The challenges for molecular nutrition research 2: quantification of the nutritional phenotype

Genes and Nutrition - Tập 3 - Trang 51-59 - 2008
Ben van Ommen1, Jaap Keijer2, Robert Kleemann1, Ruan Elliott, Christian A. Drevon3, Harry McArdle4, Mike Gibney5, Michael Müller6
1Department of BioSciences, TNO-Quality of Life, Zeist, The Netherlands
2RIKILT-Institute of Food Safety and Wageningen University, Wageningen, The Netherlands
3Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
4Rowett Research Institute, Aberdeen, UK
5UCD Institute of Food and Health, University College Dublin, Dublin, Ireland
6Division of Human Nutrition, Nutrition, Metabolism and Genomics group, Wageningen University, HD Wageningen, The Netherlands

Tóm tắt

In quantifying the beneficial effect of dietary interventions in healthy subjects, nutrition research meets a number of new challenges. Inter individual variation in biomarker values often is larger than the effect related to the intervention. Healthy subjects have a remarkable capacity to maintain homeostasis, both through direct metabolic regulation, metabolic compensation of altered diets, and effective defence and repair mechanisms in oxidative and inflammatory stress. Processes involved in these regulatory activities essentially different from processes involved in early onset of diet related diseases. So, new concepts and approaches are needed to better quantify the subtle effects possibly achieved by dietary interventions in healthy subjects. Apart from quantification of the genotype and food intake (these are discussed in separate reviews in this series), four major areas of innovation are discussed: the biomarker profile concept, perturbation of homeostasis combined with omics analysis, imaging, modelling and fluxes. All of these areas contribute to a better understanding and quantification of the nutritional phenotype.

Tài liệu tham khảo

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