The Sonic Hedgehog Signaling Network in Development and Neoplasia

Wilson, 2006, New “hogs” in Hedgehog transport and signal reception, Cell, 125, 435, 10.1016/j.cell.2006.04.016

Ingham, 2001, Hedgehog signaling in animal development: paradigms and principles, Genes Dev, 15, 3059, 10.1101/gad.938601

Nusslein-Volhard, 1980, Mutations affecting segment number and polarity in Drosophila, Nature, 287, 795, 10.1038/287795a0

Kang, 1997, CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family, J Cell Biol, 138, 203, 10.1083/jcb.138.1.203

Kang, 2002, BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation, Embo J, 21, 114, 10.1093/emboj/21.1.114

Zhang, 2006, Cdo functions at multiple points in the sonic hedgehog pathway, and cdo-deficient mice accurately model human holoprosencephaly, Dev Cell, 10, 657, 10.1016/j.devcel.2006.04.005

Tenzen, 2006, The cell surface membrane proteins cdo and boc are components and targets of the hedgehog signaling pathway and feedback network in mice, Dev Cell, 10, 647, 10.1016/j.devcel.2006.04.004

Okada, 2006, Boc is a receptor for sonic hedgehog in the guidance of commissural axons, Nature, 444, 369, 10.1038/nature05246

Cohen, 2003, The hedgehog signaling network, Am J Med Genet, 123A, 5, 10.1002/ajmg.a.20495

Sisson, 2006, Regulation of Ci and Su(fu) nuclear import in Drosophila, Dev Biol, 294, 258, 10.1016/j.ydbio.2006.02.050

Hooper, 2005, Communicating with Hedgehogs, Nat Rev Mol Cell Biol, 6, 306, 10.1038/nrm1622

Varjosalo, 2006, Divergence of hedgehog signal transduction mechanism between Drosophila and mammals, Dev Cell, 10, 177, 10.1016/j.devcel.2005.12.014

Carpenter, 1998, Characterization of two patched receptors for the vertebrate hedgehog protein family, Proc Natl Acad Sci USA, 95, 13630, 10.1073/pnas.95.23.13630

Stone, 1996, The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog, Nature, 384, 129, 10.1038/384129a0

Marigo, 1996, Biochemical evidence that patched is the Hedgehog receptor, Nature, 384, 176, 10.1038/384176a0

Haycraft, 2005, Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function, PLoS Genet, 1, e53, 10.1371/journal.pgen.0010053

Oro, 2006, Mammalian variations on a theme: a Smo and Sufu surprise, Dev Cell, 10, 156, 10.1016/j.devcel.2006.01.006

Cheng, 2002, Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex, Proc Natl Acad Sci USA, 99, 5442, 10.1073/pnas.082096999

Paces-Fessy, 2004, The negative regulator of Gli, suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins, Biochem J, 378, 353, 10.1042/bj20030786

Takenaka, 2007, GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells, Biochem Biophys Res Commun, 353, 501, 10.1016/j.bbrc.2006.12.058

Chuang, 1999, Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein, Nature, 397, 617, 10.1038/17611

Jacob, 2003, Gli proteins and the control of spinal-cord patterning, EMBO Rep, 4, 761, 10.1038/sj.embor.embor896

Matise, 1999, Gli genes in development and cancer, Oncogene, 18, 7852, 10.1038/sj.onc.1203243

Flynt, 2007, Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate, Nat Genet, 39, 259, 10.1038/ng1953

Ghali, 1999, Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin, J Invest Dermatol, 113, 595, 10.1046/j.1523-1747.1999.00729.x

Johnson, 1996, Human homolog of patched, a candidate gene for the basal cell nevus syndrome, Science, 272, 1668, 10.1126/science.272.5268.1668

Gailani, 1996, The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas, Nat Genet, 14, 78, 10.1038/ng0996-78

Xie, 1998, Activating smoothened mutations in sporadic basal-cell carcinoma, Nature, 391, 90, 10.1038/34201

Bigelow, 2004, Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1, J Biol Chem, 279, 1197, 10.1074/jbc.M310589200

