The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses
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Wu, 2018, Inflammatory health effects of indoor and outdoor particulate matter, J. Allergy Clin. Immunol., 141, 833, 10.1016/j.jaci.2017.12.981
Schraufnagel, 2019, Air pollution and noncommunicable diseases: a review by the forum of international respiratory societies' environmental committee, Part 1: the damaging effects of air pollution, Chest, 155, 409, 10.1016/j.chest.2018.10.042
Ahn, 2014, The role of air pollutants in atopic dermatitis, J. Allergy Clin. Immunol., 134, 993, 10.1016/j.jaci.2014.09.023
Heusinkveld, 2016, Neurodegenerative and neurological disorders by small inhaled particles, Neurotoxicology, 56, 94, 10.1016/j.neuro.2016.07.007
Lim, 2019, Air pollution, oxidative stress, and diabetes: a life course epidemiologic perspective, Curr. Diabetes Rep., 19, 58, 10.1007/s11892-019-1181-y
Xie, 1994, Intra-urban spatial variability and uncertainty assessment of PM2.5 sources based on carbonaceous species, Atmos. Environ., 60, 305, 10.1016/j.atmosenv.2012.06.036
Phuleria, 2006, Size-resolved emissions of organic tracers from light- and heavy-duty vehicles measured in a California roadway tunnel, Environ. Sci. Technol., 40, 4109, 10.1021/es052186d
Aristizabal, 2011, Polychlorinated dibenzo-p-dioxin and dibenzofuran in urban air of an Andean city, Chemosphere, 85, 170, 10.1016/j.chemosphere.2011.06.035
Ma, 2013, Airborne PM2.5/PM10-associated chlorinated polycyclic aromatic hydrocarbons and their parent compounds in a suburban area in Shanghai, China, Environ. Sci. Technol., 47, 7615, 10.1021/es400338h
Nebert, 2017, Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals, Prog. Lipid Res., 67, 38, 10.1016/j.plipres.2017.06.001
Rothhammer, 2019, The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease, Nat. Rev. Immunol., 19, 184, 10.1038/s41577-019-0125-8
Weng, 2018, Aryl hydrocarbon receptor activation by diesel exhaust particles mediates epithelium-derived cytokines expression in severe allergic asthma, Allergy, 73, 2192, 10.1111/all.13462
Matsumoto, 2007, Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice, Environ. Sci. Technol., 41, 3775, 10.1021/es062793g
Vogel, 2019, Inflammatory marker and aryl hydrocarbon receptor-dependent responses in human macrophages exposed to emissions from biodiesel fuels, Chemosphere, 220, 993, 10.1016/j.chemosphere.2018.12.178
Yang, 2019, Heart rate variability mediates the association between polycyclic aromatic hydrocarbons exposure and atherosclerotic cardiovascular disease risk in coke oven workers, Chemosphere, 228, 166, 10.1016/j.chemosphere.2019.04.101
Hu, 2018, Association of polycyclic aromatic hydrocarbons exposure with atherosclerotic cardiovascular disease risk: a role of mean platelet volume or club cell secretory protein, Environ. Pollut., 233, 45, 10.1016/j.envpol.2017.10.042
Hew, 2015, Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells, Clin. Exp. Allergy, 45, 238, 10.1111/cea.12377
Hidaka, 2017, The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin, Nat. Immunol., 18, 64, 10.1038/ni.3614
Karimi, 2015, Polycyclic aromatic hydrocarbons and childhood asthma, Eur. J. Epidemiol., 30, 91, 10.1007/s10654-015-9988-6
IARC, 2010, Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures, IARC Monogr. Eval. Carcinog. Risks Hum., 92, 1
Eckers, 2016, The aryl hydrocarbon receptor promotes aging phenotypes across species, Sci. Rep., 6, 19618, 10.1038/srep19618
Morita, 2009, Molecular basis of tobacco smoke-induced premature skin aging, J. Invest. Dermatol. Symp. Proc., 14, 53, 10.1038/jidsymp.2009.13
Murray, 2014, Aryl hydrocarbon receptor ligands in cancer: friend and foe, Nat. Rev. Canc., 14, 801, 10.1038/nrc3846
Dere, 2011, Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells, BMC Genom., 12, 193, 10.1186/1471-2164-12-193
Carlson, 2009, Divergent transcriptomic responses to aryl hydrocarbon receptor agonists between rat and human primary hepatocytes, Toxicol. Sci., 112, 257, 10.1093/toxsci/kfp200
Farmahin, 2016, Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time, Biochem. Pharmacol., 115, 134, 10.1016/j.bcp.2016.06.005
Nault, 2013, Comparisons of differential gene expression elicited by TCDD, PCB126, betaNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver, Toxicol. Lett., 223, 52, 10.1016/j.toxlet.2013.08.013
