The antiviral and coronavirus-host protein pathways inhibiting properties of herbs and natural compounds - Additional weapons in the fight against the COVID-19 pandemic?

2020 Wu, 2020, Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods, Acta Phamaceutica Sin B Lu, 2020, Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding, Lancet, 395, 565, 10.1016/S0140-6736(20)30251-8 2020 Li, 2020, Coronavirus infections and immune responses, J Med Virol, 92, 424, 10.1002/jmv.25685 Koren, 2003, Ribavirin in the treatment of SARS: a new trick for an old drug?, CMAJ (Can Med Assoc J), 168, 1289 Auyeung, 2005, The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study, J Infect, 51, 98 Smith, 2020, COVID-19 drug therapy — potential options Stockman, 2006, SARS: systematic review of treatment effects, PLoS Med, 3, e343, 10.1371/journal.pmed.0030343 Li 2020 Chen, 2004, In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds, J Clin Virol, 31, 69, 10.1016/j.jcv.2004.03.003 Chen, 2004, Statistical evidence for the usefulness of Chinese medicine in the treatment of SARS, Phytother Res. Published online, 10.1002/ptr.1485 Jia, 2003, Is traditional Chinese medicine useful in the treatment of SARS?, Phytother Res, 17, 840, 10.1002/ptr.1397 Lau, 2005, Using herbal medicine as a means of prevention experience during the SARS crisis, Am J Chin Med, 33, 345, 10.1142/S0192415X05002965 Lin, 2003, Clinical observation on 103 patients of severe acute respiratory syndrome treated by integrative traditional Chinese and Western Medicine, Zhongguo Zhong Xi Yi Jie He Za Zhi, 23, 4009 Li, 2004, Clinical study on treatment of severe acute respiratory syndrome with integrative Chinese and Western medicine approach, Zhongguo Zhong Xi Yi Jie He Za Zhi, 24, 28 Tong, 2004, TCM treatment of infectious atypical pneumonia — a report of 16 cases, J Tradit Chin Med, 24, 266 Zhang, 2003, Controlled clinical study on 49 patients of SARS treated by integrative Chinese and Western medicine, Zhongguo Zhong Xi Yi Jie He Za Zhi, 23, 654 Liu, 2004, Chinese herbal medicine for severe acute respiratory syndrome: a systematic review and meta-analysis, J Alternative Compl Med, 10, 1041, 10.1089/acm.2004.10.1041 Liu, 2012, Chinese herbs combined with Western medicine for severe acute respiratory syndrome (SARS), Cochrane Database Syst Rev, 10, CD004882 Leung, 2007, The efficacy of Chinese medicine for SARS: a review of Chinese publications after the crisis, Am J Chin Med, 35, 575, 10.1142/S0192415X07005077 Zhang, 2004, Effect of integrated traditional Chinese and Western medicine on SARS: a review of clinical evidence, World J Gastroenterol, 10, 3500, 10.3748/wjg.v10.i23.3500 Chen, 2007, Effect of integrated traditional Chinese medicine and western medicine on the treatment of severe acute respiratory syndrome: a meta-analysis, Pharm Pr Granada, 5, 1 Hsu, 2008, An evaluation of the additive effect of natural herbal medicine on SARS or SARS-like infectious diseases in 2003: a randomized, double-blind, and controlled pilot study, Evid Based Complement Altern Med, 5, 355, 10.1093/ecam/nem035 Zeng, 2004, Characterization of the 3a protein of SARS-associated coronavirus in infected vero E6 cells and SARS patients, J Mol Biol, 341, 271, 10.1016/j.jmb.2004.06.016 Hsu, 2006, The lesson of supplementary treatment with Chinese medicine on severe laboratory-confirmed SARS patients, Am J Chin Med, 34, 927, 10.1142/S0192415X06004405 Jiang, 2004, Effect of integrative Chinese and western medicine on T-lymphocyte subsets in treating patients with severe acute respiratory syndrome, Zhongguo Zhong Xi Yi Jie He Za Zhi, 24, 514 Han, 2003, A follow-up study of 69 discharged SARS patients, J Tradit Chin Med, 23, 214 Luo, 2020, Can Chinese medicine Be used for prevention of corona virus disease 2019 (COVID-19)? A review of historical