The STR/ort mouse and its use as a model of osteoarthritis

Sokoloff, 1962, Obstructive genitourinary disease in male STR/1N mice, Am J Pathol, 41, 233 Walton, MH, Studies of degenerative joint disease in an inbred strain of mouse, University of London, 1975 Silberberg, 1941, Age changes of bones and joints in various strains of mice, Am J Anat, 68, 69, 10.1002/aja.1000680104 Silberberg, 1950, Growth and articular changes in slowly and rapidly developing mice fed a high fat diet, Growth, 14, 213 Silberberg, 1952, Degenerative joint disease in mice fed a high fat diet at various ages, Exp Med Surg, 10, 77 Silberberg, 1958, Degenerative joint disease in castrate mice. I Effects of ovariectomy at various ages, Arch Pathol, 65, 438 Silberberg, 1958, Degenerative joint disease in castrate mice. II. Effects of orchiectomy at various ages, Arch Pathol, 65, 442 Silberberg, 1961, Male sex hormone and osteoarthritis in mice, J Bone Joint Surg, 43, 243, 10.2106/00004623-196143020-00013 Silberberg, 1963, Modifying action of estrogen on the evolution of osteoarthritis in mice of different ages, Endocrinology, 72, 449, 10.1210/endo-72-3-449 Silberberg, 1963, Role of sex hormones in the pathogenesis of osteoarthritis in mice, Lab Invest, 12, 285 Sokoloff, 1956, Natural history of degenerative joint disease in small laboratory animals. II. Epiphyseal maturation and osteoarthritis of the knee of mice of inbred strains, Arch Pathol, 62, 129 Sokoloff, 1956, Natural history of degenerative joint disease in small laboratory animals. I. Pathologic anatomy of degenerative joint disease in mice, Arch Pathol, 62, 118 Chambers, 1999, Aggrecan degradation and osteoarthritis in STR/ort mice occur independently of sex and sex hormone status, Orthop Res Soc Trans, 24, 447 Sokoloff, 1962, The genetics of degenerative joint disease in mice, Arthritis Rheum, 5, 531, 10.1002/art.1780050602 Walton, 1979, Obesity as an aetiological factor in the development of osteoarthrosis, Gerontology, 25, 36, 10.1159/000212318 Baer, 1961, Studies on peridontal disease in the mouse. II. Genetic and maternal effects, J Dent Res, 40, 23, 10.1177/00220345610400011901 Sokoloff, 1961, Failure of orchiectomy to effect degenerative joint disease in STR/1N mice, Proc Soc Exp Biol Med, 108, 792, 10.3181/00379727-108-27069 Walton, 1977, Degenerative joint disease in the mouse knee: histological observations, J Pathol, 123, 109, 10.1002/path.1711230207 Chambers, 1997, Chondrocyte cytokine and growth factor expression in murine osteoarthritis, Osteoarthritis Cartilage, 5, 301, 10.1016/S1063-4584(97)80034-9 Schunke, 1988, Morphologic characteristics of developing osteoarthrotic lesions in the knee cartilage of STR/1N mice, Arthritis Rheum, 31, 898, 10.1002/art.1780310711 Dreessen, 1990, Age-related osteoarthrotic degeneration of the temporomandibular joint in the mouse, Acta Anat, 139, 91, 10.1159/000146984 Walton, 1979, Patella displacement and osteoarthritis of the knee joint in mice, J Pathol, 127, 165, 10.1002/path.1711270402 Evans, 1994, Radiological scoring of osteoarthritis progression in STR/ort mice, Osteoarthritis Cartilage, 2, 103, 10.1016/S1063-4584(05)80060-3 Collins, 1994, Chondro-osseous metaplasia, bone density and patellar cartilage proteoglycan content in osteoarthritis of STR/ort mice, Osteoarthritis Cartilage, 2, 111, 10.1016/S1063-4584(05)80061-5 Walton, 1977, Degenerative joint disease in the mouse knee: radiological and morphological observations, J Pathol, 123, 97, 10.1002/path.1711230206 Anderson-Mackenzie, 1999, Collagen remodelling in the anterior cruciate ligament associated