Regl, 2004, Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2, Cancer Res, 64, 7724, 10.1158/0008-5472.CAN-04-1085

Bigelow, 2005, Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes, J Invest Dermatol, 124, 457, 10.1111/j.0022-202X.2004.23590.x

Taylor, 2002, Mutations in SUFU predispose to medulloblastoma, Nat Genet, 31, 306, 10.1038/ng916

Levanat, 2004, Analysis of the PTCH1 signaling pathway in ovarian dermoids, Int J Mol Med, 14, 793

Berman, 2003, Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours, Nature, 425, 846, 10.1038/nature01972

Berman, 2004, Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis, Dev Biol, 267, 387, 10.1016/j.ydbio.2003.11.018

Kubo, 2004, Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer, Cancer Res, 64, 6071, 10.1158/0008-5472.CAN-04-0416

Martin, 2005, Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms, Cancer Biol Ther, 4, 728, 10.4161/cbt.4.7.1802

Watkins, 2003, Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer, Nature, 422, 313, 10.1038/nature01493

Pepicelli, 1998, Sonic hedgehog regulates branching morphogenesis in the mammalian lung, Curr Biol, 8, 1083, 10.1016/S0960-9822(98)70446-4

Motoyama, 1998, Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus, Nat Genet, 20, 54, 10.1038/1711

Apelqvist, 1997, Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas, Curr Biol, 7, 801, 10.1016/S0960-9822(06)00340-X

Clement, 2007, HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity, Curr Biol, 17, 165, 10.1016/j.cub.2006.11.033

Ma, 2005, Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas, Carcinogenesis, 26, 1698, 10.1093/carcin/bgi130

Olsen, 2004, Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors, BMC Cancer, 4, 43, 10.1186/1471-2407-4-43

Tsuda, 2006, Synthetic microRNA designed to target glioma-associated antigen 1 transcription factor inhibits division and induces late apoptosis in pancreatic tumor cells, Clin Cancer Res, 12, 6557, 10.1158/1078-0432.CCR-06-0588

Podlasek, 1999, Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium, Dev Biol, 209, 28, 10.1006/dbio.1999.9229

Mo, 2001, Anorectal malformations caused by defects in sonic hedgehog signaling, Am J Pathol, 159, 765, 10.1016/S0002-9440(10)61747-6

Sugimura, 1986, Whole-mount autoradiography study of DNA synthetic activity during postnatal development and androgen-induced regeneration in the mouse prostate, Biol Reprod, 34, 985, 10.1095/biolreprod34.5.985

Barnett, 2002, The human prostate expresses sonic hedgehog during fetal development, J Urol, 168, 2206, 10.1016/S0022-5347(05)64356-X

Bellusci, 1997, Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis, Development, 124, 53, 10.1242/dev.124.1.53

Lamm, 2002, Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation, Dev Biol, 249, 349, 10.1006/dbio.2002.0774

Wang, 2003, Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells, J Biol Chem, 278, 18506, 10.1074/jbc.M300968200

Pu, 2004, Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching, Dev Biol, 273, 257, 10.1016/j.ydbio.2004.06.002

Lau, 2006, Hedgehog signaling in pancreas development and disease, Cell Mol Life Sci, 63, 642, 10.1007/s00018-005-5357-z

Katano, 2005, Hedgehog signaling pathway as a therapeutic target in breast cancer, Cancer Lett, 227, 99, 10.1016/j.canlet.2004.11.030

Karhadkar, 2004, Hedgehog signalling in prostate regeneration, neoplasia and metastasis, Nature, 431, 707, 10.1038/nature02962

Watkins, 2003, Hedgehog signaling: progenitor phenotype in small-cell lung cancer, Cell Cycle, 2, 196, 10.4161/cc.2.3.378

Taipale, 2001, The Hedgehog and Wnt signalling pathways in cancer, Nature, 411, 349, 10.1038/35077219

Fan, 2004, Hedgehog signaling promotes prostate xenograft tumor growth, Endocrinology, 145, 3961, 10.1210/en.2004-0079

Sheng, 2004, Activation of the hedgehog pathway in advanced prostate cancer, Mol Cancer, 3, 29, 10.1186/1476-4598-3-29