Denison, 2017, And now for something completely different: diversity in ligand-dependent activation of Ah receptor responses, Curr. Opin. Toxicol., 2, 124, 10.1016/j.cotox.2017.01.006
Guyot, 2013, The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications, Drug Discov. Today, 18, 479, 10.1016/j.drudis.2012.11.014
Matikainen, 2001, Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals, Nat. Genet., 28, 355, 10.1038/ng575
Quintana, 2008, Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor, Nature, 453, 65, 10.1038/nature06880
Apetoh, 2010, The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27, Nat. Immunol., 11, 854, 10.1038/ni.1912
Bae, 2010, Exposures to particulate matter and polycyclic aromatic hydrocarbons and oxidative stress in schoolchildren, Environ. Health Perspect., 118, 579, 10.1289/ehp.0901077
Puntarulo, 1998, Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes, Free Radic. Biol. Med., 24, 1324, 10.1016/S0891-5849(97)00463-2
Park, 1996, Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage, Proc. Natl. Acad. Sci. U. S. A., 93, 2322, 10.1073/pnas.93.6.2322
Shertzer, 1998, Dioxin causes a sustained oxidative stress response in the mouse, Biochem. Biophys. Res. Commun., 253, 44, 10.1006/bbrc.1998.9753
Albertolle, 2018, The relationships between cytochromes P450 and H2O2: production, reaction, and inhibition, J. Inorg. Biochem., 186, 228, 10.1016/j.jinorgbio.2018.05.014
Gorsky, 1984, On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction, J. Biol. Chem., 259, 6812, 10.1016/S0021-9258(17)39800-9
Ingelman-Sundberg, 1984, Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450, J. Biol. Chem., 259, 6447, 10.1016/S0021-9258(20)82163-2
Kuthan, 1982, Oxidase and oxygenase function of the microsomal cytochrome P450 monooxygenase system, Eur. J. Biochem., 126, 583, 10.1111/j.1432-1033.1982.tb06820.x
Kukielka, 1990, NADPH- and NADH-dependent oxygen radical generation by rat liver nuclei in the presence of redox cycling agents and iron, Arch. Biochem. Biophys., 283, 326, 10.1016/0003-9861(90)90650-N
Knerr, 2006, 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cytochrome P450s alter the formation of reactive oxygen species in liver cells, Mol. Nutr. Food Res., 50, 378, 10.1002/mnfr.200500183
Ayres, 2008, Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement, Inhal. Toxicol., 20, 75, 10.1080/08958370701665517
Weissenberg, 2010, Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles, Free Radic. Biol. Med., 49, 597, 10.1016/j.freeradbiomed.2010.05.011
Ovrevik, 2019, Oxidative potential versus biological effects: a review on the relevance of cell-free/abiotic assays as predictors of toxicity from airborne particulate matter, Int. J. Mol. Sci., 20, 10.3390/ijms20194772
Penning, 2014, Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons, Chem. Res. Toxicol., 27, 1901, 10.1021/tx500298n
Burczynski, 1998, Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione, Biochemistry, 37, 6781, 10.1021/bi972725u
Palackal, 2001, The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation, Biochemistry, 40, 10901, 10.1021/bi010872t
Gelboin, 1980, Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes, Physiol. Rev., 60, 1107, 10.1152/physrev.1980.60.4.1107
Penning, 1996, Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase, Chem. Res. Toxicol., 9, 84, 10.1021/tx950055s
Shou, 1993, Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts, Carcinogenesis, 14, 475, 10.1093/carcin/14.3.475
Shultz, 2011, Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone, Chem. Res. Toxicol., 24, 2153, 10.1021/tx200294c
Burczynski, 1999, Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase, Canc. Res., 59, 607
Hockley, 2006, Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2, BMC Genom., 7, 260, 10.1186/1471-2164-7-260
Yamashita, 2019, Aryl hydrocarbon receptor counteracts pharmacological efficacy of doxorubicin via enhanced AKR1C3 expression in triple negative breast cancer cells, Biochem. Biophys. Res. Commun., 516, 693, 10.1016/j.bbrc.2019.06.119
Smith, 2019, Toxicity of polycyclic aromatic hydrocarbons involves NOX2 activation, Toxicol. Rep., 6, 1176, 10.1016/j.toxrep.2019.11.006
Pinel-Marie, 2009, Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst, Free Radic. Biol. Med., 47, 825, 10.1016/j.freeradbiomed.2009.06.025
