The chemokine system in cancer biology and therapy
Tóm tắt
Từ khóa
Tài liệu tham khảo
Balkwill, 2001, Inflammation and cancer: back to Virchow?, Lancet, 357, 539, 10.1016/S0140-6736(00)04046-0
Bottazzi, 1983, Regulation of the macrophage content of neoplasms by chemoattractants, Science, 220, 210, 10.1126/science.6828888
Mantovani, 1999, The chemokine system: redundancy for robust outputs, Immunol Today, 20, 254, 10.1016/S0167-5699(99)01469-3
Mantovani, 2006, Tuning inflammation and immunity by chemokine sequestration: decoys and more, Nat Rev Immunol, 6, 907, 10.1038/nri1964
Nibbs, 2007, The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors, J Clin Invest, 117, 1884, 10.1172/JCI30068
Vetrano S, Borroni EM, Sarukhan A, et al. The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6. Gut 2009; Oct 20 [Epub ahead of print].
Mantovani, 2006, Role of tumor-associated macrophages in tumor progression and invasion, Cancer Metastasis Rev, 25, 315, 10.1007/s10555-006-9001-7
Markiewski, 2009, Is complement good or bad for cancer patients? A new perspective on an old dilemma, Trends Immunol, 30, 286, 10.1016/j.it.2009.04.002
Proost, 2006, Natural post-translational modifications of chemokines, Biochem Soc Trans, 34, 997, 10.1042/BST0340997
Proost, 2008, Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation, J Exp Med, 205, 2085, 10.1084/jem.20080305
Grisotto, 2006, The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells, J Clin Invest, 116, 1264, 10.1172/JCI26666
Yang, 2000, Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma, J Exp Med, 191, 445, 10.1084/jem.191.3.445
Sozzani, 1998, The viral chemokine macrophage inflammatory protein-II is a selective Th2 chemoattractant, Blood, 92, 4036, 10.1182/blood.V92.11.4036
Stine, 2000, KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells, Blood, 95, 1151, 10.1182/blood.V95.4.1151.004k37_1151_1157
Endres, 1999, The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8, J Exp Med, 189, 1993, 10.1084/jem.189.12.1993
Borrello, 2005, Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene, Proc Natl Acad Sci USA, 102, 14825, 10.1073/pnas.0503039102
Mestdagt, 2006, Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells, Int J Cancer, 118, 35, 10.1002/ijc.21291
Sparmann, 2004, Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis, Cancer Cell, 6, 447, 10.1016/j.ccr.2004.09.028
Yan, 2009, Identification of GRO1 as a critical determinant for mutant p53 gain of function, J Biol Chem, 284, 12178, 10.1074/jbc.M900994200
Soucek, 2007, Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors, Nat Med, 13, 1211, 10.1038/nm1649
Buonamici, 2009, CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia, Nature, 459, 1000, 10.1038/nature08020
Richmond, 2002, Nf-kappa B, chemokine gene transcription and tumour growth, Nat Rev Immunol, 2, 664, 10.1038/nri887
Schwieger, 2009, Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C, Blood, 10.1182/blood-2008-05-158196
Akekawatchai, 2005, Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells, J Biol Chem, 280, 39701, 10.1074/jbc.M509829200
Mira, 2001, A role for chemokine receptor transactivation in growth factor signaling, EMBO Rep, 2, 151, 10.1093/embo-reports/kve027
Wallace, 2009, Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma, Cancer Res, 69, 5726, 10.1158/0008-5472.CAN-09-0390
Kulbe, 2005, The inflammatory cytokine tumor necrosis factor-alpha regulates chemokine receptor expression on ovarian cancer cells, Cancer Res, 65, 10355, 10.1158/0008-5472.CAN-05-0957
Schioppa, 2003, Regulation of the chemokine receptor CXCR4 by hypoxia, J Exp Med, 198, 1391, 10.1084/jem.20030267
Staller, 2003, Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL, Nature, 425, 307, 10.1038/nature01874
Li, 2009, Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung cancer cells, Cancer Biol Ther, 8, 322, 10.4161/cbt.8.4.7332
Bierie, 2009, Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer, J Clin Invest, 119, 1571, 10.1172/JCI37480
