The Role of Mitochondria from Mature Oocyte to Viable Blastocyst

Obstetrics and Gynecology International - Tập 2013 - Trang 1-10 - 2013
Scott C. Chappel1
1OvaScience, Inc., 215 First Street, Suite 240, Cambridge, MA 02142, USA.

Tóm tắt

The oocyte requires a vast supply of energy after fertilization to support critical events such as spindle formation, chromatid separation, and cell division. Until blastocyst implantation, the developing zygote is dependent on the existing pool of mitochondria. That pool size within each cell decreases with each cell division. Mitochondria obtained from oocytes of women of advanced reproductive age harbor DNA deletions and nucleotide variations that impair function. The combination of lower number and increased frequency of mutations and deletions may result in inadequate mitochondrial activity necessary for continued embryo development and cause pregnancy failure. Previous reports suggested that mitochondrial activity within oocytes may be supplemented by donor cytoplasmic transfer at the time of intracytoplasmic sperm injection (ICSI). Those reports showed success; however, safety concerns arose due to the potential of two distinct populations of mitochondrial genomes in the offspring. Mitochondrial augmentation of oocytes is now reconsidered in light of our current understanding of mitochondrial function and the publication of a number of animal studies. With a better understanding of the role of this organelle in oocytes immediately after fertilization, blastocyst and offspring, mitochondrial augmentation may be reconsidered as a method to improve oocyte quality.

Từ khóa


Tài liệu tham khảo

2012, The New England Journal of Medicine, 366, 1132, 10.1056/NEJMra1012478

1981, Nature, 290, 457, 10.1038/290457a0

10.1186/1756-8722-5-11

10.1016/S0092-8674(03)00926-7

10.1073/pnas.94.17.9131

2012, PLoS One, 7

10.1016/j.mito.2010.08.011

10.1146/annurev-biochem-060408-093701

10.1172/JCI200319435

2007, Experimental Biology and Medicine, 232, 592

1989, Proceedings of the National Academy of Sciences of the United States of America, 86, 7952, 10.1073/pnas.86.20.7952

10.1093/molehr/gal112

10.1093/humrep/deh667

1990, Nucleic Acids Research, 18, 6927, 10.1093/nar/18.23.6927

1992, Proceedings of the National Academy of Sciences of the United States of America, 89, 7370, 10.1073/pnas.89.16.7370

10.1093/humupd/dmp016

10.1093/molehr/4.7.657

10.1093/humupd/dml011

10.1095/biolreprod.107.060806

10.1095/biolreprod.109.080564

10.1093/molehr/gat013

10.1530/rep.1.00240

10.1002/ana.21217

10.1093/humupd/dmq002

10.1093/humrep/del065

1995, Human Reproduction, 10, 415, 10.1093/oxfordjournals.humrep.a135954

10.1095/biolreprod.104.032391

2012, Cell Reports, 1, 506, 10.1016/j.celrep.2012.03.011

10.1095/biolreprod.105.040956

10.1016/j.fertnstert.2003.05.005

10.1530/rep.1.00551

10.1095/biolreprod.106.054536

2000, Biology of Reproduction, 62, 1745, 10.1095/biolreprod62.6.1745

10.1095/biolreprod.104.033589

10.1016/j.rbmo.2010.10.011

10.1002/jcp.22171

10.1242/dev.01181

10.1016/j.bpj.2008.12.3959

2001, Molecular Human Reproduction, 7, 425, 10.1093/molehr/7.5.425

10.1016/j.fertnstert.2005.09.017

10.1095/biolreprod.109.080887

10.1016/j.semcdb.2006.02.009

10.1242/dev.02744

10.1530/REP-07-0348

2011, Journal of Assisted Reproduction and Genetics, 28, 773, 10.1007/s10815-011-9588-7

