The Sexual Goals of Metoidioplasty Patients and Their Attitudes Toward Using PDE5 Inhibitors and Intracavernosal Injections as Erectile Aids

Sexual Medicine - Tập 10 - Trang 100505 - 2022
Amir Khorrami1,2, Sahil Kumar1,2, Elise Bertin2, Richard Wassersug2, Cormac O'Dwyer1,2, Smita Mukherjee2,3, Luke Witherspoon2,3, Peter Mankowski2,4, Krista Genoway2,4, Alex G. Kavanagh2,3
1Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
2Gender Surgery Program, Vancouver Coastal Health, Vancouver, British Columbia, Canada
3Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada
4Division of Plastic and Reconstructive Surgery, University of British Columbia, Vancouver, British Columbia, Canada

Tóm tắt

Abstract Background Following metoidioplasty, transmen (TM) experience sexual function challenges including erectile dysfunction, which is typically treated in cisgender men with phosphodiesterase-5 inhibitors (PDE5i) and intracavernosal injections (ICI). Aim We aim to evaluate sexual function post-metoidioplasty and explore attitudes toward using PDE5i and ICI as potential erectile aids Methods All patients who had metoidioplasty completed at the Gender Surgery Program in Vancouver, British Columbia were contacted. Participants completed an electronically accessible self-constructed questionnaire consisting of 39 items on erectile function, orgasm, and penetrative intercourse which also captured Erection Hardness Scores (EHS). Data were analyzed via t-test and 1-way ANOVA. Outcomes Our outcomes were the importance of erectile function, ability to orgasm, penetrative intercourse, and attitudes towards using PDE5i and ICI post-metoidioplasty. Results Fifteen out of 22 patients completed the survey (median age 32 years). Most had metoidioplasty within the past 2 years. The participants ranked the ability to orgasm and to achieve or maintain erections significantly higher than penetrative intercourse (P <.001, P =.005 respectively). Most participants reported facing challenges with penetrative intercourse (87%) and erectile function (80%). In contrast, a smaller proportion reported challenges with orgasm (33%). With regards to EHS, 83% of participants described their erections as either “larger but not hard,” or “hard but not hard enough for penetration.” A total of 47% of the participants had previously tried PDE5i, but none had used ICI. Although 87% were willing to use PDE5i, only 40% were willing to try ICI to improve their erections. Patients reported lack of knowledge and understanding among primary care physicians as barriers to accessing treatment for sexual dysfunction. Clinical Translation The results of this study can facilitate decision making for TM undergoing genital gender-affirmation surgery and provide potential options for improving erectile function post surgery. Strengths & Limitations This study represents the first assessment of sexual function and use of erectile aids in post-metoidioplasty patients. The results of this study are limited by the small sample size and enrolment from a single surgical center. Conclusion Metoidioplasty patients surveyed fail to achieve a fully rigid erection without treatment, typically retain the ability to orgasm, and are generally willing to try PDE5i.

