The effect of interferon on the liver in chronic hepatitis C: a quantitative evaluation of histology by meta-analysis

Knodell, 1981, Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis, Hepatology, 1, 431, 10.1002/hep.1840010511 Scheuer, 1991, Classification of chronic viral hepatitis: a need reassessment, J Hepatol, 13, 372, 10.1016/0168-8278(91)90084-O Scheuer, 1992, The hepatology of hepatitis C, Hepatology, 15, 567, 10.1002/hep.1840150402 Ludiwig, 1993, The nomenclature of chronic active hepatitis: an obituary, Gastroenterology, 105, 274, 10.1016/0016-5085(93)90037-D Pagliaro, 1994, Interferon-α for chronic hepatitis C: an analysis of pretreatment clinical predictors of response, Hepatology, 19, 820 Ricahrd, 1995, Two-year biochemical, virological, and histological follow-up in patients with chronic hepatitis C responding in a sustained fashion to interferon alfa-2b treatment, Hepatology, 21, 918 Mattsson, 1988, Long-term follow-up of chronic post-transfusion non-A, non-B hepatitis: clinical and histological outcome, Liver, 8, 184, 10.1111/j.1600-0676.1988.tb00989.x Di Bisceglie, 1991, Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis, Hepatology, 14, 969, 10.1002/hep.1840140603 Wejstål, 1991, Long-term follow-up of chronic hepatitis non-A, non-B with special reference to hepatitis C, Liver, 11, 143, 10.1111/j.1600-0676.1991.tb00507.x Seeff, 1992, Long-term mortality after transfusion associated non-A, non-B hepatitis, N Engl J Med, 327, 1906, 10.1056/NEJM199212313272703 Tremolada, 1992, Long-term follow-up of non-A, non-B (type C) post-transfusion hepatitis, J Hepatol, 16, 273, 10.1016/S0168-8278(05)80657-9 Koretz, 1993, Non-A, non-B post-transfusion hepatitis. Looking back in the second decade, Ann Intern Med, 119, 110, 10.7326/0003-4819-119-2-199307150-00003 Mattsson, 1989, Chronic non-A, non-B hepatitis developed after transfusions, illicit self-injections or sporadically. Outcome during long-term follow-up — a comparison, Liver, 9, 120, 10.1111/j.1600-0676.1989.tb00388.x Camps, 1993, Randomized trial of lymphoblastoid α-interferon in chronic hepatitis C. Effects on inflammation, fibrogenesis and viremia, J Hepatol, 17, 390, 10.1016/S0168-8278(05)80223-5 Camps, 1994, Prediction of sustained remission of chronic hepatitis C after a 12-month course of alfa interferon, J Hepatol, 21, 4, 10.1016/S0168-8278(94)80129-0 Capra, 1993, α-Interferon in the treatment of chronic viral hepatitis: effects on fibrogenesis serum markers, J Hepatol, 18, 112, 10.1016/S0168-8278(05)80018-2 Castilla, 1993, Lymphoblastoid α-interferon for chronic hepatitis C: a randomized controlled study, Am J Gastroenterol, 88, 233 Causse, 1991, Comparison of 1 or 3 MU of interferon alfa-2b and placebo in patients with chronic non-A, non-B hepatitis, Gastroenterology, 101, 497, 10.1016/0016-5085(91)90030-O Craxi, 1996, Transfusion-associated chronic hepatitis C: alpha-n1 interferon for 6 vs. 12 months, J Hepatol, 24, 539, 10.1016/S0168-8278(96)80138-3 De Alava, 1993, Histological outcome of chronic hepatitis C treated with a 12-month course of lymphoblastoid alfa interferon, Liver, 13, 73, 10.1111/j.1600-0676.1993.tb00610.x Gallorini, 1994, Serum markers of hepatic fibrogenesis in chronic hepatitis type C treated with alfa-2a interferon, Liver, 14, 125, 10.1111/j.1600-0676.1994.tb00085.x Gomez-Rubio, 1990, Prolonged treatment (18 months) of chronic hepatitis C with recombinant α-interferon in comparison with a control group, J Hepatol, 11, S63, 10.1016/0168-8278(90)90166-O Kasahara, 1995, Ability of prolonged interferon treatment to suppress relapse after cessation of therapy in patients with chronic hepatitis C: a multicenter randomized controlled trial, Hepatology, 21, 297, 10.1002/hep.1840210205 Lin, 1995, Interferon alfa-2b for chronic hepatitis C: effects of dose increment and duration of treatment on response rates, J Hepatol, 23, 487, 10.1016/0168-8278(95)80052-2 Marcellin, 1991, Recombinant human α-interferon in patients with chronic non-A, non-B hepatitis: a multicenter randomized controlled trial from France, Hepatology, 13, 393, 