Phức hợp khuyến khích anaphase/cyclosome (APC/C): Các chức năng phụ thuộc và không phụ thuộc vào chu kỳ tế bào
Tóm tắt
APC/C (phức hợp khuyến khích anaphase/cyclosome) là một E3 ubiquitin ligase có chức năng nhắm mục tiêu các cơ chất cụ thể để phân hủy bởi proteasome 26S. Hoạt động của APC/C phụ thuộc vào hai cofactor, cụ thể là Cdc20 (chu kỳ tế bào 20) và Cdh1, những thành phần này lựa chọn các mục tiêu thích hợp cho quá trình ubiquitination. Đã có rất nhiều nghiên cứu cho thấy rằng APC/C là một mục tiêu của SAC (kiểm soát lắp ráp thoi) trong quá trình phân bào và có vai trò quan trọng trong việc kiểm soát nồng độ protein của các yếu tố điều hòa chính trong phân bào và sao chép DNA. Thêm vào đó, các nghiên cứu gần đây đã gợi ý về các chức năng độc lập với chu kỳ tế bào của APC/C trong các tế bào không phân bào, đặc biệt là trong cấu trúc và chức năng thần kinh. Với những chức năng đáng chú ý của APC/C trong sự phát triển của tế bào và sinh lý thần kinh, việc điều chỉnh hoạt động của APC/C có thể đem lại những tác động tích cực trong điều trị lâm sàng.
Từ khóa
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