The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis

Adams, 2001, Essential roles of Drosophila inner centromere protein (INCENP) and Aurora-B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation, J. Cell Biol, 153, 865, 10.1083/jcb.153.4.865

Adams, 2000, INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow, Curr. Biol, 10, 1075, 10.1016/S0960-9822(00)00673-4

Afonso, 2014, Feedback control of chromosome separation by a midzone Aurora B gradient, Science, 345, 332, 10.1126/science.1251121

Agromayor, 2013, Knowing when to cut and run: mechanisms that control cytokinetic abscission, Trends Cell Biol, 23, 433, 10.1016/j.tcb.2013.04.006

Ahonen, 2009, Perturbation of Incenp function impedes anaphase chromatid movements and chromosomal passenger protein flux at centromeres, Chromosoma, 118, 71, 10.1007/s00412-008-0178-0

Ainsztein, 1998, INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1, J. Cell Biol, 143, 1763, 10.1083/jcb.143.7.1763

Andrews, 2005, Aurora kinases: shining lights on the therapeutic horizon?, Oncogene, 24, 5005, 10.1038/sj.onc.1208752

Barr, 2011, Protein phosphatases and the regulation of mitosis, J. Cell Sci, 124, 2323, 10.1242/jcs.087106

Bastos, 2014, KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle, J. Cell Biol, 207, 683, 10.1083/jcb.201409129

Boss, 2011, Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors, Ann. Oncol, 22, 431, 10.1093/annonc/mdq344

Bouchoux, 2011, A quantitative model for ordered Cdk substrate dephosphorylation during mitotic exit, Cell, 147, 803, 10.1016/j.cell.2011.09.047

Capalbo, 2012, The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis, Open Biol, 2, 120070, 10.1098/rsob.120070

Carlton, 2012, ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C, Science, 336, 220, 10.1126/science.1217180

Carmena, 2012, The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis, Nat. Rev. Mol. Cell. Biol, 13, 789, 10.1038/nrm3474

Cesario, 2006, Kinesin 6 family member Subito participates in mitotic spindle assembly and interacts with mitotic regulators, J. Cell Sci, 119, 4770, 10.1242/jcs.03235

Cooke, 1987, The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis, J. Cell Biol, 105, 2053, 10.1083/jcb.105.5.2053

Dennis, 2012, Phase I study of the Aurora B kinase inhibitor barasertib (AZD1152) to assess the pharmacokinetics, metabolism and excretion in patients with acute myeloid leukemia, Cancer Chemother. Pharmacol, 70, 461, 10.1007/s00280-012-1939-2

Dobrynin, 2011, Cdc48/p97–Ufd1–Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells, J. Cell Sci, 124, 1571, 10.1242/jcs.069500

Douglas, 2010, Aurora B and 14-3-3 coordinately regulate clustering of centralspindlin during cytokinesis, Curr. Biol, 20, 927, 10.1016/j.cub.2010.03.055

Dukes, 2008, A dominant-negative ESCRT-III protein perturbs cytokinesis and trafficking to lysosomes, Biochem. J, 411, 233, 10.1042/BJ20071296

Dultz, 2008, Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells, J. Cell Biol, 180, 857, 10.1083/jcb.200707026

Earnshaw, 1991, Chromosomal passengers: toward an integrated view of mitosis, Chromosoma, 100, 139, 10.1007/BF00337241

Earnshaw, 1991, Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation, J. Cell Sci, 98, 443, 10.1242/jcs.98.4.443

Elia, 2011, Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission, Proc. Natl. Acad. Sci. U.S.A, 108, 4846, 10.1073/pnas.1102714108

Espert, 2014, PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing, J. Cell Biol, 206, 833, 10.1083/jcb.201406109

Fededa, 2012, Molecular control of animal cell cytokinesis, Nat. Cell Biol, 14, 440, 10.1038/ncb2482

Fischle, 2005, Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation, Nature, 438, 1116, 10.1038/nature04219

Foley, 2011, Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase, Nat. Cell Biol, 13, 1265, 10.1038/ncb2327

