The association between aerobic fitness and executive function is mediated by prefrontal cortex volume

American College of Sports Medicine, 1991

Andel, 2008, Physical exercise at midlife and risk of dementia three decades later: a population-based study of Swedish twins, J. Gerontol. A Biol. Sci. Med. Sci., 63, 62, 10.1093/gerona/63.1.62

Andersson, J., Jenkinson, M., Smith, S., 2007. Non-linear optimisation, aka spatial normalisation. FMRIB technical report TR07JA1. Available from: <www.fmrib.ox.ac.uk/analysis/techrep>.

Ashburner, 2000, Voxel-based morphometry – The methods, Neuroimage, 11, 805, 10.1006/nimg.2000.0582

Black, 1990, Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats, Proc. Natl. Acad. Sci. USA, 87, 5568, 10.1073/pnas.87.14.5568

Braver, 1997, A parametric study of prefrontal cortex involvement in human working memory, Neuroimage, 5, 49, 10.1006/nimg.1996.0247

Bugg, 2011, Exercise moderates age-related atrophy of the medial temporal lobe, Neurobiol. Aging, 32, 506, 10.1016/j.neurobiolaging.2009.03.008

Burdette, 2010, Using network science to evaluate exercise-associated brain changes in older adults, Front. Aging Neurosci., 2, 23

Carro, 2000, Circulating insulin-like growth factor I mediates effects of exercise on the brain, J. Neurosci., 20, 2926, 10.1523/JNEUROSCI.20-08-02926.2000

Colcombe, 2003, Fitness effects on the cognitive function of older adults: a meta-analytic study, Psychol. Sci., 14, 125, 10.1111/1467-9280.t01-1-01430

Colcombe, 2003, Aerobic fitness reduces brain tissue loss in aging humans, J. Gerontol. A Biol. Sci. Med. Sci., 58, 176, 10.1093/gerona/58.2.M176

Colcombe, 2004, Neurocognitive aging and cardiovascular fitness: recent findings and future directions, J. Mol. Neurosci., 24, 9, 10.1385/JMN:24:1:009

Colcombe, 2006, Aerobic exercise training increases brain volume in aging humans, J. Gerontol. A Biol. Sci. Med. Sci., 61, 1166, 10.1093/gerona/61.11.1166

Cotman, 2007, Exercise builds brain health: key roles of growth factor cascades and inflammation, Trends Neurosci., 30, 464, 10.1016/j.tins.2007.06.011

Curtis, 2004, The effects of prefrontal lesions on working memory performance and theory, Cogn. Affect Behav. Neurosci., 4, 528, 10.3758/CABN.4.4.528

Ding, 2006, Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise, Curr. Neurovasc. Res., 3, 15, 10.2174/156720206775541787

Erickson, 2009, Aerobic fitness is associated with hippocampal volume in elderly humans, Hippocampus, 19, 1030, 10.1002/hipo.20547

Erickson, 2010, Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study, Neurology, 75, 1415, 10.1212/WNL.0b013e3181f88359

Erickson, 2011, Exercise training increases size of hippocampus and improves memory, Proc. Natl. Acad. Sci. USA, 108, 3017, 10.1073/pnas.1015950108

Farmer, 2004, Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague–Dawley rats in vivo, Neuroscience, 124, 71, 10.1016/j.neuroscience.2003.09.029

Floel, 2010, Physical activity and memory functions: are neurotrophins and cerebral gray matter volume the missing link?, Neuroimage, 49, 2756, 10.1016/j.neuroimage.2009.10.043

Gelfand, 2009, Mediation analysis: a retrospective snapshot of practice and more recent directions, J. Gen. Psychol., 136, 153, 10.3200/GENP.136.2.153-178

Giorgio, 2010, Age-related changes in grey and white matter structure throughout adulthood, Neuroimage, 51, 943, 10.1016/j.neuroimage.2010.03.004

Good, 2001, Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains, Neuroimage, 14, 685, 10.1006/nimg.2001.0857

Gordon, 2008, Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education, Psychophysiology, 45, 825, 10.1111/j.1469-8986.2008.00676.x

Hawkins, 1992, Aging, exercise, and attention, Psychol. Aging, 7, 643, 10.1037/0882-7974.7.4.643

Hayasaka, 2004, Nonstationary cluster-size inference with random field and permutation methods, Neuroimage, 22, 676, 10.1016/j.neuroimage.2004.01.041

Hayes, 2009, Beyond Baron and Kenny: Statistical mediation analysis in the new millennium, Commun. Monogr., 76, 408, 10.1080/03637750903310360

Heyn, 2004, The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis, Arch. Phys. Med. Rehabil., 85, 1694, 10.1016/j.apmr.2004.03.019

Hillman, 2008, Be smart, exercise your heart: exercise effects on brain and cognition, Nat. Rev. Neurosci., 9, 58, 10.1038/nrn2298

Jenkinson, 2001, A global optimisation method for robust affine registration of brain images, Med. Image Anal., 5, 143, 10.1016/S1361-8415(01)00036-6

Jernigan, 2001, Effects of age on tissues and regions of the cerebrum and cerebellum, Neurobiol. Aging, 22, 581, 10.1016/S0197-4580(01)00217-2

