The association between circulating magnesium and clinically relevant outcomes in patients with chronic kidney disease: A systematic review and meta-analysis

Matsushita, 2010, Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis, Lancet, 375, 2073, 10.1016/S0140-6736(10)60674-5 Leenders, 2019, Magnesium: a magic bullet for cardiovascular disease in chronic kidney disease?, Nutrients, 11 Jahnen-Dechent, 2012, Magnesium basics, Clin Kidney J, 5, i3, 10.1093/ndtplus/sfr163 Zelt, 2015, Magnesium modifies the impact of calcitriol treatment on vascular calcification in experimental chronic kidney disease, J Pharmacol Exp Therapeut, 355, 451, 10.1124/jpet.115.228106 Rennenberg, 2009, Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis, Vasc Health Risk Manag, 5, 185, 10.2147/VHRM.S4822 Louvet, 2013, Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells, Nephrol Dial Transplant, 28, 869, 10.1093/ndt/gfs520 Villa-Bellosta, 2017, Impact of magnesium:calcium ratio on calcification of the aortic wall, PloS One, 12, 10.1371/journal.pone.0178872 Yue, 2004, Effects of magnesium on matrix metalloproteinase-2 production in cultured rat cardiac fibroblasts, Basic Res Cardiol, 99, 257, 10.1007/s00395-004-0472-9 Mortazavi, 2013, Effect of magnesium supplementation on carotid intima-media thickness and flow-mediated dilatation among hemodialysis patients: a double-blind, randomized, placebo-controlled trial, Eur Neurol, 69, 309, 10.1159/000346427 Bressendorff, 2017, Oral magnesium supplementation in chronic kidney disease stages 3 and 4: efficacy, safety, and effect on serum calcification propensity-A prospective randomized double-blinded placebo-controlled clinical trial, Kidney Inter Rep, 2, 380, 10.1016/j.ekir.2016.12.008 Bressendorff, 2018, The effect of increasing dialysate magnesium on serum calcification propensity in subjects with end stage kidney disease: a randomized, controlled clinical trial, Clin J Am Soc Nephrol, 13, 1373, 10.2215/CJN.13921217 Pasch, 2012, Nanoparticle-based test measures overall propensity for calcification in serum, J Am Soc Nephrol, 23, 1744, 10.1681/ASN.2012030240 Smith, 2014, Serum calcification propensity predicts all-cause mortality in predialysis CKD, J Am Soc Nephrol, 25, 339, 10.1681/ASN.2013060635 Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, BMJ (Clinical research ed), 339, b2535, 10.1136/bmj.b2535 Levin, 2013, Kidney disease: improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease, Kidney Int Suppl, 3, 1 Matias, 2014, Lower serum magnesium is associated with cardiovascular risk factors and mortality in haemodialysis patients, Blood Purif, 38, 244, 10.1159/000366124 Sakaguchi, 2014, Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis, Kidney Int, 85, 174, 10.1038/ki.2013.327 Lu, 2020, Hypomagnesemia and short-term mortality in elderly maintenance hemodialysis patients, Kidney Dis (Basel), 6, 109, 10.1159/000504601 Wells Higgins, 2011, The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials, BMJ (Clinical research ed), 343, d5928, 10.1136/bmj.d5928 Lacson, 2015, Serum magnesium and mortality in hemodialysis patients in the United States: a cohort study, Am J Kidney Dis, 66, 1056, 10.1053/j.ajkd.2015.06.014 Sakaguchi, 2014, Magnesium modifies the cardiovascular mortality risk associated with hyperphosphatemia in patients undergoing hemodialysis: a cohort study, PloS One, 9, 10.1371/journal.pone.0116273 Sakaguchi, 2012, Hypomagnesemia in type 2 diabetic nephropathy: a novel predictor of end-stage renal disease, Diabetes Care, 35, 1591, 10.2337/dc12-0226 Sakaguchi, 2015, Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease, Kidney Int, 88, 833, 10.1038/ki.2015.165 Kurita, 2015, Contribution of dysregulated serum magnesium to mortality in hemodialysis patients with secondary hyperparathyroidism: a 3-year cohort study, Clin Kidney J, 8, 744, 10.1093/ckj/sfv097 Schmaderer, 2017, Reduced mortality in maintenance haemodialysis patients on high versus low dialysate magnesium: a pilot study, Nutrients, 9, 10.3390/nu9090926 Wu, 2019, Baseline serum magnesium level and its variability in maintenance hemodialysis patients: associations with mortality, Kidney Blood Pres Res, 1 Yang, 2016, Serum magnesium levels and hospitalization and mortality in incident peritoneal dialysis patients: a cohort study, Am J Kidney