The PI3K Pathway Balances Self-Renewal and Differentiation of Nephron Progenitor Cells through β-Catenin Signaling

Barak, 2012, FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man, Dev. Cell, 22, 1191, 10.1016/j.devcel.2012.04.018

Brown, 2011, FGF/EGF signaling regulates the renewal of early nephron progenitors during embryonic development, Development, 138, 5099, 10.1242/dev.065995

Brown, 2013, Role for compartmentalization in nephron progenitor differentiation, Proc. Natl. Acad. Sci. USA, 110, 4640, 10.1073/pnas.1213971110

Brunskill, 2014, Single cell dissection of early kidney development: multilineage priming, Development, 141, 3093, 10.1242/dev.110601

Carracedo, 2008, The PTEN-PI3K pathway: of feedbacks and cross-talks, Oncogene, 27, 5527, 10.1038/onc.2008.247

Cho, 1998, Differential expression and function of cadherin-6 during renal epithelium development, Development, 125, 803, 10.1242/dev.125.5.803

Costantini, 2010, Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development, Dev. Cell, 18, 698, 10.1016/j.devcel.2010.04.008

Das, 2013, Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation, Nat. Cell Biol., 15, 1035, 10.1038/ncb2828

Davies, 2009, Regulation, necessity, and the misinterpretation of knockouts, BioEssays, 31, 826, 10.1002/bies.200900044

Davies, 1995, Induction of early stages of kidney tubule differentiation by lithium ions, Dev. Biol., 167, 50, 10.1006/dbio.1995.1006

Dolt, 2013, A universal vector for high-efficiency multi-fragment recombineering of BACs and knock-in constructs, PLoS ONE, 8, e62054, 10.1371/journal.pone.0062054

Ferrer-Vaquer, 2010, A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse, BMC Dev. Biol., 10, 121, 10.1186/1471-213X-10-121

Goto, 1998, Involvement of R-cadherin in the early stage of glomerulogenesis, J. Am. Soc. Nephrol., 9, 1234, 10.1681/ASN.V971234

He, 2004, BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling, Nat. Genet., 36, 1117, 10.1038/ng1430

Karner, 2011, Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development, Development, 138, 1247, 10.1242/dev.057646

Kim, 2007, PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney, Dev. Biol., 307, 290, 10.1016/j.ydbio.2007.04.051

Klein, 1988, Neural cell adhesion molecules during embryonic induction and development of the kidney, Development, 102, 749, 10.1242/dev.102.4.749

Kuure, 2007, Glycogen synthase kinase-3 inactivation and stabilization of beta-catenin induce nephron differentiation in isolated mouse and rat kidney mesenchymes, J. Am. Soc. Nephrol., 18, 1130, 10.1681/ASN.2006111206

Lanner, 2010, The role of FGF/Erk signaling in pluripotent cells, Development, 137, 3351, 10.1242/dev.050146

Lindström, 2013, Nephrons require Rho-kinase for proximal-distal polarity development, Sci. Rep., 3, 2692, 10.1038/srep02692

Luche, 2007, Faithful activation of an extra-bright red fluorescent protein in “knock-in” Cre-reporter mice ideally suited for lineage tracing studies, Eur. J. Immunol., 37, 43, 10.1002/eji.200636745

Motamedi, 2014, WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors, Nat. Commun., 5, 4444, 10.1038/ncomms5444

Paling, 2004, Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling, J. Biol. Chem., 279, 48063, 10.1074/jbc.M406467200

Park, 2007, Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development, Development, 134, 2533, 10.1242/dev.006155

Park, 2012, Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks, Dev. Cell, 23, 637, 10.1016/j.devcel.2012.07.008

Perry, 2011, Cooperation between both Wnt/beta-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion, Genes Dev., 25, 1928, 10.1101/gad.17421911

Self, 2006, Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney, EMBO J., 25, 5214, 10.1038/sj.emboj.7601381

Tang, 2002, Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase, Dev. Biol., 243, 128, 10.1006/dbio.2001.0557

Tumaneng, 2012, YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29, Nat. Cell Biol., 14, 1322, 10.1038/ncb2615

Vestweber, 1985, Cell-adhesion molecule uvomorulin during kidney development, Dev. Biol., 112, 213, 10.1016/0012-1606(85)90135-6

Xu, 2014, Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis, Development, 141, 1442, 10.1242/dev.103283