Kennedy, 2009, Age-related differences in regional brain volumes: a comparison of optimized voxel-based morphometry to manual volumetry, Neurobiol. Aging, 30, 1657, 10.1016/j.neurobiolaging.2007.12.020

Kramer, 1999, Ageing, fitness and neurocognitive function, Nature, 400, 418, 10.1038/22682

MacLeod, 1991, Half a century of research on the Stroop effect: an integrative review, Psychol. Bull., 109, 163, 10.1037/0033-2909.109.2.163

MacLeod, 1992, The Stroop task: the “gold standard” of attentional measures, J. Exp. Psychol. Gen., 12, 14

McAuley, 2011, Growth trajectories of exercise self-efficacy in older adults: influence of measures and initial status, Health Psychol., 30, 75, 10.1037/a0021567

McAuley, 2011, Non-exercise estimated cardiorespiratory fitness: associations with brain structure, cognition, and memory complaints in older adults, Ment. Health Phys. Act., 4, 5, 10.1016/j.mhpa.2011.01.001

Milham, 2002, Attentional control in the aging brain: insights from an fMRI study of the stroop task, Brain Cogn., 49, 277, 10.1006/brcg.2001.1501

Peters, 2009, Voxel-based morphometry reveals an association between aerobic capacity and grey matter density in the right anterior insula, Neuroscience, 163, 1102, 10.1016/j.neuroscience.2009.07.030

Petersen, 2005, The anti-inflammatory effect of exercise, J. Appl. Physiol., 98, 1154, 10.1152/japplphysiol.00164.2004

Plum, 2005, The role of insulin receptor signaling in the brain, Trends Endocrinol. Metab., 16, 59, 10.1016/j.tem.2005.01.008

Podewils, 2005, Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study, Am. J. Epidemiol., 161, 639, 10.1093/aje/kwi092

Poldrack, 2007, Region of interest analysis for fMRI, Soc. Cogn. Affect Neurosci., 2, 67, 10.1093/scan/nsm006

Prakash, 2009, Age-related differences in the involvement of the prefrontal cortex in attentional control, Brain Cogn., 71, 328, 10.1016/j.bandc.2009.07.005

Prakash, 2011, Cardiorespiratory fitness and attentional control in the aging brain, Front. Hum. Neurosci., 4, 229, 10.3389/fnhum.2010.00229

Preacher, 2008, Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models, Behav. Res. Methods, 40, 879, 10.3758/BRM.40.3.879

Raz, 2000, Aging of the brain and its impact on cognitive performance: integration of structural and functional findings, 1

Raz, 2004, Differential aging of the medial temporal lobe: a study of a five-year change, Neurology, 62, 433, 10.1212/01.WNL.0000106466.09835.46

Raz, 2005, Regional brain changes in aging healthy adults: general trends, individual differences and modifiers, Cereb. Cortex, 15, 1676, 10.1093/cercor/bhi044

Salimi-Khorshidi, 2011, Adjusting the effect of nonstationarity in cluster-based and TFCE inference, Neuroimage, 54, 2006, 10.1016/j.neuroimage.2010.09.088

Schmidt-Hieber, 2004, Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus, Nature, 429, 184, 10.1038/nature02553

Sheikh, 1986, Geriatric depression scale (GDS): Recent evidence and development of a shorter version, 165

Smith, 2004, Overview of fMRI analysis, Br. J. Radiol., 77, S167, 10.1259/bjr/33553595

Smith, 2009, Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference, Neuroimage, 44, 83, 10.1016/j.neuroimage.2008.03.061

Smith, 2004, Advances in functional and structural MR image analysis and implementation as FSL, Neuroimage, 23, S208, 10.1016/j.neuroimage.2004.07.051

Szabo, 2011, Cardiorespiratory fitness, hippocampal volume, and frequency of forgetting in older adults, Neuropsychology, 25, 545, 10.1037/a0022733

van Praag, 1999, Running enhances neurogenesis, learning, and long-term potentiation in mice, Proc. Natl. Acad. Sci. USA, 96, 13427, 10.1073/pnas.96.23.13427

van Praag, 2005, Exercise enhances learning and hippocampal neurogenesis in aged mice, J. Neurosci., 25, 8680, 10.1523/JNEUROSCI.1731-05.2005

Voss, 2010, Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?, Neuropsychologia, 48, 1394, 10.1016/j.neuropsychologia.2010.01.005

Voss, 2010, Plasticity of brain networks in a randomized intervention trial of exercise training in older adults, Front. Aging Neurosci., 2

Washburn, 1993, The Physical Activity Scale for the Elderly (PASE): development and evaluation, J. Clin. Epidemiol., 46, 153, 10.1016/0895-4356(93)90053-4

Weisman, 2006, Interleukins, inflammation, and mechanisms of Alzheimer’s disease, Vitam. Horm., 74, 505, 10.1016/S0083-6729(06)74020-1

Yaffe, 2009, Predictors of maintaining cognitive function in older adults: the health ABC study, Neurology, 72, 2029, 10.1212/WNL.0b013e3181a92c36

Zhang, 2001, Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm, IEEE Trans. Med. Imaging, 20, 45, 10.1109/42.906424

Zhao, X., Lynch, J.G.J., Chen, Q., 2010. Reconsidering Baron and Kenny: myths and truths about mediation analysis. J. Consum. Res. Available at SSRN: <http://ssrn.com/abstract=1554563>.