The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: a systematic review

General Hospital Psychiatry - Tập 32 Số 4 - Trang 345-359 - 2010
Kurt Kroenke1, Robert Howard2, Janet B. W. Williams2, Bernd Löwe3
1From Regenstrief Institute, Inc. and the Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
2Biometrics Research Department, New York State Psychiatric Institute and Department of Psychiatry, Columbia University, New York, NY 10032, USA
3Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf and Schön Klinik Hamburg Eilbek, Germany

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Tài liệu tham khảo

Spitzer, 1994, Utility of new procedure for diagnosis mental-disorders in primary-care: the PRIME-MD 1000 Study, JAMA, 272, 1749, 10.1001/jama.272.22.1749

Spitzer, 1992, The Structured Clinical Interview for DSM-III-R (SCID), Arch Gen Psychiatry, 49, 624, 10.1001/archpsyc.1992.01820080032005

Robins, 1981, National Institute of Mental Health Diagnostic Interview Schedule. Its history, characteristics, and validity, Arch Gen Psychiatry, 38, 381, 10.1001/archpsyc.1981.01780290015001

Wittchen, 1994, Reliability and validity studies of the WHO–Composite International Diagnostic Interview (CIDI): a critical review, J Psychiatr Res, 28, 57, 10.1016/0022-3956(94)90036-1

Spitzer, 1999, Validation and utility of a self-report version of PRIME-MD — the PHQ primary care study, JAMA, 282, 1737, 10.1001/jama.282.18.1737

Spitzer, 2000, Validity and utility of the PRIME-MD Patient Health Questionnaire in assessment of 3000 obstetric-gynecologic patients: The PRIME-MD Patient Health Questionnaire Obstetrics Gynecology Study, Amer J Obstet Gynecol, 183, 759, 10.1067/mob.2000.106580

Spitzer, 2006, A brief measure for assessing generalized anxiety disorder — the GAD-7, Arch Intern Med, 166, 1092, 10.1001/archinte.166.10.1092

Kroenke, 2007, Anxiety disorders in primary care: Prevalence, impairment, comorbidity, and detection, Ann Intern Med, 146, 317, 10.7326/0003-4819-146-5-200703060-00004

Kroenke, 2002, The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms, Psychosom Med, 64, 258, 10.1097/00006842-200203000-00008

Kroenke, 1994, Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment, Arch Fam Med, 3, 774, 10.1001/archfami.3.9.774

Simon, 1999, An international study of the relation between somatic symptoms and depression, N Engl J Med, 341, 1329, 10.1056/NEJM199910283411801

Kroenke, 2003, Patients presenting with somatic complaints: epidemiology, psychiatric comorbidity and management, Int J Methods Psychiatr Res, 12, 34, 10.1002/mpr.140

Kroenke, 2006, Symptoms, syndromes, and the value of psychiatric diagnostics in patients who have functional somatic disorders, Med Clin North Am, 90, 603, 10.1016/j.mcna.2006.04.003

Lowe, 2008, Depression, anxiety and somatization in primary care: syndrome overlap and functional impairment, Gen Hosp Psychiatry, 30, 191, 10.1016/j.genhosppsych.2008.01.001

Helzer, 2006, The feasibility and need for dimensional psychiatric diagnoses, Psychol Med, 36, 1671, 10.1017/S003329170600821X

Gilbody, 2007, Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis, J Gen Intern Med, 22, 1596, 10.1007/s11606-007-0333-y

Wittkampf, 2007, Diagnostic accuracy of the mood module of the Patient Health Questionnaire: a systematic review, Gen Hosp Psychiatry, 29, 388, 10.1016/j.genhosppsych.2007.06.004

van Ravesteijn, 2009, Detecting somatoform disorders in primary care with the PHQ-15, Ann Fam Med, 7, 232, 10.1370/afm.985

Kroenke, 2001, The PHQ-9 — validity of a brief depression severity measure, J Gen Intern Med, 16, 606, 10.1046/j.1525-1497.2001.016009606.x

