Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Hiệu quả chẩn đoán của tỷ lệ tiểu cầu/lympho và tỷ lệ bạch cầu trung tính/lympho trong ung thư buồng trứng
Tóm tắt
Tỷ lệ tiểu cầu/lympho (PLR) và tỷ lệ bạch cầu trung tính/lympho (NLR) đã được nghiên cứu rộng rãi trong ung thư. Tuy nhiên, cho đến nay, không có hướng dẫn thực tế nào liên quan đến ung thư buồng trứng. Mục đích của bài đánh giá hệ thống hiện tại là tóm tắt các bằng chứng có sẵn. Chúng tôi đã tìm kiếm một cách hệ thống các cơ sở dữ liệu Medline (1966–2016), Scopus (2004–2016), ClinicalTrials.gov (2008–2016) và Cochrane Central Register of Controlled Trials CENTRAL (1999–2016) cùng với danh sách tham khảo từ các nghiên cứu đã được đưa vào. Mười tám nghiên cứu đã được bao gồm trong đánh giá hệ thống hiện tại với 3453 bệnh nhân. Theo dữ liệu hiện tại, cả giá trị PLR và NLR ở bệnh nhân ung thư buồng trứng có vẻ sai lệch so với các đối chứng khỏe mạnh. Hơn nữa, chúng cũng có thể chỉ ra giai đoạn của bệnh và phản ứng với hóa trị. Tuy nhiên, độ chính xác chẩn đoán của chúng vẫn còn hạn chế vì độ nhạy và độ đặc hiệu của chúng ở mức trung bình (phát hiện 55–80% phụ nữ mắc ung thư buồng trứng). Theo kết quả của nghiên cứu của chúng tôi, cả PLR và NLR dường như là những yếu tố sàng lọc và tiên lượng đầy hứa hẹn của ung thư buồng trứng biểu mô. Tuy nhiên, các giá trị cắt ngang chẩn đoán thực tế vẫn chưa được xác định cho đến bây giờ. Mặc dù độ nhạy và độ đặc hiệu bị hạn chế, chúng có thể hữu ích trong tương lai như là các dấu hiệu bổ sung để phát hiện và giám sát bệnh.
Từ khóa
#tỷ lệ tiểu cầu/lympho #tỷ lệ bạch cầu trung tính/lympho #ung thư buồng trứng #chẩn đoán #yếu tố tiên lượngTài liệu tham khảo
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