Lee, 2016, Urban particulate matter down-regulates filaggrin via COX2 expression/PGE2 production leading to skin barrier dysfunction, Sci. Rep., 6, 27995, 10.1038/srep27995
Amara, 2007, Diesel exhaust particles induce matrix metalloprotease-1 in human lung epithelial cells via a NADP(H) oxidase/NOX4 redox-dependent mechanism, Am. J. Physiol. Lung Cell Mol. Physiol., 293, L170, 10.1152/ajplung.00445.2006
Ryu, 2019, Particulate matter induces inflammatory cytokine production via activation of NFkappaB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin, Redox. Biol., 21, 101080, 10.1016/j.redox.2018.101080
Wada, 2013, Aryl hydrocarbon receptor modulates NADPH oxidase activity via direct transcriptional regulation of p40phox expression, Mol. Pharmacol., 83, 1133, 10.1124/mol.112.083303
Fisher, 2009, Redox signaling across cell membranes, Antioxidants Redox Signal., 11, 1349, 10.1089/ars.2008.2378
Mohammadi-Bardbori, 2015, NADPH oxidase-dependent mechanism explains how arsenic and other oxidants can activate aryl hydrocarbon receptor signaling, Chem. Res. Toxicol., 28, 2278, 10.1021/acs.chemrestox.5b00415
Wincent, 2012, Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor, Proc. Natl. Acad. Sci. U. S. A., 109, 4479, 10.1073/pnas.1118467109
Anwar-Mohamed, 2014, Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms, Free Radic. Biol. Med., 67, 171, 10.1016/j.freeradbiomed.2013.10.810
Wu, 2009, Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study, Toxicol. Sci., 107, 385, 10.1093/toxsci/kfn239
Kubli, 2019, AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer, Proc. Natl. Acad. Sci. U. S. A., 116, 3604, 10.1073/pnas.1815126116
Freyberger, 1987, Prostaglandin-H-synthase competent cells derived from ram seminal vesicles: a tool for studying cooxidation of xenobiotics, Mol. Toxicol., 1, 503
Eling, 1990, Prostaglandin H synthase and xenobiotic oxidation, Annu. Rev. Pharmacol. Toxicol., 30, 1, 10.1146/annurev.pa.30.040190.000245
Vogel, 1998, Modulation of prostaglandin H synthase-2 mRNA expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice, Arch. Biochem. Biophys., 351, 265, 10.1006/abbi.1997.0555
Vogel, 2000, Prostaglandin H synthases and their importance in chemical toxicity, Curr. Drug Metabol., 1, 391, 10.2174/1389200003338884
Jones, 1993, Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines, J. Biol. Chem., 268, 9049, 10.1016/S0021-9258(18)52976-8
Seibert, 1994, Role of inducible cyclooxygenase (COX-2) in inflammation, Receptor, 4, 17
Prescott, 2000, Cyclooxygenase-2 and carcinogenesis, Biochim. Biophys. Acta, 1470, M69
Vogel, 2007, Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression, Am. J. Pathol., 171, 1538, 10.2353/ajpath.2007.070406
Hussain, 2003, Cyclooxygenase-2 and prostate carcinogenesis, Canc. Lett., 191, 125, 10.1016/S0304-3835(02)00524-4
Pathak, 2005, Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies, Eur. J. Canc., 41, 61, 10.1016/j.ejca.2004.09.028
Vogel, 2000, Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway, Carcinogenesis, 21, 2267, 10.1093/carcin/21.12.2267
Fritsche, 2007, Lightning up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation, Proc. Natl. Acad. Sci. U.S.A., 104, 8851, 10.1073/pnas.0701764104
Munoz, 2015, COX-2 is involved in vascular oxidative stress and endothelial dysfunction of renal interlobar arteries from obese Zucker rats, Free Radic. Biol. Med., 84, 77, 10.1016/j.freeradbiomed.2015.03.024
Hernanz, 2004, Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries, Am. J. Physiol. Heart Circ. Physiol., 287, H225, 10.1152/ajpheart.00548.2003
Kohle, 2006, Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention, Biochem. Pharmacol., 72, 795, 10.1016/j.bcp.2006.04.017
Dohr, 1995, Different response of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-sensitive genes in human breast cancer MCF-7 and MDA-MB 231 cells, Arch. Biochem. Biophys., 321, 405, 10.1006/abbi.1995.1411
Park, 2002, The transcriptional activation of the human copper/zinc superoxide dismutase gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin through two different regulator sites, the antioxidant responsive element and xenobiotic responsive element, Mol. Cell. Biochem., 240, 47, 10.1023/A:1020600509965
Jaiswal, 1991, Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin, Biochemistry, 30, 10647, 10.1021/bi00108a007
