The effect of different Burkholderia pseudomallei isolates of varying levels of virulence on toll-like-receptor expression

Jones, 1996, Intracellular survival of Burkholderia pseudomallei, Infect Immun, 64, 782, 10.1128/IAI.64.3.782-790.1996 Stevens, 2002, An Inv/Mxi-Spa-like type III protein secretion system in Burkholderia pseudomallei modulates intracellular behaviour of the pathogen, Mol Microbiol, 46, 649, 10.1046/j.1365-2958.2002.03190.x Puthucheary, 2006, Comparison by electron microscopy of intracellular events and survival of Burkholderia pseudomallei in monocytes from normal subjects and patients with melioidosis, Singapore Med J, 47, 697 Medzhitov, 1997, A human homologue of the Drosophila Toll protein signals activation of adaptive immunity, Nature, 388, 394, 10.1038/41131 O'Neill, 2006, How Toll-like receptors signal: what we know and what we don't know, Curr Opin Immunol, 18, 3, 10.1016/j.coi.2005.11.012 Brightbill, 1999, Host defense mechanisms triggered by microbial lipoproteins through Toll-Like receptors, Science, 285, 732, 10.1126/science.285.5428.732 Hirschfeld, 2001, Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages, Infect Immun, 69, 1477, 10.1128/IAI.69.3.1477-1482.2001 Akamine, 2005, Differential roles of Toll-Like Receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila, Infect Immun, 73, 352, 10.1128/IAI.73.1.352-361.2005 Poltorak, 1998, Defective LPS signalling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene, Science, 282, 2085, 10.1126/science.282.5396.2085 Takeuchi, 1999, Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components, Immunity, 11, 443, 10.1016/S1074-7613(00)80119-3 Hayashi, 2001, The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5, Nature, 410, 1099, 10.1038/35074106 Hemmi, 2000, A Toll-like receptor recognizes bacterial DNA, Nature, 408, 740, 10.1038/35047123 Ulett, 2001, Burkholderia pseudomallei virulence: definition, stability and association with clonality, Microbes Infect, 3, 1, 10.1016/S1286-4579(01)01417-4 Green, 1982, Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids, Anal Biochem, 126, 131, 10.1016/0003-2697(82)90118-X Utaisincharoen, 2001, Burkholderia pseudomallei interferes with inducible nitric oxide synthase (iNOS) production: a possible mechanism of evading macrophage killing, Microbiol Immunol, 45, 307, 10.1111/j.1348-0421.2001.tb02623.x Wiersinga, 2007, Toll-like receptor 2 impairs host defense in Gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis), PLoS Med, 4, 1268, 10.1371/journal.pmed.0040248 Brett, 2007, Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes, Mol Microbiol, 63, 379, 10.1111/j.1365-2958.2006.05519.x Kawahara, 1992, Extraction and characterization of lipopolysaccharide from Pseudomonas pseudomallei., FEMS Microbiol Lett, 96, 129, 10.1111/j.1574-6968.1992.tb05405.x Smith, 2003, Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility, Nat Immunol, 4, 1247, 10.1038/ni1011 Chua, 2003, Flagella are virulence determinants of Burkholderia pseudomallei, Infect Immun, 71, 1622, 10.1128/IAI.71.4.1622-1629.2003 DeShazer, 1997, Mutagenesis of Burkholderia pseudomallei with Tn5-OT182: isolation of motility mutants and molecular characterisation of the flagellin structural gene, J Bacteriol, 179, 2116, 10.1128/jb.179.7.2116-2125.1997 Hii, 2008, Interleukin-8 induction by Burkholderia pseudomallei can occur without Toll-like receptor signaling but requires a functional type III secretion system, J Infect Dis, 197, 1537, 10.1086/587905 Latz, 2004, TLR9 signals after translocating from the ER to CpGDNA in the lysosome, Nat Immunol, 5, 190, 10.1038/ni1028 Breitbach, 2006, Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice, Infect Immun, 74, 6300, 10.1128/IAI.00966-06