The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: Old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension

Tarek Hakki1, Katja Hübel2, Herbert Waldmann2, Rita Bernhardt1
1Institute of Biochemistry, P.O. Box 151150, Saarland University, D-66041 Saarbrücken, Germany
2Max Planck Institute of Molecular Physiology, Otto-Hahn-Str, 11, D-44227 Dortmund, Germany

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