The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease
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Albert MS, DeKosky ST, Dickson D et al (2011) The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement J Alzheimers Assoc 7:270–279. doi: 10.1016/j.jalz.2011.03.008
Alexopoulos P, Sorg C, Förschler A et al (2012) Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer’s disease measured by pulsed arterial spin labeling MRI. Eur Arch Psychiatry Clin Neurosci 262:69–77. doi: 10.1007/s00406-011-0226-2
Alsop DC, Casement M, de Bazelaire C et al (2008) Hippocampal hyperperfusion in Alzheimer’s disease. NeuroImage 42:1267–1274. doi: 10.1016/j.neuroimage.2008.06.006
Alzheimer’s Association (2014) 2014 Alzheimer’s disease facts and figures. Alzheimers Dement 10:e47–e92. doi: 10.1016/j.jalz.2014.02.001
Ances BM, Liang CL, Leontiev O et al (2009) Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation. Hum Brain Mapp 30:1120–1132. doi: 10.1002/hbm.20574
Austin BP, Nair VA, Meier TB et al (2011) Effects of hypoperfusion in Alzheimer’s disease. J Alzheimers Dis 26:123–133. doi: 10.3233/JAD-2011-0010
Bangen KJ, Restom K, Liu TT et al (2009) Differential age effects on cerebral blood flow and BOLD response to encoding: associations with cognition and stroke risk. Neurobiol Aging 30:1276–1287. doi: 10.1016/j.neurobiolaging.2007.11.012
Bangen KJ, Restom K, Liu TT et al (2012) Assessment of Alzheimer’s disease risk with functional magnetic resonance imaging: an arterial spin labeling study. J Alzheimers Dis JAD 31(Suppl 3):S59–S74. doi: 10.3233/JAD-2012-120292
Bangen K, Nation D, Clark L et al (2014) Interactive effects of vascular risk burden and advanced age on cerebral blood flow. Front Aging Neurosci 6:159. doi: 10.3389/fnagi.2014.00159
Beason-Held LL, Goh JO, An Y et al (2013) Changes in brain function occur years before the onset of cognitive impairment. J Neurosci Off J Soc Neurosci 33:18008–18014. doi: 10.1523/JNEUROSCI.1402-13.2013
Bertsch K, Hagemann D, Hermes M et al (2009) Resting cerebral blood flow, attention, and aging. Brain Res 1267:77–88. doi: 10.1016/j.brainres.2009.02.053
Biagi L, Abbruzzese A, Bianchi MC et al (2007) Age dependence of cerebral perfusion assessed by magnetic resonance continuous arterial spin labeling. J Magn Reson Imaging 25:696–702. doi: 10.1002/jmri.20839
Binnewijzend MAA, Kuijer JPA, Benedictus MR et al (2013) Cerebral blood flow measured with 3D pseudocontinuous arterial spin-labeling MR imaging in Alzheimer disease and mild cognitive impairment: a marker for disease severity. Radiology 267:221–230. doi: 10.1148/radiol.12120928
Binnewijzend MAA, Benedictus MR, Kuijer JPA et al (2015) Cerebral perfusion in the predementia stages of Alzheimer’s disease. Eur Radiol. doi: 10.1007/s00330-015-3834-9
Biomarkers Definitions Working Group (2001) Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 69:89–95. doi: 10.1067/mcp.2001.113989
Bookheimer SY, Strojwas MH, Cohen MS et al (2000) Patterns of brain activation in people at risk for Alzheimer’s disease. N Engl J Med 343:450–456. doi: 10.1056/NEJM200008173430701
Bulte DP, Drescher K, Jezzard P (2009) Comparison of hypercapnia-based calibration techniques for measurement of cerebral oxygen metabolism with MRI. Magn Reson Med Off J Soc Magn Reson Med Soc Magn Reson Med 61:391–398. doi: 10.1002/mrm.21862
Buxton RB (2009) Introduction to functional magnetic resonance imaging: principles and techniques, 2nd edn. Cambridge University Press, New York
