The Nrf2 Pathway in Liver Diseases
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Bailey, 2002, Contribution of Mitochondria to Oxidative Stress Associated with Alcoholic Liver Disease1 1This Article Is Part of a Series of Reviews on "Alcohol, Oxidative Stress and Cell Injury". The Full List of Papers May Be Found on the Homepage of the Journal, Free Radic. Biol. Med., 32, 11, 10.1016/s0891-5849(01)00769-9
Begriche, 2006, Mitochondrial Dysfunction in NASH: Causes, Consequences and Possible Means to Prevent it, Mitochondrion, 6, 1, 10.1016/j.mito.2005.10.004
Brück, 2018, A Review of the Mechanisms of Action of Dimethylfumarate in the Treatment of Psoriasis, Exp. Dermatol., 27, 611, 10.1111/exd.13548
Carvajal-Yepes, 2011, Hepatitis C Virus Impairs the Induction of Cytoprotective Nrf2 Target Genes by Delocalization of Small Maf Proteins, J. Biol. Chem., 286, 8941, 10.1074/jbc.M110.186684
Chan, 2001, An Important Function of Nrf2 in Combating Oxidative Stress: Detoxification of Acetaminophen, Proc. Natl. Acad. Sci., 98, 4611, 10.1073/pnas.081082098
Chen, 2020, c‐Jun NH 2 ‐Terminal Protein Kinase Phosphorylates the Nrf2‐ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2 and Downregulates Cytoprotective Genes in Acetaminophen‐Induced Liver Injury in Mice, Hepatology, 71, 1787, 10.1002/hep.31116
Chowdhry, 2013, Nrf2 Is Controlled by Two Distinct β-TrCP Recognition Motifs in its Neh6 Domain, One of Which Can Be Modulated by GSK-3 Activity, Oncogene, 32, 3765, 10.1038/onc.2012.388
Cuadrado, 2019, Therapeutic Targeting of the NRF2 and KEAP1 Partnership in Chronic Diseases, Nat. Rev. Drug Discov., 18, 295, 10.1038/s41573-018-0008-x
Czaja, 2011, Promising Pharmacological, Molecular and Cellular Treatments of Autoimmune Hepatitis, Curr. Pharm. Des., 17, 3120, 10.2174/138161211798157568
Ding, 2014, Divergent Angiocrine Signals from Vascular Niche Balance Liver Regeneration and Fibrosis, Nature, 505, 97, 10.1038/nature12681
Ding, 2010, Inductive Angiocrine Signals from Sinusoidal Endothelium Are Required for Liver Regeneration, Nature, 468, 310, 10.1038/nature09493
Dinkova-Kostova, 2002, Direct Evidence that Sulfhydryl Groups of Keap1 Are the Sensors Regulating Induction of Phase 2 Enzymes that Protect against Carcinogens and Oxidants, Proc. Natl. Acad. Sci., 99, 11908, 10.1073/pnas.172398899
Dwivedi, 2020, Dimethyl Fumarate Protects Thioacetamide‐induced Liver Damage in Rats: Studies on Nrf2, NLRP3, and NF‐κB, J. Biochem. Mol. Toxicol., 34, e22476, 10.1002/jbt.22476
El-Agamy, 2018, Pristimerin as a Novel Hepatoprotective Agent against Experimental Autoimmune Hepatitis, Front. Pharmacol., 9, 292, 10.3389/fphar.2018.00292
Enomoto, 2001, High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes, Toxicol. Sci., 59, 169, 10.1093/toxsci/59.1.169
Eraky, 2020, Omega-3 Fatty Acids Protect against Acetaminophen-Induced Hepatic and Renal Toxicity in Rats through HO-1-Nrf2-BACH1 Pathway, Arch. Biochem. Biophys., 687, 108387, 10.1016/j.abb.2020.108387
Fei, 2017, Oxidative Stress-Induced Afterdepolarizations and Protein Kinase C Signaling, Int. J. Mol. Sci., 18, 688, 10.3390/ijms18040688
Finkel, 2011, Signal Transduction by Reactive Oxygen Species, J. Cel Biol, 194, 7, 10.1083/jcb.201102095
Fragoulis, 2019, Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver, Toxicol. Sci., 169, 485, 10.1093/toxsci/kfz055