Kroenke, 2002, The PHQ-9: a new depression diagnostic and severity measure, Psychiatr Ann, 32, 509, 10.3928/0048-5713-20020901-06

Williams, 2002, Identifying depression in primary care: a literature synthesis of case-finding instruments, Gen Hosp Psychiatry, 24, 225, 10.1016/S0163-8343(02)00195-0

Lowe, 2004, Comparative validity of three screening questionnaires for DSM-IV depressive disorders and physicians' diagnoses, J Affect Disord, 78, 131, 10.1016/S0165-0327(02)00237-9

Henkel, 2004, Use of brief depression screening tools in primary care: consideration of heterogeneity in performance in different patient groups, Gen Hosp Psychiatry, 26, 190, 10.1016/j.genhosppsych.2004.02.003

Fann, 2009, Depression screening using the Patient Health Questionnaire-9 administered on a touch screen computer, Psychooncology, 18, 14, 10.1002/pon.1368

Klapow, 2002, Psychological disorders and distress in older primary care patients: a comparison of older and younger samples, Psychosom Med, 64, 635, 10.1097/01.PSY.0000021942.35402.C3

Lowe, 2004, Monitoring depression treatment outcomes with the patient health questionnaire-9, Med Care, 42, 1194, 10.1097/00005650-200412000-00006

Huang, 2006, Racial and ethnic differences in the relationship between depression severity and functional status, Psychiatr Serv, 57, 498, 10.1176/appi.ps.57.4.498

Huang, 2006, Using the patient health questionnaire-9 to measure depression among racially and ethnically diverse primary care patients, J Gen Intern Med, 21, 547, 10.1111/j.1525-1497.2006.00409.x

Lowe, 2004, Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9), J Affect Disord, 81, 61, 10.1016/S0165-0327(03)00198-8

Lowe, 2006, Responsiveness of the PHQ-9 to psychopharmacological depression treatment, Psychosomatics, 47, 62, 10.1176/appi.psy.47.1.62

Wittkampf, 2009, The accuracy of Patient Health Questionnaire-9 in detecting depression and measuring depression severity in high-risk groups in primary care, Gen Hosp Psychiatry, 31, 451, 10.1016/j.genhosppsych.2009.06.001

Williams, 2007, Care management of poststroke depression — a randomized, controlled trial, Stroke, 38, 998, 10.1161/01.STR.0000257319.14023.61

Mannel M, Kuhn U, Schmidt U, Ploch M, Murck H. St. John's wort extract LI160 for the treatment of depression with atypical features — a double-blind, randomized, and placebo-controlled trial. J Psychiatr Res 2010; doi: 10.1016/j.jpsychires.2010.01.010. [in press].

Rogers, 2005, Depression screening instruments made good severity measures in a cross-sectional analysis, J Clin Epidemiol, 58, 370, 10.1016/j.jclinepi.2004.10.010

Cannon, 2007, The PHQ-9 as a brief assessment of lifetime major depression, Psychological Assessment, 19, 247, 10.1037/1040-3590.19.2.247

Callahan, 2006, Effectiveness of collaborative care for older adults with Alzheimer disease in primary care — a randomized controlled trial, JAMA, 295, 2148, 10.1001/jama.295.18.2148

Williams, 2004, Outcomes of newly referred neurology outpatients with depression and pain, Neurology, 63, 674, 10.1212/01.WNL.0000134669.05005.95

McManus, 2005, Screening for depression in patients with coronary heart disease (data from the heart and soul study), Am J Cardiology, 96, 1076, 10.1016/j.amjcard.2005.06.037

Holzapfel, 2007, Routine screening for depression and quality of life in outpatients with congestive heart failure, Psychosomatics, 48, 112, 10.1176/appi.psy.48.2.112

Stafford, 2007, Validity of the Hospital Anxiety and Depression Scale and Patient Health Questionnaire-9 to screen for depression in patients with coronary artery disease, Gen Hosp Psychiatry, 29, 417, 10.1016/j.genhosppsych.2007.06.005

Whooley, 2008, Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease, JAMA, 300, 2379, 10.1001/jama.2008.711

