Hoạt tính chống u của tác nhân gây cảm ứng interferon bropirimine được trung gian một phần bởi yếu tố hoại tử khối u α nội sinh

Springer Science and Business Media LLC - Tập 32 - Trang 251-255 - 1990
Marcel Scheringa1, Jan N. M. IJzermans1, Johannes Jeekel1, Richard L. Marquet1
1Laboratory for Experimental Surgery, Erasmus University, Rotterdam, The Netherlands

Tóm tắt

Pyrimidinones, chẳng hạn như 2-amino-5-bromo-6-phenyl-4-pyrimidinone (bropirimine), là những chất điều chỉnh miễn dịch mạnh mẽ. Hoạt động của tế bào giết tự nhiên và khả năng tiêu diệt của đại thực bào đều tăng lên sau khi điều trị bằng bropirimine, một hiệu ứng được thực hiện thông qua việc kích thích cytokine. Đến nay, các interferon đã được cho là các môi giới chính nhưng chúng tôi đã phát hiện rằng yếu tố hoại tử khối u α (TNFα) cũng có thể là một môi giới quan trọng cho các tác dụng chống u của bropirimine. Mức TNFα trong huyết thanh tăng lên được quan sát thấy ở chuột sau khi tiêm bropirimine qua phúc mạc với liều 200 mg/kg trong 2 ngày liên tiếp. Chúng tôi cũng nhận thấy rằng hiệu ứng ức chế sự phát triển của khối u của thuốc trên khối u biểu mô đại tràng ở chuột có thể bị giảm khoảng 40% khi cho chuột nhận huyết thanh kháng TNFα từ thỏ ngay trước khi điều trị bằng thuốc. Những kết quả này cho thấy bropirimine có thể kích thích sự phóng thích TNFα trong cơ thể và rằng TNFα nội sinh này có thể quan trọng trong hiệu quả chống u của thuốc.

Từ khóa

#bropirimine #yếu tố hoại tử khối u α #cytokine #điều chỉnh miễn dịch #thuốc chống u

Tài liệu tham khảo

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