The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans

Adams TH, Wieser JK, Yu JH (1998) Asexual sporulation in Aspergillus nidulans. Microbiol Mol Biol Rev 62:35–54 Aerts AM, Francois IE, Cammue BP, Thevissen K (2008) The mode of antifungal action of plant, insect and human defensins. Cell Mol Life Sci 65:2069–2079 Aguirre J, Rios-Momberg M, Hewitt D, Hansberg W (2005) Reactive oxygen species and development in microbial eukaryotes. Trends Microbiol 13:111–118 Asano Y, Hagiwara D, Yamashino T, Mizuno T (2007) Characterization of the bZip-type transcription factor NapA with reference to oxidative stress response in Aspergillus nidulans. Biosci Biotechnol Biochem 71:1800–1803 Balázs A et al (2010) AtfA bZIP-type transcription factor regulates oxidative and osmotic stress responses in Aspergillus nidulans. Mol Genet Genomics 283:289–303 Batta G et al (2009) Functional aspects of the solution structure and dynamics of PAF—a highly-stable antifungal protein from Penicillium chrysogenum. FEBS J 276:2875–2890 Brakhage AA et al (1999) HAP-Like CCAAT-binding complexes in filamentous fungi: implications for biotechnology. Fungal Genet Biol 27:243–252 Dimarcq JL, Bulet P, Hetru C, Hoffmann J (1998) Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers 47:465–477 Eisendle M, Schrettl M, Kragl C, Müller D, Illmer P, Haas H (2006) The intracellular siderophore ferricrocin is involved in iron storage, oxidative-stress resistance, germination, and sexual development in Aspergillus nidulans. Eukaryot Cell 5:1596–1603 Fourney RM, Miyakoshi J, Day RS, Paterson MC (1988) Northern blotting: efficient RNA staining and transfer. Focus 10:5–7 Gallo RL, Murakami M, Ohtake T, Zaiou M (2002) Biology and clinical relevance of naturally occurring antimicrobial peptides. J Allergy Clin Immunol 110:823–831 Hagiwara D et al (2007a) The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans. Biosci Biotechnol Biochem 71:1003–1014 Hagiwara D et al (2007b) Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses. Biosci Biotechnol Biochem 71:844–847 Hagiwara D, Asano Y, Marui J, Yoshimi A, Mizuno T, Abe K (2009) Transcriptional profiling for Aspergillus nidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress. Fungal Genet Biol 46:868–878 Hancock RE, Patrzykat A (2002) Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics. Curr Drug Targets Infect Disord 2:79–83 Hansberg W, Aguirre J (1990) Hyperoxidant states cause microbial cell differentiation by cell isolation from dioxygen. J Theor Biol 142:201–221 Hansberg W, de Groot H, Sies H (1993) Reactive oxygen species associated with cell differentiation in Neurospora crassa. Free Radic Biol Med 14:287–293 Hegedüs N et al (2011a) The small molecular mass antifungal protein of Penicillium chrysogenum—a mechanism of action oriented review. J Basic Microbiol 51:1–11 Hegedüs N, Sigl C, Zadra I, Pócsi I, Marx F (2011b) The paf gene product modulates asexual development in Penicillium chrysogenum. J Basic Microbiol 51:253–262 Izumitsu K, Yoshimi A, Tanaka C (2007) Two-component response regulators Ssk1p and Skn7p additively regulate high-osmolarity adaptation and fungicide sensitivity in Cochliobolus heterostrophus. Eukaryot Cell 6:171–181 Kaiserer L, Oberparleiter C, Weiler-Görz R, Burgstaller W, Leiter É, Marx F (2003) Characterization of the Penicillium chrysogenum antifungal protein PAF. Arch Microbiol 180:204–210 Kawasaki L, Wysong D, Diamond R, Aguirre J (1997) Two divergent catalase genes are differentially regulated during Aspergillus nidulans development and oxidative stress. J Bacteriol 179:3284–3292 Kroczek RA, Siebert E (1990) Optimization of northern analysis by vacuum-blotting, RNA-transfer visualization, and ultraviolet fixation. Anal Biochem 184:90–95 Kubodera T, Yamashita N, Nishimura A (2002) Transformation of Aspergillus sp. and Trichoderma reesei using the pyrithiamine resistance gene (ptrA) of Aspergillus oryzae. Biosci Biotechnol Biochem 66:404–406 Kulmburg P, Mathieu M, Dowzer C, Kelly J, Felenbok B (1993) Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon catabolite repression in Aspergillus nidulans. Mol Microbiol 7:847–857 Kyte J, Doolittle RF (1982) A simple method for displaying the hydropathic character of a protein. J Mol Biol 157:105–132 Lee BN, Adams TH (1994) The Aspergillus nidulans fluG gene is required for production of an extracellular developmental