The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1

Molecular and Biochemical Parasitology - Tập 158 - Trang 202-207 - 2008
Jeremy W. Chambers1, Matthew L. Fowler1, Meredith T. Morris1, James C. Morris1
1Department of Genetics and Biochemistry, Clemson University, Clemson, SC 29634, United States

Tài liệu tham khảo

Remme, 2002, Strategic emphases for tropical diseases research: a TDR perspective, Trends Parasitol, 18, 421, 10.1016/S1471-4922(02)02387-5 Pepin, 1991, African trypanosomiasis and drug-induced encephalopathy: risk factors and pathogenesis, Trans R Soc Trop Med Hyg, 85, 222, 10.1016/0035-9203(91)90032-T Willson, 2002, Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase, Chem Biol, 9, 839, 10.1016/S1074-5521(02)00169-2 Silvestrini, 1975, Antispermatogenic activity of 1-p-chlorobenzyl-1H-indazol-3-carboxylic acid (AF 1312/TS) in rats. I. Trials of single and short-term administrations with study of pharmacologic and toxicologic effects, Exp Mol Pathol, 23, 288, 10.1016/0014-4800(75)90026-X Paggi, 1988, The role of mitochondrial hexokinase in neoplastic phenotype and its sensitivity to lonidamine, Ann N Y Acad Sci, 551, 358, 10.1111/j.1749-6632.1988.tb22362.x Floridi, 1983, Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria, Arch Biochem Biophys, 226, 73, 10.1016/0003-9861(83)90272-2 Floridi, 1981, a selective inhibitor of aerobic glycolysis of murine tumor cells, J Natl Cancer Inst, 66, 497 Floridi, 1981, Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells, Cancer Res, 41, 4661 Costantini, 2000, Mitochondrion as a novel target of anticancer chemotherapy, J Natl Cancer Inst, 92, 1042, 10.1093/jnci/92.13.1042 Manganaro, 1988, Trypanosoma lewisi: study of the activity of lonidamine in vitro and in vivo in rats, Cell Mol Biol, 34, 517 Turrens, 1987, Inhibition of growth and respiration of Leishmania mexicana by the antitumor agent lonidamine, Comp Biochem Physiol C, 88, 193, 10.1016/0742-8413(87)90067-3 Turrens, 1986, Inhibitory action of the antitumor agent lonidamine on mitochondrial respiration of Trypanosoma cruzi and T. brucei, Mol Biochem Parasitol, 20, 237, 10.1016/0166-6851(86)90104-0 Morris, 2001, Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector, Mol Biochem Parasitol, 117, 111, 10.1016/S0166-6851(01)00334-6 Morris, 2002, Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library, EMBO J, 21, 4429, 10.1093/emboj/cdf474 Albert, 2005, Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei, J Biol Chem, 280, 28306, 10.1074/jbc.M502403200 Morris, 2006, Activity of a second Trypanosoma brucei hexokinase is controlled by an 18-amino-acid C-terminal tail, Eukaryot Cell, 5, 2014, 10.1128/EC.00146-06 Wirtz, 1999, A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei, Mol Biochem Parasitol, 99, 89, 10.1016/S0166-6851(99)00002-X Wang, 2000, Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters, J Biol Chem, 275, 40174, 10.1074/jbc.M008405200 Motyka, 2006, Overexpression of a cytochrome b5 reductase-like protein causes kinetoplast DNA loss in Trypanosoma brucei, J Biol Chem, 281, 18499, 10.1074/jbc.M602880200 Hudock, 2006, Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates, J Med Chem, 49, 215, 10.1021/jm0582625 Sanz-Rodriguez, 2007, Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies, J Biol Chem, 282, 12377, 10.1074/jbc.M607286200 Drew, 2003, The adenosine analog tubercidin inhibits Glycolysis in Trypanosoma brucei as revealed by an RNA interference library, J Biol Chem, 278, 46596, 10.1074/jbc.M309320200 Amadori, 1998, Modulating effect of lonidamine on response to doxorubicin in metastatic breast cancer patients: results from a multicenter prospective randomized trial, Breast Cancer Res Treat, 49, 209, 10.1023/A:1006063412726 Magno, 1994, Double-blind randomized study of lonidamine and radiotherapy in head and neck cancer, Int J Radiat Oncol Biol Phys, 29, 45, 10.1016/0360-3016(94)90225-9 Racagni, 1983, Characterization of Trypanosoma cruzi hexokinase, Mol Biochem Parasitol, 9, 181, 10.1016/0166-6851(83)90108-1 Caceres, 2003, Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi, Mol Biochem Parasitol, 126, 251, 10.1016/S0166-6851(02)00294-3 Gong, 2002, Mechanism of lonidamine inhibition of the CFTR chloride channel, Br J Pharmacol, 137, 928, 10.1038/sj.bjp.0704932 Cross, 1975, Utilization of amino acids by Trypanosoma brucei in culture: l-threonine as a precursor for acetate, Parasitology, 71, 311, 10.1017/S0031182000046758 ter Kuile, 1997, Adaptation of metabolic enzyme activities of Trypanosoma brucei promastigotes to growth rate and carbon regimen, J Bacteriol, 179, 4699, 10.1128/jb.179.15.4699-4705.1997 Bursell, 1973, The supply of substrates to the flight muscle of tsetse flies, Trans R Soc Trop Med Hyg, 67, 296, 10.1016/0035-9203(73)90222-8 Balogun, 1974, Studies on the amino acids of the tsetse fly, Glossina morsitans, maintained on in vitro and in vivo feeding systems, Comp Biochem Physiol A, 49, 215, 10.1016/0300-9629(74)90110-8 Lamour, 2005, Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose, J Biol Chem, 280, 11902, 10.1074/jbc.M414274200 van Weelden, 2005, New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle, J Biol Chem, 280, 12451, 10.1074/jbc.M412447200 Furuya, 2002, Glucose is toxic to glycosome-deficient trypanosomes, Proc Natl Acad Sci USA, 99, 14177, 10.1073/pnas.222454899 Guerra-Giraldez, 2002, Compartmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei, J Cell Sci, 115, 2651, 10.1242/jcs.115.13.2651 Grippa, 2001, Analysis of lonidamine in rat serum and testis by high performance liquid chromatography, Biomed Chromatogr, 15, 1, 10.1002/bmc.14 Newell, 1991, The pharmacokinetics of oral lonidamine in breast and lung cancer patients, Semin Oncol, 18, 11