Miao, 2005, Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes, J. Biol. Chem., 280, 20340, 10.1074/jbc.M412081200
Yeager, 2009, Introducing the “TCDD-inducible AhR-Nrf2 gene battery”, Toxicol. Sci., 111, 238, 10.1093/toxsci/kfp115
Tsuji, 2012, Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect, J. Invest. Dermatol., 132, 59, 10.1038/jid.2011.194
Haarmann-Stemmann, 2012, The AhR-Nrf2 pathway in keratinocytes: on the road to chemoprevention?, J. Invest. Dermatol., 132, 7, 10.1038/jid.2011.359
Schafer, 2014, Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice, EMBO Mol. Med., 6, 442, 10.1002/emmm.201303281
Panteleyev, 2006, Dioxin-induced chloracne--reconstructing the cellular and molecular mechanisms of a classic environmental disease, Exp. Dermatol., 15, 705, 10.1111/j.1600-0625.2006.00476.x
Sutter, 1991, Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta, Science, 254, 415, 10.1126/science.1925598
Greenlee, 1985, Actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on human epidermal keratinocytes in culture, in Vitro Cell, Dev. Biol., 21, 509
Esser, 1994, Dioxins and the immune system: mechanisms of interference. A meeting report, Int. Arch. Allergy Immunol., 104, 126, 10.1159/000236719
Jeon, 2000, The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family, J. Immunol., 165, 6975, 10.4049/jimmunol.165.12.6975
Esser, 2009, The aryl hydrocarbon receptor and immunity, Trends Immunol., 9, 447, 10.1016/j.it.2009.06.005
Veldhoen, 2008, The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins, Nature, 453, 106, 10.1038/nature06881
Funatake, 2005, Cutting edge: activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+ CD25+ cells with characteristics of regulatory T cells, J. Immunol., 175, 4184, 10.4049/jimmunol.175.7.4184
Apetoh, 2010, The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27, Nat. Immunol., 11, 854, 10.1038/ni.1912
Esser, 2015, The aryl hydrocarbon receptor (AhR) in barrier organ physiology, immunology, and toxicology, Pharmacol. Rev., 67, 259, 10.1124/pr.114.009001
Shinde, 2018, The aryl hydrocarbon receptor: connecting immunity to the microenvironment, Trends Immunol., 39, 1005, 10.1016/j.it.2018.10.010
Haarmann-Stemmann, 2015, The janus-faced role of aryl hydrocarbon receptor signaling in the skin: consequences for prevention and treatment of skin disorders, J. Invest. Dermatol., 135, 2572, 10.1038/jid.2015.285
Julliard, 2014, The aryl hydrocarbon receptor meets immunology: friend or foe? A little of both, Front. Immunol., 5, 458, 10.3389/fimmu.2014.00458
Andrysik, 2011, Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons, Mutat. Res., 714, 53, 10.1016/j.mrfmmm.2011.06.011
Arrieta, 2003, Aryl hydrocarbon receptor-mediated activity of particulate organic matter from the Paso del Norte airshed along the U.S.-Mexico border, Environ. Health Perspect., 111, 1299, 10.1289/ehp.6058
O'Driscoll, 2019, Real-world PM extracts differentially enhance Th17 differentiation and activate the aryl hydrocarbon receptor (AHR), Toxicology, 414, 14, 10.1016/j.tox.2019.01.002
O'Driscoll, 2019, Ambient urban dust particulate matter reduces pathologic T cells in the CNS and severity of EAE, Environ. Res., 168, 178, 10.1016/j.envres.2018.09.038
Julliard, 2016, Environmental exposures-the missing link in immune responses after transplantation, Am. J. Transplant., 16, 1358, 10.1111/ajt.13660
Riedl, 2008, Importance of oxidative stress in the pathogenesis and treatment of asthma, Curr. Opin. Allergy Clin. Immunol., 8, 49, 10.1097/ACI.0b013e3282f3d913
Barnes, 1990, Reactive oxygen species and airway inflammation, Free Radic. Biol. Med., 9, 235, 10.1016/0891-5849(90)90034-G
De Grove, 2018, Insights in particulate matter-induced allergic airway inflammation: focus on the epithelium, Clin. Exp. Allergy, 48, 773, 10.1111/cea.13178
Consonni, 2008, Mortality in a population exposed to dioxin after the Seveso, Italy, accident in 1976: 25 years of follow-up, Am. J. Epidemiol., 167, 847, 10.1093/aje/kwm371
Brunekreef, 2005, Epidemiological evidence of effects of coarse airborne particles on health, Eur. Respir. J., 26, 309, 10.1183/09031936.05.00001805
Jaligama, 2018, Radical containing combustion derived particulate matter enhance pulmonary Th17 inflammation via the aryl hydrocarbon receptor, Part. Fibre Toxicol., 15, 20, 10.1186/s12989-018-0255-3