Yang, 2008, Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis, Cancer Cell, 13, 23, 10.1016/j.ccr.2007.12.004
Sauve, 2009, Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway, Cancer Res, 69, 5793, 10.1158/0008-5472.CAN-08-4924
Huang, 2007, Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells, Cancer Res, 67, 5906, 10.1158/0008-5472.CAN-07-0691
Mantovani, 2004, Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors, Semin Cancer Biol, 14, 155, 10.1016/j.semcancer.2003.10.001
Pollard, 2004, Tumour-educated macrophages promote tumour progression and metastasis, Nat Rev Cancer, 4, 71, 10.1038/nrc1256
Walter, 1991, Macrophage infiltration and growth of sarcoma clones expressing different amounts of monocyte chemotactic protein/JE, Int J Cancer, 49, 431, 10.1002/ijc.2910490321
Lavergne, 2004, Intratumoral CC chemokine ligand 5 overexpression delays tumor growth and increases tumor cell infiltration, J Immunol, 173, 3755, 10.4049/jimmunol.173.6.3755
Manome, 1995, Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors, Cancer Immunol Immunother, 41, 227, 10.1007/BF01516997
Rollins, 1991, Suppression of tumor formation in vivo by expression of the JE gene in malignant cells, Mol Cell Biol, 11, 3125, 10.1128/MCB.11.6.3125
Conti, 2004, CCL2 (monocyte chemoattractant protein-1) and cancer, Semin Cancer Biol, 14, 149, 10.1016/j.semcancer.2003.10.009
Sawanobori, 2008, Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice, Blood, 111, 5457, 10.1182/blood-2008-01-136895
Soria, 2008, The inflammatory chemokines CCL2 and CCL5 in breast cancer, Cancer Lett, 267, 271, 10.1016/j.canlet.2008.03.018
Okada, 2009, Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1, Int J Oncol, 34, 1621
Fujimoto, 2009, Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression, Int J Cancer, 125, 1276, 10.1002/ijc.24378
Luboshits, 1999, Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma, Cancer Res, 59, 4681
Ueno, 2000, Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer, Clin Cancer Res, 6, 3282
Harlin, 2009, Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment, Cancer Res, 69, 3077, 10.1158/0008-5472.CAN-08-2281
Ohta, 2002, Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas, Int J Cancer, 102, 220, 10.1002/ijc.10705
Hu, 2009, Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis, Clin Cancer Res, 10.1158/1078-0432.CCR-08-2491
Loberg, 2007, CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration, Neoplasia, 9, 556, 10.1593/neo.07307
Monti, 2003, The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity, Cancer Res, 63, 7451
Karnoub, 2007, Mesenchymal stem cells within tumour stroma promote breast cancer metastasis, Nature, 449, 557, 10.1038/nature06188
Bailey, 2007, Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer, Clin Exp Metastasis, 24, 121, 10.1007/s10585-007-9060-3
Soria, 2008, Concomitant expression of the chemokines RANTES and MCP-1 in human breast cancer: a basis for tumor-promoting interactions, Cytokine, 44, 191, 10.1016/j.cyto.2008.08.002
Dwyer, 2007, Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells, Clin Cancer Res, 13, 5020, 10.1158/1078-0432.CCR-07-0731
Sugasawa, 2008, Gastric cancer cells exploit CD4+ cell-derived CCL5 for their growth and prevention of CD8+ cell-involved tumor elimination, Int J Cancer, 122, 2535, 10.1002/ijc.23401
Gabrilovich, 2009, Myeloid-derived suppressor cells as regulators of the immune system, Nat Rev Immunol, 9, 162, 10.1038/nri2506
Fridlender, 2009, Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN, Cancer Cell, 16, 183, 10.1016/j.ccr.2009.06.017
Nozawa, 2006, Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis, Proc Natl Acad Sci USA, 103, 12493, 10.1073/pnas.0601807103
Bellocq, 1998, Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome, Am J Pathol, 152, 83
Tazzyman, 2009, Neutrophils: key mediators of tumour angiogenesis, Int J Exp Pathol, 90, 222, 10.1111/j.1365-2613.2009.00641.x
Xie, 2001, Interleukin-8 and human cancer biology, Cytokine Growth Factor Rev, 12, 375, 10.1016/S1359-6101(01)00016-8