Fu, 2020, Catalpol Coordinately Regulates Phase I and II Detoxification Enzymes of Triptolide through CAR and NRF2 Pathways to Reduce Triptolide-Induced Hepatotoxicity, Biomed. Pharmacother., 129, 110379, 10.1016/j.biopha.2020.110379
Gong, 2002, Activation of the Mouse Heme Oxygenase-1 Gene by 15-Deoxy-Δ12,14-Prostaglandin J2Is Mediated by the Stress Response Elements and Transcription Factor Nrf2, Antioxid. Redox Signaling, 4, 249, 10.1089/152308602753666307
González, 2020, Downregulation of Thioredoxin-1-dependent CD95 S-Nitrosation by Sorafenib Reduces Liver Cancer, Redox Biol., 34, 101528, 10.1016/j.redox.2020.101528
Huang, 2002, Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-Mediated Transcription, J. Biol. Chem., 277, 42769, 10.1074/jbc.M206911200
Ichimura, 2013, Phosphorylation of P62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy, Mol. Cel, 51, 618, 10.1016/j.molcel.2013.08.003
Ishida, 2021, Sulforaphane Ameliorates Ethanol Plus Carbon Tetrachloride-Induced Liver Fibrosis in Mice through the Nrf2-Mediated Antioxidant Response and Acetaldehyde Metabolization with Inhibition of the LPS/TLR4 Signaling Pathway, J. Nutr. Biochem., 89, 108573, 10.1016/j.jnutbio.2020.108573
Itoh, 1997, An Nrf2/small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements, Biochem. Biophysical Res. Commun., 236, 313, 10.1006/bbrc.1997.6943
Itoh, 1999, Keap1 Represses Nuclear Activation of Antioxidant Responsive Elements by Nrf2 through Binding to the Amino-Terminal Neh2 Domain, Genes Dev., 13, 76, 10.1101/gad.13.1.76
Ivanov, 2015, HCV Core Protein Uses Multiple Mechanisms to Induce Oxidative Stress in Human Hepatoma Huh7 Cells, Viruses, 7, 2745, 10.3390/v7062745
Ivanov, 2011, Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-dependent and Independent Mechanisms in HUH7 Cells, PLoS One, 6, e24957, 10.1371/journal.pone.0024957
Jain, 2010, p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-Driven Gene Transcription, J. Biol. Chem., 285, 22576, 10.1074/jbc.M110.118976
Kaffe, 2015, Oxidative Stress and Antioxidant Status in Patients with Autoimmune Liver Diseases, Redox Rep., 20, 33, 10.1179/1351000214Y.0000000101
Kaplowitz, 2015, Targeting Signal Transduction Pathways Which Regulate Necrosis in Acetaminophen Hepatotoxicity, J. Hepatol., 63, 5, 10.1016/j.jhep.2015.02.050
Katoh, 2005, Evolutionary Conserved N-Terminal Domain of Nrf2 Is Essential for the Keap1-Mediated Degradation of the Protein by Proteasome, Arch. Biochem. Biophys., 433, 342, 10.1016/j.abb.2004.10.012
Katoh, 2001, Two Domains of Nrf2 Cooperatively Bind CBP, a CREB Binding Protein, and Synergistically Activate Transcription, Genes Cells, 6, 857, 10.1046/j.1365-2443.2001.00469.x
Katsuoka, 2005, Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response Element-dependent Genes, Mol. Cel Biol, 25, 8044, 10.1128/MCB.25.18.8044-8051.2005
Kawata, 2010, Enhanced Hepatic Nrf2 Activation after Ursodeoxycholic Acid Treatment in Patients with Primary Biliary Cirrhosis, Antioxid. Redox Signaling, 13, 259, 10.1089/ars.2009.2903
Kensler, 2007, Cell Survival Responses to Environmental Stresses via the Keap1-Nrf2-ARE Pathway, Annu. Rev. Pharmacol. Toxicol., 47, 89, 10.1146/annurev.pharmtox.46.120604.141046
Kerins, 2018, A Catalogue of Somatic NRF2 Gain-Of-Function Mutations in Cancer, Sci. Rep., 8, 12846, 10.1038/s41598-018-31281-0