classics, research evidence and current prevention programs, Chin J Integr Med. Published online February, 17 Wang, 2020, Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment, Biosci Trends, 14, 64, 10.5582/bst.2020.01030 Tao, 2014, Shufeng Jiedu Capsule protect against acute lung injury by suppressing the MAPK/NF-κB pathway, Biosci Trends, 8, 45, 10.5582/bst.8.45 Chan, 2020, COVID-19: an update on the epidemiological, clinical, preventive and therapeutic evidence and guidelines of integrative Chinese–western medicine for the management of 2019 novel coronavirus disease, Am J Chin Med, 48, 1, 10.1142/S0192415X20500378 Yang, 2020, Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective, Int J Biol Sci, 16, 1708, 10.7150/ijbs.45538 Schwarz, 2011, Emodin inhibits current through SARS-associated coronavirus 3a protein, Antivir Res, 90, 64, 10.1016/j.antiviral.2011.02.008 Wu, 2004, Small molecules targeting severe acute respiratory syndrome human coronavirus, Proc Natl Acad Sci USA, 101, 10012, 10.1073/pnas.0403596101 Chen, 2005, Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3’-digallate (TF3), Evid Based Complement Altern Med, 2, 209, 10.1093/ecam/neh081 Chen, 2005, Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors, Bioorg Med Chem Lett, 15, 3058, 10.1016/j.bmcl.2005.04.027 Lau, 2008, Immunomodulatory and anti-SARS activities of Houttuynia cordata, J Ethnopharmacol, 118, 79, 10.1016/j.jep.2008.03.018 Liu, 2005, SARS-CoV protease inhibitors design using virtual screening method from natural products libraries, J Comput Chem, 26, 484, 10.1002/jcc.20186 Zhou, 2006, Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors, J Med Chem, 49, 3440, 10.1021/jm0602357 Chen, 2006, Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features, Bioorg Med Chem, 14, 8295, 10.1016/j.bmc.2006.09.014 Wang, 2007, Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy, Amino Acids, 33, 129, 10.1007/s00726-006-0403-1 Ryu, 2010, Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition, Bioorg Med Chem, 18, 7040, 10.1016/j.bmc.2010.09.035 Ryu, 2010, SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii, Bioorg Med Chem Lett, 20, 1873, 10.1016/j.bmcl.2010.01.152 Park, 2013, Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava, Bioorg Med Chem, 21, 3730, 10.1016/j.bmc.2013.04.026 Liu, 2014, Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors, Bioorg Med Chem, 22, 292, 10.1016/j.bmc.2013.11.028 Park, 2016, Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV, J Enzym Inhib Med Chem, 31, 23, 10.3109/14756366.2014.1003215 Khan, 2020, Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach, J Biomol Struct Dyn, 2, 1013 Zhang, 2020, In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus, J Integr Med, 18, 152, 10.1016/j.joim.2020.02.005 Cinatl, 2003, Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus, Lancet, 361, 2045, 10.1016/S0140-6736(03)13615-X Wen, 2007, Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus, J Med Chem, 50, 4087, 10.1021/jm070295s Chang, 2012, Anti-human coronavirus (anti-HCoV) triterpenoids from the leaves of Euphorbia neriifolia, Nat Prod Commun, 7, 1415 Kao, 2018, The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR, PLoS Neglected Trop Dis, 21, 10.1371/journal.pntd.0006715 Irurzun, 2001, Entry of poliovirus into cells is blocked by valinomycin and concanamycin A, Biochemistry, 40, 3589, 10.1021/bi002069p Pons, 1973, The inhibition of influenza virus RNA synthesis by actinomycin D and cycloheximide, Virology, 51, 120, 10.1016/0042-6822(73)90372-3 Simmons, 2005, Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry, Proc Natl Acad Sci USA, 102, 11876, 10.1073/pnas.0505577102 Han, 2018, Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production, Clin Exp Pharmacol Physiol, 45, 84, 10.1111/1440-1681.12848 Kim, 2010, Medicinal herbal