Cuenca, 1992, Characterization of GRO alpha, beta and gamma expression in human colonic tumours: potential significance of cytokine involvement, Surg Oncol, 1, 323, 10.1016/0960-7404(92)90094-2
Eck, 2003, Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma, Clin Exp Immunol, 134, 508, 10.1111/j.1365-2249.2003.02305.x
Wislez, 2004, Upregulation of bronchioloalveolar carcinoma-derived C-X-C chemokines by tumor infiltrating inflammatory cells, Inflamm Res, 53, 4, 10.1007/s00011-003-1215-3
Gijsbers, 2005, GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors, Exp Cell Res, 303, 331, 10.1016/j.yexcr.2004.09.027
Proost, 1993, Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8, J Immunol, 150, 1000, 10.4049/jimmunol.150.3.1000
Fioretti, 1998, Reduced tumorigenicity and augmented leukocyte infiltration after monocyte chemotactic protein-3 (MCP-3) gene transfer: perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor, J Immunol, 161, 342, 10.4049/jimmunol.161.1.342
Lee, 2000, IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration, J Immunol, 164, 2769, 10.4049/jimmunol.164.5.2769
Benelli, 2002, Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation, FASEB J, 16, 267, 10.1096/fj.01-0651fje
Bell, 1999, In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas, J Exp Med, 190, 1417, 10.1084/jem.190.10.1417
Vicari, 2004, Regulation of the trafficking of tumour-infiltrating dendritic cells by chemokines, Semin Cancer Biol, 14, 161, 10.1016/j.semcancer.2003.10.002
Kleeff, 1999, Detection and localization of MIP-3alpha/LARC/Exodus, a macrophage proinflammatory chemokine, and its CCR6 receptor in human pancreatic cancer, Int J Cancer, 81, 650, 10.1002/(SICI)1097-0215(19990517)81:4<650::AID-IJC23>3.0.CO;2-#
Scarpino, 2000, Papillary carcinoma of the thyroid: hepatocyte growth factor (HGF) stimulates tumor cells to release chemokines active in recruiting dendritic cells, Am J Pathol, 156, 831, 10.1016/S0002-9440(10)64951-6
Fushimi, 2000, Macrophage inflammatory protein 3alpha transgene attracts dendritic cells to established murine tumors and suppresses tumor growth, J Clin Invest, 105, 1383, 10.1172/JCI7548
Zou, 2001, Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells, Nat Med, 7, 1339, 10.1038/nm1201-1339
Treilleux, 2004, Dendritic cell infiltration and prognosis of early stage breast cancer, Clin Cancer Res, 10, 7466, 10.1158/1078-0432.CCR-04-0684
Ishigami, 2000, Prognostic value of intratumoral natural killer cells in gastric carcinoma, Cancer, 88, 577, 10.1002/(SICI)1097-0142(20000201)88:3<577::AID-CNCR13>3.0.CO;2-V
Villegas, 2002, Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer, Lung Cancer, 35, 23, 10.1016/S0169-5002(01)00292-6
Hyakudomi, 2008, Increased expression of fractalkine is correlated with a better prognosis and an increased number of both CD8+ T cells and natural killer cells in gastric adenocarcinoma, Ann Surg Oncol, 15, 1775, 10.1245/s10434-008-9876-3
Saudemont, 2005, NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells, Blood, 105, 2428, 10.1182/blood-2004-09-3458
Lavergne, 2003, Fractalkine mediates natural killer-dependent antitumor responses in vivo, Cancer Res, 63, 7468
Wendel, 2008, Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands, Cancer Res, 68, 8437, 10.1158/0008-5472.CAN-08-1440
Ishida, 2006, CCR4 as a novel molecular target for immunotherapy of cancer, Cancer Sci, 97, 1139, 10.1111/j.1349-7006.2006.00307.x
Liu, 2008, Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice, J Clin Invest, 118, 1165
Galon, 2006, Type, density, and location of immune cells within human colorectal tumors predict clinical outcome, Science, 313, 1960, 10.1126/science.1129139
Laghi, 2009, CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study, Lancet Oncol, 10, 877, 10.1016/S1470-2045(09)70186-X
Oble, 2009, Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma, Cancer Immun, 9, 3
Pan, 2006, CXCR3/CXCR3 ligand biological axis impairs RENCA tumor growth by a mechanism of immunoangiostasis, J Immunol, 176, 1456, 10.4049/jimmunol.176.3.1456
