The Nutriss Study: A New Approach to Calibrate Diet and Exercise in Long-Term Space Missions to Maintain Body Fat, Muscle and Fluid Homeostasis

Aerotecnica Missili & Spazio - Tập 99 - Trang 121-125 - 2020
F. G. Di Girolamo1, G. Biolo1, N. Fiotti1, R. Situlin1, C. Piacenza2, P. Lepore2, R. Fortezza3, E. Carrubba4, C. Pacelli5, G. Valentini5, G. Mascetti5, S. Piccirillo5
1Dipartimento di Scienze Mediche Chirurgiche e della Salute, Università degli Studi di Trieste, Trieste, Italy
2Argotec, Torino, Italy
3Telespazio, Napoli, Italy
4Kayser Italia, Livorno, Italy
5ASI- Agenzia Spaziale Italiana, Rome, Italy

Tóm tắt

Energy balance maintenance is crucial to preserve astronaut’s wellness and quality of life during long-duration spaceflight and nutritional intervention can effectively counteract the detrimental effect of microgravity on skeletal muscle mass and metabolism. NutrISS (Nutrition monitoring for the International Space Station) is an Italian Space Agency (ASI) biomedical experiment investigating the changes in body composition during long-term spaceflight. The goal of this proof-of-concept study is to monitor the body composition of astronauts and, if needed, to provide nutritional advice during the mission. It has been executed on the ISS, from July 2019 till January 2020 and sponsored by ESA. The payloads selected for the mission “BEYOND” result from a public-call funded and coordinated by ASI, in the frame of its national mission of promoting and fostering the culture of space across the Country and providing access to the ISS as a laboratory in space to the Italian research community. The utilization support services is ensured by Argotec/Telespazio (UTISS Team). An astronaut underwent to baseline data collections, i.e. body composition, anthropometric evaluation and energy and metabolic assessment carried out by the scientific team. Body composition, estimated through resistance/reactance to a low-intensity current has been assessed with a Bio-Impedance Analyser (BIA) device manufactured by Akern and modified by Kayser Italia. To maintain the participant in near-neutral energy balance, the science team monitored monthly the astronaut body mass during the entire space flight period. Advice on energy intake was given to the astronaut when needed.

Tài liệu tham khảo

Biolo, G., Ciocchi, B., Stulle, M., Bosutti, A., Barazzoni, R., Zanetti, M., Antonione, R., Lebenstedt, M., Platen, P., Heer, M., Guarnieri, G.: Calorie restriction accelerates the catabolism of lean body mass during 2 wk of bed rest. Am. J. Clin. Nutr. 86(2), 366–372 (2007). https://doi.org/10.1093/ajcn/86.2.366 Biolo, G., Secchiero, P., De Giorgi, S., Tisato, V., Zauli, G.: The energy balance positively regulates the levels of circulating TNF-related apoptosis inducing ligand in humans. Clin. Nutr. 31(6), 1018–1021 (2012). https://doi.org/10.1016/j.clnu.2012.04.016 Biolo, G., Agostini, F., Simunic, B., Sturma, M., Torelli, L., Preiser, J.C., Deby-Dupont, G., Magni, P., Strollo, F., di Prampero, P., Guarnieri, G., Mekjavic, I.B., Pisot, R., Narici, M.V.: Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest. Am. J. Clin. Nutr. 88(4), 950–958 (2008) Biolo, G., Heer, M., Narici, M., Strollo, F.: Microgravity as a model of ageing. Curr. Opin. Clin. Nutr. Metab. Care 6(1), 31–40 (2003). https://doi.org/10.1097/00075197-200301000-00006 Smith, S.M., Zwart, S.R., Block, G., Rice, B.L., et al.: The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station. J. Nutr. 135(3), 437–443 (2005) Smith, S.M., Zwart, S.R., Heer, M.: Human adaptation to space flight: the role of nutrition. National Aeronautics and Space Administration. Book. United States Govt Printing Office (2014) Wilson, M.M., Morley, J.E.: Aging and energy balance. J. Appl. Physiol. 95, 1728–1736 (2003) World Health Organization: Energy and protein requirements. Report of a joint FAO/WHO/UNU expert consultation. World Health Organization, Geneva (1985) Institute of Medicine: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (macronutrients). The National Academies Press, Washington (2002) Jaffrin, M.Y., Morel, H.: Body fluid volumes measurements by impedance: a review of bioimpedance spectroscopy (BIS) and bioimpedance analysis (BIA) methods. Med. Eng. Phys. 30(10), 1257–1269 (2008) Wang, J., Thornton, J.C., Burastero, S., Heymsfield, S.B., Pierson Jr., R.N.: Bio-impedance analysis for estimation of total body potassium, total body water, and fat-free mass in white, black, and Asian adults. Am. J. Hum. Biol. 7(1), 33–40 (1995) Noskov, V.B., Nichiporuk, I.A., Grigorev, A.I.: Dynamics of the body liquids and composition in long-duration space flight (bio-impedance analysis). Aviakosm Ekolog Med. 41(3), 3–7 (2007) Noskov, V.B., Kotov, A.N., Morukov, B.V., Nichiporuk, I.A., Shargin, Y.: Bioimpedance analysis of fluids and body composition under the conditions of short-term space flight or hypokinesia. Hum. Physiol. 32(5), 622–625 (2006) Noskov, V.B., Nikolaev, D.V., Tuikin, S.A., Kozharinov, V.I., Grachev, V.A.: A portable impedance meter for monitoring liquid compartments of the human body under space flight conditions. Biomed. Eng. 41(2), 94–96 (2007) Wade, C.E., Miller, M.M., Baer, L.A., Moran, M.M., Steele, M.K., Stein, T.P.: Body mass, energy intake, and water consumption of rats and humans during space flight. Nutrition 18, 829–836 (2002) Rittweger, J., Albracht, K., Flück, M., Ruoss, S., Brocca, L., Longa, E., Moriggi, M., Seynnes, O., Di Giulio, I., Tenori, L., Vignoli, A., Capri, M., Gelfi, C., Luchinat, C., Francheschi, C., Bottinelli, R., Cerretelli, P., Narici, M.: Sarcolab pilot study into skeletal muscle's adaptation to long-term spaceflight. NPJ Microgravity 4, 18 (2018). https://doi.org/10.1038/s41526-018-0052-1 Capri, M., Morsiani, C., Santoro, A., Moriggi, M., Conte, M., Martucci, M., Bellavista, E., Fabbri, C., Giampieri, E., Albracht, K., Flück, M., Ruoss, S., Brocca, L., Canepari, M., Longa, E., Di Giulio, I., Bottinelli, R., Cerretelli, P., Salvioli, S., Gelfi, C., Rittweger, J.: Recovery from 6-month spaceflight at the International space station: muscle-related stress into a proinflammatory setting. FASEB J. 33(4), 5168–5180 (2019). https://doi.org/10.1096/fj.201801625R Bettis, T., Kim, B.J., Hamrick, M.W.: Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse. Osteoporos Int. 29(8), 1713–1720 (2018). https://doi.org/10.1007/s00198-018-4570-1. Epub 2018 May 18