Thombs, 2008, Depression screening and patient outcomes in cardiovascular care: a systematic review, JAMA, 300, 2161, 10.1001/jama.2008.667

Justice, 2004, Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care: Veterans Aging Cohort Five-Site Study, AIDS, 18, S49, 10.1097/00002030-200401001-00008

Monahan, 2009, Validity/reliability of PHQ-9 and PHQ-2 depression scales among adults living with HIV/AIDS in western Kenya, J Gen Intern Med, 24, 189, 10.1007/s11606-008-0846-z

Glasgow, 2004, A practical randomized trial to improve diabetes care, J Gen Intern Med, 19, 1167, 10.1111/j.1525-1497.2004.30425.x

Katon, 2004, Quality of depression care in a population-based sample of patients with diabetes and major depression, Med Care, 42, 1222, 10.1097/00005650-200412000-00009

Drayer, 2006, Characteristics of depression in hemodialysis patients: symptoms, quality of life and mortality risk, Gen Hosp Psychiatry, 28, 306, 10.1016/j.genhosppsych.2006.03.008

Dwight-Johnson, 2005, Can collaborative care address the needs of low-income Latinas with comorbid depression and cancer? Results from a randomized pilot study, Psychosomatics, 46, 224, 10.1176/appi.psy.46.3.224

Kroenke, 2009, Indiana Cancer Pain and Depression (INCPAD) Trial: design of a telecare management intervention for cancer-related symptoms and baseline characteristics of enrolled participants, Gen Hosp Psychiatry, 31, 240, 10.1016/j.genhosppsych.2009.01.007

Ell, 2008, Randomized controlled trial of collaborative care management of depression among low-income patients with cancer, J Clin Oncol, 26, 4488, 10.1200/JCO.2008.16.6371

Lowe, 2004, Psychiatric comorbidity and work disability in patients with inflammatory rheumatic diseases, Psychosom Med, 66, 395, 10.1097/01.psy.0000126203.89941.a3

Rosemann, 2007, Predictors of depression in a sample of 1,021 primary care patients with osteoarthritis, Arthritis Care Res, 57, 415, 10.1002/art.22624

Persoons, 2005, The impact of major depressive disorder on the short- and long-term outcome of Crohn's disease treatment with infliximab, Alimentary Pharmacol Therapeutics, 22, 101, 10.1111/j.1365-2036.2005.02535.x

Picardi, 2004, Recognition of depressive and anxiety disorders in dermatological outpatients, Acta Dermato-Venereologica, 84, 213, 10.1080/00015550410025264

Scholle, 2003, Addressing depression in obstetrics/gynecology practice, Gen Hosp Psychiatry, 25, 83, 10.1016/S0163-8343(03)00006-9

Leithner, 2009, Psychiatric morbidity in gynecological and otorhinolaryngological outpatients: a comparative study, Gen Hosp Psychiatry, 31, 233, 10.1016/j.genhosppsych.2008.12.007

Lamoureux, 2009, Can clinicians use the PHQ-9 to assess depression in people with vision loss?, Optometry Vision Sci, 86, 139, 10.1097/OPX.0b013e318194eb47

Maizels, 2006, A review of screening tools for psychiatric comorbidity in headache patients, Headache, 46, S98, 10.1111/j.1526-4610.2006.00561.x

Persoons, 2003, Anxiety and mood disorders in otorhinolaryngology outpatients presenting with dizziness: validation of the self-administered PRIME-MD Patient Health Questionnaire and epidemiology, Gen Hosp Psychiatry, 25, 316, 10.1016/S0163-8343(03)00072-0

Tietjen, 2007, High prevalence of somatic symptoms and depression in women with disabling chronic headache, Neurology, 68, 134, 10.1212/01.wnl.0000251195.55563.02

Turner, 2004, Screening for psychosocial risk factors in patients with chronic orofacial pain — recent advances, J Am Dent Assoc, 135, 1119, 10.14219/jada.archive.2004.0370

Gameroff, 2006, Major depressive disorder, somatic pain, and health care costs in an urban primary care practice, J Clin Psychiatry, 67, 1232, 10.4088/JCP.v67n0809