Ohtani, 2009, Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinoma, J Pathol, 217, 21, 10.1002/path.2448
Musha, 2005, Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma, Int J Cancer, 116, 949, 10.1002/ijc.21135
Zeng, 2007, Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells, Cancer Res, 67, 2331, 10.1158/0008-5472.CAN-06-3041
Ludwig, 2005, Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells, J Neurochem, 93, 1293, 10.1111/j.1471-4159.2005.03123.x
Wente, 2008, Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma, Int J Oncol, 33, 297
Meijer, 2008, The chemokine receptor CXCR6 and its ligand CXCL16 are expressed in carcinomas and inhibit proliferation, Cancer Res, 68, 4701, 10.1158/0008-5472.CAN-08-0482
Matsumura, 2008, Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells, J Immunol, 181, 3099, 10.4049/jimmunol.181.5.3099
Gutwein, 2009, Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients, Eur J Cancer, 45, 478, 10.1016/j.ejca.2008.10.023
Hojo, 2007, High-level expression of chemokine CXCL16 by tumor cells correlates with a good prognosis and increased tumor-infiltrating lymphocytes in colorectal cancer, Cancer Res, 67, 4725, 10.1158/0008-5472.CAN-06-3424
Darash-Yahana, 2009, The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers, PLoS One, 4, e6695, 10.1371/journal.pone.0006695
Gobert, 2009, Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome, Cancer Res, 69, 2000, 10.1158/0008-5472.CAN-08-2360
Olkhanud, 2009, Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells, Cancer Res, 69, 5996, 10.1158/0008-5472.CAN-08-4619
Curiel, 2004, Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival, Nat Med, 10, 942, 10.1038/nm1093
Miller, 2006, CD4+CD25 high T cells are enriched in the tumor and peripheral blood of prostate cancer patients, J Immunol, 177, 7398, 10.4049/jimmunol.177.10.7398
Mizukami, 2008, CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer, Int J Cancer, 122, 2286, 10.1002/ijc.23392
Mailloux, 2009, NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment, J Immunol, 182, 2753, 10.4049/jimmunol.0801124
Strieter, 2006, Cancer CXC chemokine networks and tumour angiogenesis, Eur J Cancer, 42, 768, 10.1016/j.ejca.2006.01.006
Li, 2005, Autocrine role of interleukin-8 in induction of endothelial cell proliferation, survival, migration and MMP-2 production and angiogenesis, Angiogenesis, 8, 63, 10.1007/s10456-005-5208-4
Aalinkeel, 2004, Gene expression of angiogenic factors correlates with metastatic potential of prostate cancer cells, Cancer Res, 64, 5311, 10.1158/0008-5472.CAN-2506-2
Mestas, 2005, The role of CXCR2/CXCR2 ligand biological axis in renal cell carcinoma, J Immunol, 175, 5351, 10.4049/jimmunol.175.8.5351
Strieter, 2004, CXC chemokines: angiogenesis, immunoangiostasis, and metastases in lung cancer, Ann N Y Acad Sci, 1028, 351, 10.1196/annals.1322.041
Kryczek, 2005, CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers, Cancer Res, 65, 465, 10.1158/0008-5472.465.65.2
Orimo, 2005, Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion, Cell, 121, 335, 10.1016/j.cell.2005.02.034
Miao, 2007, CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature, Proc Natl Acad Sci USA, 104, 15735, 10.1073/pnas.0610444104
Romagnani, 2001, Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity, J Clin Invest, 107, 53, 10.1172/JCI9775
Naschberger, 2008, Angiostatic immune reaction in colorectal carcinoma: Impact on survival and perspectives for antiangiogenic therapy, Int J Cancer, 123, 2120, 10.1002/ijc.23764
Sato, 2007, Expression of IP-10 related to angiogenesis in uterine cervical cancers, Br J Cancer, 96, 1735, 10.1038/sj.bjc.6603790
Lewis, 2006, Distinct role of macrophages in different tumor microenvironments, Cancer Res, 66, 605, 10.1158/0008-5472.CAN-05-4005
Sozzani, 2007, Dendritic cell-endothelial cell cross-talk in angiogenesis, Trends Immunol, 28, 385, 10.1016/j.it.2007.07.006
Chen, 2009, Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis, Blood, 113, 1992, 10.1182/blood-2008-02-133751
