The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb

Zeng, 1988, Morphological and histological studies of Chinese licorice, Acta Pharm Sin, 23, 200

The state Pharmacopoeia Committee of China, 2010, 80

Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae Edita, 1998, Vol. 42, 169

Adianti, 2014, Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species, Microbiol Immunol, 58, 180, 10.1111/1348-0421.12127

Huang, 2012, Inhibition of intercellular adhesion in herpex simplex virus infection by glycyrrhizin, Cell Biochem Biophys, 62, 137, 10.1007/s12013-011-9271-8

Chandrasekaran, 2011, Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products, Phytomedicine, 18, 278, 10.1016/j.phymed.2010.08.001

Wu, 2011, Anti-inflammatory/anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis, AAPS J, 13, 1, 10.1208/s12248-010-9239-4

Choi, 2014, Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca2+-, and reactive oxygen species–dependent pathway in HepG2 human hepatocellular carcinoma cells, Apoptosis, 19, 682, 10.1007/s10495-013-0955-y

Khan, 2013, Glycyrrhizic acid suppresses the development of precancerous lesions via regulating the hyperproliferation, inflammation, angiogenesis and apoptosis in the colon of Wistar rats, PLoS One, 8, e56020, 10.1371/journal.pone.0056020

Ahn, 2012, The antimicrobial effects of deglycyrrhizinated licorice root extract on Streptococcus mutans UA159 in both planktonic and biofilm cultures, Anaerobe, 18, 590, 10.1016/j.anaerobe.2012.10.005

Treutwein, 2010, Efficacy of Glycyrrhiza glabra extract fractions against phytopathogenic fungi, Julius-Kühn-Archiv, 428, 82

Bordbar, 2013, Phenotypic and functional maturation of murine dendritic cells induced by 18 alpha- and beta-glycyrrhetinic acid, Immunopharm Immunot, 36, 52, 10.3109/08923973.2013.864670

Hong, 2009, Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice, Int J Biol Macromol, 45, 61, 10.1016/j.ijbiomac.2009.04.001

Li, 2011, Screening and characterization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, J Chromatogr A, 1218, 8181, 10.1016/j.chroma.2011.09.030

Liu, 2013, Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice, J Ethnopharmacol, 146, 773, 10.1016/j.jep.2013.02.004

Matsumoto, 2013, Antiviral activity of glycyrrhizin against hepatitis C virus in vitro, PLoS One, 8, e68992, 10.1371/journal.pone.0068992

Wang, 2013, Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease, J Ethnopharmacol, 147, 114, 10.1016/j.jep.2013.02.017

Yeh, 2013, Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines, J Ethnopharmacol, 148, 466, 10.1016/j.jep.2013.04.040

Ashfaq, 2011, Glycyrrhizin as antiviral agent against Hepatitis C Virus, J Transl Med, 9, 112, 10.1186/1479-5876-9-112

Wang, 2009, Intercellular adhesion molecule 1 (ICAM-1), but not ICAM-2 and -3, is important for dendritic cell-mediated human immunodeficiency virus type 1 transmission, J Virol, 83, 4195, 10.1128/JVI.00006-09

Zhang, 2012, Glycyrrhizin administration ameliorates coxsackievirus B3–induced myocarditis in mice, Am J Med Sci, 344, 206, 10.1097/MAJ.0b013e31823e2867

Soufy, 2012, Antiviral and immune stimulant activities of glycyrrhizin against duck hepatitis virus, Afr J Tradit Complement Altern Med, 9, 389, 10.4314/ajtcam.v9i3.14

Michaelis, 2010, Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus–induced pro-inflammatory cytokine and chemokine expression in human macrophages, Med Microbiol Immunol, 199, 291, 10.1007/s00430-010-0155-0

Moisy, 2012, HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication, J Virol, 86, 9122, 10.1128/JVI.00789-12

Smirnov, 2012, Effect of a combination of glutamyl-tryptophan and glycyrrhizic acid on the course of acute infection caused by influenza (H3H2) virus in mice, Vopr Virusol, 57, 23

Laconi, 2014, Autophagy activation and antiviral activity by a licorice triterpene, Phytother Res, 28, 1890, 10.1002/ptr.5189

Hardy, 2012, 18β-glycyrrhetinic acid inhibits rotavirus replication in culture, Virol J, 9, 96, 10.1186/1743-422X-9-96

Al-Turki, 2008, Chemical and anti-bacterial characterization of aqueous extracts of oregano, marjoram, sage and licorice and their application in milk and labneh, J food Agric Environ, 6, 39

Park, 2008, In vivo fungicidal activity of medicinal plant extracts against six phytopathogenic fungi, Int J Pest Manag, 54, 63, 10.1080/09670870701549665

Bodet, 2008, A licorice extract reduces lipopolysaccharide-induced proinflammatory cytokine secretion by macrophages and whole blood, J Periodontol, 79, 1752, 10.1902/jop.2008.080052

Long, 2013, 18β-Glycyrrhetinic acid inhibits methicillin-resistant Staphylococcus aureus survival and attenuates virulence gene expression, Antimicrob Agents Chemother, 57, 241, 10.1128/AAC.01023-12

