj.onc.1210508 Marcus, 2016, Mesenchymal stem cells secretomes' affect multiple myeloma translation initiation, Cell Signal, 28, 620, 10.1016/j.cellsig.2016.03.003 Dabbah, 2016, Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation, J Leukoc Biol, 100, 761, 10.1189/jlb.3A1115-510RR Dabbah, 2017, Microvesicles derived from normal and multiple myeloma bone marrow mesenchymal stem cells differentially modulate myeloma cells' phenotype and translation initiation, Carcinogenesis, 38, 708, 10.1093/carcin/bgx045 Attar-Schneider, 2016, Multiple myeloma and bone marrow mesenchymal stem cells' crosstalk: effect on translation initiation, Mol Carcinog, 55, 1343, 10.1002/mc.22378 Pukrop, 2010, Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way, Glia, 58, 1477, 10.1002/glia.21022 Raynaud, 2010, Expression of chemokine receptor CCR6 as a molecular determinant of adrenal metastatic relapse in patients with primary lung cancer, Clin Lung Cancer, 11, 187, 10.3816/CLC.2010.n.024 Tsai, 2013, Epithelial-mesenchymal plasticity in carcinoma metastasis, Genes Dev, 27, 2192, 10.1101/gad.225334.113 Campolo, 2013, Essential role of Sox2 for the establishment and maintenance of the germ cell line, Stem Cells, 31, 1408, 10.1002/stem.1392 Kawamoto, 2012, Radiation induces epithelial-mesenchymal transition in colorectal cancer cells, Oncol Rep, 27, 51 Shintani, 2011, Epithelial to mesenchymal transition is a determinant of sensitivity to chemoradiotherapy in non-small cell lung cancer, Ann Thorac Surg, 92, 1794, 10.1016/j.athoracsur.2011.07.032 Thomson, 2005, Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition, Cancer Res, 65, 9455, 10.1158/0008-5472.CAN-05-1058 Xie, 2012, Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells, J Cell Biochem, 113, 1501 Reagan, 2011, Concise review: mesenchymal stem cell tumor-homing: detection methods in disease model systems, Stem Cells, 29, 920, 10.1002/stem.645 D'Souza-Schorey, 2012, Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers, Genes Dev, 26, 1287, 10.1101/gad.192351.112 Zhang, 2015, Transfer of microRNAs by extracellular membrane microvesicles: a nascent crosstalk model in tumor pathogenesis, especially tumor cell-microenvironment interactions, J Hematol Oncol, 8, 14, 10.1186/s13045-015-0111-y Wysoczynski, 2009, Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors, Int J Cancer, 125, 1595, 10.1002/ijc.24479