Iba, 2002, Angiogenesis by implantation of peripheral blood mononuclear cells and platelets into ischemic limbs, Circulation, 106, 2019, 10.1161/01.CIR.0000031332.45480.79
Balentien, 1991, Effects of MGSA/GRO alpha on melanocyte transformation, Oncogene, 6, 1115
Norgauer, 1996, Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cells, J Immunol, 156, 1132, 10.4049/jimmunol.156.3.1132
Owen, 1997, Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins, Int J Cancer, 73, 94, 10.1002/(SICI)1097-0215(19970926)73:1<94::AID-IJC15>3.0.CO;2-5
Takamori, 2000, Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1, Pancreas, 21, 52, 10.1097/00006676-200007000-00051
Muller, 2001, Involvement of chemokine receptors in breast cancer metastasis, Nature, 410, 50, 10.1038/35065016
Burger, 2006, CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment, Blood, 107, 1761, 10.1182/blood-2005-08-3182
Ehtesham, 2009, CXCR4 mediates the proliferation of glioblastoma progenitor cells, Cancer Lett, 274, 305, 10.1016/j.canlet.2008.09.034
Hermann, 2007, Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer, Cell Stem Cell, 1, 313, 10.1016/j.stem.2007.06.002
Varney, 2006, Distinct expression of CXCL8 and its receptors CXCR1 and CXCR2 and their association with vessel density and aggressiveness in malignant melanoma, Am J Clin Pathol, 125, 209, 10.1309/VPL5-R3JR-7F1D-6V03
Murphy, 2005, Nonapical and cytoplasmic expression of interleukin-8, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate cancer, Clin Cancer Res, 11, 4117, 10.1158/1078-0432.CCR-04-1518
Bajetto, 2006, Expression of CXC chemokine receptors 1-5 and their ligands in human glioma tissues: role of CXCR4 and SDF1 in glioma cell proliferation and migration, Neurochem Int, 49, 423, 10.1016/j.neuint.2006.03.003
Rempel, 2000, Identification and localization of the cytokine SDF1 and its receptor. CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma, Clin Cancer Res, 6, 102
Zhou, 2002, CXCR4 is a major chemokine receptor on glioma cells and mediates their survival, J Biol Chem, 277, 49481, 10.1074/jbc.M206222200
Ma, 2009, CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model, Mol Cancer Ther, 8, 490, 10.1158/1535-7163.MCT-08-0485
Walser, 2006, Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer, Cancer Res, 66, 7701, 10.1158/0008-5472.CAN-06-0709
Kawada, 2004, Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes, Cancer Res, 64, 4010, 10.1158/0008-5472.CAN-03-1757
Kawada, 2007, Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes, Oncogene, 26, 4679, 10.1038/sj.onc.1210267
Jones, 2000, The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia, Blood, 95, 627, 10.1182/blood.V95.2.627
Ghadjar, 2006, Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer, J Clin Oncol, 24, 1910, 10.1200/JCO.2005.04.1822
Meijer, 2006, The CXCR5 chemokine receptor is expressed by carcinoma cells and promotes growth of colon carcinoma in the liver, Cancer Res, 66, 9576, 10.1158/0008-5472.CAN-06-1507
Ding, 2003, Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma, Clin Cancer Res, 9, 3406
Gunther, 2005, Prediction of lymph node metastasis in colorectal carcinoma by expressionof chemokine receptor CCR7, Int J Cancer, 116, 726, 10.1002/ijc.21123
Mashino, 2002, Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma, Cancer Res, 62, 2937
Takanami, 2003, Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis, Int J Cancer, 105, 186, 10.1002/ijc.11063
Takeuchi, 2004, CCL21 chemokine regulates chemokine receptor CCR7 bearing malignant melanoma cells, Clin Cancer Res, 10, 2351, 10.1158/1078-0432.CCR-03-0195
Wiley, 2001, Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma, J Natl Cancer Inst, 93, 1638, 10.1093/jnci/93.21.1638
Cabioglu, 2005, CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer, Clin Cancer Res, 11, 5686, 10.1158/1078-0432.CCR-05-0014
Ghadjar, 2009, The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer, Int J Cancer, 125, 741, 10.1002/ijc.24468
Harasawa, 2006, Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma, Leuk Lymphoma, 47, 2163, 10.1080/10428190600775599
