The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells

Lykkesfeldt, 1996, Mechanisms of tamoxifen resistance in the treatment of advanced breast cancer, Acta Oncol, 35, 9, 10.3109/02841869609083961

Nicholson, 2005, Endocrine therapy – current benefits and limitations, Breast Cancer Res Treat, 93, S3, 10.1007/s10549-005-9036-4

Riggins, 2007, Pathways to tamoxifen resistance, Cancer Lett, 256, 1, 10.1016/j.canlet.2007.03.016

Adams, 2007, Chlorpromazine versus placebo for schizophrenia, Cochrane Database Syst Rev, 2, CD000284

Garver, 2006, Evolution of antipsychotic intervention in the schizophrenic psychosis, Curr Drug Targets, 7, 1205, 10.2174/138945006778226543

Muraoka, 2003, Inactivation of cholinesterase induced by chlorpromazine cation radicals, Pharmacol Toxicol, 92, 100, 10.1034/j.1600-0773.2003.920207.x

Sato, 1995, Pharmacokinetic analysis of chlorpromazine in rat serum, cerebrospinal fluid and striatum, Biol Pharm Bull, 18, 593, 10.1248/bpb.18.593

Zhelev, 2004, Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes. Phenothiazines and leukemia, Cancer Chemother Pharmacol, 53, 267, 10.1007/s00280-003-0738-1

Gil-Ad, 2006, Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth, Oncol Rep, 15, 107

Nordenberg, 1999, Effects of psychotropic drugs on cell proliferation and differentiation, Biochem Pharmacol, 58, 1229, 10.1016/S0006-2952(99)00156-2

Martins, 2008, Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities, Int J Antimicrob Agents, 31, 198, 10.1016/j.ijantimicag.2007.10.025

Tsakovska, 2006, Phenothiazines and structurally related compounds as modulators of cancer multidrug resistance, Curr Drug Targets, 7, 1123, 10.2174/138945006778226660

Ford, 1993, Pharmacologic circumvention of multidrug resistance, Cytotechnology, 12, 171, 10.1007/BF00744664

Michalak, 2006, Interactions of phenothiazines with lipid bilayer and their role in multidrug resistance reversal, Curr Drug Targets, 7, 1095, 10.2174/138945006778226570

Callaghan, 1995, Interaction of tamoxifen with the multidrug resistance P-glycoprotein, Br J Cancer, 71, 294, 10.1038/bjc.1995.59

Kayyali, 1994, Tamoxifen decreases drug efflux from liposomes: relevance to its ability to reverse multidrug resistance in cancer cells?, FEBS Lett, 344, 221, 10.1016/0014-5793(94)00378-5

Lykkesfeldt, 1992, Effect of estrogen and antiestrogens on cell proliferation and synthesis of secreted proteins in the human breast cancer cell line MCF-7 and a tamoxifen resistant variant subline, AL-1, Acta Oncol, 31, 131, 10.3109/02841869209088892

Lykkesfeldt, 1994, Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1, Cancer Res, 54, 1587

De Cremoux, 2003, Validation of real-time RT-PCR for analysis of human breast cancer cell lines resistant or sensitive to treatment with antiestrogens, Endocr Relat Cancer, 10, 409, 10.1677/erc.0.0100409

Lundholt, 2001, Growth inhibition and growth stimulation by estradiol of estrogen receptor transfected human breast epithelial cell lines involve different pathways, Breast Cancer Res Treat, 67, 199, 10.1023/A:1017977406429

Yde, 2007, Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death, Mol Cancer Ther, 6, 1869, 10.1158/1535-7163.MCT-07-0072

Heerklotz, 2000, Titration calorimetry of surfactant-membrane partitioning and membrane solubilization, Biochim Biophys Acta, 1508, 69, 10.1016/S0304-4157(00)00009-5

Leidy, 2006, Domain-induced activation of human phospholipase A2 type IIA: local versus global lipid composition, Biophys J, 90, 3165, 10.1529/biophysj.105.070987

Drori, 1995, Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability, Eur J Biochem, 228, 1020, 10.1111/j.1432-1033.1995.tb20352.x

Jørgensen, 1991, A general model for the interaction of foreign molecules with lipid membranes: drugs and anaesthetics, Biochim Biophys Acta, 1062, 227, 10.1016/0005-2736(91)90397-Q

Agasøsler, 2001, Chlorpromazine-induced increase in dipalmitoylphosphatidylserine surface area in monolayers at room temperature, Biochem Pharmacol, 61, 817, 10.1016/S0006-2952(01)00542-1

Trandum, 1999, Association of ethanol with lipid membranes containing cholesterol, sphingomyelin and ganglioside: a titration calorimetry study, Biochim Biophys Acta, 1420, 179, 10.1016/S0005-2736(99)00092-9

Wisniewska, 2004, ESR studies on the effect of cholesterol on chlorpromazine interaction with saturated and unsaturated liposome membranes, Biophys Chem, 111, 43, 10.1016/j.bpc.2004.04.001

Ali, 2002, Endocrine-responsive breast cancer and strategies for combating resistance, Nat Rev Cancer, 2, 101, 10.1038/nrc721

Phillips, 2001, Understanding the genotoxicity of tamoxifen?, Carcinogenesis, 22, 839, 10.1093/carcin/22.6.839

Wozniak, 2007, The DNA-damaging potential of tamoxifen in breast cancer and normal cells, Arch Toxicol, 81, 519, 10.1007/s00204-007-0188-3

Bland, 2008, Relationship between tamoxifen use and high risk endometrial cancer histologic types, Gynecol Oncol, 112, 150, 10.1016/j.ygyno.2008.08.035

Morgan, 1997, Risk of endometrial cancer after tamoxifen treatment, Oncology (Huntingt), 11, 25

Clarke, 1990, Reduction of the membrane fluidity of human breast cancer cells by tamoxifen and 17 beta-estradiol, J Natl Cancer Inst, 82, 1702, 10.1093/jnci/82.21.1702

Zeisig, 2007, Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in vitro and increased lung metastasis in NOD/SCID mice, Arch Biochem Biophys, 459, 98, 10.1016/j.abb.2006.09.030

Bursch, 1996, Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy, Carcinogenesis, 17, 1595, 10.1093/carcin/17.8.1595

Moreira, 2006, Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure, J Biol Chem, 281, 10143, 10.1074/jbc.M510249200

Frogne, 2009, Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant, Breast Cancer Res Treat, 114, 263, 10.1007/s10549-008-0011-8

Frogne, 2005, Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth, Endocr Relat Cancer, 12, 599, 10.1677/erc.1.00946

Yde, 2007, Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT, Cancer Lett, 256, 229, 10.1016/j.canlet.2007.06.010

Broniec, 2007, Trifluoperazine causes a disturbance in glycerophospholipid monolayers containing phosphatidylserine (PS): effects of pH, acyl unsaturation, and proportion of PS, Langmuir, 23, 694, 10.1021/la061628b

Wesolowska, 2004, Presence of anionic phospholipids rules the membrane localization of phenothiazine type multidrug resistance modulator, Biophys Chem, 109, 399, 10.1016/j.bpc.2003.11.004