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Mối Quan Hệ Giữa Việc Tiêu Thụ Rượu Nhẹ Đến Trung Bình với Chuyển Hóa Glucose và Kháng Insulin ở Người Trưởng Thành Không Bị Đái Tháo Đường: Những Ảnh Hưởng Điều Tiết của Mức Độ Triệu Chứng Trầm Cảm, Mỡ Thể và Giới Tính
Tóm tắt
Chúng tôi đã khảo sát mối quan hệ giữa việc tiêu thụ rượu với chuyển hóa glucose và kháng insulin (IR) như một chức năng của triệu chứng trầm cảm, tình trạng béo phì và giới tính. Những người trưởng thành khỏe mạnh (từ 18–65 tuổi) đã cung cấp mẫu máu lúc đói và thông tin về các yếu tố lối sống. Việc tiêu thụ rượu được phân loại thành không bao giờ, hiếm (1–3 ly/tháng), thỉnh thoảng (1–7 ly/tuần) và thường xuyên (≥2 ly/ngày). Bảng Đánh Giá Trầm Cảm Beck (BDI) được sử dụng để đánh giá mức độ triệu chứng. Các kết quả chính bao gồm insulin lúc đói, glucose và IR được đánh giá thông qua mô hình đánh giá trạng thái đồng sinh (HOMA). Trong phân tích đơn biến, việc tiêu thụ rượu có mối liên hệ tiêu cực với HOMA-IR (p = 0.03), insulin (p = 0.007) và chỉ số khối cơ thể (BMI) (p = 0.04), nhưng không liên quan đến glucose hoặc BDI. Sau khi điều chỉnh cho các yếu tố có thể gây nhiễu bao gồm BMI, việc tiêu thụ rượu có liên quan đến HOMA-IR (p = 0.01) và insulin (p = 0.009) tùy thuộc vào BDI và giới tính. Đối với phụ nữ có triệu chứng trầm cảm tối thiểu, việc tiêu thụ rượu nhẹ đến vừa đã liên quan đến HOMA-IR và insulin thấp hơn. Việc tiêu thụ rượu không liên quan đến các chỉ số chuyển hóa ở phụ nữ có triệu chứng trầm cảm cao hơn và ở nam giới. Trong phân tích sử dụng BMI như một yếu tố điều tiết liên tục, việc tiêu thụ rượu chỉ liên quan đến insulin (p = 0.004). So sánh hậu kiểm giữa các nhóm BMI (<25 so với ≥25 kg/m2) cho thấy rằng việc tiêu thụ rượu nhẹ đến vừa có liên quan đến insulin thấp hơn nhưng chỉ ở những đối tượng có BMI ≥ 25 kg/m2. Lợi ích của việc tiêu thụ rượu nhẹ đến vừa đối với insulin lúc đói và IR là khác biệt về giới và có vẻ được điều tiết độc lập bởi tình trạng béo phì và mức độ triệu chứng trầm cảm.
Từ khóa
#tiêu thụ rượu #chuyển hóa glucose #kháng insulin #triệu chứng trầm cảm #béo phì #giới tínhTài liệu tham khảo
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