Cabeza R (2002) Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychol Aging 17:85–100
Cantin S, Villien M, Moreaud O et al (2011) Impaired cerebral vasoreactivity to CO2 in Alzheimer’s disease using BOLD fMRI. NeuroImage 58:579–587. doi: 10.1016/j.neuroimage.2011.06.070
Chapman SB, Aslan S, Spence JS et al (2013) Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging. Front Aging Neurosci 5:75. doi: 10.3389/fnagi.2013.00075
Chen Y, Wolk DA, Reddin JS et al (2011) Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease. Neurology 77:1977–1985. doi: 10.1212/WNL.0b013e31823a0ef7
Claassen JAHR, Diaz-Arrastia R, Martin-Cook K et al (2009) Altered cerebral hemodynamics in early alzheimer disease: a pilot study using transcranial doppler. J Alzheimers Dis JAD 17:621–629. doi: 10.3233/JAD-2009-1079
Clark LR, Nation DA, Wierenga CE et al (2015) Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old. Alzheimers Res Ther 7:3. doi: 10.1186/s13195-014-0080-3
Coon KD, Myers AJ, Craig DW et al (2007) A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer’s disease. J Clin Psychiatry 68:613–618
Corder EH, Saunders AM, Strittmatter WJ et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261:921–923
Dai W, Lopez OL, Carmichael OT et al (2009) Mild cognitive impairment and alzheimers disease: patterns of altered cerebral blood flow at MR imaging. Radiology 250:856–866. doi: 10.1148/radiol.2503080751
Davis TL, Kwong KK, Weisskoff RM, Rosen BR (1998) Calibrated functional MRI: mapping the dynamics of oxidative metabolism. Proc Natl Acad Sci USA 95:1834–1839
Donahue MJ, Hussey E, Rane S et al (2014) Vessel-encoded arterial spin labeling (VE-ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance. J Magn Reson Imaging JMRI 39:377–386. doi: 10.1002/jmri.24150
Firbank MJ, He J, Blamire AM et al (2011) Cerebral blood flow by arterial spin labeling in poststroke dementia. Neurology 76:1478–1484. doi: 10.1212/WNL.0b013e318217e76a
Fleisher AS, Podraza KM, Bangen KJ et al (2009) Cerebral perfusion and oxygenation differences in Alzheimer’s disease risk. Neurobiol Aging 30:1737–1748. doi: 10.1016/j.neurobiolaging.2008.01.012
Frank RA, Galasko D, Hampel H et al (2003) Biological markers for therapeutic trials in Alzheimer’s disease. In: Proceedings of the biological markers working group; NIA initiative on neuroimaging in Alzheimer’s disease. Neurobiol Aging 24:521–536
Gietl AF, Warnock G, Riese F et al (2015) Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner. Neurobiol Aging 36:1619–1628. doi: 10.1016/j.neurobiolaging.2014.12.036
Glodzik L, Rusinek H, Brys M et al (2011) Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 31:671–679. doi: 10.1038/jcbfm.2010.145
Golanov E, Reis D (1997) Oxygen and cerebral blood flow. In: Welch KMA, Caplan LR, Reis DJ, Siesjo BK, Weir B (eds) Primer on cerebrovascular diseases. Academic Press, San Diego, pp 58–60
Gorelick PB, Scuteri A, Black SE et al (2011) Vascular contributions to cognitive impairment and dementia. Stroke J Cereb Circ 42:2672–2713. doi: 10.1161/STR.0b013e3182299496
Greicius MD, Srivastava G, Reiss AL, Menon V (2004) Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci 101:4637–4642. doi: 10.1073/pnas.0308627101
Growdon JH, Selkoe DJ, Roses A et al (1998) Consensus report of the working group on biological markers of Alzheimer’s disease.[Ronald and Nancy Reagan Institute of the Alzheimer’s Association and National Institute on Aging Working Group on Biological Markers of Alzheimer’s Disease. Neurobiol Aging 19:109–116
