The bullwhip effect, T-cell telomeres, and SARS-CoV-2

Sender, 2016, Revised estimates for the number of human and bacteria cells in the body, PLoS Biol, 14, e1002533, 10.1371/journal.pbio.1002533 Riera Romo, 2016, Innate immunity in vertebrates: an overview, Immunology, 148, 125, 10.1111/imm.12597 Boehm, 2014, Origin and evolution of adaptive immunity, Annu Rev Anim Biosci, 2, 259, 10.1146/annurev-animal-022513-114201 Sette, 2021, Adaptive immunity to SARS-CoV-2 and COVID-19, Cell, 184, 861, 10.1016/j.cell.2021.01.007 McKechnie, 2020, The innate immune system: fighting on the front lines or fanning the flames of COVID-19?, Cell Host Microbe, 27, 863, 10.1016/j.chom.2020.05.009 Vabret, 2020, Immunology of COVID-19: current state of the science, Immunity, 52, 910, 10.1016/j.immuni.2020.05.002 Wickenden Kahneman, 2011 Dingli, 2007, Compartmental architecture and dynamics of hematopoiesis, PLoS One, 2, e345, 10.1371/journal.pone.0000345 Werner, 2015, Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions, eLife, 4, e08687, 10.7554/eLife.08687 Sidorov, 2009, Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth, Exp Hematol, 37, 514, 10.1016/j.exphem.2008.11.009 Lee-Six, 2018, Population dynamics of normal human blood inferred from somatic mutations, Nature, 561, 473, 10.1038/s41586-018-0497-0 Wang, 2016, The bullwhip effect: progress, trends and directions, Eur J Oper Res, 250, 691, 10.1016/j.ejor.2015.07.022 Ohno, 2019 Forrester, 1961 Bray, 2012, Information transmission and the bullwhip effect: an empirical investigation, Manage Sci, 58, 860, 10.1287/mnsc.1110.1467 Yang, 2021, The behavioural causes of bullwhip effect in supply chains: a systematic literature review, Int J Prod Econ, 236, 108120, 10.1016/j.ijpe.2021.108120 Hummert, 2014, Evolutionary game theory: cells as players, Mol Biosyst, 10, 3044, 10.1039/C3MB70602H Mon Père, 2021, Multistage feedback-driven compartmental dynamics of hematopoiesis, iScience, 24, 102326, 10.1016/j.isci.2021.102326 Taefehshokr, 2020, COVID-19: perspectives on innate immune evasion, Front Immunol, 11, 580641, 10.3389/fimmu.2020.580641 Jenkins, 2021, The expanding world of tissue-resident macrophages, Eur J Immunol, 51, 1882, 10.1002/eji.202048881 Rivera, 2016, Innate cell communication kick-starts pathogen-specific immunity, Nat Immunol, 17, 356, 10.1038/ni.3375 Li, 2021, Pattern recognition receptors in health and diseases, Signal Transduct Target Ther, 6, 291, 10.1038/s41392-021-00687-0 Wilk, 2021, Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19, J Exp Med, 218, e20210582, 10.1084/jem.20210582 Metzemaekers, 2021, Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019, Clin Transl Immunol, 10, e1271, 10.1002/cti2.1271 Kumar, 2018, Human T cell development, localization, and function throughout life, Immunity, 48, 202, 10.1016/j.immuni.2018.01.007 LeBien, 2008, B lymphocytes: how they develop and function, Blood, 112, 1570, 10.1182/blood-2008-02-078071 Björkström, 2022, Natural killer cells in antiviral immunity, Nat Rev Immunol, 22, 112, 10.1038/s41577-021-00558-3 Adams, 2020, Clonal expansion of innate and adaptive lymphocytes, Nat Rev Immunol, 20, 694, 10.1038/s41577-020-0307-4 Juno, 2022, T follicular helper cells and their impact on humoral responses during pathogen and vaccine challenge, Curr Opin Immunol, 74, 112, 10.1016/j.coi.2021.11.004 Cui, 2021, Follicular helper T cells in the