Awandkar, 2012, Antimicrobial action of cold aqueous and cold ethanolic extracts of Glycyrrhiza glabra against bovine mammary pathogens, Anim Sci Report, 6, 88

Yoshida, 2010, Pivotal advance: glycyrrhizin restores the impaired production of β-defensins in tissues surrounding the burn area and improves the resistance of burn mice to Pseudomonas aeruginosa wound infection, J Leukoc Biol, 87, 35, 10.1189/jlb.1208760

Irani, 2010, Leaves antimicrobial activity of Glycyrrhiza glabra L, Iran J Pharm Res, 9, 425

Kim, 2013, 18β-Glycyrrhetinic acid induces immunological adjuvant activity of Th1 against Candida albicans surface mannan extract, Phytomedicine, 20, 951, 10.1016/j.phymed.2013.04.008

Zhou, 2012, Antimicrobial activity of licochalcone E against Staphylococcus aureus and its impact on the production of staphylococcal alpha-toxin, J Microbiol Biotechnol, 22, 800, 10.4014/jmb.1112.12020

Messier, 2011, Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans, Mycoses, 54, e801, 10.1111/j.1439-0507.2011.02028.x

Dai, 2013, Liquiritigenin prevents Staphylococcus aureus–mediated lung cell injury via inhibiting the production of α-hemolysin, J Asian Nat Prod Res, 15, 390, 10.1080/10286020.2013.771344

Kim, 2012, Antioxidant activities of licorice-derived prenylflavonoids, Nutr Res Pract, 6, 491, 10.4162/nrp.2012.6.6.491

Yasukawa, 2013, Inhibitory effect of a combined treatment of glycyrrhizin and caffeine on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin, J Pharm Nutr Sci, 3, 202, 10.6000/1927-5951.2013.03.03.4

Wang, 2011, Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions, J Agric Food Chem, 59, 7726, 10.1021/jf2013265

Imai, 2013, Radical scavenging ability of glycyrrhizin, Free Radic Antioxid, 3, 40, 10.1016/j.fra.2013.04.003

Li, 2013, Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release, Mol Med, 19, 203, 10.2119/molmed.2013.00064

Kim, 2013, 18β-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses, Immunopharmacol Immunotoxicol, 35, 329, 10.3109/08923973.2013.768636

Yao, 2014, Licochalcone A, a natural inhibitor of c-Jun N-terminal kinase 1, Cancer Prev Res, 7, 139, 10.1158/1940-6207.CAPR-13-0117

Park, 2012, Licochalcone E has an antidiabetic effect, J Nutr Biochem, 23, 759, 10.1016/j.jnutbio.2011.03.021

Gaur, 2014, In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin, Phytomedicine, 21, 415, 10.1016/j.phymed.2013.10.015

Wu, 2013, Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus, Mol Med Rep, 7, 1278, 10.3892/mmr.2013.1330

Park, 2009, Suppression of the TRIF-dependent signaling pathway of toll-like receptors by isoliquiritigenin in RAW264.7 macrophages, Mol Cells, 28, 365, 10.1007/s10059-009-0130-z

Choi, 2010, Inhibitory activity of diacylglycerol acyltransferase by glabrol isolated from the roots of licorice, Arch Pharm Res, 33, 237, 10.1007/s12272-010-0208-3

Seo, 2014, Protective effects of dehydroglyasperin c against carbon tetrachloride–induced liver damage in mice, Food Sci Biotechnol, 23, 547, 10.1007/s10068-014-0075-7

Sui, 2010, Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus, Antiviral Res, 85, 346, 10.1016/j.antiviral.2009.10.014

Huang, 2014, Magnesium isoglycyrrhizinate protects hepatic L02 cells from ischemia/reperfusion induced injury, Int J Clin Exp Pathol, 7, 4755

Chen, 2014, Increased elimination of paclitaxel by magnesium isoglycyrrhizinate in epithelial ovarian cancer patients treated with paclitaxel plus cisplatin: a pilot clinical study, Eur J Drug Metab Pharmacokinet, 39, 25, 10.1007/s13318-013-0136-y

Cheng, 2009, Prevention of free fatty acid-induced hepatic lipotoxicity in HepG2 cells by magnesium isoglycyrrhizinate in vitro, Pharmacology, 84, 183, 10.1159/000235873

Xiao, 2014, Therapeutic effect of magnesium isoglycyrrhizinate in rats on lung injury induced by paraquat poisoning, Eur Rev Med Pharmacol Sci, 18, 311

He, 2010, Protective effect of magnesium isoglycyrrhizinate on ethanol-induced testicular injuries in mice, J Biomed Res, 24, 153, 10.1016/S1674-8301(10)60024-3

Rey-Cuille, 2013, Hepatitis B virus exposure during childhood in Cameroon, Central African Republic and Senegal after the integration of HBV vaccine in the expanded program on immunization, Pediatr Infect Dis J, 32, 1110, 10.1097/INF.0b013e31829be401