10.1002/hep.1840130302 Mazzella, 1994, Treatment of chronic sporadic-type non-A, non-B hepatitis with lymphoblastoid interferon: gamma GT levels predictive for response, Dig Dis Sci, 39, 866, 10.1007/BF02087435 Omata, 1991, Randomized, double-blind, placebo-controlled trial of eight-week course of recombinant α-interferon for chronic non-A, non-B hepatitis, Dig Dis Sci, 36, 1217, 10.1007/BF01307512 Richen, 1993, Low-dose interferon in chronic hepatitis non-A/non-B: effects on quantitative liver function and structure in a randomized, controlled multicenter trial, Clin Invest, 71, 888 Rumi, 1995, Long-term titrated recombinant interferon-α2a in chronic hepatitis C: a randomized controlled trial, J Viral Hep, 2, 73, 10.1111/j.1365-2893.1995.tb00009.x Saez-Royuela, 1991, High doses of recombinant α-interferon or gamma-interferon for chronic hepatitis C: a randomized, controlled trial, Hepatology, 13, 327, 10.1002/hep.1840130220 Sieck, 1993, Histologically advanced chronic hepatitis C treated with recombinant alpha-interferon: a randomized placebo-controlled double-blind cross-over study, J Hepatol, 19, 418, 10.1016/S0168-8278(05)80552-5 Bresci, 1993, The use of recombinant interferon alfa-2b in elderly patients with anti-HCV-positive chronic active hepatitis, J Am Geriatr Soc, 41, 857, 10.1111/j.1532-5415.1993.tb06184.x Chemello, 1995, Randomized trial comparing three different regimens of alpha-2a interferon in chronic hepatitis C, Hepatology, 22, 700 Cimino, 1991, Treatment of chronic hepatitis C with recombiannt interferon alfa, Ital J Gastroenterol, 23, 399 David, 1992, Histologic changes in liver biopsy specimens produced by recombinant interferon α-2b therapy for chronic non-A, non-B viral hepatitis: a randomized controlled trial, Am J Clin Pathol, 98, 397, 10.1093/ajcp/98.4.397 Davis, 1989, Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized controlled trial, N Engl J Med, 321, 1501, 10.1056/NEJM198911303212203 Di Besceglie, 1989, Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial, N Engl J Med, 321, 1506, 10.1056/NEJM198911303212204 Diodati, 1994, Treatment of chronic hepatitis C with recombinant human interferon-α 2a: results of a randomized controlled clinical trial, Hepatology, 19, 1, 10.1002/hep.1840190102 Farrell, 1990, Interferon alfa-2b for chronic active hepatitis C: interim results of an Australian trial, J Hepatol, 11, S157, 10.1016/0168-8278(90)90187-V Nishiguchi, 1995, Randomized trial of effect of interferon-α on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis, Lancet, 346, 1051, 10.1016/S0140-6736(95)91739-X Pérez, 1993, Treatment of chronic hepatitis C with recombinant interferon alfa-2b for nine months, Gut, 34, S136, 10.1136/gut.34.2_Suppl.S136 Picciotto, 1993, Interferon therapy in chronic hepatitis C. Evaluation of a low dose maintenance schedule in responder patients, J Hepatol, 17, 359, 10.1016/S0168-8278(05)80218-1 Poynard, 1995, A comparison of three interferon alfa-2b regimens for the long-term treatment of chronic non-A, non-B hepatitis, N Engl J Med, 332, 1457, 10.1056/NEJM199506013322201 Realdi, 1990, Recombinant human interferon alfa-2a in community-acquired non-A, non-B chronic active hepatitis. Preliminary results of a randomized, controlled trial, J Hepatol, 11, S68, 10.1016/0168-8278(90)90167-P Saracco, 1990, A randomized controlled trial of interferon alfa-2b as therapy for chronic non-A, non-B hepatitis, J Hepatol, 11, S43, 10.1016/0168-8278(90)90162-K Schvarcz, 1991, Interferon alpha-2b treatment of chronic post-transfusion non-A non-B/C hepatitis: long-term outcome and effect of increase interferon doses in non-responders, Scand J Infect Dis, 23, 413, 10.3109/00365549109075088 Valla, 1994, Prevention of relapse in patients with chronic non-A, non-B/C hepatitis who respond to alpha-interferon. A controlled multicenter trial of low-dose maintenance therapy, J Hepatol, 21, 774, 10.1016/S0168-8278(94)80238-6 Varagona, 1990, A phase II study of interferon alfa-2b treatment of anti-HCV positive and negative chronic NANB hepatitis: interim analysis, J Hepatol, 11, S165, 10.1016/0168-8278(90)90195-W