extracts of Sophorae radix, Acanthopanacis cortex, Sanguisorbae radix and Torilis fructus inhibit coronavirus replication in vitro, Antivir Ther, 15, 697, 10.3851/IMP1615 Shen, 2019, High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses, J Virol, 93, 10.1128/JVI.00023-19 Lin, 2005, Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds, Antivir Res, 68, 36, 10.1016/j.antiviral.2005.07.002 Chiow, 2016, Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection, Asian Pac J Tro Med, 9, 1, 10.1016/j.apjtm.2015.12.002 Park, 2012, Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases, Bioorg Med Chem, 20, 5928, 10.1016/j.bmc.2012.07.038 Wen, 2011, Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication, J Tradit Complement Med, 1, 41, 10.1016/S2225-4110(16)30055-4 Yu, 2012, Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13, Bioorg Med Chem Lett, 22, 4049, 10.1016/j.bmcl.2012.04.081 Schwarz, 2014, Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus, Planta Med, 80, 177 Li, 2005, Identification of natural compounds with antiviral activities against SARS-associated coronavirus, Antivir Res, 67, 18, 10.1016/j.antiviral.2005.02.007 Zhuang, 2009, Procyanidins and butanol extract of Cinnamomi Cortex inhibit SARS-CoV infection, Antivir Res, 82, 73, 10.1016/j.antiviral.2009.02.001 Yi, 2004, Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells, J Virol, 78, 11334, 10.1128/JVI.78.20.11334-11339.2004 Kim, 2019, Natural bis-benzylisoquinoline alkaloids-tetrandrine, fangchinoline, and cepharanthine, inhibit human coronavirus OC43 infection of MRC-5 human lung cells, Biomolecules, 9, 10.3390/biom9110696 Fehr, 2015, Coronaviruses: an overview of their replication and pathogenesis, Methods Mol Biol, 10.1007/978-1-4939-2438-7_1 Ho, 2007, Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction, Antivir Res, 74, 92, 10.1016/j.antiviral.2006.04.014 Kuba, 2005, A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury, Nat Med, 11, 875, 10.1038/nm1267 Millet, 2015, Host cell proteases: critical determinants of coronavirus tropism and pathogenesis, Virus Res, 202, 120, 10.1016/j.virusres.2014.11.021 de Wit, 2016, SARS and MERS: recent insights into emerging coronaviruses, Nat Rev Microbiol, 14, 523, 10.1038/nrmicro.2016.81 Iwata-Yoshikawa, 2019, TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection, J Virol, 93, 10.1128/JVI.01815-18 Báez-Santos, 2015, The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds, Antivir Res, 115, 21, 10.1016/j.antiviral.2014.12.015 Perng, 2018, ISG15 in antiviral immunity and beyond, Nat Reriew Microbiol, 16, 423, 10.1038/s41579-018-0020-5 Venkataraman, 2018, RNA dependent RNA polymerases: insights from structure, function and evolution, Viruses, 10.3390/v10020076 Shadrick, 2013, Discovering new medicines targeting helicases: challenges and recent progress, J Biomol Screen, 18, 761, 10.1177/1087057113482586 Ivanov, 2004, Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase, J Virol, 78, 5619, 10.1128/JVI.78.11.5619-5632.2004 McBride, 2014, The coronavirus nucleocapsid is a multifunctional protein, Viruses, 6, 2991, 10.3390/v6082991 Lu, 2006, Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release, Proc Natl Acad Sci USA, 103, 12540, 10.1073/pnas.0605402103 Nukoolkarn, 2008, Molecular dynamic simulations analysis of ritonavir and lopinavir as SARS-CoV 3CL(pro) inhibitors, J Theor Biol, 254, 861, 10.1016/j.jtbi.2008.07.030 Ko, 2020, Arguments in favor of remdesivir for treating SARS-CoV-2 infections, Int J Antimicrob Agents Li, 2015, Lariciresinol-4-O-β-D-glucopyranoside from the root of Isatis indigotica inhibits influenza A virus-induced pro-inflammatory response, J Ethnopharmacol, 174, 379, 10.1016/j.jep.2015.08.037 Jie, 2017, Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling, Oncotarget, 8, 105615, 10.18632/oncotarget.22350 