signal and is related to prokaryotic glutamine synthetase I. Genes Dev 8:641–651 Lowenberger C (2001) Innate immune response of Aedes aegypti. Insect Biochem Mol Biol 31:219–229 Maeda T, Wurgler-Murphy SM, Saito H (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369:242–245 Marx F (2004) Small, basic antifungal proteins secreted from filamentous ascomycetes: a comparative study regarding expression, structure, function and potential application. Appl Microbiol Biotechnol 65:133–142 Meyer V, Wedde M, Stahl U (2002) Transcriptional regulation of the antifungal protein in Aspergillus giganteus. Mol Genet Genomics 266:747–757 Miskei M, Karányi Z, Pócsi I (2009) Annotation of stress-response proteins in the aspergilli. Fungal Genet Biol 46(Suppl 1):S105–S120 Nayak T, Szewczyk E, Oakley CE, Osmani A, Ukil L, Murray SL, Hynes MJ, Osmani SA, Oakley BR (2006) A versatile and efficient gene-targeting system for Aspergillus nidulans. Genetics 172:1557–1566 Nielsen ML, Albertsen L, Lettier G, Nielsen JB, Mortensen UH (2006) Efficient PCR-based gene targeting with a recyclable marker for Aspergillus nidulans. Fungal Genet Biol 43:54–64 Pócsi I et al (2005) Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures—linking genome-wide transcriptional changes to cellular physiology. BMC Genomics 6:182 Pontecorvo G, Roper JA, Hemmons LM, Macdonald KD, Bufton AW (1953) The genetics of Aspergillus nidulans. Adv Genet 5:141–238 Posas F, Wurgler-Murphy SM, Maeda T, Witten EA, Thai TC, Saito H (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 “two-component” osmosensor. Cell 86:865–875 Punt PJ, van den Hondel CA (1992) Transformation of filamentous fungi based on hygromycin B and phleomycin resistance markers. Methods Enzymol 216:447–457 Raina S, De Vizio D, Odell M, Clements M, Vanhulle S, Keshavarz T (2009) Microbial quorum sensing: a tool or a target for antimicrobial therapy? Biotechnol Appl Biochem 54:65–84 Raj PA, Dentino AR (2002) Current status of defensins and their role in innate and adaptive immunity. FEMS Microbiol Lett 206:9–18 Reverberi M et al (2008) Modulation of antioxidant defense in Aspergillus parasiticus is involved in aflatoxin biosynthesis: a role for the ApyapA gene. Eukaryot Cell 7:988–1000 Roncal T, Cordobes S, Sterner O, Ugalde U (2002) Conidiation in Penicillium cyclopium is induced by conidiogenone, an endogenous diterpene. Eukaryot Cell 1:823–829 Ruprich-Robert G, Chapeland-Leclerc F, Boisnard S, Florent M, Bories G, Papon N (2008) Contributions of the response regulators Ssk1p and Skn7p in the pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae. Eukaryot Cell 7:1071–1074 Sambrock J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold spring Harbour Laboratory Press, Cold Spring Harbor Scazzocchio C (2000) The fungal GATA factors. Curr Opin Microbiol 3:126–131 Theis T, Wedde M, Meyer V, Stahl U (2003) The antifungal protein from Aspergillus giganteus causes membrane permeabilization. Antimicrob Agents Chemother 47:588–593 Thevissen K, Kristensen HH, Thomma BP, Cammue BP, Francois IE (2007) Therapeutic potential of antifungal plant and insect defensins. Drug Discov Today 12:966–971 Tilburn J, Scazzocchio C, Taylor GG, Zabicky-Zissman JH, Lockington RA, Davies RW (1983) Transformation by integration in Aspergillus nidulans. Gene 26:205–221 Toke O (2005) Antimicrobial peptides: new candidates in the fight against bacterial infections. Biopolymers 80:717–735 Toone WM, Jones N (1998) Stress-activated signalling pathways in yeast. Genes Cells 3:485–498 Tsitsigiannis DI, Keller NP (2007) Oxylipins as developmental and host-fungal communication signals. Trends Microbiol 15:109–118 Vargas-Pérez I, Sánchez O, Kawasaki L, Georgellis D, Aguirre J (2007) Response regulators SrrA and SskA are central components of a phosphorelay system involved in stress signal transduction and asexual sporulation in Aspergillus nidulans. Eukaryot Cell 6:1570–1583 Verma C et al (2007) Defensins: antimicrobial peptides for therapeutic development. Biotechnol J 2:1353–1359 Zhang H et al (2010) A two-component histidine kinase, MoSLN1, is required for cell wall integrity and pathogenicity of the rice blast fungus, Magnaporthe oryzae. Curr Genet 56:517–528 Zhu S (2008) Discovery of six families of fungal defensin-like peptides provides insights into origin and evolution of the CSalphabeta defensins. Mol Immunol 45:828–838