Kroenke, 2007, Stepped Care for Affective Disorders and Musculoskeletal Pain (SCAMP) study design and practical implications of an intervention for comorbid pain and depression, Gen Hosp Psychiatry, 29, 506, 10.1016/j.genhosppsych.2007.08.005

Dobscha, 2009, Collaborative care for chronic pain in primary care: a clustered randomized trial, JAMA, 301, 1242, 10.1001/jama.2009.377

Fann, 2005, Validity of the patient health questionnaire-9 in assessing depression following traumatic brain injury, J Head Trauma Rehab, 20, 501, 10.1097/00001199-200511000-00003

Bombardier, 2004, Symptoms of major depression in people with spinal cord injury: implications for screening, Arch Physical Med Rehab, 85, 1749, 10.1016/j.apmr.2004.07.348

Lowe, 2003, Predictors of psychiatric comorbidity in medical outpatients, Psychosom Med, 65, 764, 10.1097/01.PSY.0000079379.39918.17

Turvey, 2007, Telehealth screen for depression in a chronic illness care management program, Telemed J E-Health, 13, 51, 10.1089/tmj.2006.0036

Nease, 2008, Inducing sustainable improvement in depression care in primary care practices, Jt Comm J Qual Patient Saf, 34, 247, 10.1016/S1553-7250(08)34031-8

Duffy, 2008, Systematic use of patient-rated depression severity monitoring: Is it helpful and feasible in clinical psychiatry?, Psychiatr Serv, 59, 1148, 10.1176/appi.ps.59.10.1148

Saliba, 2009, Development and validation of a revised nursing home assessment tool: MDS 3.0

Watson, 2009, Practical depression screening in residential care/assisted living: five methods compared with gold standard diagnoses, Am J Geriatric Psychiatry, 17, 556, 10.1097/JGP.0b013e31819b891c

JOHNSON, 2002, The Patient Health Questionnaire for Adolescents: validation of an instrument for the assessment of mental disorders among adolescent primary care patients, J Adolesc Health, 30, 196, 10.1016/S1054-139X(01)00333-0

Zuckerbrot, 2006, Improving recognition of adolescent depression in primary care, Arch Pediatr Adolesc Med, 160, 694, 10.1001/archpedi.160.7.694

Zuckerbrot, 2007, Guidelines for Adolescent Depression in Primary Care (GLAD-PC): I. Identification, assessment, and initial management, Pediatrics, 120, e1299, 10.1542/peds.2007-1144

Richardson, 2009, Collaborative care for adolescent depression: a pilot study, Gen Hosp Psychiatry, 31, 36, 10.1016/j.genhosppsych.2008.09.019

Gjerdingen, 2009, Postpartum depression screening at well-child visits: validity of a 2-question screen and the PHQ-9, Ann Fam Med, 7, 63, 10.1370/afm.933

Weobong, 2009, The comparative validity of screening scales for postnatal common mental disorder in Kintampo, Ghana, J Affect Disord, 113, 109, 10.1016/j.jad.2008.05.009

Bennett, 2008, Efficiency of a two-item pre-screen to reduce the burden of depression screening in pregnancy and postpartum: an IMPLICIT network study, J Am Board Fam Med, 21, 317, 10.3122/jabfm.2008.04.080048

Hanusa, 2008, Screening for depression in the postpartum period: A comparison of three instruments, J Womens Health, 17, 585, 10.1089/jwh.2006.0248

Yonkers, 2009, Depression screening of perinatal women: an evaluation of the Healthy Start Depression Initiative, Psychiatr Serv, 60, 322, 10.1176/appi.ps.60.3.322

Hewitt, 2009, Methods to identify postnatal depression in primary care: an integrated evidence synthesis and value of information analysis, Health Technol Assess, 13, 1, 10.3310/hta13360

Whooley, 1997, Case-finding instruments for depression. Two questions are as good as many, J Gen Intern Med, 12, 439, 10.1046/j.1525-1497.1997.00076.x