Hajjar I, Zhao P, Alsop D, Novak V (2010) Hypertension and cerebral vasoreactivity: a continuous arterial spin labeling magnetic resonance imaging study. Hypertension 56:859–864. doi: 10.1161/HYPERTENSIONAHA.110.160002
Hajjar I, Sorond F, Lipsitz LA (2015) Apolipoprotein E, carbon dioxide vasoreactivity, and cognition in older adults: effect of hypertension. J Am Geriatr Soc 63:276–281. doi: 10.1111/jgs.13235
Head D, Bugg JM, Goate AM et al (2012) Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition. Arch Neurol 69:636–643. doi: 10.1001/archneurol.2011.845
Hebert LE, Weuve J, Scherr PA, Evans DA (2013) Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology 80:1778–1783. doi: 10.1212/WNL.0b013e31828726f5
Heijtel DFR, Mutsaerts HJMM, Bakker E et al (2014) Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: a head-to-head comparison with (15)O H2O positron emission tomography. NeuroImage 92C:182–192. doi: 10.1016/j.neuroimage.2014.02.011
Heo S, Prakash RS, Voss MW et al (2010) Resting hippocampal blood flow, spatial memory and aging. Brain Res 1315:119–127. doi: 10.1016/j.brainres.2009.12.020
Hutchison JL, Lu H, Rypma B (2013) Neural mechanisms of age-related slowing: the ΔCBF/ΔCMRO2 ratio mediates age-differences in BOLD signal and human performance. Cereb Cortex NY N 1991 23:2337–2346. doi: 10.1093/cercor/bhs233
Iadecola C (2004) Neurovascular regulation in the normal brain and in Alzheimer’s disease. Nat Rev Neurosci 5:347–360. doi: 10.1038/nrn1387
Jack CR Jr, Knopman DS, Jagust WJ et al (2010) Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade. Lancet Neurol 9:119–128. doi: 10.1016/S1474-4422(09)70299-6
Jarvik L, LaRue A, Blacker D et al (2008) Children of persons with Alzheimer disease: what does the future hold? Alzheimer Dis Assoc Disord 22:6–20. doi: 10.1097/WAD.0b013e31816653ac
Johnson NA, Jahng G-H, Weiner MW et al (2005) Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology 234:851–859. doi: 10.1148/radiol.2343040197
Kelleher RJ, Soiza RL (2013) Evidence of endothelial dysfunction in the development of Alzheimer’s disease: is Alzheimer’s a vascular disorder? Am J Cardiovasc Dis 3:197–226
Kim SM, Kim MJ, Rhee HY et al (2013) Regional cerebral perfusion in patients with Alzheimer’s disease and mild cognitive impairment: effect of APOE epsilon4 allele. Neuroradiology 55:25–34. doi: 10.1007/s00234-012-1077-x
Knopman DS, Roberts R (2010) Vascular risk factors: imaging and neuropathologic correlates. J Alzheimers Dis JAD 20:699–709. doi: 10.3233/JAD-2010-091555
Kramer AF, Erickson KI (2007) Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function. Trends Cogn Sci 11:342–348. doi: 10.1016/j.tics.2007.06.009
Lee SP, Duong TQ, Yang G et al (2001) Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: implications for BOLD fMRI. Magn Reson Med 45:791–800
Lee C, Lopez OL, Becker JT et al (2009) Imaging cerebral blood flow in the cognitively normal aging brain with arterial spin labeling: implications for imaging of neurodegenerative disease. J Neuroimaging Off J Am Soc Neuroimaging 19:344–352. doi: 10.1111/j.1552-6569.2008.00277.x
Lee JS, Im DS, An Y-S et al (2011) Chronic cerebral hypoperfusion in a mouse model of Alzheimer’s disease: an additional contributing factor of cognitive impairment. Neurosci Lett 489:84–88. doi: 10.1016/j.neulet.2010.11.071
Liu TT, Brown GG (2007) Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods. J Int Neuropsychol Soc JINS 13:517–525. doi: 10.1017/S1355617707070646