Dis, 68, 619, 10.1053/j.ajkd.2016.03.428 Perez-Garcia, 2020, Hypomagnesaemia in haemodialysis is associated with increased mortality risk: its relationship with dialysis fluid, Nefrologia : Publ Off de la Sociedad Espanola Nefrologia Shimohata, 2019, The relationship between serum magnesium levels and mortality in non-diabetic hemodialysis patients: a 10-year follow-up study, Hemodial Int, 23, 369, 10.1111/hdi.12759 Ferre, 2018, Association of serum magnesium with all-cause mortality in patients with and without chronic kidney disease in the Dallas Heart Study, Nephrol Dial Transplant, 33, 1389, 10.1093/ndt/gfx275 Li, 2015, Hypomagnesemia and mortality in incident hemodialysis patients, Am J Kidney Dis, 66, 1047, 10.1053/j.ajkd.2015.05.024 Van Laecke, 2013, Hypomagnesemia and the risk of death and GFR decline in chronic kidney disease, Am J Med, 126, 825, 10.1016/j.amjmed.2013.02.036 Ye, 2018, Serum magnesium and cardiovascular mortality in peritoneal dialysis patients: a 5-year prospective cohort study, Br J Nutr, 120, 415, 10.1017/S0007114518001599 Azem, 2020, Serum magnesium, mortality and disease progression in chronic kidney disease, BMC Nephrol, 21, 49, 10.1186/s12882-020-1713-3 de Francisco, 2018, Proton pump inhibitor usage and the risk of mortality in hemodialysis patients, Kidney Inter Rep, 3, 374, 10.1016/j.ekir.2017.11.001 Markaki, 2012, The role of serum magnesium and calcium on the association between adiponectin levels and all-cause mortality in end-stage renal disease patients, PloS One, 7, 10.1371/journal.pone.0052350 Mizuiri, 2019, Hypomagnesemia is not an independent risk factor for mortality in Japanese maintenance hemodialysis patients, Int Urol Nephrol, 10.1007/s11255-019-02073-w Ortega, 2013, Lack of influence of serum magnesium levels on overall mortality and cardiovascular outcomes in patients with advanced chronic kidney disease, ISRN Nephrol, 2013, 191786, 10.5402/2013/191786 Selim, 2017, Hypomagnesemia and cause-specific mortality in hemodialysis patients: 5-year follow-up analysis, Int J Artif Organs, 40, 542, 10.5301/ijao.5000611 de Roij van Zuijdewijn, 2015, Serum magnesium and sudden death in European hemodialysis patients, PloS One, 10, 10.1371/journal.pone.0143104 Kanbay, 2012, Relationship between serum magnesium levels and cardiovascular events in chronic kidney disease patients, Am J Nephrol, 36, 228, 10.1159/000341868 Sakaguchi, 2018, Magnesium and risk of hip fracture among patients undergoing hemodialysis, J Am Soc Nephrol, 29, 991, 10.1681/ASN.2017080849 Xiong, 2019, Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis, J Nephrol Leenders, 2018, Routine hemodialysis induces a decline in plasma magnesium concentration in most patients: a prospective observational cohort study, Sci Rep, 8, 10256, 10.1038/s41598-018-28629-x Topf, 2003, Hypomagnesemia and hypermagnesemia, Rev Endocr Metab Disord, 4, 195, 10.1023/A:1022950321817 Gonella, 1988, Improved bone morphology by normalizing serum magnesium in chronically hemodialyzed patients, Miner Electrol Metabol, 14, 240 Ago, 2016, Hypomagnesemia as a predictor of mortality in hemodialysis patients and the role of proton pump inhibitors: a cross-sectional, 1-year, retrospective cohort study, Hemodial Int, 20, 580, 10.1111/hdi.12437 Cai, 2016, Hypomagnesemia is associated with increased mortality among peritoneal dialysis patients, PloS One, 11, 10.1371/journal.pone.0152488 Ishimura, 2007, Serum magnesium concentration is a significant predictor of mortality in maintenance hemodialysis patients, Magnes Res, 20, 237 Menez, 2020, Serum magnesium, bone-mineral metabolism markers and their interactions with kidney function on subsequent risk of peripheral artery disease: the Atherosclerosis Risk in Communities Study, Nephrol Dial Transplant, 10.1093/ndt/gfaa029 Mizuiri, 2020, Relationship of serum magnesium level with body composition and survival in hemodialysis patients, Hemodial Int, 24, 99, 10.1111/hdi.12797 Silva, 2014, Magnesium and mortality in patients with diabetes and early chronic kidney disease, J Diabetes Metabol, 5, 347 Tamura, 2019, Serum magnesium levels and mortality in Japanese maintenance hemodialysis patients, Blood Purif, 47, 88, 10.1159/000496659 Yu, 2017, Serum magnesium and mortality in maintenance hemodialysis patients, Blood Purif, 43, 31, 10.1159/000451052