immunopathogenesis of SARS-CoV-2 infection, Front Immunol, 12, 731100, 10.3389/fimmu.2021.731100 Sahin, 2021, BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans, Nature, 595, 572, 10.1038/s41586-021-03653-6 Painter, 2021, Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination, Immunity, 54, 2133, 10.1016/j.immuni.2021.08.001 Parry, 2021, Immunogenicity of single vaccination with BNT162b2 or ChAdOx1 nCoV-19 at 5–6 weeks post vaccine in participants aged 80 years or older: an exploratory analysis, Lancet Healthy Longev, 2, e554, 10.1016/S2666-7568(21)00169-0 Angyal, 2022, T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study, Lancet Microbe, 3, e21, 10.1016/S2666-5247(21)00275-5 Walsh, 2020, Safety and immunogenicity of two RNA-based COVID-19 vaccine candidates, N Engl J Med, 383, 2439, 10.1056/NEJMoa2027906 Keeton, 2022, T cell responses to SARS-CoV-2 spike cross-recognize omicron, Nature, 603, 488, 10.1038/s41586-022-04460-3 Liu, 2022, Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron, Nature, 603, 493, 10.1038/s41586-022-04465-y Munro, 2022, Lancet Infect Dis, 22, 1131, 10.1016/S1473-3099(22)00271-7 Collier, 2021, Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2, Nature, 596, 417, 10.1038/s41586-021-03739-1 Sadoff, 2021, Interim results of a phase 1–2a trial of Ad26.COV2.S COVID-19 vaccine, N Engl J Med, 384, 1824, 10.1056/NEJMoa2034201 Bates, 2021, Age-dependent neutralization of SARS-CoV-2 and P.1 variant by vaccine immune serum samples, JAMA, 326, 868, 10.1001/jama.2021.11656 Lustig, 2021, BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: a prospective, single-centre, longitudinal cohort study in health-care workers, Lancet Respir Med, 9, 999, 10.1016/S2213-2600(21)00220-4 Steensels, 2021, Comparison of SARS-CoV-2 antibody response following vaccination with BNT162b2 and mRNA-1273, JAMA, 326, 1533, 10.1001/jama.2021.15125 Bates, 2021, Age-dependent neutralization of SARS-CoV-2 and P.1 variant by vaccine immune serum samples, JAMA, 326, 868, 10.1001/jama.2021.11656 Masopust, 2013, The integration of T cell migration, differentiation and function, Nat Rev Immunol, 13, 309, 10.1038/nri3442 Blackburn, 2015, Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection, Science, 350, 1193, 10.1126/science.aab3389 Aviv, 2018, Reflections on telomere dynamics and ageing-related diseases in humans, Philos Trans R Soc Lond B Biol Sci, 373, 20160436, 10.1098/rstb.2016.0436 O’Sullivan, 2010, Telomeres: protecting chromosomes against genome instability, Nat Rev Mol Cell Biol, 11, 171, 10.1038/nrm2848 Stone, 2016, Telomere length and the cancer-atherosclerosis trade-off, PLoS Genet, 12, e1006144, 10.1371/journal.pgen.1006144 Haycock, 2014, Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis, BMJ, 349, g4227, 10.1136/bmj.g4227 McNally, 2019, Long telomeres and cancer risk: the price of cellular immortality, J Clin Invest, 129, 3474, 10.1172/JCI120851 Codd, 2021, Polygenic basis and biomedical consequences of telomere length variation, Nat Genet, 53, 1425, 10.1038/s41588-021-00944-6 Aubert, 2012, Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes, PLoS Genet, 8, e1002696, 10.1371/journal.pgen.1002696 Steenstrup, 2017, Telomeres and the natural lifespan limit in humans, Aging (Albany NY), 9, 1130, 10.18632/aging.101216 Daniali, 2013, Telomeres shorten at equivalent rates in somatic tissues of adults, Nat Commun, 4, 