Sanchez, 2004, Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling, Proc Natl Acad Sci USA, 101, 12561, 10.1073/pnas.0404956101

Svard, 2006, Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway, Dev Cell, 10, 187, 10.1016/j.devcel.2005.12.013

Meng, 2001, Suppressor of fused negatively regulates beta-catenin signaling, J Biol Chem, 276, 40113, 10.1074/jbc.M105317200

Taylor, 2004, Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling, Oncogene, 23, 4577, 10.1038/sj.onc.1207605

St-Jacques, 1999, Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation, Genes Dev, 13, 2072, 10.1101/gad.13.16.2072

Long, 2004, Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton, Development, 131, 1309, 10.1242/dev.01006

Chung, 2001, Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development, J Clin Invest, 107, 295, 10.1172/JCI11706

Kinto, 1997, Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation, FEBS Lett, 404, 319, 10.1016/S0014-5793(97)00014-8

Spinella-Jaegle, 2001, Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation, J Cell Sci, 114, 2085, 10.1242/jcs.114.11.2085

McMahon, 2003, Developmental roles and clinical significance of hedgehog signaling, Curr Top Dev Biol, 53, 1, 10.1016/S0070-2153(03)53002-2

Cooper, 1998, Teratogen-mediated inhibition of target tissue response to Shh signaling, Science, 280, 1603, 10.1126/science.280.5369.1603

Chen, 2002, Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened, Genes Dev, 16, 2743, 10.1101/gad.1025302

King, 2002, Roughing up Smoothened: chemical modulators of hedgehog signaling, J Biol, 1, 8, 10.1186/1475-4924-1-8

Kusano, 2005, Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling, Nat Med, 11, 1197, 10.1038/nm1313

Asai, 2006, Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling, Circulation, 113, 2413, 10.1161/CIRCULATIONAHA.105.603167

Chen, 2002, Small molecule modulation of Smoothened activity, Proc Natl Acad Sci USA, 99, 14071, 10.1073/pnas.182542899

Williams, 2003, Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions, Proc Natl Acad Sci USA, 100, 4616, 10.1073/pnas.0732813100

Tabs, 2004, Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity, Eur J Dermatol, 14, 96

Romer, 2004, Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/–)p53(–/–) mice, Cancer Cell, 6, 229, 10.1016/j.ccr.2004.08.019

Berman, 2002, Medulloblastoma growth inhibition by hedgehog pathway blockade, Science, 297, 1559, 10.1126/science.1073733

Mimeault, 2006, Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells, Int J Cancer, 118, 1022, 10.1002/ijc.21440

Shelton, 2005, The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?, Expert Opin Ther Targets, 9, 1009, 10.1517/14728222.9.5.1009

Cooper, 2003, A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis, Nat Genet, 33, 508, 10.1038/ng1134

Brown, 2007, Cholesterol, statins and cancer, Clin Exp Pharmacol Physiol, 34, 135, 10.1111/j.1440-1681.2007.04565.x

Kise, 2006, Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels, Biochem Biophys Res Commun, 351, 78, 10.1016/j.bbrc.2006.10.036

Kasper, 2006, GLI transcription factors: mediators of oncogenic Hedgehog signalling, Eur J Cancer, 42, 437, 10.1016/j.ejca.2005.08.039

Louro, 2002, Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation, Cancer Res, 62, 5867

Tabata, 1994, Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs, Cell, 76, 89, 10.1016/0092-8674(94)90175-9

Brewster, 2000, Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS, Mech Dev, 99, 159, 10.1016/S0925-4773(00)00469-X

Chuang, 2003, Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung, Genes Dev, 17, 342, 10.1101/gad.1026303

Teh, 2002, FOXM1 is a downstream target of Gli1 in basal cell carcinomas, Cancer Res, 62, 4773

Eichberger, 2004, FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma, J Invest Dermatol, 122, 1180, 10.1111/j.0022-202X.2004.22505.x

Hahn, 2000, Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma, J Biol Chem, 275, 28341, 10.1074/jbc.C000352200

Krishnan, 1997, Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase, Science, 278, 1947, 10.1126/science.278.5345.1947