Vogel, 2014, Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-kappaB, J. Biol. Chem., 289, 1866, 10.1074/jbc.M113.505578
Castaneda, 2018, Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization, Toxicol. Lett., 292, 85, 10.1016/j.toxlet.2018.04.020
Xia, 2015, Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade, J. Allergy Clin. Immunol., 136, 441, 10.1016/j.jaci.2015.02.014
Meyers, 2018, Environmental cues received during development shape dendritic cell responses later in life, PloS One, 13, 10.1371/journal.pone.0207007
van Voorhis, 2013, Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor, PloS One, 8, 10.1371/journal.pone.0082545
O'Driscoll, 2018, Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro, PloS One, 13
O'Driscoll, 2018, Differential effects of diesel exhaust particles on T cell differentiation and autoimmune disease, Part. Fibre Toxicol., 15, 35, 10.1186/s12989-018-0271-3
Kish, 2013, Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome, PloS One, 8, 10.1371/journal.pone.0062220
Brulport, 2017, Chronic exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces an obesogenic effect in C57BL/6J mice fed a high fat diet, Toxicology, 390, 43, 10.1016/j.tox.2017.07.017
Moyer, 2017, Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice, Nutr. Res., 44, 38, 10.1016/j.nutres.2017.06.002
Zhang, 2015, Persistent organic pollutants modify gut microbiota-host metabolic homeostasis in mice through aryl hydrocarbon receptor activation, Environ. Health Perspect., 123, 679, 10.1289/ehp.1409055
Kim, 2012, Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells, Environ. Health Perspect., 120, 508, 10.1289/ehp.1104282
Bleck, 2013, MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells, J. Immunol., 190, 3757, 10.4049/jimmunol.1201165
Saint-Georges, 2008, Gene expression induction of volatile organic compound and/or polycyclic aromatic hydrocarbon-metabolizing enzymes in isolated human alveolar macrophages in response to airborne particulate matter (PM2.5), Toxicology, 244, 220, 10.1016/j.tox.2007.11.016
Vogel, 2005, Induction of proinflammatory cytokines and C-reactive protein in human macrophage cell line U937 exposed to air pollution particulates, Environ. Health Perspect., 113, 1536, 10.1289/ehp.8094
Martin, 1993, Characterization of Clara and type II cells isolated from rat lung by fluorescence-activated flow cytometry, Biochem. J., 295, 73, 10.1042/bj2950073
Oyama, 2007, Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis, Front. Biosci. : J. Vis. Literacy, 12, 4497, 10.2741/2404
Chan, 2013, Combustion derived ultrafine particles induce cytochrome P-450 expression in specific lung compartments in the developing neonatal and adult rat, Am. J. Physiol. Lung Cell Mol. Physiol., 304, L665, 10.1152/ajplung.00370.2012
Chan, 2011, Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs, Toxicol. Sci. : Off. J. Soc. Toxicol., 124, 472, 10.1093/toxsci/kfr233
Lee, 2010, Small particles disrupt postnatal airway development, J. Appl. Physiol., 109, 1115, 10.1152/japplphysiol.00295.2010
Lee, 2011, Disruption of tracheobronchial airway growth following postnatal exposure to ozone and ultrafine particles, Inhal. Toxicol., 23, 520, 10.3109/08958378.2011.591447
Rouse, 2008, Soot nanoparticles promote biotransformation, oxidative stress, and inflammation in murine lungs, Am. J. Respir. Cell Mol. Biol., 39, 198, 10.1165/rcmb.2008-0057OC
Chan, 2013, Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs, Part. Fibre Toxicol., 10, 34, 10.1186/1743-8977-10-34
Li, 2004, Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals, J. Immunol., 173, 3467, 10.4049/jimmunol.173.5.3467
Zhou, 2003, Oxidative stress and NFkappaB activation in the lungs of rats: a synergistic interaction between soot and iron particles, Toxicol. Appl. Pharmacol., 190, 157, 10.1016/S0041-008X(03)00157-1
Beamer, 2013, Role of the aryl hydrocarbon receptor (AhR) in lung inflammation, Semin. Immunopathol., 35, 693, 10.1007/s00281-013-0391-7
Tsay, 2013, Aryl hydrocarbon receptor and lung cancer, Anticancer Res., 33, 1247
Baginski, 2006, Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli, Am. J. Respir. Cell Mol. Biol., 35, 165, 10.1165/rcmb.2005-0259OC
Marshall, 2010, Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells, Ann. N. Y. Acad. Sci., 1183, 25, 10.1111/j.1749-6632.2009.05125.x