Kroenke, 2003, The Patient Health Questionnaire-2 — Validity of a two-item depression screener, Med Care, 41, 1284, 10.1097/01.MLR.0000093487.78664.3C

Corson, 2004, Screening for depression and suicidality in a VA primary care setting: 2 items are better than 1 item, Am J Managed Care, 10, 839

Lowe, 2005, Detecting and monitoring depression with a two-item questionnaire (PHQ-2), J Psychosom Res, 58, 163, 10.1016/j.jpsychores.2004.09.006

Li, 2007, Validity of the Patient Health Questionnaire 2 (PHQ-2) in identifying major depression in older people, J Am Geriatrics Soc, 55, 596, 10.1111/j.1532-5415.2007.01103.x

Mitchell, 2009, Accuracy of specific symptoms in the diagnosis of major depressive disorder in psychiatric out-patients: data from the MIDAS project, Psychol Med, 39, 1107, 10.1017/S0033291708004674

Rief, 2004, Base rates for panic and depression according to the Brief Patient Health Questionnaire: a population-based study, J Affect Disord, 82, 271, 10.1016/j.jad.2003.11.006

Lee, 2007, Concordance between the PHQ-9 and the HSCL-20 in depressed primary care patients, J Affect Disord, 99, 139, 10.1016/j.jad.2006.09.002

Kroenke, 2009, The PHQ-8 as a measure of current depression in the general population, J Affect Disord, 114, 163, 10.1016/j.jad.2008.06.026

First, 1996

Unutzer, 2002, Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial, JAMA, 288, 2836, 10.1001/jama.288.22.2836

Dietrich, 2004, Re-engineering systems for the treatment of depression in primary care: cluster randomised controlled trial, BMJ, 329, 602, 10.1136/bmj.38219.481250.55

Dobscha, 2006, Depression decision support in primary care — a cluster randomized trial, Ann Intern Med, 145, 477, 10.7326/0003-4819-145-7-200610030-00005

Fortney, 2007, A randomized trial of telemedicine-based collaborative care for depression, J Gen Intern Med, 22, 1086, 10.1007/s11606-007-0201-9

Ell, 2007, Improving treatment of depression among low-income patients with cancer: the design of the ADAPt-C study, Gen Hosp Psychiatry, 29, 223, 10.1016/j.genhosppsych.2007.01.005

Strong, 2008, Management of depression for people with cancer (SMaRT oncology 1): a randomised trial, Lancet, 372, 40, 10.1016/S0140-6736(08)60991-5

Richards, 2008, Collaborative care for depression in UK primary care: a randomized controlled trial, Psychol Med, 38, 279, 10.1017/S0033291707001365

Kroenke, 2009, Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial, JAMA, 301, 2099, 10.1001/jama.2009.723

Strine, 2008, Depression and anxiety in the United States: findings from the 2006 Behavioral Risk Factor Surveillance System, Psychiatr Serv, 59, 1383, 10.1176/appi.ps.59.12.1383

Pratt, 2008, Depression in the United States household population, 2005-2006, NCHS Data Brief, 7

Fleishman, 2007, Global self-rated mental health: associations with other mental health measures and with role functioning, Med Care, 45, 602, 10.1097/MLR.0b013e31803bb4b0

Taylor, 2008, Strategies for identifying and channeling patients for depression care management, Am J Managed Care, 14, 497

Smith, 2007, Reliability of standard health assessment instruments in a large, population-based cohort study, Ann Epidemiol, 17, 525, 10.1016/j.annepidem.2006.12.002

Martin, 2006, Validity of the Brief Patient Health Questionnaire Mood Scale (PHQ-9) in the general population, Gen Hosp Psychiatry, 28, 71, 10.1016/j.genhosppsych.2005.07.003

Pirkis, 2009, The community prevalence of depression in older Australians, J Affective Disorders, 115, 54, 10.1016/j.jad.2008.08.014

Patten, 2009, Longitudinal epidemiology of major depression as assessed by the Brief Patient Health Questionnaire (PHQ-9), Comprehensive Psychiatry, 50, 26, 10.1016/j.comppsych.2008.05.012