Tài liệu tham khảo

van de Grift, 2017, A longitudinal study of motivations before and psychosexual outcomes after genital gender-confirming surgery in transmen, J Sex Med, 14, 1621, 10.1016/j.jsxm.2017.10.064 Akhavan, 2021, A review of gender affirmation surgery: what we know, and what we need to know, Surgery, 170, 336, 10.1016/j.surg.2021.02.013 Heston, 2019, Phalloplasty: techniques and outcomes, Transl Androl Urol, 8, 254, 10.21037/tau.2019.05.05 Djordjevic, 2013, Comparison of two different methods for urethral lengthening in female to male (metoidioplasty) surgery, J Sex Med, 10, 1431, 10.1111/jsm.12108 Djordjevic, 2009, Metoidioplasty as a single stage sex reassignment surgery in female transsexuals: belgrade experience, J Sex Med, 6, 1306, 10.1111/j.1743-6109.2008.01065.x Morrison, 2015, Current state of female-to-male gender confirming surgery, Curr Sexual Health Rep, 7, 38, 10.1007/s11930-014-0038-2 Stojanovic, 2015, Anatomy of the clitoris and its impact on neophalloplasty (metoidioplasty) in female transgenders, Clin Anat, 28, 368, 10.1002/ca.22525 Djordjevic, 2019, Metoidioplasty: techniques and outcomes, Transl Androl Urol, 8, 248, 10.21037/tau.2019.06.12 Kerckhof, 2019, Prevalence of sexual dysfunctions in transgender persons: results from the enigi follow-up study, J Sex Med, 16, 2018, 10.1016/j.jsxm.2019.09.003 Kocjancic, 2020, Masculinizing genital gender-affirming surgery: metoidioplasty and urethral lengthening, Int J Impot Res Belew, 2015, Intracavernosal injection for the diagnosis, evaluation, and treatment of erectile dysfunction: a review, Sex Med Rev, 3, 11, 10.1002/smrj.35 Burnett, 2018, Erectile dysfunction: Aua guideline, J Urol, 200, 633, 10.1016/j.juro.2018.05.004 Hatzimouratidis, 2010, Guidelines on male sexual dysfunction: Erectile dysfunction and premature ejaculation, Eur Urol, 57, 804, 10.1016/j.eururo.2010.02.020 Mulhall, 2007, Validation of the erection hardness score, J Sex Med, 4, 1626, 10.1111/j.1743-6109.2007.00600.x Korenman, 2004, Epidemiology of erectile dysfunction, Endocrine, 23, 87, 10.1385/ENDO:23:2-3:087 Pizzol, 2020, Associations between body mass index, waist circumference and erectile dysfunction: a systematic review and meta-analysis, Rev Endocr Metab Disord, 21, 657, 10.1007/s11154-020-09541-0 Sivaratnam, 2021, Behavior-related erectile dysfunction: a systematic review and meta-analysis, J Sex Med, 18, 121, 10.1016/j.jsxm.2020.09.009 de Rooij, 2021, Patient-reported outcomes after genital gender-affirming surgery with versus without urethral lengthening in transgender men, J Sex Med, 18, 974, 10.1016/j.jsxm.2021.03.002 Masumori, 2021, What is the most anticipated change induced by treatment using gender-affirming hormones in individuals with gender incongruence?, Int J Urol, 28, 526, 10.1111/iju.14499 Garcia, 2014, Overall satisfaction, sexual function, and the durability of neophallus dimensions following staged female to male genital gender confirming surgery: The institute of urology, london u.K. Experience, Transl Androl Urol, 3, 156 Klein, 2009, Sexual functioning in transsexuals following hormone therapy and genital surgery: a review, J Sex Med, 6, 2922, 10.1111/j.1743-6109.2009.01370.x Robinson, 2021, Surgical outcomes following gender affirming penile reconstruction: patient-reported outcomes from a multi-center, international survey of 129 transmasculine patients, J Sex Med, 18, 800, 10.1016/j.jsxm.2021.01.183 McPhillips, 2001, Defining (hetero)sex, Womens Stud Int Forum, 24, 229, 10.1016/S0277-5395(01)00160-1 Gavey, 2011, Viagra and the coital imperative, Introducing the new sexuality studies 2edn, 135 Willis, 2018, Are women's orgasms hindered by phallocentric imperatives?, Arch Sex Behav, 47, 1565, 10.1007/s10508-018-1149-z Ussher, 2013, Renegotiating sex and intimacy after cancer: resisting the coital imperative, Cancer Nurs, 36, 454, 10.1097/NCC.0b013e3182759e21 Rhoden, 2002, The use of the simplified international index of erectile function (iief-5) as a diagnostic tool to study the prevalence of erectile dysfunction, Int J Impot Res, 14, 245, 10.1038/sj.ijir.3900859