Kim, 2004, Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers, Toxicol. Appl. Pharmacol., 199, 210, 10.1016/j.taap.2003.11.015
Moses, 2017, Molecular impact of electronic cigarette aerosol exposure in human bronchial epithelium, Toxicol. Sci., 155, 248, 10.1093/toxsci/kfw198
Lin, 2003, Overexpression of aryl hydrocarbon receptor in human lung carcinomas, Toxicol. Pathol., 31, 22, 10.1080/01926230309746
Wong, 2010, Arylhydrocarbon receptor activation in NCI-H441 cells and C57BL/6 mice: possible mechanisms for lung dysfunction, Am. J. Respir. Cell Mol. Biol., 42, 210, 10.1165/rcmb.2008-0228OC
Chiba, 2011, Arylhydrocarbon receptor (AhR) activation in airway epithelial cells induces MUC5AC via reactive oxygen species (ROS) production, Pulm. Pharmacol. Therapeut., 24, 133, 10.1016/j.pupt.2010.08.002
Lee, 2011, 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription, Am. J. Respir. Cell Mol. Biol., 45, 270, 10.1165/rcmb.2010-0313OC
Shivanna, 2015, Omeprazole attenuates pulmonary aryl hydrocarbon receptor activation and potentiates hyperoxia-induced developmental lung injury in newborn mice, Toxicol. Sci. : Off. J. Soc. Toxicol., 148, 276, 10.1093/toxsci/kfv183
Villa, 2016, The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis, Nat. Commun., 7, 12652, 10.1038/ncomms12652
Bhattacharya, 2014, The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator, Am. J. Physiol. Lung Cell Mol. Physiol., 307, L516, 10.1152/ajplung.00200.2014
Shivanna, 2016, Gene expression profiling identifies cell proliferation and inflammation as the predominant pathways regulated by aryl hydrocarbon receptor in primary human fetal lung cells exposed to hyperoxia, Toxicol. Sci. : Off. J. Soc. Toxicol., 152, 155, 10.1093/toxsci/kfw071
Chiba, 2011, Role of the arylhydrocarbon receptor in lung disease, Int. Arch. Allergy Immunol., 155, 129, 10.1159/000327499
Toskala, 2005, Temporal and spatial distribution of ciliogenesis in the tracheobronchial airways of mice, American journal of physiology, Lung Cell. Mol. Phys., 289, L454, 10.1152/ajplung.00036.2005
Chan, 2008, Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice, Arch. Toxicol., 82, 45, 10.1007/s00204-007-0222-5
Cruzan, 2015, Evaluation of the mode of action of mouse lung tumors induced by 4-methylimidazole, Regulatory toxicology and pharmacology, RTP (Regul. Toxicol. Pharmacol.), 73, 501, 10.1016/j.yrtph.2015.10.006
Goncharov, 2008, High serum PCBs are associated with elevation of serum lipids and cardiovascular disease in a Native American population, Environ. Res., 106, 226, 10.1016/j.envres.2007.10.006
Sergeev, 2005, Hospitalization rates for coronary heart disease in relation to residence near areas contaminated with persistent organic pollutants and other pollutants, Environ. Health Perspect., 113, 756, 10.1289/ehp.7595
Sergeev, 2010, Exposure to persistent organic pollutants increases hospitalization rates for myocardial infarction with comorbid hypertension, Prim. Prev. Insights, 2, 1, 10.4137/PPRI.S4332
Flesch-Janys, 1995, Exposure to polychlorinated dioxins and furans (PCDD/F) and mortality in a cohort of workers from a herbicide-producing plant in Hamburg, Federal Republic of Germany, Am. J. Epidemiol., 142, 1165, 10.1093/oxfordjournals.aje.a117575
Kang, 2006, Health status of army chemical corps Vietnam veterans who sprayed defoliant in Vietnam, Am. J. Ind. Med., 49, 875, 10.1002/ajim.20385
Kim, 2003, Impact of agent Orange exposure among Korean Vietnam veterans, Ind. Health, 41, 149, 10.2486/indhealth.41.149
Humblet, 2008, Dioxins and cardiovascular disease mortality, Environ. Health Perspect., 116, 1443, 10.1289/ehp.11579
Brook, 2010, Metabolism, Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association, Circulation, 121, 2331, 10.1161/CIR.0b013e3181dbece1
Pope, 2004, Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease, Circulation, 109, 71, 10.1161/01.CIR.0000108927.80044.7F
Kunzli, 2010, Ambient air pollution and the progression of atherosclerosis in adults, PloS One, 5, 10.1371/journal.pone.0009096
Jerrett, 2013, Spatial analysis of air pollution and mortality in California, Am. J. Respir. Crit. Care Med., 188, 593, 10.1164/rccm.201303-0609OC
Mateen, 2011, Air pollution as an emerging global risk factor for stroke, J. Am. Med. Assoc., 305, 1240, 10.1001/jama.2011.352