Desai, 2006, Case-finding for depression among medical outpatients in the Veterans Health Administration, Med Care, 44, 175, 10.1097/01.mlr.0000196962.97345.21

Engel, 2008, RESPECT-Mil: feasibility of a systems-level collaborative care approach to depression and post-traumatic stress disorder in military primary care, Mil Med, 173, 935, 10.7205/MILMED.173.10.935

Arnow, 2006, Comorbid depression, chronic pain, and disability in primary care, Psychosom Med, 68, 262, 10.1097/01.psy.0000204851.15499.fc

Katzelnick, 2005, Applying depression-specific change concepts in a collaborative breakthrough series, Jt Comm J Qual Patient Saf, 31, 386, 10.1016/S1553-7250(05)31052-X

Bremer, 2008, Pay for performance in behavioral health, Psychiatr Serv, 59, 1419, 10.1176/appi.ps.59.12.1419

Sederer, 2006, Integrating care for medical and mental illnesses, Prev Chronic Dis, 3, A33

Kendrick, 2009, Management of depression in UK general practice in relation to scores on depression severity questionnaires: analysis of medical record data, BMJ, 338

Oxman, 2002, A three-component model for reengineering systems for the treatment of depression in primary care, Psychosomatics, 43, 441, 10.1176/appi.psy.43.6.441

Kilbourne, 2004, Translating evidence-based depression management services to community-based primary care practices, Milbank Quarterly, 82, 631, 10.1111/j.0887-378X.2004.00326.x

Lichtman, 2008, Depression and coronary heart disease. recommendations for screening, referral, and treatment, Circulation, 118, 1765

Andrews, 2008, Classification of anxiety and depressive disorders: problems and solutions, Depress Anxiety, 25, 274, 10.1002/da.20489

Lee, 2007, Sustainable impact of a primary care depression intervention, J Am Board Fam Pract, 20, 427, 10.3122/jabfm.2007.05.070045

Lowe, 2003, Detecting panic disorder in medical and psychosomatic outpatients — comparative validation of the Hospital Anxiety and Depression Scale, the Patient Health Questionnaire, a screening question, and physicians' diagnosis, J Psychosom Res, 55, 515, 10.1016/S0022-3999(03)00072-2

Corapcioglu, 2004, Adaptation of revised Brief PHQ (Brief-PHQ-r) for diagnosis of depression, panic disorder and somatoform disorder in primary healthcare settings, Int J Psychiatry Clin Pract, 8, 11, 10.1080/13651500310004452

Means-Christensen, 2005, An efficient method of identifying major depression and panic disorder in primary care, J Behav Med, 28, 565, 10.1007/s10865-005-9023-6

Rollman, 2005, Symptomatic severity of PRIME-MD diagnosed episodes of panic and generalized anxiety disorder in primary care, J Gen Intern Med, 20, 623, 10.1007/s11606-005-0108-2

Pilowsky, 2006, Panic disorder and suicidal ideation in primary care, Depress Anxiety, 23, 11, 10.1002/da.20092

Kessler, 2005, Rethinking the duration requirement for generalized anxiety disorder: evidence from the National Comorbidity Survey Replication, Psychol Med, 35, 1073, 10.1017/S0033291705004538

Lowe, 2008, Validation and standardization of the generalized anxiety disorder screener (GAD-7) in the general population, Med Care, 46, 266, 10.1097/MLR.0b013e318160d093

Issakidis, 2004, Modelling the population cost-effectiveness of current and evidence-based optimal treatment for anxiety disorders, Psychol Med, 34, 19, 10.1017/S003329170300881X

Roy-Byrne, 2009, Brief intervention for anxiety in primary care patients, J Am Board Fam Med, 22, 175, 10.3122/jabfm.2009.02.080078

Bair, 2008, Association of depression and anxiety alone and in combination with chronic musculoskeletal pain in primary care patients, Psychosom Med, 70, 890, 10.1097/PSY.0b013e318185c510

Sherbourne, 2009, Early identification of co-occurring pain, depression and anxiety, J Gen Intern Med, 24, 620, 10.1007/s11606-009-0956-2

