The Potential for Stem Cells in Cerebral Palsy—Piecing Together the Puzzle

Patoine, 2009, NerveCenter: media focus on “miracle cure” for cerebral palsy pits science vs. hype, Ann Neurol, 66, A9, 10.1002/ana.21875 Wu, 2000, Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis, J Am Med Assoc, 284, 1417, 10.1001/jama.284.11.1417 Crichton, 1972, Long-term effects of neonatal jaundice on brain function in children of low birth weight, Pediatrics, 49, 656, 10.1542/peds.49.5.656 Gordon, 2005, Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya, Trop Med Int Health, 10, 1114, 10.1111/j.1365-3156.2005.01496.x Lawn, 2005, 4 million neonatal deaths: when? Where? Why?, Lancet, 365, 891, 10.1016/S0140-6736(05)71048-5 Burd, 2010, Inflammation-induced preterm birth alters neuronal morphology in the mouse fetal brain, J Neurosci Res, 88, 1872, 10.1002/jnr.22368 Zupan, 1996, Periventricular leukomalacia: risk factors revisited, Dev Med Child Neurol, 38, 1061, 10.1111/j.1469-8749.1996.tb15068.x Meyer, 2006, The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology, J Neurosci, 26, 4752, 10.1523/JNEUROSCI.0099-06.2006 Burd, 2012, Models of fetal brain injury, intrauterine inflammation, and preterm birth, Am J Reprod Immunol, 67, 287, 10.1111/j.1600-0897.2012.01110.x Fern, 2000, Rapid ischemic cell death in immature oligodendrocytes: a fatal glutamate release feedback loop, J Neurosci, 20, 34, 10.1523/JNEUROSCI.20-01-00034.2000 Itoh, 2002, AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytes, J Neurochem, 81, 390, 10.1046/j.1471-4159.2002.00866.x Back, 2005, Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes, Ann Neurol, 58, 108, 10.1002/ana.20530 Palisano, 2012, Amount and focus of physical therapy and occupational therapy for young children with cerebral palsy, Phys Occup Ther Pediatr, 32, 368, 10.3109/01942638.2012.715620 Gordon, 2008, Both constraint-induced movement therapy and bimanual training lead to improved performance of upper extremity function in children with hemiplegia, Dev Med Child Neurol, 50, 957, 10.1111/j.1469-8749.2008.03166.x Gordon, 2011, Bimanual training and constraint-induced movement therapy in children with hemiplegic cerebral palsy: a randomized trial, Neurorehabil Neural Repair, 25, 692, 10.1177/1545968311402508 Charles, 2007, A repeated course of constraint-induced movement therapy results in further improvement, Dev Med Child Neurol, 49, 770, 10.1111/j.1469-8749.2007.00770.x Biddiss, 2010, Active video games to promote physical activity in children and youth: a systematic review, Arch Pediatr Adolesc Med, 164, 664, 10.1001/archpediatrics.2010.104 Dralle, 1985, Intrathecal baclofen for spasticity, Lancet, 326, 1003, 10.1016/S0140-6736(85)90541-0 Goldstein, 2001, Spasticity management: an overview, J Child Neurol, 16, 16, 10.1177/088307380101600104 Bakheit, 2001, Safety profile and efficacy of botulinum toxin A (Dysport) in children with muscle spasticity, Dev Med Child Neurol, 43, 234, 10.1017/S0012162201000445 Kawamura, 2007, A randomized controlled trial comparing botulinum toxin A dosage in the upper extremity of children with spasticity, Dev Med Child Neurol, 49, 331, 10.1111/j.1469-8749.2007.00331.x Wassermann, 1998, Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996, Electroencephalogr Clin Neurophysiol, 108, 1, 10.1016/S0168-5597(97)00096-8 Takahashi, 2006, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors, Cell, 126, 663, 10.1016/j.cell.2006.07.024 Takahashi, 2007, Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell, 131, 861, 10.1016/j.cell.2007.11.019 Gore, 2011, Somatic coding mutations in human induced pluripotent stem cells, Nature, 471, 63, 10.1038/nature09805 Woltjen, 2009, iggyBac transposition reprograms fibroblasts to induced pluripotent stem cells, Nature, 458, 766, 10.1038/nature07863 Loh, 2012, Excision of a viral reprogramming cassette by delivery of synthetic Cre mRNA, Curr Protoc Stem Cell Biol, 10.1002/9780470151808.sc04a05s21 