The discovery of 9-cis retinoic acid a hormone that binds the retinoid-X receptor

Allenby, 1993, Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids, 90, 30 Allenby, 1994, Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors α, β and γ: retinoic acid receptor γ binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid, J Biol Chem, 269, 16,689, 10.1016/S0021-9258(19)89445-0 Ben-Amotz, 1988, The β-carotene-rich alga Dunaliella bardawil as a source of retinol in a rat diet, Br J Nutr, 59, 443, 10.1079/BJN19880053 Ben-Amotz, 1989, Bioavailability of a natural isomer mixture as compared with synthetic all-trans-β-carotene in rats and chicks, J Nutr, 119, 1013, 10.1093/jn/119.7.1013 Brand, 1988, Identification of a second human retinoic acid receptor, Nature, 332, 850, 10.1038/332850a0 Carlberg, 1993, Two nuclear signalling pathways for vitamin D, Nature, 361, 657, 10.1038/361657a0 CreechKraft, 1993, 9-cis-Retinoic acid: a direct-acting dysmorphogen, Biochem Pharmacol, 46, 709, 10.1016/0006-2952(93)90558-E Evans, 1988, The steroid and thyroid hormone receptor superfamily., Science, 240, 889, 10.1126/science.3283939 Fiorella, 1993, Expression of cellular retinoic acid-binding protein (type II) in Escherichia-coli characterization and comparison to cellular retinoic acid binding protein (type I), J Biol Chem, 268, 21,545, 10.1016/S0021-9258(20)80576-6 Gearing, 1993, Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor, 90, 1440 Giguere, 1987, Identification of a receptor for the morphogen retinoic acid, Nature, 330, 624, 10.1038/330624a0 Green, 1988, Nuclear receptors enhance our understanding of transcription regulation, Trends Genet, 4, 309, 10.1016/0168-9525(88)90108-4 Hallenbeck, 1993, Divergent effects of 9-cis-retinoic acid receptor on positive and negative thyroid hormone receptor-dependent gene expression, J Biol Chem, 268, 3825, 10.1016/S0021-9258(18)53546-8 Hamada, 1989, H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element, 86, 8289 Heyman, 1992, 9-cis Retinoic acid is a high affinity ligand for the retinoid X receptor, Cell, 68, 397, 10.1016/0092-8674(92)90479-V Keller, 1993, Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers, 90, 2160 Kliewer, 1992, Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling, Nature, 355, 446, 10.1038/355446a0 Kliewer, 1992, Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors, Nature, 358, 771, 10.1038/358771a0 Krust, 1989, A third human retinoic acid receptor, hRAR-γ, 86, 5310 Lehmann, 1992, Retinoids selective for retinoid X receptor response pathways, Science, 258, 1944, 10.1126/science.1335166 Lehmann, 1993, Formation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching, Mol Cell Biol, 13, 7698, 10.1128/MCB.13.12.7698 Leid, 1992, Purification, cloning and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently, Cell, 68, 377, 10.1016/0092-8674(92)90478-U Leid, 1992, Multiplicity generates diversity in the retinoic acid signalling pathways, Trends Biochem Sci, 17, 427, 10.1016/0968-0004(92)90014-Z Levin, 1992, 9-cis Retinoic acid stereoisomer binds and activates the nuclear receptor RXRα, Nature, 355, 359, 10.1038/355359a0 Levin, 1992, A new pathway for vitamin A: understanding the pleiotropic effects of retinoids, Ann NY Acad Sci, 669, 70, 10.1111/j.1749-6632.1992.tb17090.x Linney, 1992, Retinoic acid receptors: transcription factors modulating gene regulation, development, and differentiation, Curr Top Dev Biol, 27, 309, 10.1016/S0070-2153(08)60538-4 MacDonald, 1993, Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene, Mol Cell Biol, 13, 5907, 10.1128/MCB.13.9.5907 Mangelsdorf, 1990, Nuclear receptor that identifies a novel retinoic acid response pathway, Nature, 345, 224, 10.1038/345224a0 Mangelsdorf, 1991, A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR, Cell, 66, 555, 10.1016/0092-8674(81)90018-0 Mangelsdorf, 1992, Characterization of three RXR genes that mediate the action of 9-cis retinoic acid, Genes Dev, 6, 329, 10.1101/gad.6.3.329 Marks, 1992, H-2-RIIBP (RXRβ) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes, EMBO J, 11, 1419, 10.1002/j.1460-2075.1992.tb05187.x 1992 Motto, 1989, Separation and identification of retinoic acid photoisomers, J Chromatogr, 481, 255, 10.1016/S0021-9673(01)96769-X Newcomer, 1993, Structure of the epididymal retinoic acid binding protein at 2.1 Å resolution, Structure, 1, 7, 10.1016/0969-2126(93)90004-Z Newcomer, 1993, X-ray crystallographic identification of a protein-binding site for both all-trans- and 9-cis-retinoic acid, 90, 9223 Pappas, 1993, Endogenous retinoids in rat epididymal tissue and rat and human spermatozoa, Biol Reprod, 48, 235, 10.1095/biolreprod48.2.235 Petkovich, 1992, Regulation of gene expression by vitamin A: the role of nuclear retinoic acid receptors, Annu Rev Nutr, 12, 443, 10.1146/annurev.nu.12.070192.002303 Petkovich, 1987, A human retinoic acid receptor which belongs to the family of nuclear receptors, Nature, 330, 444, 10.1038/330444a0 Rando, 1991, Membrane phospholipids and the dark side of vision, J Bioenerg Biomembr, 23, 133 Redfern, 1993, Ligand binding properties of human cellular retinoic acid binding protein II expressed in E. coli as a glutathione-S-transferase fusion protein, FEBS Lett, 321, 163, 10.1016/0014-5793(93)80100-9 Repa, 1993, All-trans-retinol is a ligand for the retinoic acid receptors, 90, 7293 Rosen, 1992, Ligand-dependent synergy of thyroid hormone and retinoid X receptors, J Biol Chem, 267, 22,010, 10.1016/S0021-9258(18)41627-4 Ross, 1993, Overview of retinoid metabolism, J Nutr, 123, 346, 10.1093/jn/123.suppl_2.346 Sakashita, 1993, 9-cis-Retinoic acid: effects on normal and leukemic hematopoiesis in vitro, Blood, 81, 1009, 10.1182/blood.V81.4.1009.1009 1994 Stahl, 1992, cis-trans isomers of lycopene and β-carotene in human serum and tissues, Arch Biochem Biophys, 294, 173, 10.1016/0003-9861(92)90153-N Tate, 1994, Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of the RARα, Mol Cell Biol, 14, 2323, 10.1128/MCB.14.4.2323 Thaller, 1993, 9-cis-Retinoic acid, a potent inducer of digit pattern duplications in the chick wing bud, Development, 118, 957, 10.1242/dev.118.3.957 Yang, 1993, 9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development, 90, 6170 Yu, 1991, RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements, Cell, 67, 1251, 10.1016/0092-8674(91)90301-E Zhang, 1993, Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors, Trends Endocrinol Metab, 4, 156, 10.1016/1043-2760(93)90105-N Zhang, 1992, Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors, Nature, 355, 441, 10.1038/355441a0 Zhang, 1992, Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid, Nature, 358, 587, 10.1038/358587a0