Fujiwara, 2005, Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells, Nature, 437, 1043, 10.1038/nature04217

Fuller, 2008, Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient, Nature, 453, 1132, 10.1038/nature06923

Funabiki, 2013, Making an effective switch at the kinetochore by phosphorylation and dephosphorylation, Chromosoma, 122, 135, 10.1007/s00412-013-0401-5

Gassmann, 2004, Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle, J. Cell Biol, 166, 179, 10.1083/jcb.200404001

Giet, 2001, Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis, J. Cell Biol, 152, 669, 10.1083/jcb.152.4.669

Goto, 2006, Complex formation of Plk1 and INCENP required for metaphase-anaphase transition, Nat. Cell Biol, 8, 180, 10.1038/ncb1350

Gruneberg, 2004, Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2, J. Cell Biol, 166, 167, 10.1083/jcb.200403084

Guse, 2005, Phosphorylation of ZEN-4/MKLP1 by Aurora B Regulates completion of cytokinesis, Curr. Biol, 15, 778, 10.1016/j.cub.2005.03.041

Guttinger, 2009, Orchestrating nuclear envelope disassembly and reassembly during mitosis, Nat. Rev. Mol. Cell. Biol, 10, 178, 10.1038/nrm2641

Hill, 2000, The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis, EMBO J, 19, 5711, 10.1093/emboj/19.21.5711

Hirota, 2005, Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin, Nature, 438, 1176, 10.1038/nature04254

Honda, 2003, Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis, Mol. Biol. Cell, 14, 3325, 10.1091/mbc.E02-11-0769

Hu, 2008, Cell polarization during monopolar cytokinesis, J. Cell Biol, 181, 195, 10.1083/jcb.200711105

Hudson, 2003, Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes, Dev. Cell, 5, 323, 10.1016/S1534-5807(03)00199-0

Hudson, 2009, Condensin: architect of mitotic chromosomes, Chromosome Res, 17, 131, 10.1007/s10577-008-9009-7

Hummer, 2009, Cdk1 negatively regulates midzone localization of the mitotic kinesin mklp2 and the chromosomal passenger complex, Curr. Biol, 19, 607, 10.1016/j.cub.2009.02.046

Janssen, 2011, Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations, Science, 333, 1895, 10.1126/science.1210214

Jeyaprakash, 2007, Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together, Cell, 131, 271, 10.1016/j.cell.2007.07.045

Kaitna, 2000, Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis, Curr. Biol, 10, 1172, 10.1016/S0960-9822(00)00721-1

Kaitna, 2002, The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis, Curr. Biol, 12, 798, 10.1016/S0960-9822(02)00820-5

Kawashima, 2010, Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin, Science, 327, 172, 10.1126/science.1180189

Kelly, 2010, Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B, Science, 330, 235, 10.1126/science.1189505

Kim, 2010, Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E, Cell, 142, 444, 10.1016/j.cell.2010.06.039

Kitagawa, 2014, Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis, Cell Rep, 7, 166, 10.1016/j.celrep.2014.02.034

Kitagawa, 2013, Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis, PLoS ONE, 8, e64826, 10.1371/journal.pone.0064826

Klein, 2006, Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP, Mol. Biol. Cell, 17, 2547, 10.1091/mbc.E05-12-1133

Kruse, 2013, Direct binding between BubR1 and B56–PP2A phosphatase complexes regulate mitotic progression, J. Cell Sci, 126, 1086, 10.1242/jcs.122481

Kurasawa, 2004, Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation, EMBO J, 23, 3237, 10.1038/sj.emboj.7600347

Kuriyama, 2002, CHO1, a mammalian kinesin-like protein, interacts with F-actin and is involved in the terminal phase of cytokinesis, J. Cell Biol, 156, 783, 10.1083/jcb.200109090

Lafaurie-Janvore, 2013, ESCRT-III assembly and cytokinetic abscission are induced by tension release in the intercellular bridge, Science, 339, 1625, 10.1126/science.1233866

Lavoie, 2004, In vivo requirements for rDNA chromosome condensation reveal two cell-cycle-regulated pathways for mitotic chromosome folding, Genes Dev, 18, 76, 10.1101/gad.1150404