Warren, 2010, Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA, Cell Stem Cell, 7, 1, 10.1016/j.stem.2010.08.012 Ichida, 2009, A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog, Cell Stem Cell, 5, 491, 10.1016/j.stem.2009.09.012 Fusaki, 2009, Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome, Proc Jpn Acad Ser B, 85, 348, 10.2183/pjab.85.348 Wen, 2012, Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions, BMC Genomics, 13, 566, 10.1186/1471-2164-13-566 Kim, 2011, Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells, Nat Biotechnol, 29, 1117, 10.1038/nbt.2052 Kim, 2010, Epigenetic memory in induced pluripotent stem cells, Nature, 467, 285, 10.1038/nature09342 Koga, 2008, Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit, Cell Tissue Res, 333, 207, 10.1007/s00441-008-0633-5 Deng, 2009, Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming, Nat Biotechnol, 27, 353, 10.1038/nbt.1530 Rowland JW, Lee JJ, Salewski RP, Eftekharpour E, van der Kooy D, Fehlings MG: Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization. Stem Cells Dev 20:1829–1845, 2011.[cited Sep 20, 2011] 〈http://www.ncbi.nlm.nih.gov/pubmed/21604925〉 Smukler, 2006, Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences, J Cell Biol, 172, 79, 10.1083/jcb.200508085 Marro, 2011, Direct lineage conversion of terminally differentiated hepatocytes to functional neurons, Cell Stem Cell, 9, 374, 10.1016/j.stem.2011.09.002 Rouaux, 2013, Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo, Nat Cell Biol, 15, 214, 10.1038/ncb2660 Montana, 2013, Reprogramming of adult rod photoreceptors prevents retinal degeneration, Proc Natl Acad Sci USA, 110, 1732, 10.1073/pnas.1214387110 Ruff, 2010, Neural stem cells in regenerative medicine: bridging the gap, Panminerva Med, 52, 125 Kobayashi, 2012, Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity, PLoS ONE, 7, e52787, 10.1371/journal.pone.0052787 Karimi-Abdolrezaee, 2006, Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury, J Neurosci, 26, 3377, 10.1523/JNEUROSCI.4184-05.2006 Karimi-Abdolrezaee, 2010, Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord, J Neurosci, 30, 1657, 10.1523/JNEUROSCI.3111-09.2010 Windrem, 2008, Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse, Cell Stem Cell, 2, 553, 10.1016/j.stem.2008.03.020 Obenaus, 2011, Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury, Ann Neurol, 69, 282, 10.1002/ana.22168 Fujimoto Y, Abematsu M, Falk A, et al: Treatment of a mouse model of spinal cord injury by transplantation of human iPS cell-derived long-term self-renewing neuroepithelial-like stem cells. Stem Cells 30:1163–1173, 2012 Zawadzka, 2010, CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination, Cell Stem Cell, 6, 578, 10.1016/j.stem.2010.04.002 Hunt, 2010, Cyclosporin A has direct effects on adult neural precursor cells, J Neurosci, 30, 2888, 10.1523/JNEUROSCI.5991-09.2010 Wang, 2012, Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation, Cell Stem Cell, 11, 23, 10.1016/j.stem.2012.03.016 Goldman, 2012, Glial progenitor cell-based treatment and modeling of neurological disease, Science, 338, 491, 10.1126/science.1218071 Erices, 2000, Mesenchymal progenitor cells in human umbilical cord blood, Br J Haematol, 109, 235, 10.1046/j.1365-2141.2000.01986.x Nieda, 1997, Endothelial cell precursors are normal components of human umbilical cord blood, Br J Haematol, 98, 775, 10.1046/j.1365-2141.1997.2583074.x Barbero, 2003, Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes, Arthritis Rheum, 48, 1315, 10.1002/art.10950 Battula, 2007, Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation, Differentiation, 75, 279, 10.1111/j.1432-0436.2006.00139.x De Bari, 2001, Multipotent mesenchymal stem cells from adult human synovial membrane, Arthritis Rheum, 44, 1928, 10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P Weiss, 2006, Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease, Stem Cells, 24, 781, 10.1634/stemcells.2005-0330 Zuk, 2001, Multilineage cells from human adipose tissue: implications for cell-based therapies, Tissue Eng, 7, 211, 10.1089/107632701300062859 Isa A, Nehlin JO, Sabir HJ, et al: Impaired cell surface expression of HLA-B antigens on mesenchymal stem cells and muscle cell progenitors. 