The Vasa Vasorum and Associated Endothelial Nitric Oxide Synthase is More Important for Saphenous Vein Than Arterial Bypass Grafts

Angiology - Tập 64 Số 4 - Trang 293-299 - 2013
Mats Dreifaldt1, Domingos Souza2, Lennart Bodin3, Shiwen Xu4, Audrey Dooley4, J. R. Muddle5, Andrzej Loesch6, Michael R. Dashwood7
1Department of Thoracic and Cardiovascular Surgery, Orebro University Hospital, Sweden.
2Department of Thoracic and Cardiovascular Surgery, Örebro University Hospital, Sweden
3Department of Statistics, Örebro University Hospital, Sweden
4#N# 3Department of Rheumatology, Royal Free and University College Medical School, Royal Free Campus, London, UK
5#N# 4Department of Neurological Science, Royal Free and University College Medical School, Royal Free Campus, London, UK
6#N# 5Division of Medicine, Royal Free and University College Medical School, Royal Free Campus, London, UK
7#N# 6Department of Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, London, UK

Tóm tắt

No-touch (NT) saphenous vein (SV) grafts are superior to SVs harvested by the conventional technique (CT), with a patency comparable with the internal thoracic artery (ITA). Preservation of the vasa vasorum is implicated in the success of NT harvesting. We compared the vasa vasorum and endothelial nitric oxide synthase (eNOS) in NT SV with ITA and radial artery (RA) grafts. Skeletonized SV (SSV) was also analyzed. The NT SV had a higher number and larger vasa vasorum compared with ITA ( P = .0001) and RA ( P = .0004) that correlated with eNOS protein. Activity of eNOS in SSV grafts was significantly lower than NT SV grafts ( P = 004). Since a high proportion of the vasa vasorum are removed in SSV using the CT, we suggest that preservation of the vasa vasorum and eNOS-derived NO contributes to the high patency for NT as compared with SSV grafts.

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Thông tin xuất bản

Angiology

Tập 64 Số 4

293-299

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