Lee, 2010, Mad2 inhibits the mitotic kinesin MKlp2, J. Cell Biol, 191, 1069, 10.1083/jcb.201003095

Lipp, 2007, Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes, J. Cell Sci, 120, 1245, 10.1242/jcs.03425

Liu, 2010, Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase, J. Cell Biol, 188, 809, 10.1083/jcb.201001006

Löwenberg, 2011, Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia, Blood, 118, 6030, 10.1182/blood-2011-07-366930

Mackay, 2009, The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis, Mol. Biol. Cell, 20, 1652, 10.1091/mbc.E08-08-0883

Mackay, 2010, Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint, J. Cell Biol, 191, 923, 10.1083/jcb.201007124

Maerki, 2009, The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis, J. Cell Biol, 187, 791, 10.1083/jcb.200906117

Marzo, 2013, Antimitotic drugs in cancer chemotherapy: promises and pitfalls, Biochem. Pharmacol, 86, 703, 10.1016/j.bcp.2013.07.010

Matuliene, 2002, Kinesin-like protein CHO1 is required for the formation of midbody matrix and the completion of cytokinesis in mammalian cells, Mol. Biol. Cell, 13, 1832, 10.1091/mbc.01-10-0504

Meyer, 2010, A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosis, Biochem. Cell Biol, 88, 23, 10.1139/O09-119

Mirchenko, 2010, Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset, Curr. Biol, 20, 1396, 10.1016/j.cub.2010.06.023

Mishima, 2002, Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity, Dev. Cell, 2, 41, 10.1016/S1534-5807(01)00110-1

Miyauchi, 2007, Aurora B kinase activity is required to prevent polar cortical ingression during cytokinesis, Cell Cycle, 6, 2549, 10.4161/cc.6.20.4817

Mocciaro, 2010, Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair, J. Cell Biol, 189, 631, 10.1083/jcb.200910057

Mollinari, 2002, PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone, J. Cell Biol, 157, 1175, 10.1083/jcb.200111052

Mora-Bermudez, 2007, Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase, Nat. Cell Biol, 9, 822, 10.1038/ncb1606

Morishita, 2001, Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair, Genes Cells, 6, 743, 10.1046/j.1365-2443.2001.00459.x

Murata-Hori, 2002, Both midzone and astral microtubules are involved in the delivery of cytokinesis signals: insights from the mobility of aurora B, J. Cell Biol, 159, 45, 10.1083/jcb.200207014

Nakajima, 2011, Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC–spindle interaction to ensure proper microtubule dynamics, J. Cell Biol, 194, 137, 10.1083/jcb.201009137

Nakazawa, 2011, Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2, J. Cell Sci, 124, 1795, 10.1242/jcs.078733

Nakazawa, 2008, Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis, J. Cell Biol, 180, 1115, 10.1083/jcb.200708170

Neurohr, 2011, A midzone-based ruler adjusts chromosome compaction to anaphase spindle length, Science, 332, 465, 10.1126/science.1201578

Nguyen, 2005, Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property, Mol. Cell. Biol, 25, 4977, 10.1128/MCB.25.12.4977-4992.2005

Nguyen, 2009, Deregulated Aurora-B induced tetraploidy promotes tumorigenesis, FASEB J, 23, 2741, 10.1096/fj.09-130963

Norden, 2006, The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage, Cell, 125, 85, 10.1016/j.cell.2006.01.045

Nozawa, 2010, Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation, Nat. Cell Biol, 12, 719, 10.1038/ncb2075

Nunes Bastos, 2013, Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A, J. Cell Biol, 202, 605, 10.1083/jcb.201301094

Ono, 2004, Spatial and temporal regulation of condensins I and II in mitotic chromosome assembly in human cells, Mol. Biol. Cell, 15, 3296, 10.1091/mbc.E04-03-0242

Ono, 2003, Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells, Cell, 115, 109, 10.1016/S0092-8674(03)00724-4

Ota, 2002, Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability, Cancer Res, 62, 5168