Angelini, 1995, Alpha-interferon treatment of chronic hepatitis C: a controlled, multicentre, prospective study, Digestion, 56, 199, 10.1159/000201243 Bjøro, 1995, Two dose regimes of recombinant interferon-alpha-2b in chronic hepatitis C virus infection, Scand J Gastroenterol, 30, 119, 10.3109/00365529509101617 Sacks, 1987, Meta-analyses of randomized controlled trial, N Engl J Med, 316, 450, 10.1056/NEJM198702193160806 Weiland, 1990, Therapy of chronic posttransfusion non-A, non-B hepatitis with interferon alfa-2b: Swedish experience, J Hepatol, 11, S57, 10.1016/0168-8278(90)90165-N Bonetti, 1990, Treatment of cryptogenic chronic liver diseases with recombinant alpha-2a interferon. Preliminary results of a randomized controlled clinical trial, Ann Ital Med Int, 5, 169 Giudici-Cipriani, 1991, Therapy of chronic non-A, non-B hepatitis with interferon alfa-2B. A controlled clinical study and long-term follow-up, Minerva Gastroenterol Dietol, 37, 85 Liaw, 1990, Randomized controlled trial of recombinant interferon alfa-2b in chronic NANB hepatitis: dose schedules and results, J Hepatol, 11, S160, 10.1016/0168-8278(90)90190-3 Farrell, 1991, Prediction of response to interferon in patients with chronic active hepatitis C, and evidence that this improves hepatic metabolic function, Gastroenterol Jpn, 26, 243, 10.1007/BF02779310 Makris, 1991, A randomized controlled trial of recombinant interferon-α in chronic hepatitis C in hemophiliacs, Blood, 78, 1672, 10.1182/blood.V78.7.1672.1672 Shindo, 1991, Decrease in serum hepatitis C viral RNA during alpha-interferon therapy for chronic hepatitis C, Ann Intern Med, 115, 700, 10.7326/0003-4819-115-9-700 Diodati, 1992, Interferon therapy of cryptogenic chronic active liver disease and its relationship to anti-HCV, Arch Virol, 299, 10.1007/978-3-7091-5633-9_67 Picciotto, 1993, Interferon therapy in chronic hepatitis C. Evaluation of a low-dose maintenance schedule in responder patients, J Hepatol, 17, 359, 10.1016/S0168-8278(05)80218-1 Iino, 1993, High dose interferon treatment in chronic hepatitis C, Gut, 34, S114, 10.1136/gut.34.2_Suppl.S114 Yatsuhashi, 1993, Short and long-term effects of interferon on serum markers of hepatitis C virus replication, J Gastroenterol Hep, 8, 1, 10.1111/j.1440-1746.1993.tb01167.x Solinas, 1993, Changes of serum 2′,5′-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C, Liver, 13, 253, 10.1111/j.1600-0676.1993.tb00640.x Kakumu, 1993, A pilot study of ribavirin and interferon beta for the treatment of chronic hepatitis C, Gastroenterology, 105, 507, 10.1016/0016-5085(93)90727-T Makris, 1993, Interferon alfa for chronic hepatitis C in haemophiliacs, Gut, 34, S121, 10.1136/gut.34.2_Suppl.S121 Zielinska, 1993, Treatment of six patients with chronic active HCV hepatitis, with low dose natural human interferon alpha administered orally, Arch Immunol Ther Exp Warsz, 41, 253 Davis, 1994, Assessing health-related quality of life in chronic hepatitis C using the Sickness Impact Profile, Clin Ther, 16, 334 Brillanti, 1994, A pilot study of combination therapy with ribavirin plus interferon alfa for interferon alfa-resistant chronic hepatitis C, Gastroenterology, 107, 812, 10.1016/0016-5085(94)90131-7 Watson, 1994, High-dose interferon alfa-2A for the treatment of chronic hepatitis C, Ann Pharmacother, 28, 341 Hopf, 1994, Current status of treatment for chronic viral hepatitis using recombinant interferon alpha, Dtsch Med Wochenschr, 119, 961, 10.1055/s-2008-1058787 Chayama, 1994, Anti-viral effect of lymphoblastoid interferon-alpha on hepatitis C virus in patients with chronic hepatitis type C, J Gastroenterol Hep, 9, 128, 10.1111/j.1440-1746.1994.tb01231.x Boucher, 1995, Interferon and ursodeoxycholic acid combined therapy in the treatment of chronic viral C hepatitis: result from controlled randomized trial in 80 patients, Hepatology, 21, 322 Angelico, 1995, Recombinant interferon-α and ursodeoxycholic acid versus interferon-α alone in the treatment of chronic hepatitis C: a randomized clinical trial with long-term follow-up, Am J Gastroenterol, 90, 263 Hopf, 