Luo, 2019, Epigoitrin, an alkaloid from Isatis indigotica, reduces H1N1 infection in stress-induced susceptible model in vivo and in vitro, Front Pharmacol, 10 Yang, 2012, In vitro inhibition of influenza virus infection by a crude extract from Isatis indigotica root resulting in the prevention of viral attachment, Mol Med Rep, 5, 793 Park, 2017, Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors, J Enzym Inhib Med Chem, 32, 504, 10.1080/14756366.2016.1265519 Abd-Elazem, 2002, Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza, Antivir Res, 55, 91, 10.1016/S0166-3542(02)00011-6 Zhu, 2018, Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection, J Ethnopharmacol, 218, 90, 10.1016/j.jep.2018.02.016 Kim, 2008, In vitro inhibition of coronavirus replications by the traditionally used medicinal herbal extracts, Cimicifuga rhizoma, Meliae cortex, Coptidis rhizoma, and Phellodendron cortex, J Clin Virol, 41, 122, 10.1016/j.jcv.2007.10.011 Yan, 2018, Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice, Phytother Res, 32, 2560, 10.1002/ptr.6196 Cho, 2013, Geranylated flavonoids displaying SARS-CoV papain-like protease inhibition from the fruits of Paulownia tomentosa, Bioorg Med Chem, 21, 3051, 10.1016/j.bmc.2013.03.027 Song, 2014, Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits, Biol Pharm Bull, 37, 1021, 10.1248/bpb.b14-00026 Dai, 2017, Emodin inhibition of influenza A virus replication and influenza viral pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB pathways, Molecules, 22, 10.3390/molecules22101754 Chowdhury, 2018, Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture, PloS One, 13, 10.1371/journal.pone.0198226 Liu, 2005, Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41, Biochim Biophys Acta, 1723, 270, 10.1016/j.bbagen.2005.02.012 Tu, 2016, Artemisinin-A gift from traditional Chinese medicine to the World (nobel lecture), Angew Chem Int Ed Engl, 55, 10210, 10.1002/anie.201601967 Efferth, 2017, From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy, Semin Canc Biol, 46, 65, 10.1016/j.semcancer.2017.02.009 Efferth, 2008, The antiviral activities of artemisinin and artesunate, Clin Infect Dis, 47, 804, 10.1086/591195 Zhi, 2019, In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus, Phytomedicine, 57, 105, 10.1016/j.phymed.2018.12.009 Seong, 2018, Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways, Acta Virol, 62, 78, 10.4149/av_2018_109 Dai, 2019, Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide, Crit Rev Food Sci Nutr, 59, S17, 10.1080/10408398.2018.1501657 Ding, 2017, Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway, Microb Infect, 19, 605, 10.1016/j.micinf.2017.08.009 Cvetkovic, 2003, Lopinavir/ritonavir: a review of its use in the management of HIV infection, Drugs, 63, 769, 10.2165/00003495-200363080-00004 Kim, 2019, Natural bis-benzylisoquinoline alkaloids-tetrandrine, fangchinoline, and cepharanthine, inhibit human coronavirus OC43 infection of MRC-5 human lung cells, Biomolecules, 9, 10.3390/biom9110696 Weng, 2019, Antiviral activity of Sambucus FormosanaNakai ethanol extract and related phenolic acid constituents against human coronavirus NL63, Virus Res, 10.1016/j.virusres.2019.197767 Ye, 2020, Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation, J Infect Hoever, 2005, Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus, J Med Chem, 48, 1256, 10.1021/jm0493008 Chen, 2008, Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication, J Ethnopharmacol, 120, 108, 10.1016/j.jep.2008.07.048 Yin, 2011, In vitro and in vivo effects of Houttuynia cordata on infectious bronchitis virus, Avian Pathol, 40, 491, 10.1080/03079457.2011.605107 Tsai, 2020, Antiviral action of tryptanthrin isolated from strobilanthes cusia leaf against human coronavirus NL63, Biomolecules, 10, 10.3390/biom10030366