The effect of age and calorie restriction on HIF-1-responsive genes in aged liver

Biogerontology - Tập 6 - Trang 27-37 - 2005
Min Ju Kang1, Hyon Jeen Kim1, Hyung Keun Kim2, Ji Young Lee2, Dae Hyun Kim1, Kyung Jin Jung1, Kyu Won Kim3, Hyung Suck Baik2, Mie Ae Yoo2, Byung Pal Yu4, Hae Young Chung1,2
1College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Korea
2Genetic Engineering Research Institute, Pusan National University, Busan, Korea
3Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea
4Department of Physiology, The University of Texas Health Science Center, San Antonio, USA

Tóm tắt

Hypoxia inducible factor-1 (HIF-1) regulates transactivation of several genes in response to hypoxia condition. We explore hepatic HIF-1 responsive gene regulation during aging and the age-related changes of the HIF-1 related gene activation in young and old rats. Results indicate that the aging process induces the activation of HIF-1α, which is accompanied by increased HIF-1 DNA binding. This increased binding activity is accompanied by the increase of HIF-1-dependent genes, heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), erythropoietin (EPO), and inducible nitric oxide synthase (iNOS), which all showed remarkable up-regulation during aging process. In contrast, the increased HIF-1 related gene expression was effectively blunted by the anti-oxidative action of calorie restriction in aged rat liver. We propose that age-related HIF-1 binding activity may well be influenced by the increased pro-oxidative conditions of aged animals, which up-regulate HIF-1-dependent gene expression.

Tài liệu tham khảo

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Biogerontology

Tập 6

27-37

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