The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological non-demented cohort of Australians aged 70–90 years

International Psychogeriatrics - Tập 22 Số 8 - Trang 1248-1264 - 2010
Perminder S. Sachdev1, Henry Brodaty, Simone Reppermund, Nicole A. Kochan, Julian N. Trollor, Brian Draper, Melissa J. Slavin, John B. Kwok, Kristan Kang, G A Broe, Karen A. Mather, Ora Lux
1Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia. [email protected]

Tóm tắt

ABSTRACTBackground:The Sydney Memory and Ageing Study (Sydney MAS) was initiated in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function over time.Methods:Non-demented community-dwelling individuals (N = 1037) aged 70–90 were recruited from two areas of Sydney, following a random approach to 8914 individuals on the electoral roll. They underwent detailed neuropsychiatric and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed. Structural MRI scans were performed on 554 individuals, and subgroups participated in studies of falls and balance, metabolic and inflammatory markers, functional MRI and prospective memory. The cohort is to be followed up with brief telephone reviews annually, and detailed assessments biannually.Results:This is a generally well-functioning cohort mostly living in private homes and rating their health as being better than average, although vascular risk factors are common. Most (95.5%) participants or their informants identified a cognitive difficulty, and 43.5% had impairment on at least one neuropsychological test. MCI criteria were met by 34.8%; with19.3% qualifying for amnestic MCI, whereas 15.5% had non-amnestic MCI; 1.6% had impairment on neuropsychological test performance but no subjective complaints; and 5.8% could not be classified. The rate of MCI was 30.9% in the youngest (70–75) and 39.1% in the oldest (85–90) age bands. Rates of depression and anxiety were 7.1% and 6.9% respectively.Conclusions:Cognitive complaints are common in the elderly, and nearly one in three meet criteria for MCI. Longitudinal follow-up of this cohort will delineate the progression of complaints and objective cognitive impairment, and the determinants of such change.

Từ khóa


Tài liệu tham khảo

2003, Ageing in Australia: Census of Population and Housing 2001

10.1001/jama.1997.03550160069041

10.1159/000115751

Tombaugh, 1999, Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming, Archives of Clinical Neuropsychology, 14, 167

10.1080/13854049208401877

10.1212/WNL.44.12.2308

10.1016/S0140-6736(95)92405-1

Slavin M. J. (2010). Prevalence and predictors of subjective cognitive complaints in the Sydney Memory and Ageing Study. Americal Journal of Geriatric Psychiatry. Epublished ahead of print, doi: 10.1097/JGP.0b013e3181df49fb

10.1001/archneurol.2009.266

Benton, 1966, Der Benton Test

10.1076/jcen.20.6.828.1105

Briganti, 2003, Untreated hypertension among Australian adults: the 1999–2000 Australian Diabetes, Obesity and Lifestyle Study (AusDiab), Medical Journal of Australia, 179, 135, 10.5694/j.1326-5377.2003.tb05471.x

10.1111/j.2044-8260.1989.tb01377.x

10.1212/WNL.57.9.1655

10.1212/WNL.41.7.1006

Wechsler, 1981, WAIS-R Manual

10.1037/0022-3514.54.6.1063

10.1159/000051195

10.1076/jcen.24.2.214.995

10.1097/JGP.0b013e3180590ba9

Reitan, 1993, The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation

Kessler R. and Mroczek D. (1994). Final version of our Non-specific Psychological Distress Scale. Unpublished memo. Ann Arbor, MI: Survey Research Center of the Institute for Social Research, University of Michigan.

Kaplan, 2001, The Boston Naming Test.

10.1001/archneur.61.1.59

10.1017/S1041610209009405

10.1016/S0887-6177(03)00039-8

Klove, 1963, The Medical Clinics of North America, 1647

10.1017/S0033291704003162

1998, Mental Health and Wellbeing: Profile of Adults, Australia, 1997

10.1037/0894-4105.21.1.1

10.1207/s15327752jpa4901_13

10.1001/archneur.60.10.1385

10.1212/01.WNL.0000034176.07159.F8

10.1111/j.1365-2796.2004.01380.x

10.1016/S0035-3787(04)71143-1

Hixson, 1990, Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hha1, Journal of Lipid Research, 31, 545, 10.1016/S0022-2275(20)43176-1

10.1016/j.neuroimage.2010.02.016

Spreen, 1969, Neurosensory Centre Comprehensive Examination for Aphasia Manual (NCCEA)

2006, Census of Population and Housing

McLennan, 1997, ASCO: Australian Standard Classification of Occupations

10.1016/0022-3956(75)90026-6

10.1017/S1041610207005583

2006, Dementia in the Asia Pacific Region: The Epidemic is Here

10.1093/gerona/57.8.M539

2008, Australia's Health 2008

Mathers, 1999, The Burden of Disease and Injury in Australia

10.1002/gps.830

10.1212/WNL.56.1.37

10.1136/jnnp.71.3.296

10.1017/S003329170002691X

10.1017/S1041610292000991

1999, Older People, Australia: A Social Report

Rey, 1964, L'Examen Clinique en Psychologie

10.1136/bmj.297.6653.897

10.1093/geront/9.3_Part_1.179

Nelson, 1991, National Adult Reading Test (NART): Test Manual

10.1097/00005537-199603000-00021

10.1111/j.1532-5415.1999.tb05230.x

Blossom, 2007, Early cognitive change in the general population: how do different definitions work, Journal of the American Geriatrics Society, 55, 1534, 10.1111/j.1532-5415.2007.01386.x

10.1212/WNL.59.2.198

10.1016/S0010-9452(67)80005-4

10.1111/j.1365-2796.2004.01388.x

Costa, 1992, NEO PI-R Professional Manual. Revised NEO Personality Inventory (NEO PI-R) and NEO Five-Factor Inventory (NEO-FFI)

10.1080/13854049208401880

10.1111/j.1467-8462.2004.00308.x

10.1002/hbm.20586

Kochan N. A. (2010). Effect of different impairment criteria on prevalence of “objective” mild cognitive impairment in a community sample. American Journal of Geriatric Psychiatry. Epublished ahead of print, doi: 10.1097/JGP.0b013e3181d6b6a9

Epping-Jordan, 2000, The WHODAS II: leveling the playing field for all disorders, WHO Mental Health Bulletin, 6, 5

10.1016/S0140-6736(99)06155-3

10.1016/0022-3956(82)90033-4

10.1097/JGP.0b013e3180547053

Brandt, 1988, The telephone interview for cognitive status, Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 1, 111

10.1111/j.1467-842X.2000.tb00520.x

10.1159/000082351

10.1001/archneur.58.12.1985

10.1037/1040-3590.2.3.304

10.1212/WNL.43.11.2412-a

10.1111/j.1532-5415.1991.tb01616.x

10.1161/01.STR.0000147034.25760.3d

Wechsler, 1997, Wechsler Adult Intelligence Scale-III

10.1016/S0140-6736(02)11667-9

10.1016/S0140-6736(97)01007-6

Wechsler, 1997, Wechsler Adult Intelligence Scale- 3rd Edition (WAIS-3®)

Thông tin
Thông tin xuất bản

International Psychogeriatrics

Tập 22 Số 8

1248-1264

Thông tin tác giả