The central sympatho-inhibitory effect of 5,6-dihydroxy-2-dimethylaminotetralin (M7) is mediated by α2-adrenoceptors

Burkman, A.M., 1973, Biological activity of apomorphine fragments. Dissociation of emetic and stereotypical effects, Neuropharmacology 12, 83. Cannon, J.G., 1975, Chemistry of dopaminergic agonists, Adv. Neurol. 9, 177. Cannon, J.G. and P.E. Hicks, 1979, The cardiovacular effects of some N,N-dialkylated derivatives of -2-amino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene after central or peripheral administration in rats, Br. J. Pharmacol. 68, 188 P. Cannon, J.G., J.C. Kim, M.A. Aleem and J.P. Long, 1972, Centrally acting emetics. Derivatives of beta-naphthylamine and 2-indanamine, J. Med. Chem. 15, 348. Cavero, I., N. Shepperson, F. Lefevre-Borg and S.Z. Langer, 1983, Differential inhibition of vascular smooth muscle responses to α1 and α2-adrenoceptor agonist by diltiazem and verapamil, Circ. Res. 52 (Suppl. 1), 69. Cheng, H.C., J.P. Long, L.S. Van Onden, J.G. Cannon and J.P. O'Donnell, 1976, Dopaminergic activity of some apomorphine analogs, Res. Commun. Chem. Pathol. Pharmacol. 15, 89. Clapham, J.C. and T.C. Hamilton, 1982a, Involvement of presynaptic dopamine receptors in the antihypertensive response to 2-NN-dimethylamino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene (M7), J. Pharm. Pharmacol. 34, 644. Clapham, J.C. and T.C. Hamilton, 1982b, Presynaptic dopamine receptors mediate the inhibitory action of dopamine agonists on stimulation-evoked pressor responses in the rat, J. Auton. Pharmacol. 3, 181. Costall, B., R.J. Neylor, J.G. Cannon and T. Lee, 1977, Differential activation of some 2-aminotetraline derivatives of the receptor mechanisms in the nucleus accumbens of rat which mediate hyperactivity and stereotyped biting, Eur. J. Pharmacol. 41, 307. Costall, B., S.K. Lim and R.J. Naylor, 1981, Characterization of the mechanisms by which purported dopamine agonists reduce spontaneous activity of mice, Eur. J. Pharmacol. 73, 175. Drew, G.M., 1980, Postsynaptic α2-adrenoceptors mediated pressor responses to 2-N,N-dimethylamino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene (M7), Eur. J. Pharmacol. 65, 85. Flavahan, N.A., T.J. Thomas, J.P. Cooke and P.M. Vanhoutte, 1984, Characterization of postjunctional alpha-1 and alpha-2 adrenoceptors activated by exogenous or nerve released norepinephrine in the canine saphenous vein, J. Pharmacol. Exp. Ther. 230, 669. Fowler, P.J., M. Grous, W. Price and W. Matthews, 1984, Pharmacological differentiation of postsynaptic alpha adrenoceptors in the dog saphenous vein, J. Pharmacol. Exp. Ther. 229, 712. Garcin, A.M. and S.Z. Langer, 1985, Inhibition by 5,6-dihydro-2-dimethylaminotetralin (M7) of noradrenergic neurotransmission in the rabbit hypothalamus: role of alpha-2 adrenoceptors and of dopamine receptors, J. Pharmacol. Exp. Ther. 233, 459. Hicks, P.E. and J.G. Cannon, 1979, NN-Dialkyl derivatives of 2-amino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene as selective agonists at presynaptic α-adrenoceptors in the rat, J. Pharm. Pharmacol. 31, 494. Kitzen, J.M., J.P. Long and J.G. Cannon, 1978, Pharmacology of 6,7-dihydro-2-dimethylaminotetralin (TL99). Cardiovascular activity in the dog and cat, J. Pharmacol. Exp. Ther. 206, 239. Long, J.P., S. Heintz, J.G. Cannon and J. Kim, 1975, Inhibition of the sympathetic nervous system by 5,6-dihydroxy-2-dimethylaminotetralin (M7) apomorphine and dopamine, J. Pharmacol. Exp. Ther. 192, 336. Maixmer, W., S.P. Arneric, M. Abou, J. Lecompte, T. Veriner, J.G. Cannon, T. Lee and J.P. Long, 1981, Pharmacological effects of 2-aminotetralins, octahydrobenzo(f)quinolines and clonidine on the guinea pig ileum, Eur. J. Pharmacol. 71, 475. Rusterholz, D.B., C.F. Barfnecht and J.A. Clemens, 1974, Ergoline congeners as potential inhibitors of prolactine release, J. Med. Chem. 19, 99. Shepperson, N.B. and S.Z. Langer, 1981, The effects of the 2-amino-tetrahydronaphthalene derivative M7, a selective α2-adrenoceptor agonist in vitro, Naunyn-Schmiedeberg's Arch. Pharmacol. 318, 10. Timmermans, P.B., B. Wilffert, D. Davidesko, M.J. Mathy, D. Dijkstra, A.S. Horn and P.A. Van Zwieten, 1983, Re-evaluation of the selectivity of 2-N,N-dimethylamino-5,6-dihydroxy-1,2,3,4-tetrahydronaphthalene (M7) as an agonist of postjunctional alpha-2 adrenoceptors in the pithed normotensive rat, J. Pharmacol. Exp. Ther. 225, 407. Vayssettes-Courchay, C., F. Bouysset, T.J. Verbeuren, M. Laubie and H. Schmitt, 1990, The cardiovascular effects of quipazine are mediated by peripheral 5-HT2 and 5-HT3 receptors in anesthetized rats, Eur. J. Pharmacol. 184, 75. Vayssettes-Courchay, C., F. Bouysset, T.J. Verbeuren and M. Laubie, 1993, Role of the lateral tegmental field in the central sympatho-inhibitory effect of 8-OH-DPAT in the cat, Eur. J. Pharmacol. 236, 121. Vayssettes-Courchay, C., F. Bouysset, A.A. Cordi, T.J. Verbeuren and M. Laubie, 1996, A comparative study of the reversal by different α2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine, Br. J. Pharmacol. 117, 587. Woodruff, G.N., K.J. Watling, C.D. Andrews, J.A. Poat and J.D. McDermed, 1977, Dopamine receptors in rat striatum and nucleus accumbens, J. Pharm. Pharmacol. 19, 422.