Ishida, 2003, Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome, Clin Cancer Res, 9, 3625
Kleinhans, 2003, Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma, Blood, 101, 1487, 10.1182/blood-2002-02-0475
Letsch, 2004, Functional CCR9 expression is associated with small intestinal metastasis, J Invest Dermatol, 122, 685, 10.1111/j.0022-202X.2004.22315.x
Simonetti, 2006, Potential role of CCL27 and CCR10 expression in melanoma progression and immune escape, Eur J Cancer, 42, 1181, 10.1016/j.ejca.2006.01.043
Buri, 2001, CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease, Blood, 97, 1543, 10.1182/blood.V97.6.1543
Shulby, 2004, CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells, Cancer Res, 64, 4693, 10.1158/0008-5472.CAN-03-3437
Marchesi, 2008, The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma, Cancer Res, 68, 9060, 10.1158/0008-5472.CAN-08-1810
Darash-Yahana, 2004, Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis, FASEB J, 18, 1240, 10.1096/fj.03-0935fje
Singh, 2009, CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion, Br J Cancer, 100, 1638, 10.1038/sj.bjc.6605055
Wang, 2006, A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer, Cancer Res, 66, 3071, 10.1158/0008-5472.CAN-05-2871
Wang, 2008, Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy, J Natl Cancer Inst, 100, 502, 10.1093/jnci/djn059
Murakami, 2003, Immune evasion by murine melanoma mediated through CC chemokine receptor-10, J Exp Med, 198, 1337, 10.1084/jem.20030593
Manes, 2003, CCR5 expression influences the progression of human breast cancer in a p53-dependent manner, J Exp Med, 198, 1381, 10.1084/jem.20030580
Mooi, 2006, Oncogene-induced cell senescence—halting on the road to cancer, N Engl J Med, 355, 1037, 10.1056/NEJMra062285
d’Adda di Fagagna, 2008, Living on a break: cellular senescence as a DNA-damage response, Nat Rev Cancer, 8, 512, 10.1038/nrc2440
Coppe, 2008, Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor, PLoS Biol, 6, 2853, 10.1371/journal.pbio.0060301
Acosta, 2008, Chemokine signaling via the CXCR2 receptor reinforces senescence, Cell, 133, 1006, 10.1016/j.cell.2008.03.038
Kuilman, 2008, Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network, Cell, 133, 1019, 10.1016/j.cell.2008.03.039
Acosta, 2009, A role for CXCR2 in senescence, but what about in cancer?, Cancer Res, 69, 2167, 10.1158/0008-5472.CAN-08-3772
Mangalmurti, 2009, Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation, Blood, 113, 1158, 10.1182/blood-2008-07-166264
Pruenster, 2009, The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity, Nat Immunol, 10, 101, 10.1038/ni.1675
Addison, 2004, Overexpression of the Duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis, BMC Cancer, 4, 28, 10.1186/1471-2407-4-28
Horton, 2007, Opposing roles of murine Duffy antigen receptor for chemokine and murine CXC chemokine receptor-2 receptors in murine melanoma tumor growth, Cancer Res, 67, 9791, 10.1158/0008-5472.CAN-07-0246
Lentsch, 2002, The Duffy antigen/receptor for chemokines (DARC) and prostate cancer. A role as clear as black and white?, FASEB J, 16, 1093, 10.1096/fj.02-0066hyp
Waugh, 2008, Multi-faceted roles for CXC-chemokines in prostate cancer progression, Front Biosci, 13, 4595, 10.2741/3025
Shen, 2006, The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth, Faseb J, 20, 59, 10.1096/fj.05-4764com
Bandyopadhyay, 2006, Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression, Nat Med, 12, 933, 10.1038/nm1444
Hemler, 2005, Tetraspanin functions and associated microdomains, Nat Rev Mol Cell Biol, 6, 801, 10.1038/nrm1736
Horuk, 1994, Identification and characterization of a promiscuous chemokine-binding protein in a human erythroleukemic cell line, J Biol Chem, 269, 17730, 10.1016/S0021-9258(17)32501-2
Desbaillets, 1997, Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis, J Exp Med, 186, 1201, 10.1084/jem.186.8.1201
Tang, 1998, Molecular cloning and characterization of a mouse gene with homology to the Duffy-antigen receptor for chemokines, DNA Seq, 9, 129, 10.3109/10425179809072188
