The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women

Borriello, 1985, Production and metabolism of lignans by the human faecal flora, J Appl Bacteriol, 58, 37, 10.1111/j.1365-2672.1985.tb01427.x Martin, 1996, Interactions between phytoestrogens and human sex steroid binding protein, Life Sci, 58, 429, 10.1016/0024-3205(95)02308-9 Vanharanta, 1999, Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study, Lancet, 354, 2112, 10.1016/S0140-6736(99)05031-X Van der Schouw, 2002, Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women, Arterioscler Thromb Vasc Biol, 22, 1316, 10.1161/01.ATV.0000027176.83618.1A Van der Schouw, 2005, Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women, Circulation, 111, 465, 10.1161/01.CIR.0000153814.87631.B0 Vanharanta, 2003, Risk of cardiovascular disease-related and all-cause death according to serum concentrations of enterolactone: Kuopio Ischaemic Heart Disease Risk Factor Study, Arch Intern Med, 163, 1099, 10.1001/archinte.163.9.1099 Hallund, 2006, A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women, J Nutr, 136, 112, 10.1093/jn/136.1.112 Hallund, 2006, Daily consumption for six weeks of a lignan complex isolated from flaxseed does not affect endothelial function in healthy postmenopausal women, J Nutr, 136, 2314, 10.1093/jn/136.9.2314 Cunnane, 1995, Nutritional attributes of traditional flaxseed in healthy young adults, Am J Clin Nutr, 61, 62, 10.1093/ajcn/61.1.62 Arjmandi, 1998, Whole flaxseed consumption lowers serum LDL-cholesterol and lipoprotein(a) concentrations in postmenopausal women, Nutr Res, 18, 1203, 10.1016/S0271-5317(98)00100-6 Jenkins, 1999, Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial, Am J Clin Nutr, 69, 395, 10.1093/ajcn/69.3.395 Prasad, 1999, Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed, Circulation, 99, 1355, 10.1161/01.CIR.99.10.1355 Prasad, 2005, Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed, Atherosclerosis, 179, 269, 10.1016/j.atherosclerosis.2004.11.012 Ross, 1999, Atherosclerosis—an inflammatory disease, N Engl J Med, 340, 115, 10.1056/NEJM199901143400207 Ridker, 2002, Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events, N Engl J Med, 347, 1557, 10.1056/NEJMoa021993 Weinhold, 1997, Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene, Biochem J, 327, 425, 10.1042/bj3270425 Weinhold, 1997, Interleukin-6 is necessary, but not sufficient, for induction of the human C-reactive protein gene in vivo, Biochem J, 325, 617, 10.1042/bj3250617 Calabro, 2003, Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells, Circulation, 108, 1930, 10.1161/01.CIR.0000096055.62724.C5 Kobayashi, 2003, Interaction of oxidative stress and inflammatory response in coronary plaque instability: important role of C-reactive protein, Arterioscler Thromb Vasc Biol, 23, 1398, 10.1161/01.ATV.0000081637.36475.BC Pasceri, 2000, Direct proinflammatory effect of C-reactive protein on human endothelial cells, Circulation, 102, 2165, 10.1161/01.CIR.102.18.2165 Pasceri, 2001, Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs, Circulation, 103, 2531, 10.1161/01.CIR.103.21.2531 Libby, 2002, Inflammation in atherosclerosis, Nature, 420, 868, 10.1038/nature01323 Pradhan, 2002, Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study, JAMA, 288, 980, 10.1001/jama.288.8.980 Hall, 2005, Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equal production, Am J Clin Nutr, 82, 1260, 10.1093/ajcn/82.6.1260 Nikander, 2003, Evidence of a lack of effect of a phytoestrogen regimen on the levels of C-reactive protein, E-selectin, and nitrate in postmenopausal women, J Clin Endocrinol Metab, 88, 5180, 10.1210/jc.2003-030362 Teede, 2003, Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women, Arterioscler Thromb Vasc Biol, 23, 1066, 10.1161/01.ATV.0000072967.97296.4A Steinberg, 2003, Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women, Am J Clin Nutr, 78, 123, 10.1093/ajcn/78.1.123 Blum, 2003, Effects of oral soy protein on markers of inflammation in postmenopausal women with mild hypercholesterolemia, Am Heart J, 145, e7, 10.1067/mhj.2003.115 Kitts, 1999, Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone, Mol Cell Biochem, 202, 91, 10.1023/A:1007022329660 Niemeyer, 2003, Differences in the antioxidant activity of plant and mammalian lignans, J Food Eng, 56, 255, 10.1016/S0260-8774(02)00263-7