The Novel γ Secretase Inhibitor <i>N</i>-[<i>cis</i>-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse

Journal of Pharmacology and Experimental Therapeutics - Tập 320 Số 2 - Trang 552-558 - 2007
Jonathan D. Best1, David W. Smith, Michael Reilly, Ruth O’Donnell, Huw D. Lewis, Semantha Ellis, Neil Wilkie, Thomas W. Rosahl, Philippe A Laroque, Christine Boussiquet-Leroux, Ian Churcher, John Atack, Timothy Harrison, Mark S. Shearman
1Department of In Vivo Neuroscience, Merck Sharp And Dohme, Neurosciene Research Centre, Harlow, UK. [email protected]

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