Ruckerl, 2007, Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors, Environ. Health Perspect., 115, 1072, 10.1289/ehp.10021
Grunig, 2014, Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature, Pulm. Circ., 4, 25, 10.1086/674902
Brugge, 2007, Near-highway pollutants in motor vehicle exhaust: a review of epidemiologic evidence of cardiac and pulmonary health risks, Environ. Health, 6, 23, 10.1186/1476-069X-6-23
Hoffmann, 2006, Residence close to high traffic and prevalence of coronary heart disease, Eur. Heart J., 27, 2696, 10.1093/eurheartj/ehl278
Aguilera, 2016, Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study, Environ. Health Perspect., 124, 1700, 10.1289/EHP161
Boothe, 2008, Potential health effects associated with residential proximity to freeways and primary roads: review of scientific literature, 1999-2006, J. Environ. Health, 70, 55
Ban-Weiss, 2010, Size-resolved particle number and volume emission factors for on-road gasoline and diesel motor vehicles, J. Aerosol Sci., 41, 5, 10.1016/j.jaerosci.2009.08.001
Aung, 2011, Comparative gene responses to collected ambient particles in vitro: endothelial responses, Physiol. Genom., 43, 917, 10.1152/physiolgenomics.00051.2011
Ferecatu, 2010, Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor, Part. Fibre Toxicol., 7, 18, 10.1186/1743-8977-7-18
Salcido-Neyoy, 2015, Induction of c-Jun by air particulate matter (PM(1)(0)) of Mexico city: participation of polycyclic aromatic hydrocarbons, Environ. Pollut., 203, 175, 10.1016/j.envpol.2015.03.051
Lauer, 2009, Temporal-spatial analysis of U.S.-Mexico border environmental fine and coarse PM air sample extract activity in human bronchial epithelial cells, Toxicol. Appl. Pharmacol., 238, 1, 10.1016/j.taap.2009.04.021
Gualtieri, 2011, Airborne urban particles (Milan winter-PM2.5) cause mitotic arrest and cell death: effects on DNA, mitochondria, AhR binding and spindle organization, Mutat. Res., 713, 18, 10.1016/j.mrfmmm.2011.05.011
Keebaugh, 2015, Is atherosclerotic disease associated with organic components of ambient fine particles?, Sci. Total Environ., 533, 69, 10.1016/j.scitotenv.2015.06.048
Korashy, 2006, The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases, Drug Metab. Rev., 38, 411, 10.1080/03602530600632063
Puga, 2011, Perspectives on the potential involvement of the AH receptor-dioxin axis in cardiovascular disease, Toxicol. Sci., 120, 256, 10.1093/toxsci/kfq393
Kim, 2014, Individual-level concentrations of fine particulate matter chemical components and subclinical atherosclerosis: a cross-sectional analysis based on 2 advanced exposure prediction models in the multi-ethnic study of atherosclerosis, Am. J. Epidemiol., 180, 718, 10.1093/aje/kwu186
Vogel, 2004, Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation, Cardiovasc. Toxicol., 4, 363, 10.1385/CT:4:4:363
Wu, 2011, Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice, Arterioscler. Thromb. Vasc. Biol., 31, 1260, 10.1161/ATVBAHA.110.220202
Gough, 2006, Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice, J. Clin. Invest., 116, 59, 10.1172/JCI25074
Dalton, 2001, Dioxin exposure is an environmental risk factor for ischemic heart disease, Cardiovasc. Toxicol., 1, 285, 10.1385/CT:1:4:285
Haberzettl, 2018, Inhalation of fine particulate matter impairs endothelial progenitor cell function via pulmonary oxidative stress, Arterioscler. Thromb. Vasc. Biol., 38, 131, 10.1161/ATVBAHA.117.309971
Wang, 2017, Aryl hydrocarbon receptor ablation in cardiomyocytes protects male mice from heart dysfunction induced by NKX2.5 haploinsufficiency, Toxicol. Sci., 160, 74, 10.1093/toxsci/kfx164
Niermann, 2003, Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells, Biochem. Biophys. Res. Commun., 300, 943, 10.1016/S0006-291X(02)02970-4
Karyala, 2004, Different global gene expression profiles in benzo[a]pyrene- and dioxin-treated vascular smooth muscle cells of AHR-knockout and wild-type mice, Cardiovasc. Toxicol., 4, 47, 10.1385/CT:4:1:47
Kim, 2017, TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells,, PLoS Genet., 13, 10.1371/journal.pgen.1006750
Wolf, 2019, Immunity and inflammation in atherosclerosis, Circ. Res., 124, 315, 10.1161/CIRCRESAHA.118.313591
Lanham, 2014, Cardiac myocyte-specific AHR activation phenocopies TCDD-induced toxicity in zebrafish, Toxicol. Sci., 141, 141, 10.1093/toxsci/kfu111