Kikuchi, 2015, Sulforaphane-rich Broccoli Sprout Extract Improves Hepatic Abnormalities in Male Subjects, World J. Gastroenterol., 21, 12457, 10.3748/wjg.v21.i43.12457
Kim, 2020, Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte, Nutrients, 12, 3585, 10.3390/nu12113585
Kobayashi, 2004, Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase to Regulate Proteasomal Degradation of Nrf2, Mol. Cel Biol, 24, 7130, 10.1128/MCB.24.16.7130-7139.2004
Kobayashi, 2006, Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1, Mol. Cel Biol, 26, 221, 10.1128/MCB.26.1.221-229.2006
Kobayashi, 2002, Identification of the Interactive Interface and Phylogenic Conservation of the Nrf2-Keap1 System, Genes Cells, 7, 807, 10.1046/j.1365-2443.2002.00561.x
Komatsu, 2010, The Selective Autophagy Substrate P62 Activates the Stress Responsive Transcription Factor Nrf2 through Inactivation of Keap1, Nat. Cel Biol, 12, 213, 10.1038/ncb2021
Kudo, 2020, Pkcλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression, Cancer Cell, 38, 247, 10.1016/j.ccell.2020.05.018
Lee, 2020, SQSTM1/p62 Activates NFE2L2/NRF2 via ULK1-Mediated Autophagic KEAP1 Degradation and Protects Mouse Liver from Lipotoxicity, Autophagy, 16, 1949, 10.1080/15548627.2020.1712108
Li, 2014, Activation of Nrf2 Protects against Triptolide-Induced Hepatotoxicity, PLoS One, 9, e100685, 10.1371/journal.pone.0100685
Li, 2006, Peroxynitrite Induces HO-1 Expression via PI3K/Akt-dependent Activation of NF-E2-Related Factor 2 in PC12 Cells, Free Radic. Biol. Med., 41, 1079, 10.1016/j.freeradbiomed.2006.06.010
Li, 2019, Protective Effect of Herbal Medicine Huangqi Decoction against Chronic Cholestatic Liver Injury by Inhibiting Bile Acid-Stimulated Inflammation in DDC-Induced Mice, Phytomedicine, 62, 152948, 10.1016/j.phymed.2019.152948
Lieber, 1970, Hepatic Microsomal Ethanol Oxidizing System (MEOS): Differentiation from Alcohol Dehydrogenase and NADPH Oxidase, Biochem. Biophysical Res. Commun., 40, 858, 10.1016/0006-291x(70)90982-4
Linker, 2011, Fumaric Acid Esters Exert Neuroprotective Effects in Neuroinflammation via Activation of the Nrf2 Antioxidant Pathway, Brain, 134, 678, 10.1093/brain/awq386
Liu, 2015, Hepatitis B Virus Stimulates G6PD Expression through HBx-Mediated Nrf2 Activation, Cell Death Dis, 6, e1980, 10.1038/cddis.2015.322
Liu, 2020, TRIM25 Promotes the Cell Survival and Growth of Hepatocellular Carcinoma through Targeting Keap1-Nrf2 Pathway, Nat. Commun., 11, 348, 10.1038/s41467-019-14190-2
Lu, 2010, Chronic Alcohol-Induced Liver Injury and Oxidant Stress Are Decreased in Cytochrome P4502E1 Knockout Mice and Restored in Humanized Cytochrome P4502E1 Knock-In Mice, Free Radic. Biol. Med., 49, 1406, 10.1016/j.freeradbiomed.2010.07.026
Mansouri, 2018, Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases, Gastroenterology, 155, 629, 10.1053/j.gastro.2018.06.083
Martin, 2004, Regulation of Heme Oxygenase-1 Expression through the Phosphatidylinositol 3-kinase/Akt Pathway and the Nrf2 Transcription Factor in Response to the Antioxidant Phytochemical Carnosol, J. Biol. Chem., 279, 8919, 10.1074/jbc.M309660200
Mitsuishi, 2012, Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming, Cancer Cell, 22, 66, 10.1016/j.ccr.2012.05.016
Mohs, 2021, Hepatocyte-specific NRF2 Activation Controls Fibrogenesis and Carcinogenesis in Steatohepatitis, J. Hepatol., 74, 638, 10.1016/j.jhep.2020.09.037
