The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

Clinical Immunology - Tập 114 Số 2 - Trang 154-163 - 2005
Andrew Johnston1, Jóhann E. Guðjónsson, Hekla Sigmundsdóttir, Björn R. Lúdvíksson, H Valdimarsson
1Department of Immunology, Landspitali University Hospital, 101 Reykjavik, Iceland

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Williams, 1985, Comparison of low-dose oral pulse methotrexate and placebo in the treatment of rheumatoid arthritis. A controlled clinical trial, Arthritis Rheum., 28, 721, 10.1002/art.1780280702

Furst, 1997, The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases, Rheumatology, 36, 1196, 10.1093/rheumatology/36.11.1196

Heydendael, 2003, Methotrexate versus cyclosporine in moderate to severe chronic plaque psoriasis, N. Engl. J. Med., 349, 658, 10.1056/NEJMoa021359

Valdimarsson, 1986, Psoriasis: a disease of abnormal keratinocyte proliferation induced by T lymphocytes, Immunol. Today, 7, 256, 10.1016/0167-5699(86)90005-8

Prinz, 1999, Which T cells cause psoriasis?, Clin. Exp. Dermatol., 24, 291, 10.1046/j.1365-2230.1999.00483.x

Stewart, 1972, Absorption and local action of methotrexate in human and mouse skin, Arch. Dermatol., 106, 357, 10.1001/archderm.106.3.357

Syed, 2001, Management of psoriasis vulgaris with methotrexate 0.25% in a hydrophilic gel: a placebo-controlled, double-blind study, J. Cutan. Med. Surg., 5, 299, 10.1007/s102270000032

Bjerring, 1986, Topical treatment of psoriatic skin with methotrexate cream: a clinical, pharmacokinetic, and histological study, Acta Derm.-Venereol., 66, 515

Mueller, 1979, Cyclosporin A for psoriasis, N. Engl. J. Med., 301, 555, 10.1056/NEJM197909063011015

Gottlieb, 1995, Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis, Nat. Med., 1, 442, 10.1038/nm0595-442

Cronstein, 1993, The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation, J. Clin. Invest., 92, 2675, 10.1172/JCI116884

Morabito, 1998, Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5′-nucleotidase-mediated conversion of adenine nucleotides, J. Clin. Invest., 101, 295, 10.1172/JCI1554

Fredholm, 2001, International Union of Pharmacology. XXV: Nomenclature and classification of adenosine receptors, Pharmacol. Rev., 53, 527

Cronstein, 1990, The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively, J. Clin. Invest., 85, 1150, 10.1172/JCI114547

Cronstein, 1992, Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors, J. Immunol., 148, 2201, 10.4049/jimmunol.148.7.2201

Genestier, 1998, Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells, J. Clin. Invest., 102, 322, 10.1172/JCI2676

Paillot, 1998, Activation-dependent lymphocyte apoptosis induced by methotrexate*1, Transplant. Proc., 30, 2348, 10.1016/S0041-1345(98)00648-4

Chow, 1997, Purines and their roles in apoptosis, Neuropharmacology, 36, 1149, 10.1016/S0028-3908(97)00123-8

Yamasaki, 2003, Methotrexate inhibits proliferation and regulation of the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by cultured human umbilical vein endothelial cells, Br. J. Dermatol., 149, 30, 10.1046/j.1365-2133.2003.05407.x

Dolhain, 1998, Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis, Rheumatology, 37, 502, 10.1093/rheumatology/37.5.502

Ciesielski, 1998, Methotrexate regulates ICAM-1 expression in recipients of rat cardiac allografts, Transplant. Immunol., 6, 111, 10.1016/S0966-3274(98)80026-9

Dahlman-Ghozlan, 2000, Circulating levels of soluble E-selectin, ICAM-1 and VCAM-1 in bullous pemphigoid during low-dose methotrexate therapy. A prospective study, Exp. Dermatol., 9, 336, 10.1034/j.1600-0625.2000.009005336.x