2000, Human Reproduction, 15, 2621, 10.1093/humrep/15.12.2621

10.1042/BJ20021594

10.1186/1477-7827-3-28

2013, Mitochondrion, 13, 96, 10.1016/j.mito.2013.01.002

10.1007/s00404-010-1444-y

10.1095/biolreprod.104.038141

2011, Journal of Assisted Reproduction and Genetics, 28, 517, 10.1007/s10815-011-9592-y

10.1371/journal.pone.0010074

10.1095/biolreprod.110.087262

10.1093/molehr/gah227

10.1095/biolreprod.102.008656

2012, Reproduction, Fertility and Development, 24, 945, 10.1071/RD11212

10.1038/sj.cr.7310095

2012, Biology of Reproduction, 86, 1

10.1093/molehr/gar024

2012, European Journal of Human Genetics, 20, 742, 10.1038/ejhg.2011.272

10.1093/humupd/dmm043

2001, Molecular Human Reproduction, 7, 49, 10.1093/molehr/7.1.49

10.1016/S0015-0282(02)04678-2

10.1620/tjem.210.137

2001, Reproduction, 122, 155, 10.1530/rep.0.1220155

2005, Journal of Mammalian Ova Research, 22, 163, 10.1274/jmor.22.163

1993, Biology of Reproduction, 49, 730, 10.1095/biolreprod49.4.730

10.1093/molehr/4.9.887

10.1093/molehr/gah243

10.1016/S0015-0282(02)04214-0

10.1016/S0015-0282(02)02994-1

10.1016/j.fertnstert.2003.11.013

10.1016/j.fertnstert.2011.05.056

1990, Fertility and Sterility, 53, 1049, 10.1016/S0015-0282(16)53583-3

2001, Human Reproduction, 16, 513, 10.1093/humrep/16.3.513

10.1016/S0140-6736(05)62353-7

10.1016/S0015-0282(98)00504-4

10.1093/humupd/7.4.428

10.1016/S0015-0282(99)00309-X

2001, Human Reproduction, 16, 1469, 10.1093/humrep/16.7.1469

10.1016/S0015-0282(00)00681-6

2011, Experimental Animals, 60, 421, 10.1538/expanim.60.421

10.1016/j.fertnstert.2009.07.988

10.1038/cr.2007.66

1998, Human Reproduction, 13, 2857, 10.1093/humrep/13.10.2857

10.1038/35000651

2004, Human Cell, 17, 195

10.1095/biolreprod.104.036129

10.1095/biolreprod.108.073593

10.1007/s10815-007-9161-6

2005, Electronic Journal of Biology, 1, 6

10.1095/biolreprod.103.026104

10.1017/S0967199411000487

1997, Transgenic Research, 6, 379, 10.1023/A:1018431316831

10.1016/j.mito.2009.12.144

1996, Human Reproduction, 11, 1287, 10.1093/oxfordjournals.humrep.a019373

1998, Genetics, 148, 877, 10.1093/genetics/148.2.877

10.1089/clo.2006.0020

2004, Fertility and Sterility, 82, S53

10.1093/molehr/4.3.269

10.1196/annals.1338.014

10.1016/S0015-0282(97)81521-X

2012, Journal of Reproduction and Development, 58, 44, 10.1262/jrd.2011-012

10.1186/1471-2164-11-481

10.1002/em.20574

10.1016/j.cellsig.2010.11.023

10.1038/nature02316

2012, Nature Medicine, 18, 413, 10.1038/nm.2669

10.1038/ncb1869

10.1186/1477-7827-2-20

10.1186/1477-7827-3-17

2011, Histology and Histopathology, 26, 1071

10.1155/2013/690415

10.1073/pnas. 1206600109

10.1093/humrep/den249

10.1093/humrep/13.9.2371

2000, Human Reproduction Update, 6, 532, 10.1093/humupd/6.6.532

2013, Nature, 493, 632, 10.1038/nature11800

Thông tin
Thông tin xuất bản

Obstetrics and Gynecology International

Tập 2013

1-10

Thông tin tác giả