Wang, 2006, Enhanced expression of Duffy antigen receptor for chemokines by breast cancer cells attenuates growth and metastasis potential, Oncogene, 25, 7201, 10.1038/sj.onc.1209703
Martinez de la Torre, 2007, Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6, Proc Natl Acad Sci USA, 104, 2319, 10.1073/pnas.0607514104
Nibbs, 2001, The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors, Am J Pathol, 158, 867, 10.1016/S0002-9440(10)64035-7
McKimmie, 2008, Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1, J Immunol, 181, 8171, 10.4049/jimmunol.181.5.3353
Daibata, 2004, Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia, Int J Cancer, 108, 845, 10.1002/ijc.11647
Wu, 2008, Chemokine decoy receptor d6 plays a negative role in human breast cancer, Mol Cancer Res, 6, 1276, 10.1158/1541-7786.MCR-07-2108
Wang, 2008, The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer, J Biol Chem, 283, 4283, 10.1074/jbc.M707465200
Burns, 2006, A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development, J Exp Med, 203, 2201, 10.1084/jem.20052144
Raggo, 2005, Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus, Cancer Res, 65, 5084, 10.1158/0008-5472.CAN-04-2822
Iwakiri, 2009, Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer, Cancer, 115, 2580, 10.1002/cncr.24281
Broberg, 2002, Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15, Int J Oncol, 21, 321
van Rechem, 2009, The scavenger chemokine (C-X-C motif)receptor7 CXCR7 is a direct target gene of hypermethylated in cancer 1 HIC1, J Biol Chem, 10.1074/jbc.M109.022350
Takenaga, 2004, A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma, Biochem Biophys Res Commun, 320, 226, 10.1016/j.bbrc.2004.05.155
Tamamura, 2003, T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer, FEBS Lett, 550, 79, 10.1016/S0014-5793(03)00824-X
Kim, 2008, Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases, Clin Exp Metastasis, 25, 201, 10.1007/s10585-007-9133-3
Porvasnik, 2009, Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth, Prostate, 10.1002/pros.21008
Richert, 2009, Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone, Oncol Rep, 21, 761
Kwong, 2009, An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells, Mol Cancer Ther, 8, 1893, 10.1158/1535-7163.MCT-08-0966
Liles, 2003, Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist, Blood, 102, 2728, 10.1182/blood-2003-02-0663
De Clercq, 2009, The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil), Biochem Pharmacol, 77, 1655, 10.1016/j.bcp.2008.12.014
Perissinotto, 2005, Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression, Clin Cancer Res, 11, 490, 10.1158/1078-0432.490.11.2
Li, 2009, A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone, Cancer Res, 69, 1685, 10.1158/0008-5472.CAN-08-2164
Rozel, 2009, Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model, J Cell Biochem, 107, 58, 10.1002/jcb.22056
Ito, 2009, Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid. IL-2Rgamma(null) mouse model, Cancer Immunol Immunother, 58, 1195, 10.1007/s00262-008-0632-0
Huang, 2002, Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma, Am J Pathol, 161, 125, 10.1016/S0002-9440(10)64164-8
Melnikova, 2006, Bioimmunotherapy for melanoma using fully human antibodies targeting MCAM/MUC18 and IL-8, Pigment Cell Res, 19, 395, 10.1111/j.1600-0749.2006.00331.x
Mian, 2003, Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB, Clin Cancer Res, 9, 3167
Zigler, 2008, Tumor immunotherapy in melanoma: strategies for overcoming mechanisms of resistance and escape, Am J Clin Dermatol, 9, 307, 10.2165/00128071-200809050-00004
DeNardo, 2009, CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages, Cancer Cell, 16, 91, 10.1016/j.ccr.2009.06.018
Ohta, 2005, The high expression of Fractalkine results in a better prognosis for colorectal cancer patients, Int J Oncol, 26, 41
Orjalo, 2009, Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network, Proc Natl Acad Sci USA, 106, 17031, 10.1073/pnas.0905299106