The Role of Hypocretins (Orexins) in Sleep Regulation and Narcolepsy

Annual Review of Neuroscience - Tập 25 Số 1 - Trang 283-313 - 2002
Shahrad Taheri1, Jamie M. Zeitzer1, Emmanuel Mignot1
1Stanford University Center for Narcolepsy, 701 Welch Road B, Basement, Palo Alto, California 94304-5742;

Tóm tắt

▪ Abstract  The hypocretins (orexins) are two novel neuropeptides (Hcrt-1 and Hcrt-2), derived from the same precursor gene, that are synthesized by neurons located exclusively in the lateral, posterior, and perifornical hypothalamus. Hypocretin-containing neurons have widespread projections throughout the CNS with particularly dense excitatory projections to monoaminergic centers such as the noradrenergic locus coeruleus, histaminergic tuberomammillary nucleus, serotoninergic raphe nucleus, and dopaminergic ventral tegmental area. The hypocretins were originally believed to be primarily important in the regulation of appetite; however, a major function emerging from research on these neuropeptides is the regulation of sleep and wakefulness. Deficiency in hypocretin neurotransmission results in the sleep disorder narcolepsy in mice, dogs, and humans. The hypocretins are also uniquely positioned to link sleep, appetite, and neuroendocrine control. The aim of this review is to describe and discuss the current knowledge regarding the hypocretin neurotransmitter system in narcolepsy and normal sleep.

Từ khóa


Tài liệu tham khảo

Abrahamson EE, 2001, Neuro. Rep., 12, 435

10.1093/brain/49.3.257

10.1046/j.1365-2826.2001.00655.x

10.1212/WNL.50.2_Suppl_1.S2

American Sleep Disorders Association (ASDA)., 1997, The International Classification of Sleep Disorders, Revised: Diagnostic and Coding Manual.

10.1038/89522

10.1016/S0006-3223(99)00140-7

Baker TL, Dement WC. 1985. Canine narcolepsy-cataplexy syndrome: evidence for an inherited monoaminergic-cholinergic imbalance. InBrain Mechanisms of Sleep, ed. DJ McGinty, R Drucker-Colin, A Morisson, PL Parmengiani, pp. 199–233. New York: Raven

10.1093/brain/120.8.1423

Bassetti CL, 2001, Actas Fisiolog., 7, 205

10.1016/S0165-6147(99)01341-3

10.1016/S0304-3959(00)00470-X

10.1210/jc.86.4.1616

10.1523/JNEUROSCI.20-20-07760.2000

10.1093/sleep/17.suppl_8.S45

10.1016/S0028-3908(00)00178-7

10.2337/diabetes.48.11.2132

Chemelli RM, 2000, Sleep, 23, A296

10.1016/S0092-8674(00)81973-X

10.1523/JNEUROSCI.21-19-j0003.2001

10.1016/0013-4694(94)90110-4

10.1073/pnas.96.2.748

10.1073/pnas.95.1.322

10.1016/0304-3940(94)90841-9

10.1016/S0196-9781(00)00311-9

Dugovic C, 2001, Neuro. Rep., 12, 3085

10.1007/s002130000550

10.1677/joe.0.160R007

10.1523/JNEUROSCI.21-23-09273.2001

10.1523/JNEUROSCI.21-05-01656.2001

Fujiki N, 2001, Neuro. Rep., 12, 993

10.1523/JNEUROSCI.21-18-07273.2001

10.1016/S0006-8993(01)02792-5

10.1016/0278-5846(83)90123-9

10.1016/S0169-328X(01)00039-0

10.1212/WNL.33.12.1584

10.1001/archinte.1986.00360190107014

10.1073/pnas.96.19.10911

10.1046/j.1365-2826.1999.00378.x

10.1016/S0896-6273(01)00293-8

10.1016/S0167-0115(00)00199-3

10.1210/jcem-49-2-197

10.1093/sleep/9.1.254

Honda Y, Matuski K. 1990. Genetic aspects of narcolepsy. InHandbook of Sleep Disorders, ed. MJ Thorpy, pp. 217–34. New York: Dekker