Liu TT, Wong EC (2005) A signal processing model for arterial spin labeling functional MRI. NeuroImage 24:207–215. doi: 10.1016/j.neuroimage.2004.09.047
Luchsinger J, Reitz C, Honig MDLS et al (2005) Aggregation of vascular risk factors and risk of incident Alzheimer’s disease. Neurology 65:545–551. doi: 10.1212/01.wnl.0000172914.08967.dc
Maalikjy Akkawi N, Borroni B, Agosti C et al (2003) Volume reduction in cerebral blood flow in patients with Alzheimer’s disease: a sonographic study. Dement Geriatr Cogn Disord 16:163–169. doi: 10.1159/000071005
Maalikjy Akkawi N, Borroni B, Agosti C et al (2005) Volume cerebral blood flow reduction in pre-clinical stage of Alzheimer disease: evidence from an ultrasonographic study. J Neurol 252:559–563. doi: 10.1007/s00415-005-0689-z
Maass A, Düzel S, Goerke M et al (2015) Vascular hippocampal plasticity after aerobic exercise in older adults. Mol Psychiatry 20:585–593. doi: 10.1038/mp.2014.114
Maier FC, Wehrl HF, Schmid AM et al (2014) Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion. Nat Med 20:1485–1492. doi: 10.1038/nm.3734
Marra C, Ferraccioli M, Vita MG et al (2011) Patterns of cognitive decline and rates of conversion to dementia in patients with degenerative and vascular forms of MCI. Curr Alzheimer Res 8:24–31
Mattsson N, Tosun D, Insel PS et al (2014) Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer’s disease and mild cognitive impairment. Brain J Neurol 137:1550–1561. doi: 10.1093/brain/awu043
McKhann GM, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement J Alzheimers Assoc 7:263–269. doi: 10.1016/j.jalz.2011.03.005
McLaren, Schultz, Chhatwal (2013) ApoE e4 and amyloid burden independently increase cerebral blood flow in cognitively normal older adults. In: Seventh Human Amyloid Imaging Conference, Miami
Morris JC (2005) Early-stage and preclinical Alzheimer disease. Alzheimer Dis Assoc Disord 19:163–165
Mozolic JL, Hayasaka S, Laurienti PJ (2010) A Cognitive training intervention increases resting cerebral blood flow in healthy older adults. Front Hum Neurosci. doi: 10.3389/neuro.09.016.2010
Mozolic JL, Long AB, Morgan AR et al (2011) A cognitive training intervention improves modality-specific attention in a randomized controlled trial of healthy older adults. Neurobiol Aging 32:655–668. doi: 10.1016/j.neurobiolaging.2009.04.013
Muller M, van der Graaf Y, Visseren FL et al (2012) Hypertension and longitudinal changes in cerebral blood flow: the SMART-MR study. Ann Neurol 71:825–833. doi: 10.1002/ana.23554
Nation DA, Wierenga CE, Clark LR et al (2013) Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis JAD 36:689–698. doi: 10.3233/JAD-130086
Okonkwo OC, Xu G, Oh JM et al (2014) Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer’s disease. Cereb Cortex N Y N 1991 24:978–988. doi: 10.1093/cercor/bhs381
Ostergaard L, Aamand R, Gutierrez-Jimenez E et al (2013) The capillary dysfunction hypothesis of Alzheimer’s disease. Neurobiol Aging 34:1018–1031
Pantano P, Baron JC, Lebrun-Grandié P et al (1984) Regional cerebral blood flow and oxygen consumption in human aging. Stroke J Cereb Circ 15:635–641
Park DC, Reuter-Lorenz P (2009) The adaptive brain: aging and neurocognitive scaffolding. Annu Rev Psychol 60:173–196. doi: 10.1146/annurev.psych.59.103006.093656
Parkes LM, Rashid W, Chard DT, Tofts PS (2004) Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects. Magn Reson Med 51:736–743. doi: 10.1002/mrm.20023
Pfefferkorn T, von Stuckrad-Barre S, Herzog J et al (2001) Reduced cerebrovascular CO(2) reactivity in CADASIL: a transcranial Doppler sonography study. Stroke J Cereb Circ 32:17–21
