The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents

Lashner, 1989, The effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis, Gastroenterology, 97, 255, 10.1016/0016-5085(89)90058-9 Benito, 1991, Nutritional factors in colorectal cancer risk: a case-control study in Majorca, Int. J. Cancer, 49, 161, 10.1002/ijc.2910490202 Giovannucci, 1995, Alcohol, low-methionine–low-folate diets, and risk of colon cancer in men, J. Natl. Cancer Inst., 87, 265, 10.1093/jnci/87.4.265 Giovannucci, 1998, Multivitamin use, folate and colon cancer in women in the Nurses' Health Study, Ann. Int. Med., 129, 517, 10.7326/0003-4819-129-7-199810010-00002 Kim, 1996, Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats, Gut, 39, 732, 10.1136/gut.39.5.732 Cravo, 1992, Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats, Cancer Res., 52, 5002 Glynn, 1994, Folate and cancer: a review of the literature, Nutr. Cancer, 22, 101, 10.1080/01635589409514336 Mason, 1996, Folate: effects on carcinogenesis and the potential for cancer prevention, Oncology, 10, 1727 Koury, 1997, Folate deficiency delays the onset but increases the incidence of leukemia in Friend Virus-infected mice, Blood, 90, 4054, 10.1182/blood.V90.10.4054 Hoffbrand, 1976, Megaloblastic anaemia. Initiation of DNA synthesis in excess of DNA chain elongation as the underlying mechanism, Clin. Haematol., 5, 727, 10.1016/S0308-2261(21)00117-X Wickremasinghe, 1980, Reduced rate of DNA replication fork movement in megaloblastic anemia, J. Clin. Invest., 65, 26, 10.1172/JCI109656 Michel, 1997, DNA double-strand breaks caused by replication arrest, EMBO J., 16, 430, 10.1093/emboj/16.2.430 Bierne, 1997, Deletions at stalled replication forks occur by two different pathways, EMBO J., 16, 3332, 10.1093/emboj/16.11.3332 Wickramsinghe, 1993, Misincorporation of uracil into the DNA of folate- and B12-deficient HL60 cells, Eur. J. Haematol., 50, 127, 10.1111/j.1600-0609.1993.tb00080.x Blount, 1997, Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage, Proc. Natl. Acad. Sci. U.S.A., 94, 3290, 10.1073/pnas.94.7.3290 Duthie, 1997, Uracil misincorporation in human DNA detected using single cell gel electrophoresis, Carcinogenesis, 18, 1709, 10.1093/carcin/18.9.1709 Dianov, 1991, Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation, Mol. Gen. Genet., 225, 448, 10.1007/BF00261686 James, 1994, In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells, Cancer Res., 54, 5075 S.J. James, L. Yin, Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats, Carcinogenesis (1989) 1209–1214. Kunz, 1994, Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability, Mutat. Res., 318, 1, 10.1016/0165-1110(94)90006-X Branda, 1993, Folate deficiency increases genetic damage caused by alkylating agents and γ-irradiation in Chinese hamster ovary cells, Cancer Res., 53, 5401 Borchers, 1990, Inhibition of DNA excision repair by methotrexate in Chinese hamster ovary cells following exposure to ultraviolet irradiation or ethylmethanesulfonate, Cancer Res., 50, 1786 Choi, 1998, Folate depletion impairs DNA excision repair in the colon of the rat, Gut, 43, 93, 10.1136/gut.43.1.93 Pogribny, 1997, Alterations in hepatic p53 gene methylation patterns during tumor progression in folate/methyl deficiency in the rat, Cancer Lett., 115, 31, 10.1016/S0304-3835(97)04708-3 Kim, 1997, Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene, Am. J. Clin. Nutr., 65, 46, 10.1093/ajcn/65.1.46 Hansen, 1988, Demethylation of specific sites in the 5′ region of the inactive X-linked human phosphoroglycerate kinase gene correlates with the appearance of nuclease sensitivity and gene expression, Mol. Cell Biol., 8, 4692, 10.1128/MCB.8.11.4692 Leteurtre, 1994, Effects of DNA methylation on topoisomerase I and II cleavage activities, J. Biol. Chem., 269, 7893, 10.1016/S0021-9258(17)37135-1 R.F. Branda, Effects of folic acid deficiency on tumor cell biology, in: M.M. Jacobs (Ed.), Vitamins and Minerals in the Prevention and Treatment of Cancer, CRC Press, Boca Raton, FL, 1991, pp. 136–160. Everson, 1988, Association of marginal folate depletion with increased human chromosomal damage in vivo: demonstration by analysis of micronucleated erythrocytes, J. Natl. Cancer Inst., 80, 525, 10.1093/jnci/80.7.525 Branda, 1998, Nutritional folate deficiency augments the in vivo