2010 May 28;5(5):e10900. doi: 10.1371/journal.pone.0010900. PubMed PMID: 20531935; PubMed Central PMCID: PMC2878340 Liao, 2009, Therapeutic effect of human umbilical cord multipotent mesenchymal stromal cells in a rat model of stroke, Transplantation, 87, 350, 10.1097/TP.0b013e318195742e Chen, 2003, Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats, Circ Res, 92, 692, 10.1161/01.RES.0000063425.51108.8D Prockop, 2009, Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms, Mol Ther, 17, 939, 10.1038/mt.2009.62 Meletis, 2003, Blood on the tracks: a simple twist of fate?, Trends Neurosci, 26, 292, 10.1016/S0166-2236(03)00125-5 Bennet, 2012, Cell therapy for neonatal hypoxia–ischemia and cerebral palsy, Ann Neurol, 71, 589, 10.1002/ana.22670 Ikehara, 2002, Bone marrow transplantation: a new strategy for intractable diseases, Drugs Today, 38, 103, 10.1358/dot.2002.38.2.820106 Pearse, 2007, Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: survival, migration, axon association, and functional recovery, Glia, 55, 976, 10.1002/glia.20490 Duncan, 1981, Transplantation of rat Schwann cells grown in tissue culture into the mouse spinal cord, J Neurol Sci, 49, 241, 10.1016/0022-510X(81)90082-4 Raisman, 1997, Use of Schwann cells to induce repair of adult CNS tracts, Rev Neurol, 153, 521 Campbell, 2005, Upregulation of activating transcription factor 3 (ATF3) by intrinsic CNS neurons regenerating axons into peripheral nerve grafts, Exp Neurol, 192, 340, 10.1016/j.expneurol.2004.11.026 Mackay-Sim, 2011, Olfactory ensheathing cells from the nose: clinical application in human spinal cord injuries, Exp Neurol, 229, 174, 10.1016/j.expneurol.2010.08.025 Chen, 2010, Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells and Schwann cells, Chin Med J, 123, 2424 Home—ClinicalTrials.gov [Internet]. 〈http://www.clinicaltrials.gov/〉; [cited Jan 15, 2013]. StemCells, Inc. : Groundbreaking Science. Breakthrough Medicine [Internet]. 〈http://www.stemcellsinc.com/〉; [cited Jan 17, 2013]. StemCells finds early data from spinal cord injury trial promising—San Francisco Business Times [Internet]. 〈http://www.bizjournals.com/sanfrancisco/blog/biotech/2012/09/stemcells-neural-stem-cells-spinal-cord.html〉; [cited Sep 20, 2012]. Lau, 2008, Stem cell clinics online: the direct-to-consumer portrayal of stem cell medicine, Cell Stem Cell, 3, 591, 10.1016/j.stem.2008.11.001 Hwang, 2011, Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair, Cell Transplant, 20, 1361, 10.3727/096368910X557155 Prestwich, 2011, Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine, J Control Release, 155, 193, 10.1016/j.jconrel.2011.04.007 Wang, 2011, Combination of hyaluronic acid hydrogel scaffold and PLGA microspheres for supporting survival of neural stem cells, Pharm Res, 28, 1406, 10.1007/s11095-011-0452-3 Wang, 2012, Design and fabrication of a biodegradable, covalently crosslinked shape-memory alginate scaffold for cell and growth factor delivery, Tissue Eng, 18, 2000, 10.1089/ten.tea.2011.0663 Tysseling-Mattiace, 2008, Self-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury, J Neurosci, 28, 3814, 10.1523/JNEUROSCI.0143-08.2008 Leung, 2012, Peptide nanofiber scaffold for brain tissue reconstruction, Meth Enzymol, 508, 177, 10.1016/B978-0-12-391860-4.00009-4 Wright, 2012, Neuromuscular electrical stimulation for children with cerebral palsy: a review, Arch Dis Child, 97, 364, 10.1136/archdischild-2011-300437 Bolognini, 2011, Neurophysiological and behavioral effects of tDCS combined with constraint-induced movement therapy in poststroke patients, Neurorehabil Neural Repair, 25, 819, 10.1177/1545968311411056