with developing spontaneous murine osteoarthritis, Biochem Biophys Res Commun, 258, 753, 10.1006/bbrc.1999.0713 Walton, 1979, A spontaneous ankle deformity in an inbred strain of mouse, J Pathol, 124, 189, 10.1002/path.1711240403 Das-Gupta, 1993, New histological observations in spontaneously developing osteoarthritis in the STR/ort mouse questioning its acceptability as a model of human osteoarthritis, Int J Exp Path, 74, 627 Altman, 1980, A metabolic dysfunction in early murine osteoarthritis, Ann Rheum Dis, 40, 303, 10.1136/ard.40.3.303 Dunham, 1988, Changes in oxidative activities of chondrocytes during the early development of natural murine osteoarthritis, Br J Exp Path, 69, 845 Chambers, MG, The development of natural murine osteoarthritis: a quantitative cytochemical study, Brunel University, 1991 Chambers, MG, Kuttner, T, Cowen, SK, Cheah, K, Mason, RM Oue, Y, Chambers, MG, Bayliss, MT, Mason, RM, Chondrocyte apoptosis accompanies lesion development in murine osteoarthritis Hashimoto, 1998, Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis, Arthritis Rheum, 41, 1632, 10.1002/1529-0131(199809)41:9<1632::AID-ART14>3.0.CO;2-A Chambers, 1992, Chondrocytic monoamine oxidase activity in the development of natural murine osteoarthritis, Int J Exp Path, 73, 15 Flannelly, 1999, Differential gene expression and protein localization of MMP-13 in a murine (STR/ort) model of degenerative joint disease, Orthop Res Soc Trans, 24, 456 Brewster, 1998, Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ort mouse model of osteoarthritis, Arthritis Rheum, 41, 1639, 10.1002/1529-0131(199809)41:9<1639::AID-ART15>3.0.CO;2-0 Billinghurst, 1997, Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage, J Clin Invest, 99, 1534, 10.1172/JCI119316 Price, JS, Chambers, MG, Poole, AR, Fradin, A, Mason, RM, Comparison of type II collagen cleavage by collagenase in the naturally occurring STR/ort mouse model of osteoarthritis with a collagen-induced inflammatory arthritis model, Arthritis Rheum Lark, 1997, Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic and rheumatoid joints, J Clin Invest, 100, 93, 10.1172/JCI119526 Chambers, 1998, Localisation of neoepitopes for “aggrecanase” and general metalloproteinases in normal and osteoarthritis murine articular cartilage, Orthop Res Soc Trans, 23, 436 Dunham, 1990, Changes in the orientation of proteoglycans during the early development of natural murine osteoarthritis, J Orthop Res, 8, 101, 10.1002/jor.1100080113 Rostand, 1982, Isolation and characterization of mouse articular cartilage proteoglycans using preformed CsCl density gradients in the Becknam-Airfuge, J Biol Chem, 257, 703, 10.1016/S0021-9258(19)68252-9 Rostand, 1986, Articular cartilage proteoglycans from normal and osteoarthritis mice, Arthritis Rheum, 29, 95, 10.1002/art.1780290113 Gaffen, 1995, Articular cartilage proteoglycans in osteoarthritic STR/ort mice, Osteoarthritis Cartilage, 3, 95, 10.1016/S1063-4584(05)80042-1 Gaffen, 1997, Elevated aggrecan mRNA in early murine osteoarthritis, Osteoarthritis Cartilage, 5, 227, 10.1016/S1063-4584(97)80018-0 Chambers, 1994, Two colonies of STR/ort mice develop osteoarthritis of differing severity, Orthop Res Soc Trans, 19, 343 von der Mark, 1992, Type X collagen synthesis in human osteoarthritis cartilage. Indication of chondrocyte hypertrophy, Arthritis Rheum, 35, 806, 10.1002/art.1780350715 Eerola, 1998, Type X collagen, a natural component of mouse articular cartilage. Association with growth, aging and osteoarthritis, Arthritis Rheum, 41, 1287, 10.1002/1529-0131(199807)41:7<1287::AID-ART20>3.0.CO;2-D