Moi, 1994, Isolation of NF-E2-Related Factor 2 (Nrf2), a NF-E2-like Basic Leucine Zipper Transcriptional Activator that Binds to the Tandem NF-E2/ap1 Repeat of the Beta-Globin Locus Control Region, Proc. Natl. Acad. Sci., 91, 9926, 10.1073/pnas.91.21.9926
Ogura, 2010, Keap1 Is a Forked-Stem Dimer Structure with Two Large Spheres Enclosing the Intervening, Double glycine Repeat, and C-Terminal Domains, Proc. Natl. Acad. Sci., 107, 2842, 10.1073/pnas.0914036107
Otani, 2005, Hepatitis C Virus Core Protein, Cytochrome P450 2E1, and Alcohol Produce Combined Mitochondrial Injury and Cytotoxicity in Hepatoma Cells, Gastroenterology, 128, 96, 10.1053/j.gastro.2004.10.045
Padmanabhan, 2006, Structural Basis for Defects of Keap1 Activity Provoked by its point Mutations in Lung Cancer, Mol. Cel, 21, 689, 10.1016/j.molcel.2006.01.013
Rada, 2012, Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/-TrCP Axis, Mol. Cell Biol., 32, 3486, 10.1128/MCB.00180-12
Reisman, 2009, CDDO-im Protects from Acetaminophen Hepatotoxicity through Induction of Nrf2-dependent Genes, Toxicol. Appl. Pharmacol., 236, 109, 10.1016/j.taap.2008.12.024
Ruart, 2019, Impaired Endothelial Autophagy Promotes Liver Fibrosis by Aggravating the Oxidative Stress Response during Acute Liver Injury, J. Hepatol., 70, 458, 10.1016/j.jhep.2018.10.015
Rushing, 2019, Aflatoxin B1: A Review on Metabolism, Toxicity, Occurrence in Food, Occupational Exposure, and Detoxification Methods, Food Chem. Toxicol., 124, 81, 10.1016/j.fct.2018.11.047
Rushmore, 1990, Transcriptional Regulation of the Rat Glutathione S-Transferase Ya Subunit Gene. Characterization of a Xenobiotic-Responsive Element Controlling Inducible Expression by Phenolic Antioxidants, J. Biol. Chem., 265, 14648, 10.1016/s0021-9258(18)77351-1
Ryter, 2016, Targeting Heme Oxygenase-1 and Carbon Monoxide for Therapeutic Modulation of Inflammation, Translational Res., 167, 7, 10.1016/j.trsl.2015.06.011
Salazar, 2006, Glycogen Synthase Kinase-3β Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2, J. Biol. Chem., 281, 14841, 10.1074/jbc.M513737200
Sano, 2021, Steatotic Hepatocytes Release Mature VLDL through Methionine and Tyrosine Metabolism in a Keap1‐Nrf2-dependent Manner, Hepatology, 74, 1271, 10.1002/hep.31808
Schaedler, 2010, Hepatitis B Virus Induces Expression of Antioxidant Response Element-Regulated Genes by Activation of Nrf2, J. Biol. Chem., 285, 41074, 10.1074/jbc.M110.145862
Shearn, 2019, Cholestatic Liver Disease Results Increased Production of Reactive Aldehydes and an Atypical Periportal Hepatic Antioxidant Response, Free Radic. Biol. Med., 143, 101, 10.1016/j.freeradbiomed.2019.07.036
Shen, 2019, Aucubin Inhibited Lipid Accumulation and Oxidative Stress via Nrf2/HO ‐1 and AMPK Signalling Pathways, J. Cel Mol Med, 23, 4063, 10.1111/jcmm.14293
Shen, 2018, Caffeic Acid Inhibits HCV Replication via Induction of IFNα Antiviral Response through P62-Mediated Keap1/Nrf2 Signaling Pathway, Antiviral Res., 154, 166, 10.1016/j.antiviral.2018.04.008
Shen, 2019, Incidence and Etiology of Drug-Induced Liver Injury in Mainland China, Gastroenterology, 156, 2230, 10.1053/j.gastro.2019.02.002
Shin, 2009, Role of Nrf2 in Prevention of High-Fat Diet-Induced Obesity by Synthetic Triterpenoid CDDO-Imidazolide, Eur. J. Pharmacol., 620, 138, 10.1016/j.ejphar.2009.08.022