Popa-Wagner A, Buga A-M, Popescu B, Muresanu D (2013) Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle. J Neural Transm Vienna Austria 1996. doi: 10.1007/s00702-013-1129-3
Prakash RS, Voss MW, Erickson KI, Kramer AF (2015) Physical activity and cognitive vitality. Annu Rev Psychol 66:769–797. doi: 10.1146/annurev-psych-010814-015249
Restom K, Bangen KJ, Bondi MW et al (2007) Cerebral blood flow and BOLD responses to a memory encoding task: a comparison between healthy young and elderly adults. NeuroImage 37:430–439. doi: 10.1016/j.neuroimage.2007.05.024
Rolland Y, Abellan van Kan G, Vellas B (2010) Healthy brain aging: role of exercise and physical activity. Clin Geriatr Med 26:75–87. doi: 10.1016/j.cger.2009.11.002
Ruitenberg A, den Heijer T, Bakker SLM et al (2005) Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam study. Ann Neurol 57:789–794. doi: 10.1002/ana.20493
Sandson TA, O’Connor M, Sperling RA et al (1996) Noninvasive perfusion MRI in Alzheimer’s disease: a preliminary report. Neurol Novemb 47:1339–1342
Saunders AM, Strittmatter WJ, Schmechel D et al (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease. Neurology 43:1467–1472
Schuff N, Matsumoto S, Kmiecik J et al (2009) Cerebral blood flow in ischemic vascular dementia and Alzheimer’s disease, measured by arterial spin-labeling magnetic resonance imaging. Alzheimers Dement J Alzheimers Assoc 5:454–462. doi: 10.1016/j.jalz.2009.04.1233
Sheline YI, Morris JC, Snyder AZ et al (2010) APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42. J Neurosci Off J Soc Neurosci 30:17035–17040. doi: 10.1523/JNEUROSCI.3987-10.2010
Silverman JM, Ciresi G, Smith CJ et al (2005) Variability of familial risk of Alzheimer disease across the late life span. Arch Gen Psychiatry 62:565–573. doi: 10.1001/archpsyc.62.5.565
Silvestrini M, Pasqualetti P, Baruffaldi R et al (2006) Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke J Cereb Circ 37:1010–1015. doi: 10.1161/01.STR.0000206439.62025.97
Singh M, Mensah GA, Bakris G (2010) Pathogenesis and clinical physiology of hypertension. Cardiol Clin 28:545–559. doi: 10.1016/j.ccl.2010.07.001
Smith CD, Andersen AH, Kryscio RJ et al (1999) Altered brain activation in cognitively intact individuals at high risk for Alzheimer’s disease. Neurology 53:1391–1396
Smith JC, Paulson ES, Cook DB et al (2010) Detecting changes in human cerebral blood flow after acute exercise using arterial spin labeling: implications for fMRI. J Neurosci Methods 191:258–262. doi: 10.1016/j.jneumeth.2010.06.028
Sojkova J, Beason-Held L, Zhou Y et al (2008) Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern? J Nucl Med 49:1465–1471. doi: 10.2967/jnumed.108.051946
Sojkova, Goh, Beason-Held (2011) Increased beta-amyloid deposition is related to regional cerebral blood flow in nondemented older adults. In: Fifth Human Amyloid Imaging Conference, Miami
Sperling RA, Aisen PS, Beckett LA et al (2011) Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement J Alzheimers Assoc 7:280–292. doi: 10.1016/j.jalz.2011.03.003
Stomrud E, Forsberg A, Hägerström D et al (2012) CSF biomarkers correlate with cerebral blood flow on SPECT in healthy elderly. Dement Geriatr Cogn Disord 33:156–163. doi: 10.1159/000338185
Sun Z-W, Zhu Y-X, Liu H-Y et al (2007) Decreased cerebral blood flow velocity in apolipoprotein E epsilon4 allele carriers with mild cognitive impairment. Eur J Neurol 14:150–155. doi: 10.1111/j.1468-1331.2006.01579.x
