The Protective Effect of Bergamot Oil Extract on Lecitine-like OxyLDL Receptor-1 Expression in Balloon Injury-related Neointima Formation

Journal of Cardiovascular Pharmacology and Therapeutics - Tập 13 Số 2 - Trang 120-129 - 2008
Vincenzo Mollace1, Salvatore Ragusa2, Iolanda Sacco2, Carolina Muscoli3, Francesca Sculco2, Valeria Visalli2, Ernesto Palma2, Saverio Muscoli4, Luigi Mondello5, Paola Dugo5, Domenicantonio Rotiroti2, Francesco Romeo4
1University “Magna Graecia" of Catanzaro, Italy, , San Raffaele Pisana IRCCS, Rome, Italy, Centro di Ricerca Salus, Bruzzano Zeffirio (Rc), Italy, Institute Mondino-Tor Vergata, Rome, Italy
2University Magna Graecia of Catanzaro, Italy
3University "Magna Graecia" of Catanzaro, Italy, San Raffaele Pisana IRCCS, Rome, Italy, Institute Mondino-Tor Vergata, Rome, Italy
4University of Rome Tor Vergata, Rome, Italy
5University of Messina, Italy

Tóm tắt

Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved in smooth muscle cell (SMC) proliferation and neointima formation in injured blood vessels. This study evaluates the effect of the nonvolatile fraction (NVF), the antioxidant component of bergamot essential oil (BEO), on LOX-1 expression and free radical generation in a model of rat angioplasty. Common carotid arteries injured by balloon angioplasty were removed after 14 days for histopathological, biochemical, and immunohistochemical studies. Balloon injury led to a significant restenosis with SMC proliferation and neointima formation, accompanied by increased expression of LOX-1 receptor, malondialdehyde and superoxide formation, and nitrotyrosine staining. Pretreatment of rats with BEO-NVF reduced the neointima proliferation together with free radical formation and LOX-1 expression in a dose-dependent manner. These results suggest that natural antioxidants may be relevant in the treatment of vascular disorders in which proliferation of SMCs and oxyLDL-related endothelial cell dysfunction are involved.

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Journal of Cardiovascular Pharmacology and Therapeutics

Tập 13 Số 2

120-129

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