Smirnova, 2016, Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1, Oxidative Med. Cell Longevity, 2016, 1, 10.1155/2016/8341937
Sunny, 2017, Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies, Trends Endocrinol. Metab., 28, 250, 10.1016/j.tem.2016.11.006
Svegliati Baroni, 1998, Fibrogenic Effect of Oxidative Stress on Rat Hepatic Stellate Cells, Hepatology, 27, 720, 10.1002/hep.510270313
Taguchi, 2012, Keap1 Degradation by Autophagy for the Maintenance of Redox Homeostasis, Proc. Natl. Acad. Sci., 109, 13561, 10.1073/pnas.1121572109
Taguchi, 2016, Generation of a New Model Rat:Nrf2Knockout Rats Are Sensitive to Aflatoxin B1Toxicity, Toxicol. Sci., 152, 40, 10.1093/toxsci/kfw065
Tong, 2006, Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model, Mol. Cel Biol, 26, 2887, 10.1128/MCB.26.8.2887-2900.2006
Tseng, 2017, Celastrol Inhibits Hepatitis C Virus Replication by Upregulating Heme Oxygenase-1 via the JNK MAPK/Nrf2 Pathway in Human Hepatoma Cells, Antiviral Res., 146, 191, 10.1016/j.antiviral.2017.09.010
Turrens, 2003, Mitochondrial Formation of Reactive Oxygen Species, J. Physiol., 552, 335, 10.1113/jphysiol.2003.049478
van Rongen, 2016, Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen, Clin. Pharmacokinet., 55, 833, 10.1007/s40262-015-0357-0
Xu, 2019, Protective Effect of Vitamin C on Triptolide-Induced Acute Hepatotoxicity in Mice through Mitigation of Oxidative Stress, Acad. Bras. Ciênc., 91, e20181257, 10.1590/0001-3765201920181257
Xu, 2008, The Nrf2 Transcription Factor Protects from Toxin-Induced Liver Injury and Fibrosis, Lab. Invest., 88, 1068, 10.1038/labinvest.2008.75
Yamamoto, 2018, The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis, Physiol. Rev., 98, 1169, 10.1152/physrev.00023.2017
Yan, 2018, Curcumin Regulates Endogenous and Exogenous Metabolism via Nrf2-FXR-LXR Pathway in NAFLD Mice, Biomed. Pharmacother., 105, 274, 10.1016/j.biopha.2018.05.135
Yan, 2018, Natural Product Andrographolide Alleviated APAP-Induced Liver Fibrosis by Activating Nrf2 Antioxidant Pathway, Toxicology, 1, 10.1016/j.tox.2018.01.007
Yang, 2020, Limonin Ameliorates Acetaminophen-Induced Hepatotoxicity by Activating Nrf2 Antioxidative Pathway and Inhibiting NF-Κb Inflammatory Response via Upregulating Sirt1, Phytomedicine, 69, 153211, 10.1016/j.phymed.2020.153211
Yang, 2020, Study on the Attenuated Effect of Ginkgolide B on Ferroptosis in High Fat Diet Induced Nonalcoholic Fatty Liver Disease, Toxicology, 445, 152599, 10.1016/j.tox.2020.152599
You, 2018, SNX10 Mediates Alcohol-Induced Liver Injury and Steatosis by Regulating the Activation of Chaperone-Mediated Autophagy, J. Hepatol., 69, 129, 10.1016/j.jhep.2018.01.038
Yu, 2016, Sulforaphane Suppresses Hepatitis C Virus Replication by Up-Regulating Heme Oxygenase-1 Expression through PI3K/Nrf2 Pathway, PLoS One, 11, e0152236, 10.1371/journal.pone.0152236
Yu, 2014, High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes Are Two Important Predictors of Drug-Induced Liver Injury, Drug Metab. Dispos, 42, 744, 10.1124/dmd.113.056267
Zhao, 2015, Dihydroquercetin (DHQ) Ameliorated Concanavalin A-Induced Mouse Experimental Fulminant Hepatitis and Enhanced HO-1 Expression through MAPK/Nrf2 Antioxidant Pathway in RAW Cells, Int. Immunopharmacology, 28, 938, 10.1016/j.intimp.2015.04.032