Takahashi H, Ishii K, Hosokawa C et al (2013) Clinical application of 3D arterial spin-labeled brain perfusion imaging for Alzheimer disease: comparison with brain perfusion SPECT. AJNR Am J Neuroradiol. doi: 10.3174/ajnr.A3780
Thambisetty M, Beason-Held L, An Y et al (2010) APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging. Arch Neurol 67:93–98. doi: 10.1001/archneurol.2009.913
Thomas BP, Yezhuvath US, Tseng BY et al (2013) Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2. J Magn Reson Imaging JMRI 38:1177–1183. doi: 10.1002/jmri.24090
Tiraboschi P, Hansen LA, Masliah E et al (2004) Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease. Neurology 62:1977–1983
Uchihashi Y, Hosoda K, Zimine I et al (2011) Clinical application of arterial spin-labeling MR imaging in patients with carotid stenosis: quantitative comparative study with single-photon emission CT. AJNR Am J Neuroradiol 32:1545–1551. doi: 10.3174/ajnr.A2525
Vicenzini E, Ricciardi MC, Altieri M et al (2007) Cerebrovascular reactivity in degenerative and vascular dementia: a transcranial Doppler study. Eur Neurol 58:84–89. doi: 10.1159/000103642
Villien M, Bouzat P, Rupp T et al (2013) Changes in cerebral blood flow and vasoreactivity to CO2 measured by arterial spin labeling after 6 days at 4350m. NeuroImage 72:272–279. doi: 10.1016/j.neuroimage.2013.01.066
Wang Z (2014) Characterizing early Alzheimer’s disease and disease progression using hippocampal volume and arterial spin labeling perfusion MRI. J Alzheimers Dis JAD 42(Suppl 4):S495–S502. doi: 10.3233/JAD-141419
Wierenga CE, Dev SI, Shin DD et al (2012) Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition. J Cereb Blood Flow Metab 32:1589–1599. doi: 10.1038/jcbfm.2012.58
Wierenga CE, Clark LR, Dev SI et al (2013) Interaction of age and APOE genotype on cerebral blood flow at rest. J Alzheimers Dis JAD 34:921–935. doi: 10.3233/JAD-121897
Wierenga CE, Hays CC, Zlatar ZZ (2014) Cerebral blood flow measured by arterial spin labeling MRI as a preclinical marker of Alzheimer’s disease. J Alzheimers Dis JAD. doi: 10.3233/JAD-141467
Wolk DA, Detre JA (2012) Arterial spin labeling MRI: an emerging biomarker for Alzheimer’s disease and other neurodegenerative conditions. Curr Opin Neurol 25:421–428. doi: 10.1097/WCO.0b013e328354ff0a
Wong EC (2013) New developments in arterial spin labeling pulse sequences. NMR Biomed 26:887–891. doi: 10.1002/nbm.2954
Xekardaki A, Rodriguez C, Montandon M-L et al (2015) Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals. Radiology 274:490–499. doi: 10.1148/radiol.14140680
Xu G, Antuono PG, Jones J et al (2007) Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects. Neurology 69:1650–1656. doi: 10.1212/01.wnl.0000296941.06685.22
Yip AG, McKee AC, Green RC et al (2005) APOE, vascular pathology, and the AD brain. Neurology 65:259–265. doi: 10.1212/01.wnl.0000168863.49053.4d
Yoon HJ, Park KW, Jeong YJ, Kang D-Y (2012) Correlation between neuropsychological tests and hypoperfusion in MCI patients: anatomical labeling using xj view and Talairach Daemon software. Ann Nucl Med 26:656–664. doi: 10.1007/s12149-012-0625-0
Zavoreo I, Bašić Kes V, Lisak M et al (2013) Cognitive decline and cerebral vasoreactivity in asymptomatic patients with severe internal carotid artery stenosis. Acta Neurol Belg 113:453–458. doi: 10.1007/s13760-013-0196-4
Zlatar ZZ, Wierenga CE, Bangen KJ et al (2014) Increased hippocampal blood flow in sedentary older adults at genetic risk for Alzheimer’s disease. J Alzheimers Dis JAD. doi: 10.3233/JAD-132252