Bello, 2004, 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits regression of the common cardinal vein in developing zebrafish, Toxicol. Sci., 78, 258, 10.1093/toxsci/kfh065
Ren, 2019, AHR-mediated ROS production contributes to the cardiac developmental toxicity of PM2.5 in zebrafish embryos, Sci. Total Environ., 135097
Schmuth, 2015, Epidermal barrier in hereditary ichthyoses, atopic dermatitis, and psoriasis, J. Dtsch Dermatol. Ges., 13, 1119
Proksch, 2012, Abnormal epidermal barrier in the pathogenesis of contact dermatitis, Clin. Dermatol., 30, 335, 10.1016/j.clindermatol.2011.08.019
Acheva, 2017, Pro-inflammatory signaling in a 3D organotypic skin model after low LET irradiation-NF-kappaB, COX-2 activation, and impact on cell differentiation, Front. Immunol., 8, 82, 10.3389/fimmu.2017.00082
Howell, 2009, Cytokine modulation of atopic dermatitis filaggrin skin expression, J. Allergy Clin. Immunol., 124, R7, 10.1016/j.jaci.2009.07.012
Kim, 2008, Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6, Clin. Immunol., 126, 332, 10.1016/j.clim.2007.11.006
Diaz-Sanchez, 2000, Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity, J. Allergy Clin. Immunol., 106, 1140, 10.1067/mai.2000.111144
Gutowska-Owsiak, 2012, IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion, Exp. Dermatol., 21, 104, 10.1111/j.1600-0625.2011.01412.x
van den Bogaard, 2013, Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis, J. Clin. Invest., 123, 917
DiMeglio, 2014, Activation of the aryl hydrocarbon receptor dampens the severity of inflammatory skin conditions, Immunity, 40, 989, 10.1016/j.immuni.2014.04.019
Stefanovic, 2019, The exposome in atopic dermatitis, Allergy
Yi, 2012, Effect of environmental tobacco smoke on atopic dermatitis among children in Korea, Environ. Res., 113, 40, 10.1016/j.envres.2011.12.012
Lee, 2011, Lifetime exposure to cigarette smoking and the development of adult-onset atopic dermatitis, Br. J. Dermatol., 164, 483
Lee, 2008, Traffic-related air pollution, climate, and prevalence of eczema in Taiwanese school children, J. Invest. Dermatol., 128, 2412, 10.1038/jid.2008.110
Schnass, 2018, Traffic-related air pollution and eczema in the elderly: findings from the SALIA cohort, Int. J. Hyg Environ. Health, 221, 861, 10.1016/j.ijheh.2018.06.002
Grandjean, 2010, Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutants, Environ. Health Perspect., 118, 1429, 10.1289/ehp.1002289
Nakamoto, 2013, Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population, Int. Arch. Occup. Environ. Health, 86, 849, 10.1007/s00420-012-0819-8
Ye, 2018, Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study, Environ. Health, 17, 22, 10.1186/s12940-018-0365-2
Kennedy, 2013, 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation, Toxicol. Sci., 132, 235, 10.1093/toxsci/kfs325
Sutter, 2019, AHR regulates metabolic reprogramming to promote SIRT1-dependent keratinocyte differentiation, J. Invest. Dermatol., 139, 818, 10.1016/j.jid.2018.10.019
Peppers, 2019, A phase 2, randomized dose-finding study of tapinarof (GSK2894512 cream) for the treatment of atopic dermatitis, J. Am. Acad. Dermatol., 80, 89, 10.1016/j.jaad.2018.06.047
Furue, 2018, Antioxidative phytochemicals accelerate epidermal terminal differentiation via the AHR-OVOL1 pathway: implications for atopic dermatitis, Acta Derm. Venereol., 98, 918, 10.2340/00015555-3003
Smith, 2017, Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans, J. Invest. Dermatol., 137, 2110, 10.1016/j.jid.2017.05.004
Furue, 2019, Aryl hydrocarbon receptor in atopic dermatitis and psoriasis, Int. J. Mol. Sci., 20, 10.3390/ijms20215424
Smits, 2019, Targeting the cutaneous microbiota in atopic dermatitis by coal tar via AHR-dependent induction of antimicrobial peptides, J. Invest. Dermatol., 10.1016/j.jid.2019.07.215
Richardson, 1988, Identification of an anthraquinone pigment and a hydroxystilbene antibiotic from Xenorhabdus luminescens, Appl. Environ. Microbiol., 54, 1602, 10.1128/AEM.54.6.1602-1605.1988
Paller, 2019, The microbiome in patients with atopic dermatitis, J. Allergy Clin. Immunol., 143, 26, 10.1016/j.jaci.2018.11.015
Fyhrquist, 2019, Microbe-host interplay in atopic dermatitis and psoriasis, Nat. Commun., 10, 4703, 10.1038/s41467-019-12253-y
Kim, 2002, Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses, J. Immunol., 169, 1535, 10.4049/jimmunol.169.3.1535