The development of inflammatory TH-17 cells requires interferon-regulatory factor 4

Nature Immunology - Tập 8 Số 9 - Trang 958-966 - 2007
Anne Brüstle1, Sylvia Heink2, Magdalena Huber1, Christine Rosenplänter1, Christine Stadelmann3, Philipp Yu4, Enrico Arpaia5, Tak W. Mak5, Thomas Kamradt2, Michael Lohoff1
1Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Marburg, 35043, Germany
2Institut für Immunologie, Universitätsklinikum Jena, Jena, 07740, Germany
3Institut für Neuropathologie, Universität Göttingen, Göttingen, 37075, Germany
4Institut für Immunologie, Marburg, 35043, Germany
5Advanced Medical Discovery Institute, University of Toronto, Toronto, M5G2C1, Ontario, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

Harrington, L.E. et al. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123–1132 (2005).

Infante-Duarte, C., Horton, H.F., Byrne, M.C. & Kamradt, T. Microbial lipopeptides induce the production of IL-17 in TH cells. J. Immunol. 165, 6107–6115 (2000).

Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133–1141 (2005).

Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233–240 (2005).

Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235–238 (2006).

Mangan, P.R. et al. Transforming growth factor-β induces development of the TH17 lineage. Nature 441, 231–234 (2006).

Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179–189 (2006).

Weaver, C.T., Harrington, L.E., Mangan, P.R., Gavrieli, M. & Murphy, K.M. TH17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24, 677–688 (2006).

Ivanov, I.I. et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121–1133 (2006).

Korn, T. et al. IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells. Nature 448, 484–488 (2007).

Zhou, L. et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. advance online publication, 20 June 2007 (doi:10.1038/ni1488).

Honda, K., Takaoka, A. & Taniguchi, T. Type I interferon gene induction by the interferon regulatory factor family of transcription factors 6. Immunity 25, 349–360 (2006).

Honda, K. & Taniguchi, T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors 7. Nat. Rev. Immunol. 6, 644–658 (2006).

Lohoff, M. & Mak, T.W. Roles of interferon-regulatory factors in T-helper-cell differentiation. Nat. Rev. Immunol. 5, 125–135 (2005).

Giese, N.A. et al. Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J. Exp. Med. 186, 1535–1546 (1997).

Lohoff, M. et al. Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity 6, 681–689 (1997).

Lohoff, M. et al. Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells. J. Exp. Med. 192, 325–336 (2000).

Scharton, K.T., Contursi, C., Masumi, A., Sher, A. & Ozato, K. Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 186, 1523–1534 (1997).

Taki, S. et al. Multistage regulation of TH1-type immune responses by the transcription factor IRF-1. Immunity 6, 673–679 (1997).

Hu, C.M., Jang, S.Y., Fanzo, J.C. & Pernis, A.B. Modulation of T cell cytokine production by interferon regulatory factor-4. J. Biol. Chem. 277, 49238–49246 (2002).

Lohoff, M. et al. Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4. Proc. Natl. Acad. Sci. USA 99, 11808–11812 (2002).

Rengarajan, J. et al. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J. Exp. Med. 195, 1003–1012 (2002).

Lohoff, M. et al. Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4+ Th cells. J. Exp. Med. 200, 247–253 (2004).

Liang, S.C. et al. Interleukin (IL)-22 and IL-17 are coexpressed by TH17 cells and cooperatively enhance expression of antimicrobial peptides 1. J. Exp. Med. 203, 2271–2279 (2006).

Nogai, A. et al. Lipopolysaccharide injection induces relapses of experimental autoimmune encephalomyelitis in nontransgenic mice via bystander activation of autoreactive CD4+ cells. J. Immunol. 175, 959–966 (2005).

Chen, W. et al. Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875–1886 (2003).

Wu, Y. et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126, 375–387 (2006).

Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057–1061 (2003).

Yang, X.O. et al. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells 1. J. Biol. Chem. 282, 9358–9363 (2007).

Floess, S. et al. Epigenetic control of the foxp3 locus in regulatory T cells 1. PLoS Biol. 5, e38 (2007).

Mantel, P.Y. et al. Molecular mechanisms underlying FOXP3 induction in human T cells 1. J. Immunol. 176, 3593–3602 (2006).

Zorn, E. et al. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108, 1571–1579 (2006).

Brass, A.L., Kehrli, E., Eisenbeis, C.F., Storb, U. & Singh, H. Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1. Genes Dev. 10, 2335–2347 (1996).

Gupta, S., Jiang, M., Anthony, A. & Pernis, A.B. Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J. Exp. Med. 190, 1837–1848 (1999).

Diehl, S. et al. Inhibition of TH1 differentiation by IL-6 is mediated by SOCS1. Immunity 13, 805–815 (2000).

Rincon, M., Anguita, J., Nakamura, T., Fikrig, E. & Flavell, R.A. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J. Exp. Med. 185, 461–469 (1997).

Nessler, S. et al. Suppression of autoimmune encephalomyelitis by a neurokinin-1 receptor antagonist–a putative role for substance P in CNS inflammation. J. Neuroimmunol. 179, 1–8 (2006).

Grogan, J.L. et al. Cross-reactivity of myelin basic protein-specific T cells with multiple microbial peptides: experimental autoimmune encephalomyelitis induction in TCR transgenic mice. J. Immunol. 163, 3764–3770 (1999).