1990, Long-term treatment of cryptogenic hepatitis C using recombinant interferon alpha, Z Gastroenterol, 28, 453 Jacyna, 1989, A controlled trial of interferon alfa (lymphoblastoid interferon) in chronic non-A non-B hepatitis., Br Med J, 298, 80, 10.1136/bmj.298.6666.80 Kakumu, 1990, Recombinant human-interferon therapy for chronic non-A, non-B hepatitis: second report, Am J Gastroenterol, 85, 655 Lin, 1991, Can the response to interferon treatment be predicted in patients with chronic active hepatitis C?, Aust NZ J Med, 21, 387, 10.1111/j.1445-5994.1991.tb04715.x Terranova, 1992, Treatment of chronic hepatitis C with recombinant interferon alpha 2b, J Chemother, 4, 297, 10.1080/1120009X.1992.11739181 Wejstål, 1992, Peripheral blood lymphocyte subset in patients with chronic hepatitis C — effect of interferon treatment, Liver, 12, 162, 10.1111/j.1600-0676.1992.tb01041.x Alberti, 1983, Treatment with interferon(s) of community-acquired chronic hepatitis and cirrhosis type C, J Hepatol, 17 1993, Benelux multicentre trial of alpha interferon treatment for chronic hepatitis C: standard v high dose treatment monitored by biochemical and virological markers (interim analysis), Gut, 34, S119, 10.1136/gut.34.2_Suppl.S119 Caporaso, 1993, Recombinant human interferon alfa-2a therapy of chronic hepatitis C with or without cirrhosis: comparison of 3 or 6 MU for 1 year, Ital J Gastroenterol, 25, 482 De Bac, 1993, Efficacy of different regimens of interferon alfa-2b treatment in chronic hepatitis C, Gut, 34, S135, 10.1136/gut.34.2_Suppl.S135 Douglas, 1993, Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C: comparison of alanine aminotransferase normalization versus loss of HCV RNA and anti-HCV IgM, Dig Dis Sci, 38, 601, 10.1007/BF01316787 Hagiwara, 1993, Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy, Gastroenterology, 104, 877, 10.1016/0016-5085(93)91025-D Iino, 1193, Treatment of chronic hepatitis C with hig-dose interferon a-2b: a multicenter study, Dig Dis Sci, 38, 612, 10.1007/BF01316789 Kagawa, 1993, A randomized controlled trial of weekly administration of lymphoblastoid interferon in patients with chronic hepatitis C, J Hepatol, 17, 91, 10.1016/S0168-8278(05)80527-6 Kleter, 1993, Detection of hepatitis C virus RNA in patients with chronic hepatitis C virus infections during and after therapy with alpha interferon, Antimicrob Agents Chemother, 37, 595, 10.1128/AAC.37.3.595 Metreau, 1993, Gut, S112, 10.1136/gut.34.2_Suppl.S112 Attili, 1994, Treatment of type C chronic active hepatitis with interferon-α-2a: treatment duration does not influence biochemical remission but does decrease the relapse rate, J Clin Gastroenterol, 19, 214, 10.1097/00004836-199410000-00009 Budillon, 1994, Long-term follow-up evaluation in HCV chronic hepatitis treated with alpha-2b interferon. A comparison of two protocols, Ital J Gastroenterol, 26, 16 Jouët, 1994, Comparative efficacy of interferon alfa in cirrhotic and noncirrhotic patients with non-A, non-B, C hepatitis, Gastroenterology, 106, 686, 10.1016/0016-5085(94)90703-X Matsumoto, 1994, Viral and host factors that contribute to efficacy of interferon-α2a therapy in patients with chronic hepatitis C, Dig Dis Sci, 39, 1273, 10.1007/BF02093793 Negro, 1994, Continuous versus intermittent therapy for chronic hepatitis C with recombinant interferon alfa-2a, Gastroenterology, 107, 479, 10.1016/0016-5085(94)90174-0 Saito, 1994, A randomized controlled trial of human lymphoblastoid interferon in patients with compensated type C cirrhosis, Am J Gastroenterol, 89, 681 Marcellin, 1995, Lack of benefit of escalating dosage of interferon alfa in patients with chronic hepatitis C, Gastroenterology, 109, 156, 10.1016/0016-5085(95)90281-3 Yokosuka, 1995, Efficacy of longterm interferon treatment in chronic liver disease evaluated by sensitive polymerase chain reaction assay for hepatitis C virus RNA, Gut, 37, 721, 10.1136/gut.37.5.721 Shadish, 1994, Combining estimates of effect size, 261 Fleiss, 1981 1988 1994, Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C, Hepatology, 20, 15, 10.1002/hep.1840200104