The cargo of CRPPR-conjugated liposomes crosses the intact murine cardiac endothelium

van Rooy, 2011, Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain, J. Control. Release, 150, 30, 10.1016/j.jconrel.2010.11.014 Maruyama, 1990, Lipid-composition is important for highly efficient target binding and retention of immunoliposomes, Proc. Natl. Acad. Sci. U. S. A., 87, 5744, 10.1073/pnas.87.15.5744 Kelly, 2005, Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle, Circ. Res., 96, 327, 10.1161/01.RES.0000155722.17881.dd Zhang, 2008, Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse model, Biomaterials, 29, 1976, 10.1016/j.biomaterials.2007.12.033 Pasqualini, 1996, Organ targeting in vivo using phage display peptide libraries, Nature, 380, 364, 10.1038/380364a0 Fan, 2007, An in vivo approach to structure activity relationship analysis of peptide ligands, Pharm. Res., 24, 868, 10.1007/s11095-007-9238-z Rajotte, 1999, Membrane dipeptidase is the receptor for a lung-targeting peptide identified by in vivo phage display, J. Biol. Chem., 274, 11593, 10.1074/jbc.274.17.11593 Zhang, 2005, Molecular profiling of heart endothelial cells, Circulation, 112, 1601, 10.1161/CIRCULATIONAHA.104.529537 Arap, 2002, Targeting the prostate for destruction through a vascular address, Proc. Natl. Acad. Sci. U. S. A., 99, 1527, 10.1073/pnas.241655998 Essler, 2002, Molecular specialization of breast vasculature: a breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature, Proc. Natl. Acad. Sci. U. S. A., 99, 2252, 10.1073/pnas.251687998 Teesalu, 2009, C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration, Proc. Natl. Acad. Sci. U. S. A., 106, 16157, 10.1073/pnas.0908201106 Sugahara, 2010, Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs, Science, 328, 1031, 10.1126/science.1183057 Torchilin, 1996, Poly(ethylene glycol)-coated anti-cardiac myosin immunoliposomes: factors influencing targeted accumulation in the infarcted myocardium, Biochim. Biophys. Acta-Biomembr., 1279, 75, 10.1016/0005-2736(95)00248-0 Dvir, 2011, Nanoparticles targeting the infarcted heart, Nano Lett., 11, 4411, 10.1021/nl2025882 Kanki, 2011, Identification of targeting peptides for ischemic myocardium by in vivo phage display, J. Mol. Cell. Cardiol., 50, 841, 10.1016/j.yjmcc.2011.02.003 Arap, 1998, Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model, Science, 279, 377, 10.1126/science.279.5349.377 Porkka, 2002, A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo, Proc. Natl. Acad. Sci. U. S. A., 99, 7444, 10.1073/pnas.062189599 Corti, 2008, The neovasculature homing motif NGR: more than meets the eye, Blood, 112, 2628, 10.1182/blood-2008-04-150862 Ruoslahti, 2004, Vascular zip codes in angiogenesis and metastasis, Biochem. Soc. Trans., 32, 397, 10.1042/bst0320397 Abu Lila, 2009, Recent advances in tumor vasculature targeting using liposomal drug delivery systems, Expert Opin. Drug Deliv., 6, 1297, 10.1517/17425240903289928 Neri, 2005, Tumour vascular targeting, Nat. Rev. Cancer, 5, 436, 10.1038/nrc1627 Kelly, 2006, In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging, Mol. Imaging Biol., 8, 201, 10.1007/s11307-006-0043-6 Lindner, 2010, Molecular imaging of vascular phenotype in cardiovascular disease: new diagnostic opportunities on the horizon, J. Am. Soc. Echocardiogr., 23, 343, 10.1016/j.echo.2010.01.025 Godin, 2010, Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases, Trends Pharmacol. Sci., 31, 199, 10.1016/j.tips.2010.01.003 Mulder, 2008, Nanomedicine captures cardiovascular disease, Arterioscler. Thromb. Vasc. Biol., 28, 801, 10.1161/ATVBAHA.108.165332 Greig, 2010, Vascular-targeting antioxidant therapy in a model of hypertension and stroke, J. Cardiovasc. Pharmacol., 56, 642, 10.1097/FJC.0b013e3181f8f19f Pastorino, 2003, Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy, Cancer Res., 63, 7400 Maeda, 2004, Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome, J. Control. Release, 100, 41, 10.1016/j.jconrel.2004.07.033 Oh, 2007, Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung, Nat. Biotechnol., 25, 327, 10.1038/nbt1292 Inai, 2004, Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts, Am. J. Pathol., 165, 35, 10.1016/S0002-9440(10)63273-7 Borden, 2008, A stimulus-responsive contrast agent for ultrasound molecular imaging, Biomaterials, 29, 597, 10.1016/j.biomaterials.2007.10.011 Wang, 2006, A simple and fast experimental model of myocardial infarction in the mouse, Tex. Heart Inst. J., 33, 290 Camus, 2004, Amiodarone pulmonary toxicity, Clin. Chest Med., 25, 65-+, 10.1016/S0272-5231(03)00144-8 Naccarelli, 2000, Amiodarone: clinical trials, Curr. Opin. Cardiol., 15, 64, 10.1097/00001573-200001000-00009 Schmidt, 2010, Arginine-rich cell-penetrating peptides, FEBS Lett., 584, 1806, 10.1016/j.febslet.2009.11.046 Di Marco, 2010, Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation, Int. J. Nanomedicine, 5, 37 Tahara, 2011, Brain targeting with surface-modified poly(D, L-lactic-co-glycolic acid) nanoparticles delivered via carotid artery administration, Eur. J. Pharm. Biopharm., 77, 84, 10.1016/j.ejpb.2010.11.002 Liehn, 2011, Repair after myocardial infarction, between fantasy and reality, J. Am. Coll. Cardiol., 58, 2357, 10.1016/j.jacc.2011.08.034