The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia

Rademakers, 2013, Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial, Radiother Oncol, 108, 517, 10.1016/j.radonc.2013.04.022 Nordsmark, 2005, Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study, Radiother Oncol, 77, 18, 10.1016/j.radonc.2005.06.038 Dewhirst, 2008, Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response, Nat Rev Cancer, 8, 425, 10.1038/nrc2397 Simonsen, 2012, Vascular abnormalities associated with acute hypoxia in human melanoma xenografts, Radiother Oncol, 105, 72, 10.1016/j.radonc.2012.08.018 Durand, 2001, Clinical relevance of intermittent tumour blood flow, Acta Oncol, 40, 929, 10.1080/02841860152708206 Magagnin, 2006, Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies, Drug Resist Updat, 9, 185, 10.1016/j.drup.2006.07.002 Toustrup, 2012, Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck, Radiother Oncol, 102, 122, 10.1016/j.radonc.2011.09.010 Sun, 2012, Hypoxia targeted bifunctional suicide gene expression enhances radiotherapy in vitro and in vivo, Radiother Oncol, 105, 57, 10.1016/j.radonc.2012.07.011 Ron, 2007, Signal integration in the endoplasmic reticulum unfolded protein response, Nat Rev Mol Cell Biol, 8, 519, 10.1038/nrm2199 Rouschop, 2010, The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5, J Clin Invest, 120, 127, 10.1172/JCI40027 Egan, 2011, Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy, Science, 331, 456, 10.1126/science.1196371 Hosokawa, 2009, Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy, Mol Biol Cell, 20, 1981, 10.1091/mbc.E08-12-1248 Mizushima, 2010, The role of the Atg1/ULK1 complex in autophagy regulation, Curr Opin Cell Biol, 22, 132, 10.1016/j.ceb.2009.12.004 Zhao, 2011, AMPK-dependent phosphorylation of ULK1 induces autophagy, Cell Metab, 13, 119, 10.1016/j.cmet.2011.01.009 Pike, 2013, Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival, Biochem J, 449, 389, 10.1042/BJ20120972 Rouschop, 2009, Autophagy is required during cycling hypoxia to lower production of reactive oxygen species, Radiother Oncol, 92, 411, 10.1016/j.radonc.2009.06.029 Stegeman, 2013, Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models, Radiother Oncol, 106, 383, 10.1016/j.radonc.2013.02.001 Wijffels, 2001, Patterns of proliferation related to vasculature in human head-and-neck carcinomas before and after transplantation in nude mice, Int J Radiat Oncol Biol Phys, 51, 1346, 10.1016/S0360-3016(01)02605-0 Pramana, 2007, Gene expression profiling to predict outcome after chemoradiation in head and neck cancer, Int J Radiat Oncol Biol Phys, 69, 1544, 10.1016/j.ijrobp.2007.08.032 Ramaekers, 2011, Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T, Radiother Oncol, 101, 190, 10.1016/j.radonc.2011.05.059 Theys, 2011, E-cadherin loss associated with EMT promotes radioresistance in human tumor cells, Radiother Oncol, 99, 392, 10.1016/j.radonc.2011.05.044 Wouters, 2004, Targeting hypoxia tolerance in cancer, Drug Resist Updat, 7, 25, 10.1016/j.drup.2003.12.004 Koritzinsky, 2007, Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia, Radiother Oncol, 83, 353, 10.1016/j.radonc.2007.04.031 Pastorekova, 1992, A novel quasi-viral agent, MaTu, is a two-component system, Virology, 187, 620, 10.1016/0042-6822(92)90464-Z Janssens, 2012, Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial, J Clin Oncol, 30, 1777, 10.1200/JCO.2011.35.9315 Jiang, 2011, Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma, Cancer Sci, 102, 1568, 10.1111/j.1349-7006.2011.01964.x Starmans, 2012, The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer, Radiother Oncol, 102, 436, 10.1016/j.radonc.2012.02.002 Rouschop, 2013, PERK/eIF2alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS, Proc Natl Acad Sci USA, 110, 4622, 10.1073/pnas.1210633110