The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

Risau, W. Mechanisms of angiogenesis. Nature 386, 671–674 (1997).

Folkman, J. & D'Amore, P. A. Blood vessel formation: what is its molecular basis? Cell 87, 1153–1155 (1996).

Lindahl, P., Johansson, B. R., Leveen, P. & Betsholtz, C. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277, 242–245 (1997).

Bleul, C. C.et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382, 829–833 (1996).

Oberlin, E.et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382, 833–835 (1996).

Nagasawa, T.et al. Molecular cloning and characterization of a murine pre-B-cell growth-stimualting factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc. Natl Acad. Sci. USA 93, 14726–14729 (1996).

Nagasawa, T.et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382, 635–638 (1996).

Feng, Y., Broder, C. C., Kennedy, P. E. & Berger, E. A. HIV-1 entry corecptor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872–877 (1996).

Baggiolini, M., Dewald, B. & Moser, B. Human chemokines: an update. Annu. Rev. Immunol. 15, 675–705 (1997).

Vecchi, A.et al. Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium. Eur. J. Cell Biol. 63, 247–255 (1994).

Baldwin, H. S.et al. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development 120, 2539–2553 (1994).

Shalaby, F.et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nautre 376, 62–66 (1995).

Fong, G.-H., Rossant, J., Gertsenstein, M. & Breitman, M. L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66–70 (1995).

Dumont, D. J.et al. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 8, 1897–1909 (1994).

Sato, T. N.et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376, 70–74 (1995).

Carmeliet, P.et al. Abnormal blood vessel development and lethality in embryos lacking a single vEGF allele. Nature 380, 435–439 (1996).

Ferrara, N.et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439–442 (1996).

Suri, C.et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171–1180 (1996).

Maione, T. E.et al. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 247, 77–79 (1990).

Koch, A. E.et al. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258, 1798–1801 (1992).

Luster, A. D., Greenberg, S. M. & Leder, P. The IP-10 chemokine bind to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J. Exp. Med. 182, 219–231 (1995).

Cao, Y., Chen, C., Weatherbee, J. A., Tsang, M. & Folkman, J. gro-β, a CXC chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice. J. Exp. Med. 182, 2069–2077 (1995).

Cui, J., Sue O'Shea,, Purkayastha, A., Saunders, T. L. & Ginsburg, D. Fatal haemorrhage and incomplete block ot embryogenesis in mice lacking coagulation factor V. Nature 384, 66–68 (1996).

Carmeliet, P.et al. Role of tissue factor in embryonic blood vessel development. Nature 383, 73–75 (1996).

Offermanns, S., Mancino, V., Revel, J.-P. & Simon, M. I. Vascular system defects and impaired cell chemokinesis as a result of Gα13deficiency. Science 275, 533–535 (1997).

Fauci, A. S. Host factors and the pathogenesis of HIV-induced disease. Nature 384, 529–535 (1996).

Liu, R.et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86, 367–377 (1996).

Samson, M.et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the R-5 chemokine receptor gene. Nature 382, 722–725 (1996).

Dean, M.et al. Genetic restriction of HIV-1 infection and progression to AIDS by a detection allele of the CCR5 structural gene. Science 273, 1856–1861 (1996).

Adachi, S., Yoshida, H., Kataoka, H. & Nishikawa, S.-I. Three distinctive steps in Peyer's patch formation of murine embryo. Int. Immunol. 9, 507–514 (1997).