mutagenic and lymphocytotoxic activities of alkylating agents, Environ. Mol. Mutagen., 32, 33, 10.1002/(SICI)1098-2280(1998)32:1<33::AID-EM4>3.0.CO;2-C Branda, 1997, Effect of folate deficiency on mutations at the hprt locus in Chinese hamster ovary cells exposed to monofunctional alkylating agents, Cancer Res., 57, 2586 Xu, 1993, Multiplex DNA amplification and solid-phase direct sequencing for mutation analysis at the hprt locus in Chinese hamster cells, Mutat. Res., 288, 237, 10.1016/0027-5107(93)90090-3 Cariello, 1993, Analysis of mutations occurring at the human hprt locus, J. Mol. Biol., 231, 41, 10.1006/jmbi.1993.1255 Beranek, 1990, Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents, Mutat. Res., 231, 11, 10.1016/0027-5107(90)90173-2 Vogel, 1994, The subtlety of alkylating agents in reactions with biological macromolecules, Mutat. Res., 305, 13, 10.1016/0027-5107(94)90123-6 Laval, 1981, Release of 7-methylguanine residues from alkylated DNA by extracts of Micrococcus luteus and Escherichia coli, Proc. Natl. Acad. Sci. U.S.A., 78, 852, 10.1073/pnas.78.2.852 Singer, 1981, Human lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladenines, Proc. Natl. Acad. Sci. U.S.A., 78, 856, 10.1073/pnas.78.2.856 Margison, 1981, Enzymatic release of 7-methyl-guanine from methylated DNA by rodent liver extracts, Proc. Natl. Acad. Sci. U.S.A., 78, 861, 10.1073/pnas.78.2.861 Swan, 1990, Why do O6-alkylguanine and O4-alkylthymine miscode? The relationship between the structure of DNA containing O6-alkylguanine and O4-alkylthymine and the mutagenic properties of these bases, Mutat. Res., 233, 81, 10.1016/0027-5107(90)90153-U Goth-Goldstein, 1980, Inability of Chinese hamster ovary cells to excise O6-alkylguanine, Cancer Res., 40, 2623 Kaina, 1991, Transfection and expression of human O6-methylguanine–DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents, Carcinogenesis, 12, 1857, 10.1093/carcin/12.10.1857 Op het Veld, 1997, Effect of nucleotide excision repair on hprt gene mutations in rodent cells exposed to DNA ethylating agents, Mutagenesis, 12, 417, 10.1093/mutage/12.6.417 Maher, 1990, Alkylation damage, DNA repair and mutagenesis in human cells, Mutat. Res., 233, 235, 10.1016/0027-5107(90)90166-2 Op het Veld, 1994, Molecular analysis of ethyl methanesulfonate-induced mutations at the hprt gene in the ethyl methanesulfonate-sensitive Chinese hamster cell line EM-C11 and its parental line CHO9, Cancer Res., 54, 3001 A. Sitaram, G. Plitas, W. Wang, D.A. Scicchitano, Functional nucleotide excision repair is required for the preferential removal of N-ethylpurines from the transcribed strand of the dihydrofolate reductase gene of Chinese hamster ovary cells, Mol. Cell. Biol. (1997) 564–570. Jansen, 1995, Marked differences in the role of O6-alkylguanine in hprt mutagenesis in T-lymphocytes of rats exposed in vivo to ethylmethanesulfonate, N-(2-hydroxyethyl)-N-nitrososurea, or N-ethyl-N-nitrosourea, Cancer Res., 55, 1875 Op het Veld, 1998, Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11, Mutat. Res., 398, 83, 10.1016/S0027-5107(97)00243-1 Sakumi, 1990, Structures and functions of DNA glycosylases, Mutat. Res., 236, 161, 10.1016/0921-8777(90)90003-N Shibuya, 1993, A review of the genotoxicity of 1-ethyl-1-nitrosurea, Mutat. Res., 297, 3, 10.1016/0165-1110(93)90005-8 Yang, 1994, Comparison of mutation spectra induced by N-ethyl-N-nitrosurea in the hprt gene of Mer+ and Mer− diploid human fibroblasts, Carcinogenesis, 15, 939, 10.1093/carcin/15.5.939 Jansen, 1994, Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea, Cancer Res., 54, 2478 Mittelstaedt, 1995, Analysis of in vivo mutation induced by N-ethyl-N-nitrosourea in the hprt gene of rat lymphocytes, Environ. Mol. Mutagen., 26, 261, 10.1002/em.2850260402 Harbach, 1999, DNA sequence analysis of hprt mutants persisting in peripheral blood of cynomolgus monkeys more than two years after ENU treatment, Environ. Mol. Mutagen., 33, 42, 10.1002/(SICI)1098-2280(1999)33:1<42::AID-EM5>3.0.CO;2-P Schmutte, 1998, Involvement of DNA methylation in human carcinogenesis, Biol. Chem., 379, 377 Shen, 1992, High-frequency mutagenesis by a DNA methyltransferase, Cell, 71, 1073, 10.1016/S0092-8674(05)80057-1 Singer, 1986, O-Alkyl pyrimidines in mutagenesis and carcinogenesis: occurrence and significance, Cancer Res., 46, 4879