The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae
Tóm tắt
Từ khóa
Tài liệu tham khảo
Adari, 1988, Guanosine triphosphate activating protein (GAP) interacts with the p21 ras effector binding domain, Science, 240, 518, 10.1126/science.2833817
Ballester, 1989, Genetic analysis of mammalian GAP expressed in yeast, Cell, 59, 681, 10.1016/0092-8674(89)90014-7
Calés, 1988, The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product, Nature, 332, 548, 10.1038/332548a0
Cawthon, 1990, A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations, Cell, 62, 193, 10.1016/0092-8674(90)90253-B
Dower, 1988, High efficiency transformation of E. coli by high voltage electroporation, Nucl. Acids Res., 16, 6127, 10.1093/nar/16.13.6127
Friedman, 1988, Enzymatic amplification of specific cDNA inserts from λ-gt11 libraries, Nucl. Acids Res., 16, 8718, 10.1093/nar/16.17.8718
Gibbs, 1988, Purification of ras GTPase-activating protein from bovine brain, 85, 5026
Kaplan, 1890, PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex, Cell, 61, 125, 10.1016/0092-8674(90)90220-9
Kazlauskas, 1990, Binding of GAP to activated PDGF receptors, Science, 247, 1578, 10.1126/science.2157284
Marshall, 1989, A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity, EMBO J., 8, 1105, 10.1002/j.1460-2075.1989.tb03480.x
McCormick, 1989, ras GTPase activating protein: signal transmitter and signal terminator, Cell, 56, 5, 10.1016/0092-8674(89)90976-8
Molloy, 1989, PDGF induction of tyrosine phosphorylation of GTPase activating protein, Nature, 342, 711, 10.1038/342711a0
Riccardi, 1986
Smith, 1988, Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase, Gene, 67, 31, 10.1016/0378-1119(88)90005-4
Stumpf, 1987, Neurofibromatosis, Arch. Neurol., 45, 575
Tabor, 1989, Effect of manganese ions on the incorporation of dideoxynucleotides by bacteriophage T7 DNA polymerase and Escherichia coli DNA polymerase I, 86, 4076
Tanaka, 1989, IRA1, an inhibitory regulator of the RAS/cyclic AMP pathway in Saccharomyces cerevisiae, Mol. Cell. Biol., 9, 757, 10.1128/MCB.9.2.757
Tanaka, 1990, IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein, Mol. Cell. Biol., 10, 4303, 10.1128/MCB.10.8.4303
Tanaka, 1990, S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein, Cell, 60, 803, 10.1016/0092-8674(90)90094-U
Tanaka, 1991, IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein (GAP)
Trahey, 1987, A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants, Science, 238, 542, 10.1126/science.2821624
Viskochil, 1990, Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus, Cell, 62, 187, 10.1016/0092-8674(90)90252-A
Wallace, 1990, Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients, Science, 249, 181, 10.1126/science.2134734