Dahlman-Ghozlan, 2004, Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy, Exp. Dermatol., 13, 65, 10.1111/j.0906-6705.2004.00113.x

Fuhlbrigge, 1997, Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells, Nature, 389, 978, 10.1038/40166

Berg, 1991, The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1, J. Exp. Med., 174, 1461, 10.1084/jem.174.6.1461

Picker, 1990, A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites, Am. J. Pathol., 136, 1053

de Boer, 1994, Increased expression of adhesion receptors in both lesional and non-lesional psoriatic skin, Arch. Dermatol. Res., 286, 304, 10.1007/BF00402220

Sigmundsdottir, 2001, The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease, Clin. Exp. Immunol., 126, 365, 10.1046/j.1365-2249.2001.01688.x

Sigmundsdottir, 2004, Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin, Exp. Dermatol., 13, 426, 10.1111/j.0906-6705.2004.00177.x

Pruksakorn, 1992, Conserved T and B cell epitopes on the M protein of group A streptococci. Induction of bactericidal antibodies, J. Immunol., 149, 2729, 10.4049/jimmunol.149.8.2729

Baker, 1993, Group A streptococcal antigen-specific T lymphocytes in guttate psoriatic lesions, Br. J. Dermatol., 128, 493, 10.1111/j.1365-2133.1993.tb00224.x

Ekert, 1999, Caspase inhibitors, Cell Death Differ., 6, 1081, 10.1038/sj.cdd.4400594

Telford, 1994, Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry, J. Immunol. Methods, 172, 1, 10.1016/0022-1759(94)90373-5

Gudjonsson, 2004, Immunopathogenic mechanisms in psoriasis, Clin. Exp. Immunol., 135, 1, 10.1111/j.1365-2249.2004.02310.x

Davison, 2001, Early migration of cutaneous lymphocyte-associated antigen (CLA) positive T cells into evolving psoriatic plaques, Exp. Dermatol., 10, 280, 10.1034/j.1600-0625.2001.100408.x

Jolivet, 1983, Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase, J. Clin. Invest., 72, 773, 10.1172/JCI111048

Bouma, 1986, Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells, Am. J. Physiol., 270, C522, 10.1152/ajpcell.1996.270.2.C522

Allison, 1993, Inhibitors of de novo purine and pyrimidine synthesis as immunosuppressive drugs, Transplant. Proc., 25, 8

Blaheta, 2000, Inhibition of endothelial receptor expression and of T-cell ligand activity by mycophenolate mofetil, Immunopharmacology, 47, 85

Blaheta, 1999, Mycophenolate mofetil impairs transendothelial migration of allogeneic CD4 and CD8 T-cells, Transplant. Proc., 31, 1250, 10.1016/S0041-1345(98)01984-8

Allison, 2000, Mycophenolate mofetil and its mechanisms of action, Immunopharmacology, 47, 85, 10.1016/S0162-3109(00)00188-0

Carlos, 1994, Leukocyte-endothelial adhesion molecules, Blood, 84, 2068, 10.1182/blood.V84.7.2068.2068

Stuyt, 2003, Selective regulation of intercellular adhesion molecule-1 expression by interleukin-18 and interleukin-12 on human monocytes, Immunology, 110, 329, 10.1046/j.1365-2567.2003.01747.x

Nooteboom, 2004, Modulation of adhesion molecule expression on endothelial cells after induction by lipopolysaccharide-stimulated whole blood, Scand. J. Immunol., 59, 440, 10.1111/j.0300-9475.2004.01413.x

Espinoza, 1992, Psoriatic arthritis: clinical response and side effects to methotrexate therapy, J. Rheumatol., 1, 872

Fairbanks, 1999, Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?, Biochem. J., 342, 143, 10.1042/0264-6021:3420143

Baggott, 1993, Antifolates in rheumatoid arthritis: a hypothetical mechanism of action, Clin. Exp. Rheumatol., 11, S101

Kozarek, 1989, Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease, Ann. Intern. Med., 110, 353, 10.7326/0003-4819-110-5-353