The drying rates of spray freeze drying systems increase through the use of stratified packed bed structures

International Journal of Heat and Mass Transfer - Tập 90 - Trang 515-522 - 2015
R. Bruttini1, A.I. Liapis2
1Criofarma-Freeze Drying Equipment, Strada del Francese 97/2L, 10156 Turin, Italy
2Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 100 Bertelsmeyer Hall, 1101 North State Street, Rolla, MO 65409-1230, USA

Tài liệu tham khảo

Schiffter, 2007, Spray-freeze-drying in the manufacture of pharmaceuticals, Eur. Pharm. Rev., 12, 67 Liapis, 2009, A mathematical model for the spray freeze drying process: the drying of frozen particles in trays and in vials on trays, Int. J. Heat Mass Transfer, 52, 100, 10.1016/j.ijheatmasstransfer.2008.06.026 A.I. Liapis, R. Bruttini, Fundamentals of modeling and analysis of spray freeze drying: The drying of frozen pharmaceutical and food particles in packed beds, in: Proceedings of the 17th International Drying Symposium (IDS 2010, October 3–6, 2010, Magdeburg, Germany), volume A (2010) 71–80. Song, 2009, Experiment and numerical simulation of heat and mass transfer during a spray freeze-drying process of ovalbumin in a tray, Heat Mass Transfer, 46, 39, 10.1007/s00231-009-0542-5 Her, 2010, Preparation of kanamycin powder by an optimized spray freeze-drying method, Powder Technol., 199, 159, 10.1016/j.powtec.2009.12.018 Schiffter, 2010, Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery, J. R. Soc. Interface, 7, S483, 10.1098/rsif.2010.0114.focus Kasper, 2013, Recent advances and further challenges in lyophilization, Eur. J. Pharm. Biopharm., 85, 162, 10.1016/j.ejpb.2013.05.019 Gan, 2005, Freeze-drying of pharmaceuticals in vials on trays: effects of drying chamber wall temperature and tray side on lyophilization performance, Int. J. Heat Mass Transfer, 48, 1675, 10.1016/j.ijheatmasstransfer.2004.12.004 Campanone, 2005, Food freezing with simultaneous surface dehydration: approximate prediction of freezing time, Int. J. Heat Mass Transfer, 48, 1205, 10.1016/j.ijheatmasstransfer.2004.09.030 Kaviany, 1999 Fey, 1987, An analytical study of the effect of the Darcy and Ficks laws on the sublimation of a frozen porous medium, ASME J. Heat Transfer, 109, 1045, 10.1115/1.3248181 Meyers, 1999, Network modeling of the convective flow and diffusion of molecules adsorbing in monoliths and in porous particles packed in a chromatographic column, J. Chromatogr. A, 852, 3, 10.1016/S0021-9673(99)00443-4 Bird, 2002 Li, 2012, Adsorption in a stratified column bed packed with porous particles having partially fractal structures and a distribution of particle diameters, J. Sep. Sci., 35, 947, 10.1002/jssc.201101030 Li, 2013, Adsorption in columns packed with porous adsorbent particles having partially fractal structures, J. Sep. Sci., 36, 1913, 10.1002/jssc.201300126 Froment, 2011 A.I. Liapis, R. Bruttini, Freeze Drying, Handbook of Industrial Drying (fourth ed.), A.S. Mujumdar (Ed.), CRC Press, Boca Raton, Florida, USA, 2014, pp. 259–282. Rolland, 2005, Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials, J. Am. Chem. Soc., 127, 10096, 10.1021/ja051977c Chow, 2007, Particle engineering for pulmonary delivery, Pharm. Res., 24, 411, 10.1007/s11095-006-9174-3 Sheehan, 1998, Modeling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials: numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies, Biotechnol. Bioeng., 60, 712, 10.1002/(SICI)1097-0290(19981220)60:6<712::AID-BIT8>3.0.CO;2-4 Song, 2002, A finite volume analysis of vacuum freeze drying process of skim milk solution in trays and vials, Drying Technol., 20, 283, 10.1081/DRT-120002543 Geankoplis, 2003 Swirska-Perkowska, 2011, Estimation of moisture superficial diffusivity in porous materials, Int. J. Heat Mass Transfer, 54, 692, 10.1016/j.ijheatmasstransfer.2010.09.001 Sadikoglu, 1998, Optimal control of the primary and secondary drying stages of bulk solution freeze drying in trays, Drying Technol., 16, 399, 10.1080/07373939808917417 Liapis, 1993, Affinity adsorption separations in high performance liquid chromatography and perfusion chromatography systems: the effects of pore-size distribution and fractal pores on column performance, Math. Model. Sci. Comput., 1, 397