Pereira, 2003, Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14, Science, 302, 2120, 10.1126/science.1091936

Petersen, 2003, S. pombe Aurora kinase/Survivin is required for chromosome condensation and the spindle checkpoint attachment response, Curr. Biol, 13, 590, 10.1016/S0960-9822(03)00205-7

Qian, 2013, Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man, Curr. Biol, 23, 1136, 10.1016/j.cub.2013.05.017

Qian, 2011, PP1/Repo-Man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal Aurora B targeting, Curr. Biol, 21, 766, 10.1016/j.cub.2011.03.047

Ramadan, 2007, Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin, Nature, 450, 1258, 10.1038/nature06388

Ricke, 2011, Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation, J. Cell Biol, 193, 1049, 10.1083/jcb.201012035

Suijkerbuijk, 2012, Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments, Dev. Cell, 23, 745, 10.1016/j.devcel.2012.09.005

Steigemann, 2009, Aurora B-mediated abscission checkpoint protects against tetraploidization, Cell, 136, 473, 10.1016/j.cell.2008.12.020

Sumara, 2007, A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells, Dev. Cell, 12, 887, 10.1016/j.devcel.2007.03.019

Tada, 2011, Condensin association with histone H2A shapes mitotic chromosomes, Nature, 474, 477, 10.1038/nature10179

Takemoto, 2009, The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A, Nat. Struct. Mol. Biol, 16, 1302, 10.1038/nsmb.1708

Takemoto, 2007, Analysis of the role of Aurora B on the chromosomal targeting of condensin I, Nucleic Acids Res, 35, 2403, 10.1093/nar/gkm157

Thadani, 2012, Condensin, chromatin crossbarring and chromosome condensation, Curr. Biol, 22, 1012, 10.1016/j.cub.2012.10.023

Thoresen, 2014, ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4, Nat. Cell Biol, 16, 547, 10.1038/ncb2959

Tsukahara, 2010, Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation, Nature, 467, 719, 10.1038/nature09390

Uehara, 2013, Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase, J. Cell Biol, 202, 623, 10.1083/jcb.201302123

Vader, 2006, Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody, EMBO Rep, 7, 85, 10.1038/sj.embor.7400562

Vagnarelli, 2006, Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis, Nat. Cell Biol, 8, 1133, 10.1038/ncb1475

Vagnarelli, 2011, Repo-Man coordinates chromosomal reorganization with nuclear envelope reassembly during mitotic exit, Dev. Cell, 21, 328, 10.1016/j.devcel.2011.06.020

van der Horst, 2014, Cell division: control of the chromosomal passenger complex in time and space, Chromosoma, 123, 25, 10.1007/s00412-013-0437-6

Varela, 2009, Lte1, Cdc14 and MEN−controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression, EMBO J, 28, 1562, 10.1038/emboj.2009.111

Vazquez-Novelle, 2010, Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase, Curr. Biol, 20, 1402, 10.1016/j.cub.2010.06.036

Wang, 2010, Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis, Science, 330, 231, 10.1126/science.1189435

Wurzenberger, 2012, Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores, J. Cell Biol, 198, 173, 10.1083/jcb.201112112

Xu, 2013, BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression, Biol. Open, 2, 479, 10.1242/bio.20134051

Xu, 2014, B56-PP2A regulates motor dynamics for mitotic chromosome alignment, J. Cell Sci, 127, 4567, 10.1242/jcs.154609

Xu, 2009, INCENP–aurora B interactions modulate kinase activity and chromosome passenger complex localization, J. Cell Biol, 187, 637, 10.1083/jcb.200906053

Yamagishi, 2010, Two histone marks establish the inner centromere and chromosome bi-orientation, Science, 330, 239, 10.1126/science.1194498

Yeong, 2003, Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A, Curr. Biol, 13, 2058, 10.1016/j.cub.2003.10.032

Zasadil, 2014, Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles, Sci. Transl. Med, 6, 229, 10.1126/scitranslmed.3007965

Zimniak, 2012, Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation, Curr. Biol, 22, 787, 10.1016/j.cub.2012.03.007