The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Nature Immunology - Tập 15 Số 8 - Trang 727-737 - 2014
Bernardo S. Franklin1, Lukas Bossaller2,3, Dominic De Nardo1, Sandra Trenkamp1, Andrea Stutz1, Gudrun Engels1, Christoph Brenker4, Mark Nordhoff4, Sandra R. Mirandola4, Ashraf Al‐Amoudi4, Matthew Mangan4,1, Sebastian Zimmer5, Brian G. Monks3,1, Martin Fricke2, Reinhold E. Schmidt2, Terje Espevik6, Bernadette Jones7, Andrew Jarnicki7, Philip M. Hansbro7, Patricia Busto3, Ann Marshak‐Rothstein3, Simone Hornemann8, Adriano Aguzzi8, Wolfgang Kastenmüller9, Eicke Latz6,3,4,1
1Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany
2Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
3Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, USA
4German Center for Neurodegenerative Diseases, Bonn, Germany
5Department of Medicine/Cardiology, University Hospitals, University of Bonn, Bonn, Germany
6Department of Cancer Research and Molecular Medicine, Center of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway
7Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, Australia
8University Hospital Zürich, Institute of Neuropathology, Zürich, Switzerland
9Institute of Molecular Medicine and Experimental Immunology, University Hospitals, University of Bonn, Bonn, Germany

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