L. Kernoff1, B. L. Pimstone1, Jon Solomon1, J. F. Brock1
1Medical Research Council Clinical Nutrition Research Unit and Isotope Laboratory, Department of Medicine, University of Cape Town, Observatory, Cape Town, South Africa
Tóm tắt
Albumin synthesis and catabolism were respectively measured by McFarlane's (1963) sodium [14C]carbonate method and I-labelled albumin in hypophysectomized rats, both untreated and treated with growth hormone. Hypophysectomy resulted in a decrease in both albumin synthesis and catabolic rates. These changes as shown by pair-feeding experiments could not be ascribed to decreased food intake alone. Growth hormone was shown to partially restore both albumin synthesis and catabolic rates. It is proposed that growth hormone stimulates albumin synthesis and that its effect on albumin catabolism is secondary to changes in the mass of the intravascular albumin pool.