Kroenke, 2007, Revising the classification of somatoform disorders: key questions and preliminary recommendations, Psychosomatics, 48, 277, 10.1176/appi.psy.48.4.277

Dimsdale, 2009, The proposed diagnosis of somatic symptom disorders in DSM-V to replace somatoform disorders in DSM-IV–a preliminary report, J Psychosom Res, 66, 473, 10.1016/j.jpsychores.2009.03.005

Katon, 2007, The association of depression and anxiety with medical symptom burden in patients with chronic medical illness, Gen Hosp Psychiatry, 29, 147, 10.1016/j.genhosppsych.2006.11.005

Kroenke, 2007, Somatoform disorders and recent diagnostic controversies, Psychiatr Clin North Am, 30, 593, 10.1016/j.psc.2007.08.002

Kroenke, 1997, Multisomatoform disorder. An alternative to undifferentiated somatoform disorder for the somatizing patient in primary care, Arch Gen Psychiatry, 54, 352, 10.1001/archpsyc.1997.01830160080011

Kroenke, 1998, A symptom checklist to screen for somatoform disorders in primary care, Psychosomatics, 39, 263, 10.1016/S0033-3182(98)71343-X

Interian, 2006, Somatic complaints in primary care: Further examining the validity of the patient health questionnaire (PHQ-15), Psychosomatics, 47, 392, 10.1176/appi.psy.47.5.392

Kroenke, 2006, Venlafaxine extended release in the short-term treatment of depressed and anxious primary care patients with multisomatoform disorder, J Clin Psychiatry, 67, 72, 10.4088/JCP.v67n0111

Gerber, 2008, Intimate partner violence exposure and change in women's physical symptoms over time, J Gen Intern Med, 23, 64, 10.1007/s11606-007-0463-2

Escobar, 2007, Effectiveness of a time-limited cognitive behavior therapy type intervention among primary care patients with medically unexplained symptoms, Ann Fam Med, 5, 328, 10.1370/afm.702

Kroenke, 2001, Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: a randomized trial, JAMA, 286, 2947, 10.1001/jama.286.23.2947

Reuber, 2007, Tailored psychotherapy for patients with functional neurological symptoms: a pilot study, J Psychosom Res, 63, 625, 10.1016/j.jpsychores.2007.06.013

Kroenke, 2006, Physical symptom disorder: a simpler diagnostic category for somatization-spectrum conditions, J Psychosom Res, 60, 335, 10.1016/j.jpsychores.2006.01.022

Barsky, 2005, Somatization increases medical utilization and costs independent of psychiatric and medical comorbidity, Arch Gen Psychiatry, 62, 903, 10.1001/archpsyc.62.8.903

Barsky, 2006, Distinctive patterns of medical care utilization in patients who somatize, Med Care, 44, 803, 10.1097/01.mlr.0000228028.07069.59

Rost, 2006, Multisomatoform disorder: agreement between patient and physician report of criterion symptom explanation, CNS Spectr, 11, 383, 10.1017/S1092852900014516

Hahn, 2001, Physical symptoms and physician-experienced difficulty in the physician-patient relationship, Ann Intern Med, 134, 897, 10.7326/0003-4819-134-9_Part_2-200105011-00014

Jackson, 2001, The effect of unmet expectations among adults presenting with physical symptoms, Ann Intern Med, 134, 889, 10.7326/0003-4819-134-9_Part_2-200105011-00013

Smith, 2003, Treating patients with medically unexplained symptoms in primary care, J Gen Intern Med, 18, 478, 10.1046/j.1525-1497.2003.20815.x

Jackson, 2006, Antidepressants and cognitive-behavioral therapy for symptom syndromes, CNS Spectr, 11, 212, 10.1017/S1092852900014383

Kroenke, 2007, Efficacy of treatment for somatoform disorders: a review of randomized controlled trials, Psychosom Med, 69, 881, 10.1097/PSY.0b013e31815b00c4

Sha, 2005, Physical symptoms as a predictor of health care use and mortality among older adults, Am J Med, 118, 301, 10.1016/j.amjmed.2004.12.015