1597, 10.1038/ncomms2602 Slagboom, 1994, Genetic determination of telomere size in humans: a twin study of three age groups, Am J Hum Genet, 55, 876 Hjelmborg, 2015, The heritability of leucocyte telomere length dynamics, J Med Genet, 52, 297, 10.1136/jmedgenet-2014-102736 Shay, 2016, Role of telomeres and telomerase in aging and cancer, Cancer Discov, 6, 584, 10.1158/2159-8290.CD-16-0062 Blackburn, 2011, Telomerase: an RNP enzyme synthesizes DNA, Cold Spring Harb Perspect Biol, 3, a003558, 10.1101/cshperspect.a003558 Hodes, 2002, Telomeres in T and B cells, Nat Rev Immunol, 2, 699, 10.1038/nri890 Weng, 1997, Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging, Immunol Rev, 160, 43, 10.1111/j.1600-065X.1997.tb01026.x Patrick, 2019, Expression and regulation of telomerase in human T cell differentiation, activation, aging and diseases, Cell Immunol, 345, 103989, 10.1016/j.cellimm.2019.103989 Steenstrup, 2013, The telomere lengthening conundrum--artifact or biology?, Nucleic Acids Res, 41, e131, 10.1093/nar/gkt370 Nettle, 2021, Measurement of telomere length for longitudinal analysis: implications of assay precision, Am J Epidemiol, 190, 1406, 10.1093/aje/kwab025 Benetos, 2013, Tracking and fixed ranking of leukocyte telomere length across the adult life course, Aging Cell, 12, 615, 10.1111/acel.12086 Anderson, 2022, Telomere-length dependent T-cell clonal expansion: a model linking ageing to COVID-19 T-cell lymphopenia and mortality, EBioMedicine, 78, 103978, 10.1016/j.ebiom.2022.103978 Vrisekoop, 2008, Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool, Proc Natl Acad Sci USA, 105, 6115, 10.1073/pnas.0709713105 Diao, 2020, Reduction and functional exhaustion of T cells in patients with Coronavirus Disease 2019 (COVID-19), Front Immunol, 11, 827, 10.3389/fimmu.2020.00827 Chen, 2020, T cell responses in patients with COVID-19, Nat Rev Immunol, 20, 529, 10.1038/s41577-020-0402-6 Rydyznski Moderbacher, 2020, Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity, Cell, 183, 996, 10.1016/j.cell.2020.09.038 Bartleson, 2021, SARS-CoV-2, COVID-19 and the ageing immune system, Nat Aging, 1, 769, 10.1038/s43587-021-00114-7 Jin, 2021, Age cohorts stratified according to age-distributions of COVID-19 morbidity statistics identify uniquely age-dependent CD3+CD8+ T-cell lymphocytopenia in COVID-19 patients without comorbidities on admission, Aging (Albany NY), 13, 7713, 10.18632/aging.202691 Aviv, 2021, Short telomeres and severe COVID-19: the connection conundrum, eBioMedicine, 70, 103513, 10.1016/j.ebiom.2021.103513 Benetos, 2021, The nexus between telomere length and lymphocyte count in seniors hospitalized with COVID-19, J Gerontol A Biol Sci Med Sci, 76, e97, 10.1093/gerona/glab026 Wang, 2021, Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: a cohort study in UK Biobank, eBioMedicine, 70, 103485, 10.1016/j.ebiom.2021.103485 Froidure, 2020, Short telomeres increase the risk of severe COVID-19, Aging (Albany NY), 12, 19911, 10.18632/aging.104097 Sanchez-Vazquez, 2021, Shorter telomere lengths in patients with severe COVID-19 disease, Aging (Albany NY), 13, 1, 10.18632/aging.202463 McGroder, 2021, Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length, Thorax, 76, 1242, 10.1136/thoraxjnl-2021-217031 Tsilingiris, 2020, Telomere length, epidemiology and pathogenesis of severe COVID-19, Eur J Clin Invest, 50, e13376, 10.1111/eci.13376