10.1523/JNEUROSCI.19-03-01072.1999

10.1002/(SICI)1096-9861(19991213)415:2<145::AID-CNE1>3.0.CO;2-2

10.1073/pnas.181330998

10.1002/bies.1058

10.1016/S0006-8993(99)01131-2

10.1006/bbrc.2000.2412

10.1046/j.1365-2826.2001.00719.x

10.1097/00001756-200006050-00031

10.1016/S0167-0115(99)00102-0

10.1046/j.1365-2826.2001.00654.x

10.1210/endo.142.8.8299

10.1007/s002130000551

Kastin AJ, 1999, J. Pharmacol. Exp. Ther., 289, 219

10.1016/S0166-2236(00)01594-0

10.1210/edrv.23.1.0454

10.1016/S0896-6273(00)81041-7

10.1152/jn.2001.85.5.2008

Kummer M, 2001, Neuro. Rep., 12, 2117

10.1016/S0006-8993(99)01884-3

Kuru M, 2000, Neuro. Rep., 11, 1977

10.1093/sleep/17.suppl_8.S25

10.1016/S0092-8674(00)81965-0

10.1016/S0165-5728(01)00333-2

10.1210/endo.140.12.7287

10.1006/bbrc.1998.9750

10.1002/cne.1190

10.1111/j.1365-2869.1992.tb00026.x

10.1016/S0006-8993(01)02463-5

10.1016/S0959-4388(00)00079-9

10.1016/S0960-0760(99)00110-7

Methippara MM, 2000, Neuro. Rep., 11, 3423

10.1212/WNL.50.2_Suppl_1.S16

Mignot E, 2001, Arch. Ital. Biol., 139, 207

10.1016/S0893-133X(01)00316-5

10.1086/318799

10.1523/JNEUROSCI.13-03-01057.1993

10.1007/BF02244337

10.1016/0006-8993(90)90328-9

10.1055/s-2007-978805

Moore RY, 2001, Arch. Ital. Biol., 139, 195

Mullett MA, 2000, Neuro. Rep., 11, 103

10.1016/S0006-8993(00)02555-5

10.1152/jn.1946.9.4.285

10.1016/S0304-3940(01)02270-4

Nishino S, 1998, Sleep Res. Online, 1, 49

10.1016/S0301-0082(96)00070-6

10.1016/S0140-6736(99)05582-8

10.1016/S0024-3205(99)00611-6

10.1097/00004691-200103000-00002

10.1038/79690

10.1523/JNEUROSCI.18-23-09996.1998

10.1046/j.1460-9568.2000.00919.x

10.1016/S0167-0115(98)00128-1

10.1210/jcem.86.10.7921

10.1016/0166-4328(95)00020-T

10.1006/nbdi.2001.0389

10.1212/WNL.57.12.2253

10.1046/j.1365-2826.2000.00582.x

10.1016/S0092-8674(00)80949-6

10.1074/jbc.274.25.17771

10.1016/S0006-8993(99)01457-2

10.1016/S0960-9822(01)00466-3

10.1016/S0140-6736(05)74704-8

10.1126/science.271.5246.216

10.1152/ajpregu.1999.277.6.R1780

10.1016/S0006-8993(01)02344-7

10.1002/1097-4547(20001015)62:2<161::AID-JNR1>3.0.CO;2-1

Szymusiak R, 2001, Arch. Ital. Biol., 139, 77

10.1046/j.1365-2265.2001.01247.x

Taheri S, 2001, Neuro. Rep., 12, 459

10.1016/S0014-5793(99)01030-3

10.1016/S0304-3940(99)00955-6

Thakkar MM, 2001, Arch. Ital. Biol., 139, 313

10.1016/S0896-6273(00)00058-1

Torterolo P, 2001, Sleep Res. Online, 4, 25

10.1016/S0014-5793(98)01266-6

10.1523/JNEUROSCI.19-08-03171.1999

10.1523/JNEUROSCI.18-19-07962.1998

10.1097/00005053-193003000-00001

10.1146/annurev.neuro.24.1.429

10.1523/JNEUROSCI.21-05-01787.2001

10.1016/S0006-8993(01)02317-4

10.1016/S0361-9230(99)00271-3

10.1016/S0006-8993(00)02043-6

Yamanaka A, 2001, Soc. Neurosci.

10.1046/j.0953-816x.2001.01725.x

10.1177/153537020122600513

Thông tin
Thông tin xuất bản

Annual Review of Neuroscience

Tập 25 Số 1

283-313

Thông tin tác giả