Clarke, 2008, Somatic symptoms, hypochondriasis and psychological distress: a study of somatisation in Australian general practice, Med J Aust, 189, 560, 10.5694/j.1326-5377.2008.tb02180.x

Mewes, 2008, Lower decision threshold for doctor visits as a predictor of health care use in somatoform disorders and in the general population, Gen Hosp Psychiatry, 30, 349, 10.1016/j.genhosppsych.2008.04.007

Ryan, 2007, Millennium Cohort: enrollment begins a 21-year contribution to understanding the impact of military service, J Clin Epidemiol, 60, 181, 10.1016/j.jclinepi.2006.05.009

Kang, 2009, Health of US veterans of 1991 Gulf War: a follow-up survey in 10 years, J Occup Environ Med, 51, 401, 10.1097/JOM.0b013e3181a2feeb

Hoge, 2008, Mild traumatic brain injury in U.S. Soldiers returning from Iraq, N Engl J Med, 358, 453, 10.1056/NEJMoa072972

Harris, 2009, Somatization increases disability independent of comorbidity, J Gen Intern Med, 24, 155, 10.1007/s11606-008-0845-0

Hanel, 2009, Depression, anxiety, and somatoform disorders: vague or distinct categories in primary care? Results from a large cross-sectional study, J Psychosom Res, 67, 189, 10.1016/j.jpsychores.2009.04.013

Ormel, 1994, Common mental disorders and disability across cultures. Results from the WHO Collaborative Study on Psychological Problems in General Health Care, JAMA, 272, 1741, 10.1001/jama.272.22.1741

Spitzer, 1995, Health-related quality-of-life in primary-care patients with mental disorders — Results from the PRIME-MD 1000 Study, JAMA, 274, 1511, 10.1001/jama.274.19.1511

Patel, 2008, Detecting common mental disorders in primary care in India: a comparison of five screening questionnaires, Psychol Med, 38, 221, 10.1017/S0033291707002334

Gilbody, 2007, Diagnosing depression in primary care using self-completed instruments: UK validation of PHQ-9 and CORE-OM, Br J Gen Pract, 57, 650

Clark, 2009, Improving access to psychological therapy: initial evaluation of two UK demonstration sites, Behav Res Ther, 47, 910, 10.1016/j.brat.2009.07.010

Mitchell, 2007, Do ultra-short screening instruments accurately detect depression in primary care? A pooled analysis and meta-analysis of 22 studies, Br J Gen Pract, 57, 144

Kroenke, 2009, An ultra-brief screening scale for anxiety and depression: the PHQ-4, Psychosomatics, 50, 613, 10.1176/appi.psy.50.6.613

Lowe, 2009, A 4-item measure of depression and anxiety: validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population, J Affect Disord

Gilbody, 2008, Screening and case-finding instruments for depression: a meta-analysis, CMAJ, 178, 997, 10.1503/cmaj.070281

Gilbody, 2006, Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes, Arch Intern Med, 166, 2314, 10.1001/archinte.166.21.2314

Williams, 2007, Systematic review of multifaceted interventions to improve depression care, Gen Hosp Psychiatry, 29, 91, 10.1016/j.genhosppsych.2006.12.003

U.S. Preventive Services Task Force, 2009, Screening for depression in adults: U.S. Preventive Services Task Force recommendation statement, Ann Intern Med, 151, 784, 10.7326/0003-4819-151-11-200912010-00006

Gaynes, 2008, Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*D, J Gen Intern Med, 23, 551, 10.1007/s11606-008-0522-3

Gilbody, 2002, Psychiatrists in the UK do not use outcomes measures. National survey, Br J Psychiatry, 180, 101, 10.1192/bjp.180.2.101

Zimmerman, 2008, An inadequate community standard of care: lack of measurement of outcome when treating depression in clinical practice, Primary Psychiatry, 15, 67

Trivedi, 2009, Tools and strategies for ongoing assessment of depression: a measurement-based approach to remission, J Clin Psychiatry, 70, 26, 10.4088/JCP.8133su1c.04