The biological response to three different nanostructures applied on smooth implant surfaces

Clinical Oral Implants Research - Tập 23 Số 6 - Trang 706-712 - 2012
Ryo Jimbo1,2, Javier Sotres3, Carina B. Johansson4, Karin Breding5, Fredrik Currie5, Ann Wennerberg1,2
1Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
2Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
3Department of Biomedical Laboratory Science and Technology, Faculty of Health and Society, Malmö University, Malmö, Sweden
4Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
5Promimic AB, Göteborg, Sweden.

Tóm tắt

Abstract

Objective: To evaluate the biological effects of three calcium phosphate (CaP) coatings with nanostructures on relatively smooth implant surfaces.

Material and methods: Stable CaP nanoparticle suspensions of different particle sizes and structures were coated onto implants by immersion and subsequent heat treatment. An uncoated implant was used as the control. After topographical and chemical characterizations, implants were randomly inserted into rabbit tibiae for removal torque (RTQ) testing. To confirm the biological reaction, implants were placed in the bilateral femurs of three rabbits.

Results: The topographical characterization showed that each surface had different nanostructural characteristics and X‐ray photon spectroscopy showed various CaP compositions. The control and test groups had different nanotopographies; however, the differences among the test groups were only significant for Surfaces B and C and the rest were insignificant. The RTQ tests showed significantly higher values in two test groups (Surface A and Surface C). Histologically, no adverse effects were seen in any group. Histomorphometrical evaluation showed comparable or better osseointegration along the implant threads in the test groups.

Conclusion: The three different CaP coatings with nanostructures on the implant surfaces had enhancing effects on osseointegration. Along with the surface nanotopography, the CaP chemistry might have influenced the biological outcomes.

Từ khóa


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Thông tin xuất bản

Clinical Oral Implants Research

Tập 23 Số 6

706-712

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